KR850008665A - 시클로알칸-인덴-카르복시미드아미드 유도체의 제조방법 - Google Patents

시클로알칸-인덴-카르복시미드아미드 유도체의 제조방법 Download PDF

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Publication number
KR850008665A
KR850008665A KR1019850003600A KR850003600A KR850008665A KR 850008665 A KR850008665 A KR 850008665A KR 1019850003600 A KR1019850003600 A KR 1019850003600A KR 850003600 A KR850003600 A KR 850003600A KR 850008665 A KR850008665 A KR 850008665A
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KR
South Korea
Prior art keywords
compound
formula
alkyl
hydrogen
acid addition
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KR1019850003600A
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English (en)
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비츠 톰
Original Assignee
에이.지. 제이. 베르메렌, 에이. 디. 도우마
아크조엔. 브이
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Application filed by 에이.지. 제이. 베르메렌, 에이. 디. 도우마, 아크조엔. 브이 filed Critical 에이.지. 제이. 베르메렌, 에이. 디. 도우마
Publication of KR850008665A publication Critical patent/KR850008665A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/16—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용없음

Description

시클로알칸-인덴-카르복시미드아미드 유도체의 제조방법
내용없음

Claims (3)

  1. 일반식(I)의 화합물 및 그것의 약학적으로 알맞은 염을 활성성분으로서 함유하는 약학적 조성물.
    상기식에서, Ry1이나Ry2와 함께 Rx는 성분을 나타내고(다른 Ry는 수소이다)
    n은 1,2 또는 3, R은 수소 또는 (1-4c)-알킬기, R1은수소, (1-4c)-알킬, 히드록실, (1-4c)-알콕시 또는 (1-4c)-알킬에 의해서 비치환되거나 치환된 아미노기, R2는 수소, 히드록실 또는 (1-4c)-알킬이다.
  2. 유사한 화합물에 대한 공지방법으로 제조함을 특징으로 하는 일반식(I)의 화합물을 제조하는 방법.
    상기식에서, Rx,Ry1,Ry2,n,R,R1,R2는 전술한 바와 같다.
  3. 제2항에 있어서, 일반식(Ⅱ)의 화합물이나 그의 산부가염을 일반식(Ⅲ)의 화합물이나 그것의 산부가염과 축합반응시키고, 또는 일반식(Ⅳ)의 화합물을 일반식(Ⅲ)의 화합물이나, 그것의 산부가염과 반응시킨 후, 질소원자나 히드록실기로 알킬화하고, 분리된 광학 에난티오머로 용해시키고 그것의 약학적으로 알맞은 염으로 전환시킴을 특징으로 하는 일반식(I)의 화합물을 제조하는 방법.
    상기식에서, Rx,Ry1,Ry2,R,n 및 R1은 전술한 바와같고, R2`는 (1-4c)-알킬에 의해서 비치환 되거나 치환된 아미노기인 것 외에는 R2와 동일하고, Z는 산소 또는 황 원자이고, R0는 저급알킬기, 바람직하게 메틸 또는 에틸.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003600A 1984-05-24 1985-05-24 시클로알칸-인덴-카르복시미드아미드 유도체의 제조방법 KR850008665A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8401653 1984-05-24
NL84.01653 1984-05-24

Publications (1)

Publication Number Publication Date
KR850008665A true KR850008665A (ko) 1985-12-21

Family

ID=19843996

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003600A KR850008665A (ko) 1984-05-24 1985-05-24 시클로알칸-인덴-카르복시미드아미드 유도체의 제조방법

Country Status (5)

Country Link
JP (1) JPS617244A (ko)
KR (1) KR850008665A (ko)
CA (1) CA1254230A (ko)
ES (1) ES8704884A1 (ko)
ZA (1) ZA853764B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007086559A1 (ja) * 2006-01-27 2007-08-02 Ube Industries, Ltd. テトラヒドロピラン化合物の製造方法

Also Published As

Publication number Publication date
ES543440A0 (es) 1987-04-16
ZA853764B (en) 1986-01-29
ES8704884A1 (es) 1987-04-16
CA1254230A (en) 1989-05-16
JPS617244A (ja) 1986-01-13

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