KR910001042B1 - 4-아미노알킬-2(3h)-인돌론 및 이의 제조방법 - Google Patents

4-아미노알킬-2(3h)-인돌론 및 이의 제조방법 Download PDF

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Publication number
KR910001042B1
KR910001042B1 KR1019830005790A KR830005790A KR910001042B1 KR 910001042 B1 KR910001042 B1 KR 910001042B1 KR 1019830005790 A KR1019830005790 A KR 1019830005790A KR 830005790 A KR830005790 A KR 830005790A KR 910001042 B1 KR910001042 B1 KR 910001042B1
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KR
South Korea
Prior art keywords
acid
hydrogen
indoleone
compound
solution
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830005790A
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English (en)
Korean (ko)
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KR840006963A (ko
Inventor
쥬니어 그레고리 갤러거
Original Assignee
스미스 클라인 비참 코퍼레이션
리챠드 도미니크 포기오
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23776840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR910001042(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 스미스 클라인 비참 코퍼레이션, 리챠드 도미니크 포기오 filed Critical 스미스 클라인 비참 코퍼레이션
Publication of KR840006963A publication Critical patent/KR840006963A/ko
Application granted granted Critical
Publication of KR910001042B1 publication Critical patent/KR910001042B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019830005790A 1982-12-07 1983-12-07 4-아미노알킬-2(3h)-인돌론 및 이의 제조방법 Expired KR910001042B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/447,564 US4452808A (en) 1982-12-07 1982-12-07 4-Aminoalkyl-2(3H)-indolones
US447.564 1982-12-07
US447564 1982-12-07

Publications (2)

Publication Number Publication Date
KR840006963A KR840006963A (ko) 1984-12-04
KR910001042B1 true KR910001042B1 (ko) 1991-02-21

Family

ID=23776840

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005790A Expired KR910001042B1 (ko) 1982-12-07 1983-12-07 4-아미노알킬-2(3h)-인돌론 및 이의 제조방법

Country Status (27)

Country Link
US (1) US4452808A (enExample)
EP (1) EP0113964B1 (enExample)
JP (1) JPS59112964A (enExample)
KR (1) KR910001042B1 (enExample)
AU (1) AU560170B2 (enExample)
BR (1) BR1100036A (enExample)
CA (1) CA1208650A (enExample)
CY (1) CY1497A (enExample)
CZ (1) CZ398191A3 (enExample)
DE (1) DE3367090D1 (enExample)
DK (1) DK156514C (enExample)
DZ (1) DZ587A1 (enExample)
EG (1) EG16556A (enExample)
ES (2) ES527827A0 (enExample)
FI (1) FI77849C (enExample)
GR (1) GR79121B (enExample)
HK (1) HK82089A (enExample)
IE (1) IE56347B1 (enExample)
IL (1) IL70311A (enExample)
LU (1) LU90097I2 (enExample)
NL (1) NL970005I2 (enExample)
NO (2) NO160135C (enExample)
NZ (1) NZ206344A (enExample)
PH (1) PH22067A (enExample)
PT (1) PT77739B (enExample)
ZA (1) ZA839094B (enExample)
ZW (1) ZW25883A1 (enExample)

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US4588740A (en) * 1982-12-07 1986-05-13 Smithkline Beckman Corporation Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
GB8621040D0 (en) * 1986-08-30 1986-10-08 Smith Kline French Lab Process
GB8712073D0 (en) * 1987-05-21 1987-06-24 Smith Kline French Lab Medicament
GB8714371D0 (en) * 1987-06-19 1987-07-22 Smith Kline French Lab Process
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
GB9015095D0 (en) * 1990-07-09 1990-08-29 Smith Kline French Lab Therapeutic method
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JPH07506823A (ja) * 1992-05-18 1995-07-27 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 記憶障害，性的機能不全およびパーキンソン氏病の治療のためのインドロン誘導体の使用
GB9300309D0 (en) * 1993-01-08 1993-03-03 Smithkline Beecham Plc Process
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
ES2179362T3 (es) * 1996-08-27 2003-01-16 Wyeth Corp Derivados de 4-aminoetoxi indolona.
WO1999052870A1 (en) * 1998-04-13 1999-10-21 American Home Products Corporation 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists
US6218421B1 (en) * 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6277875B1 (en) * 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
WO2002069974A1 (en) * 2001-03-05 2002-09-12 Andrew Holman Administration of sleep restorative agents
FR2821843B1 (fr) * 2001-03-12 2003-05-09 Servier Lab Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
AU2003263357B2 (en) * 2002-09-13 2009-02-26 Motac Neuroscience Limited Treatment of basal ganglia-related movement disorders with 2,3-benzodiazepines
ES2286453T3 (es) * 2002-09-17 2007-12-01 Motac Neuroscience Limited Tratamiento de la discinesia.
ES2237307B1 (es) 2003-10-14 2006-11-01 Urquima, S.A. Procedimiento para la preparacion de ropinirol.
WO2005074387A2 (en) * 2003-12-30 2005-08-18 Sun Pharmaceutical Industries Limited Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) * 2004-01-20 2008-05-27 Usv, Ltd. Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) * 2004-02-11 2005-11-10 Sun Pharmaceutical Industries Limited Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
WO2005080333A1 (en) * 2004-02-19 2005-09-01 Torrent Pharmaceuticals Ltd Process for purification of ropinirole
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
SK51112006A3 (sk) * 2004-05-11 2007-05-03 Egis Gy�gyszergy�r Nyrt. Piperazínové deriváty
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
US20080214622A1 (en) * 2005-03-21 2008-09-04 Alan Daniel Brown Substituted Triazole Derivatives As Oxytocin Antagonists
CN100457711C (zh) * 2005-06-27 2009-02-04 上海奥博生物医药技术有限公司 2-甲基-3-硝基苯基烷基胺衍生物或其盐的制备方法
WO2007010557A2 (en) * 2005-07-22 2007-01-25 Ind-Swift Laboratorie Limted Process for the preparation of highly pure ropinirole
BRPI0709184A2 (pt) 2006-03-29 2011-06-28 Alembic Ltd processo para a purificação de cloridrato de ropinirol
WO2007117687A2 (en) * 2006-04-06 2007-10-18 Nupathe Inc. Implants for the treatment of dopamine associated states
US20070254941A1 (en) * 2006-04-21 2007-11-01 Glenmark Pharmaceuticals Limited Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) * 2006-05-25 2009-02-04 药源药物化学（上海）有限公司 罗匹尼罗的制备方法
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
TW200815045A (en) * 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
CA2686394A1 (en) * 2007-05-11 2008-11-20 Santen Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for posterior ocular disease comprising non-ergot selective d2 receptor agonist as active ingredient
US20090076124A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched ropinirole
US20090247537A1 (en) * 2008-03-25 2009-10-01 William Dale Overfield Methods for preventing or treating bruxism using dopaminergic agents
CN101574341B (zh) * 2008-05-05 2012-12-19 北京德众万全医药科技有限公司 一种罗匹尼罗的口服固体药物组合物
WO2010023693A2 (en) * 2008-09-01 2010-03-04 Lupin Limited Novel controlled release compositions of ropinirole
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CN101891641B (zh) * 2010-07-27 2015-06-10 北京华禧联合科技发展有限公司 盐酸罗匹尼罗关键中间体的稳定形态及其制备
TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
KR101853082B1 (ko) 2011-03-24 2018-04-27 테이코쿠 팔마 유에스에이, 인코포레이티드 활성제층 및 활성제 변환층을 포함하는 경피 조성물
EP2776020B1 (en) 2011-11-09 2019-09-11 Teikoku Seiyaku Co., Ltd. Methods for the treatment of skin neoplasms
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JP6242811B2 (ja) 2012-12-10 2017-12-06 キッセイ薬品工業株式会社 新規なオクタヒドロピリドキナゾリン誘導体、それを含有する医薬組成物およびそれらの用途
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WO2018227553A1 (zh) 2017-06-16 2018-12-20 浙江华海立诚药业有限公司 盐酸罗匹尼罗的纯化方法
CN115466209A (zh) * 2022-09-29 2022-12-13 南通大学 一种罗匹尼罗环戊烷并吲哚酮杂质的合成方法

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JPS5840539B2 (ja) * 1976-03-31 1983-09-06 大塚製薬株式会社 α−置換アミノアルカノイルオキシインド−ル誘導体
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US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones

Also Published As

Publication number Publication date
EG16556A (en) 1989-01-30
PT77739A (en) 1983-12-01
IL70311A (en) 1986-11-30
DK562183D0 (da) 1983-12-06
NL970005I1 (nl) 1997-04-01
EP0113964B1 (en) 1986-10-22
NL970005I2 (nl) 1997-10-01
CZ398191A3 (en) 1993-02-17
NO834485L (no) 1984-06-08
FI77849B (fi) 1989-01-31
DK562183A (da) 1984-06-08
ES8600239A1 (es) 1985-10-01
FI834421A0 (fi) 1983-12-02
IL70311A0 (en) 1984-02-29
CY1497A (en) 1990-02-16
NZ206344A (en) 1987-03-31
GR79121B (enExample) 1984-10-02
ES527827A0 (es) 1985-10-01
JPS59112964A (ja) 1984-06-29
NO1999011I1 (no) 1999-06-18
ZW25883A1 (en) 1984-04-18
DK156514B (da) 1989-09-04
LU90097I2 (fr) 1997-07-16
US4452808A (en) 1984-06-05
IE832866L (en) 1984-06-07
AU2158583A (en) 1984-06-14
DZ587A1 (fr) 2004-09-13
DE3367090D1 (de) 1986-11-27
HK82089A (en) 1989-10-20
NO160135B (no) 1988-12-05
IE56347B1 (en) 1991-07-03
EP0113964A1 (en) 1984-07-25
ES543593A0 (es) 1986-01-16
ES8604143A1 (es) 1986-01-16
AU560170B2 (en) 1987-04-02
PT77739B (en) 1986-03-27
NO160135C (no) 1989-03-15
JPH0150703B2 (enExample) 1989-10-31
ZA839094B (en) 1985-02-27
CA1208650A (en) 1986-07-29
KR840006963A (ko) 1984-12-04
FI77849C (fi) 1989-05-10
BR1100036A (pt) 2000-01-11
DK156514C (da) 1990-03-12
PH22067A (en) 1988-05-20
FI834421L (fi) 1984-06-08

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