PT101729A - Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos - Google Patents

Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos Download PDF

Info

Publication number
PT101729A
PT101729A PT101729A PT10172995A PT101729A PT 101729 A PT101729 A PT 101729A PT 101729 A PT101729 A PT 101729A PT 10172995 A PT10172995 A PT 10172995A PT 101729 A PT101729 A PT 101729A
Authority
PT
Portugal
Prior art keywords
chelates
complex
complexes
functional group
group linked
Prior art date
Application number
PT101729A
Other languages
English (en)
Other versions
PT101729B (pt
Inventor
Jaime Simon
Joseph R Garlich
Kenneth Mcmillan
David A Wilson
Richard K Frank
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of PT101729A publication Critical patent/PT101729A/pt
Publication of PT101729B publication Critical patent/PT101729B/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT101729A 1988-10-31 1995-06-27 Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos PT101729B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26515888A 1988-10-31 1988-10-31

Publications (2)

Publication Number Publication Date
PT101729A true PT101729A (pt) 1996-01-31
PT101729B PT101729B (pt) 1999-11-30

Family

ID=23009266

Family Applications (3)

Application Number Title Priority Date Filing Date
PT92157A PT92157B (pt) 1988-10-31 1989-10-30 Processo para a preparacao de quelantes, que posuuem um grupo funcional ligado na posicao orto, e de seus complexos
PT101728A PT101728B (pt) 1988-10-31 1995-06-27 Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos
PT101729A PT101729B (pt) 1988-10-31 1995-06-27 Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT92157A PT92157B (pt) 1988-10-31 1989-10-30 Processo para a preparacao de quelantes, que posuuem um grupo funcional ligado na posicao orto, e de seus complexos
PT101728A PT101728B (pt) 1988-10-31 1995-06-27 Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos

Country Status (23)

Country Link
EP (3) EP0566166B1 (pt)
JP (1) JP2845328B2 (pt)
KR (1) KR0153468B1 (pt)
CN (2) CN1038929C (pt)
AT (3) ATE121727T1 (pt)
AU (1) AU628095B2 (pt)
BR (1) BR8905657A (pt)
CA (1) CA2001765C (pt)
DE (3) DE68927271T2 (pt)
DK (1) DK541389A (pt)
ES (2) ES2090787T3 (pt)
FI (1) FI895141A0 (pt)
HK (3) HK122796A (pt)
HU (3) HU207710B (pt)
IE (2) IE980696A1 (pt)
IL (1) IL92160A (pt)
NO (1) NO178571C (pt)
NZ (1) NZ231180A (pt)
PH (1) PH31170A (pt)
PT (3) PT92157B (pt)
SG (1) SG44640A1 (pt)
TW (1) TW201694B (pt)
ZA (1) ZA898271B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10206690A1 (de) 2002-02-18 2003-08-28 Bsh Bosch Siemens Hausgeraete Dampfgarer sowie Anordnung und Verfahren zum Dampfgaren
US5342925A (en) * 1991-01-30 1994-08-30 The Dow Chemical Company Radioactive compositions for soft tissue tumors
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
DE4136489A1 (de) * 1991-11-06 1993-05-13 Bayer Ag Neue diethylentriamin-derivate und deren verwendung zu diagnostischen und therapeutischen zwecken
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5250728A (en) * 1991-12-12 1993-10-05 Hampshire Chemical Corp. Preparation of ethylenediaminetriacetic acid
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5703095A (en) * 1992-11-13 1997-12-30 L'oreal Use of N-arylmethylene, ethylenediaminetriacetates, N-arymethylene iminodiacetates or N,N'-diarylmethylene ethylenediamineacetates against oxidative stress
FR2706889A1 (en) * 1993-06-23 1994-12-30 Oreal Use of N-(arylmethylene)ethylenediaminetriacetate, N-(arylmethylene)iminodiacetate or N,N'-di(arylmethylene)ethylenediaminediacetate compounds against oxidative stress
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
DE19507820A1 (de) 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
FR2737204B1 (fr) * 1995-07-26 1997-09-12 Oreal Derives de n,n'-di(aralkyl)n,n'-di(carboxylakyl)alkylene di- ou triamine et de n-(aralkyl)n'-(carboxyalkyl) n,n'-di(carboxyalkyl)alkylene di- ou triamine et leur utilisation en pharmacie et en cosmetique
EP1052985B1 (en) 1998-02-04 2004-12-22 University Of Florida Research Foundation, Inc. N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid and sodium salts thereof for iron chelating therapy
AU2456201A (en) * 1999-12-21 2001-07-03 University Of Florida Research Foundation, Inc. N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid in iron chelating therapy
EP2039679B1 (en) * 2007-09-20 2015-08-12 Przedsiebiorstwo Produkcyjno-Consultingowe ADOB sp. z o.o. sp. k. A process for the preparation of N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and its derivatives
CN102746341A (zh) * 2012-07-20 2012-10-24 武汉工程大学 硫代氨基脲类席夫碱铋配合物及其制备方法
CN104840563A (zh) * 2015-05-09 2015-08-19 马德亮 一种治疗骨转移癌的中药制剂
CN115466194B (zh) * 2022-09-14 2023-08-04 江苏省农业科学院 一种溶杆菌来源的嗜铁素及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2763680A (en) * 1953-12-15 1956-09-18 Ciba Ltd Imino-dicarboxylic acids and functional derivatives thereof and process of making same
CH353747A (de) * 1955-12-06 1961-04-30 Geigy Ag J R Verfahren zur Herstellung von Schwermetallkomplexverbindungen und Verwendung derselben zur Bekämpfung von Schwermetallmangelerscheinungen von Pflanzen
DE1187132B (de) * 1963-08-24 1965-02-11 Agfa Ag Photographisches Material
US4046793A (en) * 1971-10-01 1977-09-06 Ciba-Geigy Corporation Chelates for the regulation of metal-deficiency phenomena in plants
US3994966A (en) 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
ES415154A1 (es) * 1973-05-15 1976-02-16 Dabeer Sa Procedimiento para la obtencion de derivados fenolicos de acidos hidro-xialquil-alquilenodiamino aceticos y sus sales.
US3965254A (en) 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
ES417766A1 (es) * 1973-07-28 1976-02-16 Dabeer Sa Procedimiento para la obtencion de quelatos de hierro apli-cables como correctores de la clorosis ferrica en los vege- tales.
US4043998A (en) 1974-10-09 1977-08-23 The Board Of Trustees Of The Leland Stanford Junior University 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid
US4091088A (en) 1975-02-19 1978-05-23 Australian Atomic Energy Commission Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals
US4088747A (en) 1975-02-19 1978-05-09 Australian Atomic Energy Commission Phenolic amino-carboxylic acid radiopharmaceuticals
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4432907A (en) 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4352751A (en) 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4622420A (en) 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4399817A (en) 1981-06-30 1983-08-23 The Procter & Gamble Company Boron containing polyphosphonates for the treatment of calcific tumors
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4454106A (en) 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4479930A (en) 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
SE8301395L (sv) 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4824986A (en) 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US4678667A (en) 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate

Also Published As

Publication number Publication date
DE68926913T2 (de) 1997-01-09
PT101729B (pt) 1999-11-30
HU895608D0 (en) 1990-01-28
NO894326L (no) 1990-05-02
HU911929D0 (en) 1991-12-30
KR900006273A (ko) 1990-05-07
HU207710B (en) 1993-05-28
NO178571B (no) 1996-01-15
JPH02196761A (ja) 1990-08-03
ES2090787T3 (es) 1996-10-16
TW201694B (pt) 1993-03-11
EP0367223A2 (en) 1990-05-09
NO894326D0 (no) 1989-10-30
AU628095B2 (en) 1992-09-10
AU4391689A (en) 1990-10-04
DE68927271T2 (de) 1997-03-06
IL92160A (en) 1994-07-31
ZA898271B (en) 1991-06-26
IE980696A1 (en) 2000-12-13
EP0570022A3 (en) 1993-11-24
CN1042536A (zh) 1990-05-30
HK122796A (en) 1996-07-19
CN1038929C (zh) 1998-07-01
EP0570022A2 (en) 1993-11-18
DE68922368D1 (de) 1995-06-01
PT101728A (pt) 1996-01-31
CA2001765A1 (en) 1990-04-30
DE68927271D1 (de) 1996-10-31
NO178571C (no) 1996-04-24
HK1007554A1 (en) 1999-04-16
IE980697A1 (en) 2000-12-13
HU911928D0 (en) 1991-12-30
PH31170A (en) 1998-03-20
DE68926913D1 (de) 1996-09-05
PT101728B (pt) 1999-11-30
PT92157A (pt) 1990-05-31
ES2092188T3 (es) 1996-11-16
JP2845328B2 (ja) 1999-01-13
DE68922368T2 (de) 1995-08-31
EP0367223B1 (en) 1995-04-26
PT92157B (pt) 1997-01-31
ATE121727T1 (de) 1995-05-15
EP0566166A1 (en) 1993-10-20
CN1090286A (zh) 1994-08-03
EP0570022B1 (en) 1996-07-31
DK541389D0 (da) 1989-10-30
IL92160A0 (en) 1990-07-12
KR0153468B1 (ko) 1998-12-01
ATE140917T1 (de) 1996-08-15
HUT51594A (en) 1990-05-28
DK541389A (da) 1990-05-01
EP0566166B1 (en) 1996-09-25
CN1045290C (zh) 1999-09-29
EP0367223A3 (en) 1990-09-05
FI895141A0 (fi) 1989-10-30
BR8905657A (pt) 1990-06-05
CA2001765C (en) 2003-12-30
HK1007555A1 (en) 1999-04-16
SG44640A1 (en) 1997-12-19
ATE143353T1 (de) 1996-10-15
NZ231180A (en) 1994-11-25

Similar Documents

Publication Publication Date Title
PT101729A (pt) Quelantes que possuem um grupo funcional ligado na posicao orto e seus complexos
KR900701765A (ko) 마이크로사이클릭 이작용성 킬레이트제, 이들의 착화합물 및 이들의 항체 결합물
DK165488D0 (da) Metalchelaterende forbindelser og chelatforbindelser
NZ222677A (en) Pharmaceutical compositions and diagnostic agents comprising metal chelate complexes and additional metal complexing agent and/or weak metal chelate to enhance tolerance
SG48889A1 (en) Bicycle-polyamacrocyclocarboxylic acid complexes conjugates preparation and use as contrast agents
KR930700163A (ko) 연조직 종양의 치료 및/또는 진단 방법
GR3020861T3 (en) Mri image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
PT95620A (pt) Processo para a preparacao de pro-drogas glicosil-etoposido e de composicoes farmaceuticas que as contem em combinacao com conjugados de enzima especificos para tumor funcionalizados

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19951025

FG3A Patent granted, date of granting

Effective date: 19990802