ES2053133T3 - Nuevas sulfonamidas derivadas de acidos benzociclicos o benzoheterociclicos, su preparacion y su aplicacion en terapeutica. - Google Patents

Nuevas sulfonamidas derivadas de acidos benzociclicos o benzoheterociclicos, su preparacion y su aplicacion en terapeutica.

Info

Publication number
ES2053133T3
ES2053133T3 ES90400923T ES90400923T ES2053133T3 ES 2053133 T3 ES2053133 T3 ES 2053133T3 ES 90400923 T ES90400923 T ES 90400923T ES 90400923 T ES90400923 T ES 90400923T ES 2053133 T3 ES2053133 T3 ES 2053133T3
Authority
ES
Spain
Prior art keywords
branched
radical
lower alkyl
substituted
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400923T
Other languages
English (en)
Inventor
Dennis Bigg
Alain Duflos
Jean-Pierre Rieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Application granted granted Critical
Publication of ES2053133T3 publication Critical patent/ES2053133T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVAS SULFONAMIDAS DERIVADAS DE ACIDOS BENZOCICLICOS O BENZOHETEROCICLICOS Y SUS DERIVADOS DE FORMULA GENERAL (I), EN LA QUE R ES UN RADICAL ALCOHILO INFERIOR DE 1 A 9 C LINEAL O RAMIFICADO; UN RADICAL FENILO SUSTITUIDO O NO POR UNO O VARIOS GRUPOS; ALCOHILO INFERIOR RAMIFICADO O NO DE 1 A 4 C, HALOGENO, ALCOHILOXI, NITRO, AMINO, DIALQUILAMINO, CF3; UN NAFTALENO SUSTITUIDO O NO; UN RADICAL TIOFENILO; R1 ES HIDROGENOO UN ALCOHILO INFERIOR RAMIFICADO O NO, BENCILO; R2 ES HIDROGENO, GRUPO ALCOHILO INFERIOR RAMIFICADO O NO, GRUPO FENILO SUSTITUIDO O NO, GRUPO ARILALCOHILO; R3 ES HIDROGENO O UN ALCOHILO INFERIOR, RAMIFICADO O NO (1 A 6 C); X ES UN RADICAL FUNCIONAL DIVALENTE ELEGIDO ENTRE LOS SIGUIENTES: -CH2-; -CH-OR4; -C=O; -C=N-OR4; Y RADICAL DE FORMULA: (FIG. A), CON R4 = H O ME; CON -X- DIFERENTE DE -CH2- CUANDO -A- REPRESENTA RADICALES DIVALENTES DE FORMULAS (A), (B), (C), (D) Y (E). -A- REPRESENTA UN RADICAL DIVALENTE BENZOCICLICO ELEGIDO ENTRE LOS REPRESENTADOS POR LAS FORMULAS (A) A (J); N PUEDE TOMAR LOS VALORES DE 1 A 4 INCLUSIVE; ASI COMO LAS SALES ORGANICAS O MINERALES (R3 = H) TERAPEUTICAMENTE ACEPTABLES, LOS ISOMEROS O DIASTEREOISOMEROS PUROS O SUS MEZCLAS Y TODAS LAS COMPOSICIONES FARMACEUTICAS DE FORMULA (I) CON OTROS PRINCIPIOS ACTIVOS. LA INVENCION SE REFIERE A LA APLICACION DE (I) COMO MEDICAMENTO Y A LOS PROCEDIMIENTO DE OBTENCION.
ES90400923T 1989-04-05 1990-04-04 Nuevas sulfonamidas derivadas de acidos benzociclicos o benzoheterociclicos, su preparacion y su aplicacion en terapeutica. Expired - Lifetime ES2053133T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR898904470A FR2645537B1 (fr) 1989-04-05 1989-04-05 Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2053133T3 true ES2053133T3 (es) 1994-07-16

Family

ID=9380405

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400923T Expired - Lifetime ES2053133T3 (es) 1989-04-05 1990-04-04 Nuevas sulfonamidas derivadas de acidos benzociclicos o benzoheterociclicos, su preparacion y su aplicacion en terapeutica.

Country Status (14)

Country Link
US (1) US5385931A (es)
EP (1) EP0391799B1 (es)
JP (1) JPH03505335A (es)
AT (1) ATE81337T1 (es)
AU (1) AU624951B2 (es)
CA (1) CA2030566A1 (es)
DE (1) DE69000364T2 (es)
DK (1) DK0391799T3 (es)
ES (1) ES2053133T3 (es)
FR (1) FR2645537B1 (es)
GR (1) GR3006746T3 (es)
HU (2) HU210746B (es)
WO (1) WO1990012007A1 (es)
ZA (1) ZA902633B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2105067C (en) * 1991-03-01 2002-05-14 Kiyoshi Yoshida Indan derivative and thromboxane antagonist containing the same
CN1092639C (zh) 1995-01-06 2002-10-16 东丽株式会社 苯稠合杂环衍生物及其用途
US5686471A (en) * 1996-02-01 1997-11-11 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5618835A (en) * 1996-02-01 1997-04-08 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
DK0896533T3 (da) * 1996-02-22 2004-01-26 Tularik Inc Pentafluorbenzensulfonamider og analoger
JP2001505533A (ja) * 1996-07-03 2001-04-24 ファルマシア・アンド・アップジョン・カンパニー スルホンアミド誘導体を用いた標的化ドラッグデリバリー
PT939627E (pt) * 1996-07-19 2004-02-27 Tularik Inc Pentafluorobenzenossulfonamidas e analogos
CA2335559A1 (en) 1998-06-25 1999-12-29 Tularik Inc. Arylsulfonanilide phosphates
US6153585A (en) 1998-07-20 2000-11-28 Tularik Inc. Arylsulfonanilide derivatives
KR100642184B1 (ko) 1998-09-23 2006-11-10 암젠 인크 아릴술폰아닐리드 우레아
EP1206256B8 (en) 1999-07-29 2005-06-29 Amgen, Inc. Combination therapy using pentafluorobenzenesulfonamide and platin compound
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
AU2002234165A1 (en) 2000-11-03 2002-05-27 Tularik, Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US7524882B2 (en) * 2002-07-30 2009-04-28 Merck & Co., Inc. PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US7514461B2 (en) * 2003-09-19 2009-04-07 Edison Pharmaceuticals, Inc. Chroman derivatives
US20060025445A1 (en) * 2004-08-02 2006-02-02 Xiang Jason S 11-Beta HSD1 inhibitors
JP5563282B2 (ja) * 2009-12-04 2014-07-30 株式会社Ａｄｅｋａ ポリエステル樹脂用結晶核剤の製造方法
KR101729049B1 (ko) * 2009-09-30 2017-04-21 가부시키가이샤 아데카 폴리에스테르 수지 조성물, 폴리에스테르 섬유, 폴리에스테르 수지 성형체 및 폴리에스테르 수지용 결정핵제의 제조 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1007772A (en) * 1960-12-22 1965-10-22 Rieter Ag Maschf Improvements in or relating to an automatic carding plant
FR1461111A (fr) * 1965-12-21 1966-01-07 Ethyl Corp Procédé de fabrication d'éthers thiophényliques
CH612221A5 (en) * 1976-08-12 1979-07-13 Fiber Controls Corp Apparatus for forming a fibre web
DE2939968C2 (de) * 1979-10-02 1982-09-02 Temafa, Textilmaschinenfabrik Meissner, Morgner & Co Gmbh, 5070 Bergisch Gladbach Füllschacht für eine Krempelspeiseeinrichtung
GB2118552A (en) * 1982-04-15 1983-11-02 Pfizer Ltd Thromboxane synthetase inhibitors
JPS60181067A (ja) * 1984-02-27 1985-09-14 Takeda Chem Ind Ltd ベンゾイル尿素誘導体，その製造法及び殺虫剤
EP0176668B1 (de) * 1984-09-18 1989-03-29 Maschinenfabrik Rieter Ag Füllschachtanordnung für Fasermaterial
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL83230A (en) * 1986-08-06 1992-06-21 Tanabe Seiyaku Co Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3734140C2 (de) * 1987-10-09 1999-01-28 Truetzschler Gmbh & Co Kg Vorrichtung zur Vergleichmäßigung des einer Karde, Krempel, Reiniger o. dgl. zuzuführenden Faserflockenvlieses
US4918809A (en) * 1987-12-18 1990-04-24 Steinhilber Wilhelm A Nail making machine
DE3861963D1 (de) * 1987-12-24 1991-04-11 Boehringer Mannheim Gmbh Heterocyclisch substituierte alkylsulfonamide, verfahren zu ihrer herstellung sowie arzneimittel.

Also Published As

Publication number Publication date
HU210746B (en) 1995-07-28
CA2030566A1 (fr) 1990-10-06
DE69000364D1 (de) 1992-11-12
HU903397D0 (en) 1991-08-28
WO1990012007A1 (fr) 1990-10-18
GR3006746T3 (es) 1993-06-30
DK0391799T3 (da) 1993-02-22
ZA902633B (en) 1991-01-30
AU5541890A (en) 1990-11-05
HUT57758A (en) 1991-12-30
AU624951B2 (en) 1992-06-25
US5385931A (en) 1995-01-31
EP0391799B1 (fr) 1992-10-07
JPH03505335A (ja) 1991-11-21
DE69000364T2 (de) 1993-05-06
ATE81337T1 (de) 1992-10-15
FR2645537A1 (fr) 1990-10-12
FR2645537B1 (fr) 1994-03-04
HU211872A9 (en) 1995-12-28
EP0391799A1 (fr) 1990-10-10

Similar Documents

Publication Publication Date Title
ES2053133T3 (es) Nuevas sulfonamidas derivadas de acidos benzociclicos o benzoheterociclicos, su preparacion y su aplicacion en terapeutica.
ATE26120T1 (de) Substituierte acyl-derivate von 1,2,3,4tetrahydro-6,7-dimethoxy-3-isoquinolincarbons|ure.
BRPI0211844B8 (pt) composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica
DE122009000040I2 (de) Naphthalin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
DE3850742D1 (de) Neue 4-Oxobenzotriazine und 4-Oxochinazoline.
TR199701355A2 (xx) L�kozit adhasyonu inhibit�rleri olarak yeni heterosiklenler ve vla-4-antagonistleri.
ATE175661T1 (de) Benzamid-derivate als vasopressin-antagonisten
FI930974A (fi) Substituerade aminofosfonatderivat, foerfarande foer framstaellning av desamma och farmaceutiska kompositioner innehaollande desamma
DE68926981D1 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung
ES8609276A1 (es) Un procedimiento para la preparacion de nuevos compuestos de sulfonil urea.
ES2094324T3 (es) Nuevos derivados de pirrolidina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
RU93004472A (ru) Полициклические биоцидные соединения и композиция на их основе
DK0538517T3 (da) Nye organo-tinforbindelser med antitumoraktivitet og antitumormidler
ATE128131T1 (de) Substituierte pyridinsulfonamide oder deren salze, verfahren zur herstellung und diese enthaltende herbizide.
DE69521895D1 (de) Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten
ES2024332A6 (es) Procedimiento para la obtencion de nuevas sulfonamidas.
DE69111311D1 (de) 2-Tetrahydrofuran-Enantiomerderivate, Zwischenprodukte davon und ihre Herstellung.
DE69828037D1 (de) Pyrroloindol-derivate und zwischenprodukte zu ihrer herstellung
SE8100122L (sv) Nya 2-aminometyl-6-halo-fenoler, framstellning derav och farmaceutiska kompositioner innehallande dessa
TH6029A (th) อนุพันธ์ของควิโนลิเนียม และไอโซควิโนลิเนียมที่ควบแน่น
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
TH6029EX (th) อนุพันธ์ของควิโนลิเนียม และไอโซควิโนลิเนียมที่ควบแน่น

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 391799

Country of ref document: ES