KR920000772A - 2-테트라하이드로푸란 유도체의 에난티오머, 이들의 중간체 및 이들의 제조방법 - Google Patents
2-테트라하이드로푸란 유도체의 에난티오머, 이들의 중간체 및 이들의 제조방법 Download PDFInfo
- Publication number
- KR920000772A KR920000772A KR1019910010079A KR910010079A KR920000772A KR 920000772 A KR920000772 A KR 920000772A KR 1019910010079 A KR1019910010079 A KR 1019910010079A KR 910010079 A KR910010079 A KR 910010079A KR 920000772 A KR920000772 A KR 920000772A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- tetrahydrofuran
- enantiomers
- enantiomer
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title claims 4
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- IXZHWGJCHBDVLV-UHFFFAOYSA-N C(CCC)(=O)O.C(CCC)(=O)O.OCC1(OCCC1)CO Chemical compound C(CCC)(=O)O.C(CCC)(=O)O.OCC1(OCCC1)CO IXZHWGJCHBDVLV-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000010511 deprotection reaction Methods 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- -1 2-octadecyloxymethyl tetrahydrofuran-2-ylmethoxy Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 하기 일반식(I)의 화합물, 즉, (R)-2-[(2-옥타데실옥시메틸 테트라하이드로푸란-2-일메톡시)하이드록시포스피닐옥시]-N,N,N-트리메틸에탄아미늄 하이드록사이드 내부염-4-옥사이드 및 그의 에난티오머
- 제1항에서 정의된 바와 같은 일반식(I)의 화합물.
- 제1항에서 정의된 바와 같은 일반식(I)의 화합물의 에난티오머.
- 하기 일반식(Ⅱ)의 (R)-2,2-비스(하이드록시메틸)테트라하이드로 푸란 모노부-티레이트를, 경우에 따라서는 중간체 보호 및 탈보호 단계와 함께, 옥타데실화시키고 포스포릴콜린화(phosphoryl cholinating)시킴을 포함하는, 제1항에서 정의된 바와 같은 일반식(I)의 화합물 및 그의 에난티오머의 제조방법.
- 제4항에 있어서, 다음 반응순서에 따라 일반식(I)의 화합물을 제조하는 방법.보호된 형태의 일반식(Ⅱ)의 화합물.일반식(I)의 화합물
- 제4항에 있어서, 다음 반응순서에 따라 일반식(I) 화합물의 에난티오머를 제조하는 방법.일반식(I)화합물의 에난티오머
- 제1항에 정의된 바와 같은 일반식(I)의 화합물 또는 그의 에난티오머를 적어도 하나의 약제학적으로 허용 가능한 담체 또는 희석제와 함께 포함하는 약제학적 조성물.
- 유리 형태 또는 보호된 형태의 하기 일반식(Ⅱ)의 (R)-2,2-비스(하이드록시메틸)테트라하이드로푸란 모노부티레이트.
- 하기 일반식(Ⅲ)의 2,2-비스(하이드록시메틸)테트라하이드로푸란 디부티레이트를 에난티오특이적 모노 가수분해시키고, 임의로는 생성된 유리 형태의 일반식(Ⅱ)의 화합물을 보호함을 포함하는, 제8항에 따른 화합물의 제조방법.
- 제8항에 따른 화합물의 중간체로서의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54043890A | 1990-06-19 | 1990-06-19 | |
US540,438 | 1990-06-19 | ||
US64739691A | 1991-01-29 | 1991-01-29 | |
US647396 | 1991-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920000772A true KR920000772A (ko) | 1992-01-29 |
Family
ID=27066435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910010079A KR920000772A (ko) | 1990-06-19 | 1991-06-18 | 2-테트라하이드로푸란 유도체의 에난티오머, 이들의 중간체 및 이들의 제조방법 |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0462935B1 (ko) |
JP (1) | JP2709330B2 (ko) |
KR (1) | KR920000772A (ko) |
AT (1) | ATE125261T1 (ko) |
AU (2) | AU649681B2 (ko) |
CA (1) | CA2044786A1 (ko) |
CS (1) | CS185191A3 (ko) |
DE (1) | DE69111311T2 (ko) |
DK (1) | DK0462935T3 (ko) |
ES (1) | ES2076502T3 (ko) |
FI (1) | FI912964A (ko) |
GR (1) | GR3017437T3 (ko) |
HK (1) | HK111996A (ko) |
HU (1) | HU210548B (ko) |
IE (1) | IE68417B1 (ko) |
IL (1) | IL98524A (ko) |
MY (1) | MY107022A (ko) |
NZ (1) | NZ238573A (ko) |
PL (1) | PL164981B1 (ko) |
PT (1) | PT97994B (ko) |
TW (1) | TW255897B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5208352A (en) * | 1992-04-02 | 1993-05-04 | Sandoz Ltd. | Process for preparing the R- and S-isomers of 2-hydroxy-methyl-2-octadecyloxymethyl-tetrahydrofuran and their use in preparing stereoisomers of pharmacologically active compounds |
EP0973181B1 (en) * | 1998-07-17 | 2002-10-09 | Fuji Photo Film Co., Ltd. | Photoelectric conversion device and photoelectrochemical cell |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0178261A3 (en) * | 1984-10-10 | 1986-12-30 | Sandoz Ag | Substituted 2-furanyl or 5-oxo-2-furanyl-alkoxy phosphoryl alkyl cyclimmonium salts |
US4601987A (en) * | 1985-02-27 | 1986-07-22 | Massachusetts Institute Of Technology | Enzymatic production of optical isomers of 2-halopropionic acids |
EP0213082B1 (en) * | 1985-08-30 | 1989-10-18 | Sandoz Ag | Substituted hydroxy-heterocyclyl-alkoxy phosphinyloxy trialkylaminium hydroxide inner salt oxides, processes for their preparation and their use as pharmaceuticals |
US4673672A (en) | 1985-10-28 | 1987-06-16 | Sandoz Pharmaceuticals Corp. | Substituted-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl)alkoxyphosphinyloxy]-alkanaminium hydroxide, inner salt oxides |
US4868319A (en) * | 1987-12-22 | 1989-09-19 | Sandoz Pharm. Corp. | Process for the preparation of monoalkylcarbamate group-containing compounds |
-
1991
- 1991-06-06 HU HU911882A patent/HU210548B/hu not_active IP Right Cessation
- 1991-06-17 PT PT97994A patent/PT97994B/pt not_active IP Right Cessation
- 1991-06-17 IL IL9852491A patent/IL98524A/en not_active IP Right Cessation
- 1991-06-17 CA CA002044786A patent/CA2044786A1/en not_active Abandoned
- 1991-06-17 CS CS911851A patent/CS185191A3/cs unknown
- 1991-06-17 AU AU78439/91A patent/AU649681B2/en not_active Ceased
- 1991-06-17 NZ NZ238573A patent/NZ238573A/en unknown
- 1991-06-18 PL PL91290719A patent/PL164981B1/pl unknown
- 1991-06-18 KR KR1019910010079A patent/KR920000772A/ko not_active Application Discontinuation
- 1991-06-18 FI FI912964A patent/FI912964A/fi not_active Application Discontinuation
- 1991-06-18 JP JP3173245A patent/JP2709330B2/ja not_active Expired - Lifetime
- 1991-06-18 MY MYPI91001089A patent/MY107022A/en unknown
- 1991-06-18 IE IE208191A patent/IE68417B1/en not_active IP Right Cessation
- 1991-06-19 DE DE69111311T patent/DE69111311T2/de not_active Expired - Fee Related
- 1991-06-19 ES ES91810477T patent/ES2076502T3/es not_active Expired - Lifetime
- 1991-06-19 EP EP91810477A patent/EP0462935B1/en not_active Expired - Lifetime
- 1991-06-19 DK DK91810477.9T patent/DK0462935T3/da active
- 1991-06-19 AT AT91810477T patent/ATE125261T1/de not_active IP Right Cessation
- 1991-07-09 TW TW080105309A patent/TW255897B/zh active
-
1994
- 1994-08-23 AU AU71407/94A patent/AU677403B2/en not_active Ceased
-
1995
- 1995-09-18 GR GR950402562T patent/GR3017437T3/el unknown
-
1996
- 1996-06-27 HK HK111996A patent/HK111996A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI912964A (fi) | 1991-12-20 |
JPH04270276A (ja) | 1992-09-25 |
AU7140794A (en) | 1994-11-03 |
ATE125261T1 (de) | 1995-08-15 |
FI912964A0 (fi) | 1991-06-18 |
PL164981B1 (pl) | 1994-10-31 |
IL98524A (en) | 1995-12-31 |
DK0462935T3 (da) | 1995-11-06 |
AU677403B2 (en) | 1997-04-24 |
PT97994B (pt) | 1998-11-30 |
TW255897B (ko) | 1995-09-01 |
IE912081A1 (en) | 1992-01-01 |
NZ238573A (en) | 1993-11-25 |
HUT58340A (en) | 1992-02-28 |
DE69111311T2 (de) | 1996-03-14 |
EP0462935A1 (en) | 1991-12-27 |
IE68417B1 (en) | 1996-06-12 |
CA2044786A1 (en) | 1991-12-20 |
PL290719A1 (en) | 1992-07-27 |
EP0462935B1 (en) | 1995-07-19 |
IL98524A0 (en) | 1992-07-15 |
AU649681B2 (en) | 1994-06-02 |
ES2076502T3 (es) | 1995-11-01 |
PT97994A (pt) | 1992-03-31 |
HU210548B (en) | 1995-05-29 |
CS185191A3 (en) | 1992-01-15 |
DE69111311D1 (de) | 1995-08-24 |
AU7843991A (en) | 1992-01-02 |
JP2709330B2 (ja) | 1998-02-04 |
GR3017437T3 (en) | 1995-12-31 |
HK111996A (en) | 1996-07-05 |
MY107022A (en) | 1995-08-30 |
HU911882D0 (en) | 1991-12-30 |
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