JPS5668619A - Nifedipine-containing solid composition - Google Patents
Nifedipine-containing solid compositionInfo
- Publication number
- JPS5668619A JPS5668619A JP14220980A JP14220980A JPS5668619A JP S5668619 A JPS5668619 A JP S5668619A JP 14220980 A JP14220980 A JP 14220980A JP 14220980 A JP14220980 A JP 14220980A JP S5668619 A JPS5668619 A JP S5668619A
- Authority
- JP
- Japan
- Prior art keywords
- nifedipine
- blending
- titled composition
- base agent
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: The titled composition having remydying effects for a spasm of angina pectoris comparable to a liquid pharmaceutical preparation, obtained by blending nifedipine with a specific base agent, e.g., polyvinyl pyrrolidone, urea, methyl cellulose, etc.
CONSTITUTION: Nifedipine is blended with one or more selected from the group consisting of polyvinyl pyrrolidone, urea, mannitol, succinic acid, methyl cellulose, hydroxypropyl cellulose, and hydroxypropylmethyl cellulose, to give the titled composition. In blending, one part by wt. nifedipine is mixed with 5W50pts.wt., preferably 5W20pts.wt. base agent. The addition of a small amount of a surface active agent or polyethylene glycol can reduce a blending ratio of the base agent. The titled composition exhibits its effects quickly and has improved bioavaiability. It can be stored for a long time and is suitable for manufacturing a solid oral pharmaceutical preparation of nifedipine, e.g., tablets, powders, etc.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14220980A JPS5668619A (en) | 1980-10-09 | 1980-10-09 | Nifedipine-containing solid composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14220980A JPS5668619A (en) | 1980-10-09 | 1980-10-09 | Nifedipine-containing solid composition |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6703977A Division JPS542316A (en) | 1977-06-07 | 1977-06-07 | Solid pharmaceutical composition containing nifedipene |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5668619A true JPS5668619A (en) | 1981-06-09 |
JPH037645B2 JPH037645B2 (en) | 1991-02-04 |
Family
ID=15309931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14220980A Granted JPS5668619A (en) | 1980-10-09 | 1980-10-09 | Nifedipine-containing solid composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5668619A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2550444A1 (en) * | 1983-08-11 | 1985-02-15 | Fujisawa Pharmaceutical Co | SOLID PREPARATION CAPABLE OF RAPIDLY RELEASING DIHYDROPYRIDINE A, AND PROCESS FOR OBTAINING SAME |
JPS6092212A (en) * | 1983-10-26 | 1985-05-23 | Kyowa Hakko Kogyo Co Ltd | Pharmaceutical of doxorubicin salt |
EP0152281A2 (en) * | 1984-02-08 | 1985-08-21 | Yamanouchi Pharmaceutical Co. Ltd. | Transdermal formulation of nicardipine hydrochloride |
US4562069A (en) * | 1983-05-21 | 1985-12-31 | Bayer Aktiengesellschaft | Two-phase formulation |
US5854233A (en) * | 1993-09-08 | 1998-12-29 | Pharmacy And Therapeutic Advisory Consultancy Ltd. | Method of treating liver disease and like indications with vasodilating agents |
US6174917B1 (en) | 1993-09-08 | 2001-01-16 | Pharmacy And Therapeutic Advisory Consultancy Ltd. | Method of treating liver disease and like indications with vasodilating agents |
-
1980
- 1980-10-09 JP JP14220980A patent/JPS5668619A/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4562069A (en) * | 1983-05-21 | 1985-12-31 | Bayer Aktiengesellschaft | Two-phase formulation |
FR2550444A1 (en) * | 1983-08-11 | 1985-02-15 | Fujisawa Pharmaceutical Co | SOLID PREPARATION CAPABLE OF RAPIDLY RELEASING DIHYDROPYRIDINE A, AND PROCESS FOR OBTAINING SAME |
JPS6038322A (en) * | 1983-08-11 | 1985-02-27 | Fujisawa Pharmaceut Co Ltd | Easily soluble solid preparation containing dihydropyridine-a substance |
EP0137198A2 (en) * | 1983-08-11 | 1985-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Fast release solid preparation of dihydropyridine A compound and process for preparing it |
JPH0412245B2 (en) * | 1983-08-11 | 1992-03-04 | Fujisawa Pharmaceutical Co | |
JPS6092212A (en) * | 1983-10-26 | 1985-05-23 | Kyowa Hakko Kogyo Co Ltd | Pharmaceutical of doxorubicin salt |
EP0152281A2 (en) * | 1984-02-08 | 1985-08-21 | Yamanouchi Pharmaceutical Co. Ltd. | Transdermal formulation of nicardipine hydrochloride |
US5854233A (en) * | 1993-09-08 | 1998-12-29 | Pharmacy And Therapeutic Advisory Consultancy Ltd. | Method of treating liver disease and like indications with vasodilating agents |
US6174917B1 (en) | 1993-09-08 | 2001-01-16 | Pharmacy And Therapeutic Advisory Consultancy Ltd. | Method of treating liver disease and like indications with vasodilating agents |
Also Published As
Publication number | Publication date |
---|---|
JPH037645B2 (en) | 1991-02-04 |
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