DE69111311D1 - 2-Tetrahydrofuran-Enantiomerderivate, Zwischenprodukte davon und ihre Herstellung. - Google Patents

2-Tetrahydrofuran-Enantiomerderivate, Zwischenprodukte davon und ihre Herstellung.

Info

Publication number
DE69111311D1
DE69111311D1 DE69111311T DE69111311T DE69111311D1 DE 69111311 D1 DE69111311 D1 DE 69111311D1 DE 69111311 T DE69111311 T DE 69111311T DE 69111311 T DE69111311 T DE 69111311T DE 69111311 D1 DE69111311 D1 DE 69111311D1
Authority
DE
Germany
Prior art keywords
compound
formula
tetrahydrofuran
enantiomer
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69111311T
Other languages
English (en)
Other versions
DE69111311T2 (de
Inventor
Heinrich Estermann
William Joseph Houlihan
Prasad Koteswara Kapa
Russell Lee Underwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Sandoz Patent GmbH
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Application granted granted Critical
Publication of DE69111311D1 publication Critical patent/DE69111311D1/de
Publication of DE69111311T2 publication Critical patent/DE69111311T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69111311T 1990-06-19 1991-06-19 2-Tetrahydrofuran-Enantiomerderivate, Zwischenprodukte davon und ihre Herstellung. Expired - Fee Related DE69111311T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54043890A 1990-06-19 1990-06-19
US64739691A 1991-01-29 1991-01-29

Publications (2)

Publication Number Publication Date
DE69111311D1 true DE69111311D1 (de) 1995-08-24
DE69111311T2 DE69111311T2 (de) 1996-03-14

Family

ID=27066435

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69111311T Expired - Fee Related DE69111311T2 (de) 1990-06-19 1991-06-19 2-Tetrahydrofuran-Enantiomerderivate, Zwischenprodukte davon und ihre Herstellung.

Country Status (21)

Country Link
EP (1) EP0462935B1 (de)
JP (1) JP2709330B2 (de)
KR (1) KR920000772A (de)
AT (1) ATE125261T1 (de)
AU (2) AU649681B2 (de)
CA (1) CA2044786A1 (de)
CS (1) CS185191A3 (de)
DE (1) DE69111311T2 (de)
DK (1) DK0462935T3 (de)
ES (1) ES2076502T3 (de)
FI (1) FI912964A (de)
GR (1) GR3017437T3 (de)
HK (1) HK111996A (de)
HU (1) HU210548B (de)
IE (1) IE68417B1 (de)
IL (1) IL98524A (de)
MY (1) MY107022A (de)
NZ (1) NZ238573A (de)
PL (1) PL164981B1 (de)
PT (1) PT97994B (de)
TW (1) TW255897B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208352A (en) * 1992-04-02 1993-05-04 Sandoz Ltd. Process for preparing the R- and S-isomers of 2-hydroxy-methyl-2-octadecyloxymethyl-tetrahydrofuran and their use in preparing stereoisomers of pharmacologically active compounds
DE69903381T2 (de) * 1998-07-17 2003-06-18 Fuji Photo Film Co Ltd Photozelle und photoelektrochemische Zelle

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0178261A3 (de) * 1984-10-10 1986-12-30 Sandoz Ag Substituierte 2-Furanyl- oder -5-Oxo-2-furanyl-alkoxy-phosphorylalkylcyclimmoniumsalze
US4601987A (en) * 1985-02-27 1986-07-22 Massachusetts Institute Of Technology Enzymatic production of optical isomers of 2-halopropionic acids
EP0213082B1 (de) * 1985-08-30 1989-10-18 Sandoz Ag Substituierte Hydroxy-heterocyclyl-alkoxy-phosphinyloxy-trialkylaminium-hydroxid-Innersalzoxyde, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US4673672A (en) 1985-10-28 1987-06-16 Sandoz Pharmaceuticals Corp. Substituted-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl)alkoxyphosphinyloxy]-alkanaminium hydroxide, inner salt oxides
US4868319A (en) * 1987-12-22 1989-09-19 Sandoz Pharm. Corp. Process for the preparation of monoalkylcarbamate group-containing compounds

Also Published As

Publication number Publication date
EP0462935B1 (de) 1995-07-19
AU649681B2 (en) 1994-06-02
KR920000772A (ko) 1992-01-29
HU911882D0 (en) 1991-12-30
PL164981B1 (pl) 1994-10-31
NZ238573A (en) 1993-11-25
PT97994A (pt) 1992-03-31
MY107022A (en) 1995-08-30
FI912964A (fi) 1991-12-20
DE69111311T2 (de) 1996-03-14
EP0462935A1 (de) 1991-12-27
HUT58340A (en) 1992-02-28
HU210548B (en) 1995-05-29
ATE125261T1 (de) 1995-08-15
JPH04270276A (ja) 1992-09-25
AU677403B2 (en) 1997-04-24
DK0462935T3 (da) 1995-11-06
FI912964A0 (fi) 1991-06-18
IE68417B1 (en) 1996-06-12
CS185191A3 (en) 1992-01-15
IL98524A0 (en) 1992-07-15
PL290719A1 (en) 1992-07-27
AU7140794A (en) 1994-11-03
AU7843991A (en) 1992-01-02
IE912081A1 (en) 1992-01-01
TW255897B (de) 1995-09-01
CA2044786A1 (en) 1991-12-20
JP2709330B2 (ja) 1998-02-04
ES2076502T3 (es) 1995-11-01
HK111996A (en) 1996-07-05
GR3017437T3 (en) 1995-12-31
IL98524A (en) 1995-12-31
PT97994B (pt) 1998-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee