DE3484259D1 - Dihydropyridin a-verbindung enthaltende feste zubereitung mit schneller freisetzung sowie verfahren zu deren herstellung. - Google Patents

Dihydropyridin a-verbindung enthaltende feste zubereitung mit schneller freisetzung sowie verfahren zu deren herstellung.

Info

Publication number
DE3484259D1
DE3484259D1 DE8484109470T DE3484259T DE3484259D1 DE 3484259 D1 DE3484259 D1 DE 3484259D1 DE 8484109470 T DE8484109470 T DE 8484109470T DE 3484259 T DE3484259 T DE 3484259T DE 3484259 D1 DE3484259 D1 DE 3484259D1
Authority
DE
Germany
Prior art keywords
dihydropyridine
production
quick release
solid preparation
compound solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484109470T
Other languages
English (en)
Inventor
Kiyoshi Okuda
Renji Aoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3484259D1 publication Critical patent/DE3484259D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE8484109470T 1983-08-11 1984-08-09 Dihydropyridin a-verbindung enthaltende feste zubereitung mit schneller freisetzung sowie verfahren zu deren herstellung. Expired - Lifetime DE3484259D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58147871A JPS6038322A (ja) 1983-08-11 1983-08-11 ジヒドロピリジンａ物質含有易溶性固形製剤

Publications (1)

Publication Number Publication Date
DE3484259D1 true DE3484259D1 (de) 1991-04-18

Family

ID=15440116

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484109470T Expired - Lifetime DE3484259D1 (de) 1983-08-11 1984-08-09 Dihydropyridin a-verbindung enthaltende feste zubereitung mit schneller freisetzung sowie verfahren zu deren herstellung.

Country Status (24)

Country Link
US (1) US4654206A (de)
EP (1) EP0137198B1 (de)
JP (1) JPS6038322A (de)
KR (1) KR910003559B1 (de)
AT (1) AT382779B (de)
AU (1) AU564506B2 (de)
BE (1) BE900348A (de)
CA (1) CA1228815A (de)
CH (1) CH660967A5 (de)
DE (1) DE3484259D1 (de)
DK (1) DK164020C (de)
ES (1) ES535019A0 (de)
FI (1) FI83839C (de)
FR (1) FR2550444B1 (de)
GB (1) GB2145332B (de)
GR (1) GR80004B (de)
HK (1) HK6688A (de)
IE (1) IE57757B1 (de)
IL (1) IL72565A (de)
IT (1) IT1183062B (de)
MY (1) MY100042A (de)
PH (1) PH21551A (de)
SG (1) SG73087G (de)
ZA (1) ZA845844B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
GB8608080D0 (en) * 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
DE3887179T2 (de) * 1987-03-02 1994-06-16 Brocades Pharma Bv Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung.
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
NO883326L (no) * 1987-08-11 1989-02-13 Bayer Ag Dhp-retard-tilberedning.
JPH02206A (ja) * 1987-11-11 1990-01-05 Fujisawa Pharmaceut Co Ltd エキシホンと水溶性高分子化合物とを含有することを特徴とする新規製剤
EP0315964B1 (de) * 1987-11-11 1993-01-07 Laboratoires Pharmascience Exifon und ein wasserlösliches Polymer enthaltende pharmazeutische Zubereitung
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
JPH0347124A (ja) * 1989-04-20 1991-02-28 Fujisawa Pharmaceut Co Ltd 経口吸収用製剤
WO1991007385A1 (en) * 1989-11-18 1991-05-30 Schering Agrochemicals Limited Preparation of propenoic acid derivatives
JP3110794B2 (ja) * 1991-06-05 2000-11-20 ユーシービージャパン株式会社 １，４−ジヒドロピリジン誘導体を含有する製剤
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
DE69301742T2 (de) * 1992-02-17 1996-08-14 Siegfried Ag Pharma Darreichungsformen mit verlaengerter Wirkstoffreigabe
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
DE4316537A1 (de) * 1993-05-18 1994-11-24 Basf Ag Zubereitungen in Form fester Lösungen
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
DE19511131A1 (de) * 1995-03-27 1996-10-02 Basf Ag Mechanisch stabile feste Wirkstoffzubereitungsformen
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
HN1998000115A (es) * 1997-08-21 1999-06-02 Warner Lambert Co Formas de dosificación farmacéuticas sólidas
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
JP2003146878A (ja) * 2002-11-22 2003-05-21 Sawai Pharmaceutical Co Ltd ニルバジピン含有易溶性固形製剤およびその製造法
CA2525970C (en) * 2003-05-15 2011-03-22 Roskamp Research, Llc Use of nilvadipine for reducing amyloid deposition, amyloid neurotoxicity and microgliosis
TWI346114B (en) * 2003-09-29 2011-08-01 Method for stabilization of diarylvinylene compounds
ATE495746T1 (de) * 2003-11-14 2011-02-15 Ajinomoto Kk Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats
US20100093810A1 (en) * 2007-10-05 2010-04-15 Alzheimer's Institute Of America, Inc. Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
BRPI0817516A2 (pt) * 2007-10-05 2015-06-16 Alzheimer S Inst Of America Inc Método para reduzir deposição de amilóide, neurotoxicidade de amilóide e microgliose com o enantiômero de (-)-nilvadipino
EP2814466B1 (de) * 2012-02-15 2018-12-26 Takeda Pharmaceutical Company Limited Tablette enthaltend 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamid oder ein salz davon
RU2019109050A (ru) * 2016-09-07 2020-10-08 Саниона А/С Композиции тезофензина

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852421A (en) * 1970-03-23 1974-12-03 Shinetsu Chemical Co Excipient and shaped medicaments prepared therewith
GB1593261A (en) * 1976-07-23 1981-07-15 Inveresk Res Int Controlled release suppository
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS5668619A (en) * 1980-10-09 1981-06-09 Yamanouchi Pharmaceut Co Ltd Nifedipine-containing solid composition
JPS5877811A (ja) * 1981-11-04 1983-05-11 Kanebo Ltd 安定な易吸収性ニフエジピン製剤の製法
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
JPS58109412A (ja) * 1981-12-23 1983-06-29 Toa Eiyou Kagaku Kogyo Kk ニフエジピン固形製剤
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen

Also Published As

Publication number Publication date
FI843083A (fi) 1985-02-12
AU564506B2 (en) 1987-08-13
IT1183062B (it) 1987-10-05
GB2145332A (en) 1985-03-27
IL72565A (en) 1988-01-31
FI83839B (fi) 1991-05-31
CA1228815A (en) 1987-11-03
EP0137198A3 (en) 1986-10-01
KR910003559B1 (ko) 1991-06-05
AT382779B (de) 1987-04-10
CH660967A5 (de) 1987-06-30
GB2145332B (en) 1987-03-25
JPS6038322A (ja) 1985-02-27
AU3130684A (en) 1985-02-14
IE841974L (en) 1985-02-11
IL72565A0 (en) 1984-11-30
BE900348A (fr) 1985-02-11
ES8601686A1 (es) 1985-11-01
FI843083A0 (fi) 1984-08-06
FI83839C (fi) 1991-09-10
ATA251584A (de) 1986-09-15
MY100042A (en) 1989-06-29
DK164020B (da) 1992-05-04
IE57757B1 (en) 1993-03-24
SG73087G (en) 1988-03-04
GR80004B (en) 1984-11-30
US4654206A (en) 1987-03-31
DK164020C (da) 1992-09-28
EP0137198B1 (de) 1991-03-13
ES535019A0 (es) 1985-11-01
GB8419815D0 (en) 1984-09-05
HK6688A (en) 1988-01-29
ZA845844B (en) 1985-05-29
KR850001691A (ko) 1985-04-01
FR2550444A1 (fr) 1985-02-15
PH21551A (en) 1987-12-11
JPH0412245B2 (de) 1992-03-04
DK388884D0 (da) 1984-08-10
DK388884A (da) 1985-02-12
FR2550444B1 (fr) 1988-09-16
IT8422294A0 (it) 1984-08-09
EP0137198A2 (de) 1985-04-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition