FR2550444B1 - Preparation solide capable de liberer rapidement la dihydropyridine a, et son procede d'obtention - Google Patents

Preparation solide capable de liberer rapidement la dihydropyridine a, et son procede d'obtention

Info

Publication number
FR2550444B1
FR2550444B1 FR8412706A FR8412706A FR2550444B1 FR 2550444 B1 FR2550444 B1 FR 2550444B1 FR 8412706 A FR8412706 A FR 8412706A FR 8412706 A FR8412706 A FR 8412706A FR 2550444 B1 FR2550444 B1 FR 2550444B1
Authority
FR
France
Prior art keywords
dihydropyridine
solid preparation
preparation capable
obtaining same
rapidly releasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8412706A
Other languages
English (en)
Other versions
FR2550444A1 (fr
Inventor
Kiyoshi Okuda
Renji Aoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of FR2550444A1 publication Critical patent/FR2550444A1/fr
Application granted granted Critical
Publication of FR2550444B1 publication Critical patent/FR2550444B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
FR8412706A 1983-08-11 1984-08-10 Preparation solide capable de liberer rapidement la dihydropyridine a, et son procede d'obtention Expired FR2550444B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58147871A JPS6038322A (ja) 1983-08-11 1983-08-11 ジヒドロピリジンａ物質含有易溶性固形製剤

Publications (2)

Publication Number Publication Date
FR2550444A1 FR2550444A1 (fr) 1985-02-15
FR2550444B1 true FR2550444B1 (fr) 1988-09-16

Family

ID=15440116

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8412706A Expired FR2550444B1 (fr) 1983-08-11 1984-08-10 Preparation solide capable de liberer rapidement la dihydropyridine a, et son procede d'obtention

Country Status (24)

Country Link
US (1) US4654206A (fr)
EP (1) EP0137198B1 (fr)
JP (1) JPS6038322A (fr)
KR (1) KR910003559B1 (fr)
AT (1) AT382779B (fr)
AU (1) AU564506B2 (fr)
BE (1) BE900348A (fr)
CA (1) CA1228815A (fr)
CH (1) CH660967A5 (fr)
DE (1) DE3484259D1 (fr)
DK (1) DK164020C (fr)
ES (1) ES8601686A1 (fr)
FI (1) FI83839C (fr)
FR (1) FR2550444B1 (fr)
GB (1) GB2145332B (fr)
GR (1) GR80004B (fr)
HK (1) HK6688A (fr)
IE (1) IE57757B1 (fr)
IL (1) IL72565A (fr)
IT (1) IT1183062B (fr)
MY (1) MY100042A (fr)
PH (1) PH21551A (fr)
SG (1) SG73087G (fr)
ZA (1) ZA845844B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
GB8608080D0 (en) * 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
DE3887179T2 (de) * 1987-03-02 1994-06-16 Brocades Pharma Bv Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung.
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
NO883326L (no) * 1987-08-11 1989-02-13 Bayer Ag Dhp-retard-tilberedning.
JPH02206A (ja) * 1987-11-11 1990-01-05 Fujisawa Pharmaceut Co Ltd エキシホンと水溶性高分子化合物とを含有することを特徴とする新規製剤
ATE84213T1 (de) * 1987-11-11 1993-01-15 Pharmascience Lab Exifon und ein wasserloesliches polymer enthaltende pharmazeutische zubereitung.
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
JPH0347124A (ja) * 1989-04-20 1991-02-28 Fujisawa Pharmaceut Co Ltd 経口吸収用製剤
EP0594573A1 (fr) * 1989-11-18 1994-05-04 AgrEvo UK Limited Preparation de derives d'acide propenoique
JP3110794B2 (ja) * 1991-06-05 2000-11-20 ユーシービージャパン株式会社 １，４−ジヒドロピリジン誘導体を含有する製剤
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
ATE135214T1 (de) * 1992-02-17 1996-03-15 Siegfried Ag Pharma Darreichungsformen mit verlaengerter wirkstoffreigabe
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
DE4316537A1 (de) * 1993-05-18 1994-11-24 Basf Ag Zubereitungen in Form fester Lösungen
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
DE19511131A1 (de) * 1995-03-27 1996-10-02 Basf Ag Mechanisch stabile feste Wirkstoffzubereitungsformen
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
HN1998000115A (es) * 1997-08-21 1999-06-02 Warner Lambert Co Formas de dosificación farmacéuticas sólidas
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
JP2003146878A (ja) * 2002-11-22 2003-05-21 Sawai Pharmaceutical Co Ltd ニルバジピン含有易溶性固形製剤およびその製造法
CN100444840C (zh) * 2003-05-15 2008-12-24 罗斯坎普研究有限公司 减少淀粉样沉积、淀粉样神经毒性和小胶质增生的药物
TWI346114B (en) * 2003-09-29 2011-08-01 Method for stabilization of diarylvinylene compounds
CN101664411A (zh) 2003-11-14 2010-03-10 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
US20100093810A1 (en) * 2007-10-05 2010-04-15 Alzheimer's Institute Of America, Inc. Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
MX2010003669A (es) * 2007-10-05 2010-11-25 Alzheimer S Inst Of America Inc Metodo para reducir la deposicion de amiloide, neurotoxicidad y microgliosis con el enantiomero (-)-nilvadipina.
EP2814466B1 (fr) * 2012-02-15 2018-12-26 Takeda Pharmaceutical Company Limited Comprimé comprenant 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide ou son sel
JP2019526641A (ja) * 2016-09-07 2019-09-19 ソニオナ エー／エス テソフェンシン組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852421A (en) * 1970-03-23 1974-12-03 Shinetsu Chemical Co Excipient and shaped medicaments prepared therewith
GB1593261A (en) * 1976-07-23 1981-07-15 Inveresk Res Int Controlled release suppository
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CA1117117A (fr) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. Derives de la 2-methyl-dihydropyridine, methodes de preparation, et composition pharmaceutique de ces derives
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
CA1146866A (fr) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Procede de production d'un compose pharmaceutique a liberation continue sous forme solide
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS5668619A (en) * 1980-10-09 1981-06-09 Yamanouchi Pharmaceut Co Ltd Nifedipine-containing solid composition
JPS5877811A (ja) * 1981-11-04 1983-05-11 Kanebo Ltd 安定な易吸収性ニフエジピン製剤の製法
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
JPS58109412A (ja) * 1981-12-23 1983-06-29 Toa Eiyou Kagaku Kogyo Kk ニフエジピン固形製剤
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen

Also Published As

Publication number Publication date
DK164020B (da) 1992-05-04
IT8422294A0 (it) 1984-08-09
FI83839C (fi) 1991-09-10
ZA845844B (en) 1985-05-29
IL72565A0 (en) 1984-11-30
AU564506B2 (en) 1987-08-13
FI843083A (fi) 1985-02-12
AT382779B (de) 1987-04-10
CH660967A5 (de) 1987-06-30
PH21551A (en) 1987-12-11
GB8419815D0 (en) 1984-09-05
DK388884D0 (da) 1984-08-10
MY100042A (en) 1989-06-29
ATA251584A (de) 1986-09-15
JPS6038322A (ja) 1985-02-27
DK164020C (da) 1992-09-28
EP0137198A2 (fr) 1985-04-17
GB2145332A (en) 1985-03-27
FI83839B (fi) 1991-05-31
IL72565A (en) 1988-01-31
FI843083A0 (fi) 1984-08-06
EP0137198B1 (fr) 1991-03-13
KR910003559B1 (ko) 1991-06-05
HK6688A (en) 1988-01-29
FR2550444A1 (fr) 1985-02-15
ES535019A0 (es) 1985-11-01
AU3130684A (en) 1985-02-14
KR850001691A (ko) 1985-04-01
DE3484259D1 (de) 1991-04-18
SG73087G (en) 1988-03-04
IT1183062B (it) 1987-10-05
CA1228815A (fr) 1987-11-03
JPH0412245B2 (fr) 1992-03-04
GB2145332B (en) 1987-03-25
IE841974L (en) 1985-02-11
US4654206A (en) 1987-03-31
EP0137198A3 (en) 1986-10-01
BE900348A (fr) 1985-02-11
DK388884A (da) 1985-02-12
GR80004B (en) 1984-11-30
ES8601686A1 (es) 1985-11-01
IE57757B1 (en) 1993-03-24

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