KR910003559B1 - 디하이드로피리딘 a 화합물의 속효성 고형제제의 제조방법 - Google Patents

디하이드로피리딘 a 화합물의 속효성 고형제제의 제조방법 Download PDF

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Publication number
KR910003559B1
KR910003559B1 KR1019840004787A KR840004787A KR910003559B1 KR 910003559 B1 KR910003559 B1 KR 910003559B1 KR 1019840004787 A KR1019840004787 A KR 1019840004787A KR 840004787 A KR840004787 A KR 840004787A KR 910003559 B1 KR910003559 B1 KR 910003559B1
Authority
KR
South Korea
Prior art keywords
dihydropyridine
compound
fast
acting solid
hydroxypropylmethylcellulose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840004787A
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English (en)
Korean (ko)
Other versions
KR850001691A (ko
Inventor
기요시 오꾸다
렌지 아오이
Original Assignee
후지사와 야꾸힝 고교 가부시끼가이샤
후지사와 도모기찌로
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Publication of KR850001691A publication Critical patent/KR850001691A/ko
Application granted granted Critical
Publication of KR910003559B1 publication Critical patent/KR910003559B1/ko
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019840004787A 1983-08-11 1984-08-10 디하이드로피리딘 a 화합물의 속효성 고형제제의 제조방법 Expired KR910003559B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP147871 1983-08-11
JP58147871A JPS6038322A (ja) 1983-08-11 1983-08-11 ジヒドロピリジンａ物質含有易溶性固形製剤

Publications (2)

Publication Number Publication Date
KR850001691A KR850001691A (ko) 1985-04-01
KR910003559B1 true KR910003559B1 (ko) 1991-06-05

Family

ID=15440116

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004787A Expired KR910003559B1 (ko) 1983-08-11 1984-08-10 디하이드로피리딘 a 화합물의 속효성 고형제제의 제조방법

Country Status (24)

Country Link
US (1) US4654206A (enExample)
EP (1) EP0137198B1 (enExample)
JP (1) JPS6038322A (enExample)
KR (1) KR910003559B1 (enExample)
AT (1) AT382779B (enExample)
AU (1) AU564506B2 (enExample)
BE (1) BE900348A (enExample)
CA (1) CA1228815A (enExample)
CH (1) CH660967A5 (enExample)
DE (1) DE3484259D1 (enExample)
DK (1) DK164020C (enExample)
ES (1) ES8601686A1 (enExample)
FI (1) FI83839C (enExample)
FR (1) FR2550444B1 (enExample)
GB (1) GB2145332B (enExample)
GR (1) GR80004B (enExample)
HK (1) HK6688A (enExample)
IE (1) IE57757B1 (enExample)
IL (1) IL72565A (enExample)
IT (1) IT1183062B (enExample)
MY (1) MY100042A (enExample)
PH (1) PH21551A (enExample)
SG (1) SG73087G (enExample)
ZA (1) ZA845844B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
GB8608080D0 (en) * 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
DE3887179T2 (de) * 1987-03-02 1994-06-16 Brocades Pharma Bv Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung.
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
NO883326L (no) * 1987-08-11 1989-02-13 Bayer Ag Dhp-retard-tilberedning.
ATE84213T1 (de) * 1987-11-11 1993-01-15 Pharmascience Lab Exifon und ein wasserloesliches polymer enthaltende pharmazeutische zubereitung.
JPH02206A (ja) * 1987-11-11 1990-01-05 Fujisawa Pharmaceut Co Ltd エキシホンと水溶性高分子化合物とを含有することを特徴とする新規製剤
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
JPH0347124A (ja) * 1989-04-20 1991-02-28 Fujisawa Pharmaceut Co Ltd 経口吸収用製剤
JPH05501563A (ja) * 1989-11-18 1993-03-25 シエーリング・アグロケミカルズ・リミテツド プロペン酸誘導体の製造
JP3110794B2 (ja) * 1991-06-05 2000-11-20 ユーシービージャパン株式会社 １，４−ジヒドロピリジン誘導体を含有する製剤
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
ES2084478T3 (es) * 1992-02-17 1996-05-01 Siegfried Ag Pharma Formas de dosificacion que tienen liberacion prolongada del ingrediente activo.
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
DE4316537A1 (de) * 1993-05-18 1994-11-24 Basf Ag Zubereitungen in Form fester Lösungen
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
DE19511131A1 (de) * 1995-03-27 1996-10-02 Basf Ag Mechanisch stabile feste Wirkstoffzubereitungsformen
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
HN1998000115A (es) * 1997-08-21 1999-06-02 Warner Lambert Co Formas de dosificación farmacéuticas sólidas
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
JP2003146878A (ja) * 2002-11-22 2003-05-21 Sawai Pharmaceutical Co Ltd ニルバジピン含有易溶性固形製剤およびその製造法
CN100444840C (zh) * 2003-05-15 2008-12-24 罗斯坎普研究有限公司 减少淀粉样沉积、淀粉样神经毒性和小胶质增生的药物
TWI346114B (en) * 2003-09-29 2011-08-01 Method for stabilization of diarylvinylene compounds
KR101118930B1 (ko) * 2003-11-14 2012-03-14 아지노모토 가부시키가이샤 페닐알라닌 유도체의 고체 분산체 또는 고체 분산체 의약제제
BRPI0817516A2 (pt) * 2007-10-05 2015-06-16 Alzheimer S Inst Of America Inc Método para reduzir deposição de amilóide, neurotoxicidade de amilóide e microgliose com o enantiômero de (-)-nilvadipino
US20100093810A1 (en) * 2007-10-05 2010-04-15 Alzheimer's Institute Of America, Inc. Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
JP6077555B2 (ja) * 2012-02-15 2017-02-08 武田薬品工業株式会社 錠剤
US9949964B2 (en) * 2016-09-07 2018-04-24 Saniona A/S Tesofensine compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852421A (en) * 1970-03-23 1974-12-03 Shinetsu Chemical Co Excipient and shaped medicaments prepared therewith
GB1593261A (en) * 1976-07-23 1981-07-15 Inveresk Res Int Controlled release suppository
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS5668619A (en) * 1980-10-09 1981-06-09 Yamanouchi Pharmaceut Co Ltd Nifedipine-containing solid composition
JPS5877811A (ja) * 1981-11-04 1983-05-11 Kanebo Ltd 安定な易吸収性ニフエジピン製剤の製法
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
JPS58109412A (ja) * 1981-12-23 1983-06-29 Toa Eiyou Kagaku Kogyo Kk ニフエジピン固形製剤
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen

Also Published As

Publication number Publication date
US4654206A (en) 1987-03-31
IT8422294A0 (it) 1984-08-09
FR2550444A1 (fr) 1985-02-15
GB2145332B (en) 1987-03-25
AT382779B (de) 1987-04-10
DK388884A (da) 1985-02-12
AU564506B2 (en) 1987-08-13
JPS6038322A (ja) 1985-02-27
BE900348A (fr) 1985-02-11
CH660967A5 (de) 1987-06-30
ZA845844B (en) 1985-05-29
DK388884D0 (da) 1984-08-10
FR2550444B1 (fr) 1988-09-16
DK164020C (da) 1992-09-28
ATA251584A (de) 1986-09-15
PH21551A (en) 1987-12-11
EP0137198A2 (en) 1985-04-17
HK6688A (en) 1988-01-29
IL72565A0 (en) 1984-11-30
DK164020B (da) 1992-05-04
IL72565A (en) 1988-01-31
FI83839B (fi) 1991-05-31
FI843083A0 (fi) 1984-08-06
IE841974L (en) 1985-02-11
EP0137198B1 (en) 1991-03-13
CA1228815A (en) 1987-11-03
IT1183062B (it) 1987-10-05
KR850001691A (ko) 1985-04-01
AU3130684A (en) 1985-02-14
ES535019A0 (es) 1985-11-01
SG73087G (en) 1988-03-04
GB8419815D0 (en) 1984-09-05
DE3484259D1 (de) 1991-04-18
FI83839C (fi) 1991-09-10
MY100042A (en) 1989-06-29
EP0137198A3 (en) 1986-10-01
IE57757B1 (en) 1993-03-24
GB2145332A (en) 1985-03-27
GR80004B (en) 1984-11-30
JPH0412245B2 (enExample) 1992-03-04
ES8601686A1 (es) 1985-11-01
FI843083L (fi) 1985-02-12

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