ES2146213T3 - Compuestos de porficeno para terapia fotodinamica. - Google Patents

Compuestos de porficeno para terapia fotodinamica.

Info

Publication number
ES2146213T3
ES2146213T3 ES92913690T ES92913690T ES2146213T3 ES 2146213 T3 ES2146213 T3 ES 2146213T3 ES 92913690 T ES92913690 T ES 92913690T ES 92913690 T ES92913690 T ES 92913690T ES 2146213 T3 ES2146213 T3 ES 2146213T3
Authority
ES
Spain
Prior art keywords
compounds
photodynamic therapy
porficene
nhr2
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913690T
Other languages
English (en)
Inventor
Emanuel Vogel
Thomas Benninghaus
Clemens Richert
Martin Muller
Alexander Dennis Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytopharm Inc
Original Assignee
Cytopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytopharm Inc filed Critical Cytopharm Inc
Application granted granted Critical
Publication of ES2146213T3 publication Critical patent/ES2146213T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Developing Agents For Electrophotography (AREA)

Abstract

UN PORFICENO QUE TIENE LA ESTRUCTURA (I) EN DONDE CADA R1 ES, INDEPENDIENTEMENTE, (A) -(CH2)N-X, DONDE N = 1-4, X ES OR2 Y R2 ES ALKILO C1-6, ARALKILO O ARILO; CN; OH; OSO2R2; NH2; NHR2; NR22; SH; SR2; S(O)1-2R2; COOH; CO2R2; C(O)NH2; C(O)NHR2; C(O)NR22; HALOGENO; O CHO; (B) -(CH2)MCH = CH2 DONDE M ES DE 0 A 2; O (C) -(CH2)N-O-G DONDE G ES UN MONO -(CH2)2N-X, DONDE X ES UN AMINOACIDO, UN OLIGOPEPTIDO ENLAZADO COVALENTEMENTE MEDIANTE UN ENLACE DE ETER, ESTER O AMINA O -Y-(CH2)N-PORFICENO2 (SIENDO EL PORFICENO2 UN COMPUESTO DE LA MISMA ESTRUCTURA E Y UN ENLACE DIRECTO; -O-; O -CH = CH2); O (E) DONDE UNO, DOS O TRES DE LOS SUSTITUYENTES R1 SON ALKILO C1-6 O ARILO Y EL RESTO DE LOS SUSTITUYENTES SON COMO SE HA INDICADO ANTERIORMENTE EN DE (A) A (D) Y LAS SALES Y COMPLEJOS METALICOS DE LOS MISMOS. LOS COMPUESTOS DE PORFICENO Y LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENE LOS COMPUESTOS SON UTILES EN UNA TERAPIA FOTODINAMICA PARA EL TRATAMIENTO DE TUMORES Y DE LA PSORIASIS.
ES92913690T 1991-06-28 1992-06-05 Compuestos de porficeno para terapia fotodinamica. Expired - Lifetime ES2146213T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/723,394 US5179120A (en) 1991-06-28 1991-06-28 Porphycene compounds for photodynamic therapy

Publications (1)

Publication Number Publication Date
ES2146213T3 true ES2146213T3 (es) 2000-08-01

Family

ID=24906063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913690T Expired - Lifetime ES2146213T3 (es) 1991-06-28 1992-06-05 Compuestos de porficeno para terapia fotodinamica.

Country Status (11)

Country Link
US (1) US5179120A (es)
EP (1) EP0591355B1 (es)
JP (1) JP3184218B2 (es)
AT (1) ATE190309T1 (es)
AU (1) AU664377B2 (es)
CA (1) CA2111323A1 (es)
DE (1) DE69230755T2 (es)
ES (1) ES2146213T3 (es)
FI (1) FI935878A (es)
NO (1) NO301981B1 (es)
WO (1) WO1993000087A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2372854A1 (es) * 2010-07-02 2012-01-27 Institut Quimic De Sarria Cets, Fundacio Privada Derivados catiónicos de 2, 7, 12, 17-arilporficenos. procedimiento de preparación y uso como fotosensibilizadores en terapia fotodinámica antimicrobiana.

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US5262401A (en) * 1991-06-28 1993-11-16 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
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US5298018A (en) * 1992-08-14 1994-03-29 Pdt Cardiovascular, Inc. Method for treating cardiovascular disease through adjunctive photodynamic therapy
DE4311627B4 (de) * 1993-04-08 2005-08-25 Robert Bosch Gmbh Kraftstoffeinspritzeinrichtung für Brennkraftmaschinen
JPH0753381A (ja) * 1993-07-09 1995-02-28 Ciba Geigy Ag 局所投与可能な亜鉛フタロシアニン組成物
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GB9500116D0 (en) * 1995-01-05 1995-03-01 Ciba Geigy Ag Pharmaceutical compositions
US5610175A (en) * 1995-04-06 1997-03-11 Cytopharm, Inc. 9-Substituted porphycenes
US5637608A (en) * 1995-04-06 1997-06-10 Cytopharm, Inc. 9-substituted porphycenes
US5616342A (en) * 1995-04-11 1997-04-01 Pdt, Inc. Emulsioin suitable for administering a poorly water-soluble photosensitizing compound and use thereof
JP2012092145A (ja) * 1996-03-11 2012-05-17 Qlt Inc 眼の光力学的治療による視力改善用組成物
US5756541A (en) 1996-03-11 1998-05-26 Qlt Phototherapeutics Inc Vision through photodynamic therapy of the eye
GB9608484D0 (en) * 1996-04-25 1996-07-03 Glaxo Group Ltd Flourescent lamp photodynamic therapy (PDT) apparatus and method
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
AU4668097A (en) * 1996-10-09 1998-05-05 Alexander D. Cross 9-substituted porphycenes
US6458547B1 (en) 1996-12-12 2002-10-01 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
US5756724A (en) * 1997-04-22 1998-05-26 Cytopharm, Inc. High-yielding ullmann reaction for the preparation of bipyrroles
US6107326A (en) * 1999-04-12 2000-08-22 Cytopharm, Inc. Porphycenes for treatment of microbial populations
US6627288B1 (en) * 2000-08-10 2003-09-30 Mitsui Chemicals, Inc. Optical recording medium and porphycene compound
WO2002044396A1 (en) 2000-11-29 2002-06-06 Pci Biotech As Photochemical internalization for delivery of molecules into the cytosol
KR20030074633A (ko) 2000-11-29 2003-09-19 피씨아이 바이오테크 에이에스 사이토졸 내로의 바이러스 매개된 분자 전달을 위한광화학적 내부이행
WO2003072581A1 (en) 2002-02-26 2003-09-04 Board Of Regents, The University Of Texas System Cyclo[n]pyrroles and methods thereto
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
EP2401962A1 (en) * 2002-05-08 2012-01-04 Yeda Research And Development Co., Ltd. Sensitized online BOLD-MRI imaging method
ES2197818B1 (es) * 2002-06-11 2005-02-01 Institut Quimic De Sarria Cets 2,7,12,17 alquenil, aril y heteroaril derivados del 3,6,13,16-tetraazaporficeno, y procedimiento, compuesto intermedio y utilizaciones correspondientes.
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US8703050B2 (en) * 2009-03-16 2014-04-22 Ondine International Ltd. Composition for photodynamic disinfection
JP2012520876A (ja) * 2009-03-16 2012-09-10 オンディーヌ インターナショナル リミテッド 光線力学殺菌用の組成物
US8715920B2 (en) 2010-07-27 2014-05-06 Biovec Transfusion, Llc Composition for preserving platelets during photosensitization
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
US11135316B2 (en) 2014-01-31 2021-10-05 Washington University Imaging and treatment of pathophysiologic conditions by Cerenkov radiation
US9974870B2 (en) 2014-06-09 2018-05-22 Washington University Compositions and methods for treatment and imaging using nanoparticles
CN104522058A (zh) * 2014-12-18 2015-04-22 安徽大学 一种含有藻胆蛋白的光敏杀菌剂及其制备方法及其杀菌的用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2372854A1 (es) * 2010-07-02 2012-01-27 Institut Quimic De Sarria Cets, Fundacio Privada Derivados catiónicos de 2, 7, 12, 17-arilporficenos. procedimiento de preparación y uso como fotosensibilizadores en terapia fotodinámica antimicrobiana.

Also Published As

Publication number Publication date
JPH06508834A (ja) 1994-10-06
NO934837D0 (no) 1993-12-27
JP3184218B2 (ja) 2001-07-09
DE69230755T2 (de) 2000-11-02
FI935878A0 (fi) 1993-12-27
WO1993000087A1 (en) 1993-01-07
AU2187092A (en) 1993-01-25
NO934837L (no) 1994-02-24
FI935878A (fi) 1993-12-27
CA2111323A1 (en) 1993-01-07
EP0591355B1 (en) 2000-03-08
AU664377B2 (en) 1995-11-16
ATE190309T1 (de) 2000-03-15
EP0591355A4 (en) 1995-01-18
NO301981B1 (no) 1998-01-05
EP0591355A1 (en) 1994-04-13
US5179120A (en) 1993-01-12
DE69230755D1 (de) 2000-04-13

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