KR900006273A - 오르토 결합 작용기를 갖는 킬란트 및 그의 착물 - Google Patents

오르토 결합 작용기를 갖는 킬란트 및 그의 착물 Download PDF

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KR900006273A
KR900006273A KR1019890015647A KR890015647A KR900006273A KR 900006273 A KR900006273 A KR 900006273A KR 1019890015647 A KR1019890015647 A KR 1019890015647A KR 890015647 A KR890015647 A KR 890015647A KR 900006273 A KR900006273 A KR 900006273A
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amino
carboxymethyl
bis
ethyl
hydrogen
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에이.윌슨 데이비트
알.갈리취 조세프
케이.프랑크 리챠드
멕밀란 케네쓰
시몬 제이미
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리챠드 지.워터맨
더 다우 케미칼 캄파니
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Abstract

내용 없음

Description

오르토 결합 작용기를 갖느 킬란트 및 그의 착물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (36)

  1. 오르토 결합 작용기를 갖는 하기 일반식(Ⅰ)의 이작용성 킬란트 또는 그의 약제학적으로 허용가능한 염 :
    상기식에서, Z는 항체 또는 그의 단편에 공유결합 될수 있는 친전자성 또는 친핵성 잔기, 또는 방사성핵종과의 착물형성을 방해하지 않고 항체 또는 그의 단편에 결합될 수 있는 합성 결합기이고 ; X는 수소, C1내지 C3알킬 또는 CR3R4CO2H 이며 ; R1,R2,R3및 R4는 각각 독립적으로 수소, 하이드록시, CO2H 또는 C1내지 C3알킬 그룹이고 ; R5는 수소 또는 (CR1CR2)nCR3R4B이며 ; B는 아민 수소중 최소한 하나가 CR3R4CO2H 그룹으로 치환된 선형 또는 분자형 아민, 또는 폴리알킬렌 아민을 나타내고 ; n은 0 또는 1이다.
  2. 제 1 항에 있어서, n이 0인 이작영성 킬란트.
  3. 제 1 항 또는 제 2 항에 있어서, R4가 CO2H인 이작용성 킬란트.
  4. 제 1,2 또는 3항에 있어서, X가 수소인 이작용성 킬란트.
  5. 제 1 항 내지 4 항중의 어느 한 항에 있어서, R1,R2및 R3가 각각 수소인 이작용성 킬란트.
  6. 제 1 항 내지 5 항중의 어느 한 항에 있어서, Z이 아미노, 이소티오시아네이토, 세미카바자이드, 티오세미카바자이드, 카복실, 브로모아세트아미도 또는 말레이미도인 이작용성 킬란트.
  7. 제 1 항에 있어서, 2-[(2-{[비스(카복시메틸)]아미노}에틸)아미노]-2-(5-아세트아미도-2-하이드록시페닐)에타노산인 이작용성 킬란트.
  8. 제 1 항에 있어서, 2-[(2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]-2-[5-아세트아미도-2-(카복시메틸옥시)페닐]에타노산인 이작용성 킬란트.
  9. 제 1 항에 있어서, 2-[(2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]-2-(5-아미노-2-(카복시메틸옥시)페닐]에타노산인 이작용성 킬란트.
  10. 제 1 항에 있어서, 2-[(2-{[비스(카복시메틸)]아미노}에틸)(시아노메틸)아미노]-2-(5-아세트아미도-2-하이드록시페닐)에타노산인 이작용성 킬란트.
  11. 제 1 항에 있어서, 2-[(2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]-2-(5-아미노-2-하이드록시페닐)에타노산인 이작용성 킬란트.
  12. 제 1 항에 있어서, 2-[비스(2-{[비스(카복시메틸)]아미노}에틸)아미노]-2-[5-아세트아미도-2-(카복시메틸옥시)페닐]에타노산인 이작용성 킬란트.
  13. 제 1 항에 있어서, 2-[{2-[(2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]에틸}(카복시메틸)아미노]-2-[5-아세트아미도-2-(카복시메틸옥시)페닐]에타노산인 이작용성 킬란트.
  14. 제 1 항에 있어서, 2-[(2-[(2-[(2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]에틸)(카복시메틸)아미노]에틸)(카복시메틸)아미노]-2-[5-아세트아미도-2-(카복시메틸옥시)페닐]에타노산인 이작용성 킬란트.
  15. 제 1 항에 있어서, 2-[(2-[(2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]에틸)-(2-{[비스(카복시메틸)]아미노}에틸)아미노]-2-[5-아세트아미도-2-(카복시메틸옥시)페닐]에타노산인 이작용성 킬란트.
  16. 제 1 항에 있어서, 2, 6-비스{[비스(카복시메틸)]아미노}(카복시)메틸}-4-(아세트아미도)페놀인 이작용성 킬란트.
  17. 제 1 항에 있어서, 2, 6-비스{[2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)]아미노메틸}-4-(아세트아미도)페놀인 이작용성 킬란트.
  18. 제 1 항에 있어서, 2, 6-비스{[2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)]아미노메틸}-4-(아미노)페놀인 이작용성 킬란트.
  19. 제 1 항에 있어서, 2, 6-비스{[2-{[비스(카복시메틸)]아미노}에틸)(카복시메틸)]아미노메틸}-4-(이소티오시아네이토)페놀인 이작용성 킬란트.
  20. 제 1 항에 있어서, 2-({[비스(카복시메틸)]아미노}메틸)2-({[비스(카복시메틸)]아미노}에틸)-6-{[({[비스(카복시메틸)]아미노}에틸)(카복시메틸)아미노]메틸}-4-(아세트아미도)페놀인 이작용성 킬란트.
  21. 오르토 결합 작용기를 갖는 하기 일반식(Ⅱ)의 킬란트 또는 그의 약제학적으로 허용가능한 염 :
    상기식에 Z'는 수소, NH2, NO2, NHC(O)CH3또는 N(R')2(여기에서, R'는 수소 또는 C1내지 C3알킬이다)이고 ; X는 수소, C1내지 C3알킬 또는 CR3R4COOH 이며 ; R'1는 수소 또는 COOH이고 ; R'3, R'4및 R'5는 독립적으로 수소 또는 CR3R4COOH이다(단, R'1,R'3,R'4및 R'5중 최소한 하나는 수소이다.)
  22. 제 21 항에 있어서, R'1이 COOH이고, R'3가 수소이며, R'4및 R'5가 CH2COOH인 킬란트.
  23. 제 22 항에 있어서, Z'가 NCH(O)CH3이고, X가 수소인 킬란트.
  24. 오르토 결합 작용기를 갖는 하기 일반식(Ⅲ)의 킬란트 또는 그의 약제학적으로 허용가능한 염 :
    상기식에서, Z'는 수소, NH2, NO2, NHC(O)CH3또는 N(R')2(여기에서, R'는 수소 또는 C1내지 C3알킬이다)이고 ; X는 수소, C1내지 C3알킬 또는 CR3R4COOH 이며 ; R'1및 R'2는 각각 수소 또는 COOH 이고(단, 최소한 하나는 COOH이다) ; R'3, R'4, R'5및 R'6독립적으로 수소 또는 CR3R4COOH이다(단, 최소한 셋은 CR3R4COOH이다.)
  25. 제 24 항에 있어서, R'1및 R'2가 COOH이고, R'3,R'4, R'5및 R'6가 CH2COOH인 킬란트.
  26. 제 25 항에 있어서, Z'가 NHC(O)CH3이고 X가 수소인 킬란트.
  27. La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y 또는 Sc 중에서 선택된 금속 이온과 착물을 이룬, 제 1 항 내지 26 항중 어느 한 항에서 청구한 킬란트, 또는 그의 약제학적으로 허용가능한 염을 포함하는 착물.
  28. 제 27 항에 있어서, 금속이온이153Sm,166Ho,90Y,149Pm,159Gd,140La,177Lu,175Yb,47Sc 또는142Pr인 작물.
  29. 항체 또는 항체 단편에 공유 결합된, 제 27 항 또는 28 항에서 청구한 착물을 포함하는 결합물.
  30. 제 29 항에 있어서, 항체 또는 그의 단편이 모노클론성 항체 또는 그의 단편인 결합물.
  31. 제 30 항에 있어서, 항체 또는 그의 단편이 CC-46, CC-49, CC-49F(ab')2, CC-83, CC-83F(ab')2또는 B 72.3 인 결합물.
  32. 제 27 항 또는 제 28 항중에서 청구한 착물, 및 생리학적으로 허용가능한 담체를 포함하는 약제학적 제제.
  33. 제 29 항에서 청구한 결합물 및 생리학적으로 허용 가능한 담체를 포함하는 약제학적 제제.
  34. 포유 동물에게 제 32 항 또는 제 33항의 제제 효과량을 투여함을 포함하는, 상기 포유동물의 질병 상태를 진단 및/또는 치료하는 방법.
  35. 제 34 항에 있어서, 상기 질병상태가 암인 방법.
  36. 골 통증이 있는 동물에게 제 32항 또는 제 33항의 제제 치료 효과량을 투여함을 포함하는, 골 통증이 있는 동물을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890015647A 1988-10-31 1989-10-30 오르토 결합 작용기를 갖는 킬란트 및 그의 착물 KR0153468B1 (ko)

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10206690A1 (de) 2002-02-18 2003-08-28 Bsh Bosch Siemens Hausgeraete Dampfgarer sowie Anordnung und Verfahren zum Dampfgaren
US5342925A (en) * 1991-01-30 1994-08-30 The Dow Chemical Company Radioactive compositions for soft tissue tumors
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
DE4136489A1 (de) * 1991-11-06 1993-05-13 Bayer Ag Neue diethylentriamin-derivate und deren verwendung zu diagnostischen und therapeutischen zwecken
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5250728A (en) * 1991-12-12 1993-10-05 Hampshire Chemical Corp. Preparation of ethylenediaminetriacetic acid
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
FR2706889A1 (en) * 1993-06-23 1994-12-30 Oreal Use of N-(arylmethylene)ethylenediaminetriacetate, N-(arylmethylene)iminodiacetate or N,N'-di(arylmethylene)ethylenediaminediacetate compounds against oxidative stress
US5703095A (en) * 1992-11-13 1997-12-30 L'oreal Use of N-arylmethylene, ethylenediaminetriacetates, N-arymethylene iminodiacetates or N,N'-diarylmethylene ethylenediamineacetates against oxidative stress
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
FR2737204B1 (fr) * 1995-07-26 1997-09-12 Oreal Derives de n,n'-di(aralkyl)n,n'-di(carboxylakyl)alkylene di- ou triamine et de n-(aralkyl)n'-(carboxyalkyl) n,n'-di(carboxyalkyl)alkylene di- ou triamine et leur utilisation en pharmacie et en cosmetique
CA2319255C (en) 1998-02-04 2010-01-26 University Of Florida Research Foundation, Inc. Pharmaceuticals comprising n,n'-bis(2- hydroxybenzyl) ethylenediamine-n, n'-diacetic acid for iron chelating therapy
AU2456201A (en) * 1999-12-21 2001-07-03 University Of Florida Research Foundation, Inc. N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid in iron chelating therapy
ES2551880T3 (es) * 2007-09-20 2015-11-24 Przedsiebiorstwo Produkcyjno-Consultingowe Adob Sp. Z O.O. Sp. K. Un proceso para la preparación de ácido N,N'-bis(2-hidroxibencil)etilenodiamino-N,N'-diacético y sus derivados
CN102746341A (zh) * 2012-07-20 2012-10-24 武汉工程大学 硫代氨基脲类席夫碱铋配合物及其制备方法
CN104840563A (zh) * 2015-05-09 2015-08-19 马德亮 一种治疗骨转移癌的中药制剂
CN116806830A (zh) * 2022-09-14 2023-09-29 江苏省农业科学院 一种溶杆菌来源嗜铁素的应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2763680A (en) * 1953-12-15 1956-09-18 Ciba Ltd Imino-dicarboxylic acids and functional derivatives thereof and process of making same
CH353747A (de) * 1955-12-06 1961-04-30 Geigy Ag J R Verfahren zur Herstellung von Schwermetallkomplexverbindungen und Verwendung derselben zur Bekämpfung von Schwermetallmangelerscheinungen von Pflanzen
DE1187132B (de) * 1963-08-24 1965-02-11 Agfa Ag Photographisches Material
US4046793A (en) * 1971-10-01 1977-09-06 Ciba-Geigy Corporation Chelates for the regulation of metal-deficiency phenomena in plants
US3994966A (en) 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
ES415154A1 (es) * 1973-05-15 1976-02-16 Dabeer Sa Procedimiento para la obtencion de derivados fenolicos de acidos hidro-xialquil-alquilenodiamino aceticos y sus sales.
US3965254A (en) 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
ES417766A1 (es) * 1973-07-28 1976-02-16 Dabeer Sa Procedimiento para la obtencion de quelatos de hierro apli-cables como correctores de la clorosis ferrica en los vege- tales.
US4043998A (en) 1974-10-09 1977-08-23 The Board Of Trustees Of The Leland Stanford Junior University 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid
US4088747A (en) 1975-02-19 1978-05-09 Australian Atomic Energy Commission Phenolic amino-carboxylic acid radiopharmaceuticals
US4091088A (en) 1975-02-19 1978-05-23 Australian Atomic Energy Commission Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4352751A (en) 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4432907A (en) 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4622420A (en) 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4399817A (en) 1981-06-30 1983-08-23 The Procter & Gamble Company Boron containing polyphosphonates for the treatment of calcific tumors
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4454106A (en) 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4479930A (en) 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
SE8301395L (sv) 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4824986A (en) 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US4678667A (en) 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate

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