KR890006657A - 6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2- 티아진-3 -카복스아미드 1,1- 디옥사이드의 엔올에테르 이의 제조방법 및 이의 용도 - Google Patents

6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2- 티아진-3 -카복스아미드 1,1- 디옥사이드의 엔올에테르 이의 제조방법 및 이의 용도 Download PDF

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Publication number
KR890006657A
KR890006657A KR1019880014013A KR880014013A KR890006657A KR 890006657 A KR890006657 A KR 890006657A KR 1019880014013 A KR1019880014013 A KR 1019880014013A KR 880014013 A KR880014013 A KR 880014013A KR 890006657 A KR890006657 A KR 890006657A
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KR
South Korea
Prior art keywords
formula
compound
thieno
carboxamide
pyridyl
Prior art date
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KR1019880014013A
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English (en)
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KR970011395B1 (ko
Inventor
빈더 디이터
로벤스즈키 프란쯔
페터 훼버 후버트
Original Assignee
맥.랄프 베른 하르트,졸프 에프.플뢰르케
씨엘 파마 아크티엘게젤샤프트
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Publication of KR890006657A publication Critical patent/KR890006657A/ko
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Publication of KR970011395B1 publication Critical patent/KR970011395B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)

Abstract

내용 없음

Description

6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노-(2,3-e)-1,2-티아진-3-카복스아미드 1,1-디옥사이드의 엔올에테르 이의 제조방법 및 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 다음 일반식 (I)의 화합물.
    상기식에서 R은 (C1-C6)-알킬, (C3-C7)사이클로알킬 또는 벤질이다.
  2. 6-클로로-4-1(1-에톡시카르보닐옥시)에톡시-2-메틸-N-(2-피리딜)-2H-티에노-(2,3-e)-1,2-티아진-3-카복스아미드 1,1-디옥사이드.
  3. 일반식(II)의 클로르텐옥시캄의 염을 반응에 대해 불활성인 극성 비양성자성 용매중에서 일반식(III)의 화합물과 반응시킴을 특징으로 하여 일반식(I)의 화합물을 제조하는 방법.
    상기식에서, R은 제1항에서 정의한 바와 같고, M+는 알칼리 금속 양이온 또는 알칼리토금속 양이온 또는 테트라알킬암모늄이며, X는 할로겐이다.
  4. 염증 질환을 치료하기에 유효한 양의 제1항에 따른 일반식(I)의 화합물을 약제학적으로 허용되는 부형제, 담체 또는 희석제와 함께 혼합 함유하는 약제학적 조성물.
  5. 염증질환을 치료하기에 유효한 양의 제1항에 따른 일반식(I)의 화합물을 다른 치료학적 활성 화합물 약제학적으로 허용되는 부형제, 담체 또는 희석제와 함께 혼합 함유하는 약제학적 조성물.
  6. 유효량의 제1항에 따른 일반식(I)의 화합물을 약제학적으로 허용되는 부형제, 담체 또는 희석제와 배합하여 환자에게 투여함을 특징으로 하여, 염증질환을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880014013A 1987-10-29 1988-10-27 6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2-티아진-3-카복스아미드 1,1-디옥사이드의 에놀 에테르, 이의 제조방법 및 이를 함유하는 약제학적 조성물 KR970011395B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA2855/87 1987-10-29
AT285587 1987-10-29

Publications (2)

Publication Number Publication Date
KR890006657A true KR890006657A (ko) 1989-06-15
KR970011395B1 KR970011395B1 (ko) 1997-07-10

Family

ID=3541372

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880014013A KR970011395B1 (ko) 1987-10-29 1988-10-27 6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2-티아진-3-카복스아미드 1,1-디옥사이드의 에놀 에테르, 이의 제조방법 및 이를 함유하는 약제학적 조성물

Country Status (25)

Country Link
US (1) US4927821A (ko)
EP (1) EP0313935B1 (ko)
JP (1) JP2588598B2 (ko)
KR (1) KR970011395B1 (ko)
CN (1) CN1019577B (ko)
AT (1) ATE109152T1 (ko)
AU (1) AU613416B2 (ko)
CA (1) CA1314883C (ko)
CZ (1) CZ278281B6 (ko)
DD (1) DD275689A5 (ko)
DE (1) DE3850845D1 (ko)
DK (1) DK168384B1 (ko)
ES (1) ES2056868T3 (ko)
FI (1) FI86855C (ko)
HU (1) HU201082B (ko)
IL (1) IL87951A (ko)
MY (1) MY103782A (ko)
NO (1) NO174928C (ko)
NZ (1) NZ226477A (ko)
PL (1) PL150950B1 (ko)
SK (1) SK278141B6 (ko)
SU (1) SU1591813A3 (ko)
UA (1) UA5916A1 (ko)
YU (1) YU48037B (ko)
ZA (1) ZA887731B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399880B (de) * 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
DE4400867A1 (de) * 1994-01-14 1995-07-20 Nycomed Arzneimittel Gmbh Neue Thienothiazinderivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US6254057B1 (en) * 1998-10-22 2001-07-03 Integra Dynamics Inc. Valve control system
AT413944B (de) * 2003-05-27 2006-07-15 Binder Eva Dkfm Verwendung von oxicam-verbindungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
ATE26720T1 (de) * 1982-09-09 1987-05-15 Hoffmann La Roche Thieno(2,3-e)-1,2-thiazin-derivate.
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor

Also Published As

Publication number Publication date
PL150950B1 (en) 1990-07-31
ATE109152T1 (de) 1994-08-15
NO884543L (no) 1989-05-02
DK168384B1 (da) 1994-03-21
EP0313935A2 (de) 1989-05-03
NO174928C (no) 1994-08-03
JPH01149792A (ja) 1989-06-12
DK600188A (da) 1989-04-30
US4927821A (en) 1990-05-22
NO174928B (no) 1994-04-25
EP0313935B1 (de) 1994-07-27
EP0313935A3 (en) 1990-10-31
AU613416B2 (en) 1991-08-01
JP2588598B2 (ja) 1997-03-05
DD275689A5 (de) 1990-01-31
SK695188A3 (en) 1996-02-07
CZ695188A3 (en) 1993-07-14
YU48037B (sh) 1996-10-18
UA5916A1 (uk) 1994-12-29
PL275523A1 (en) 1989-06-12
DK600188D0 (da) 1988-10-28
SK278141B6 (en) 1996-02-07
CA1314883C (en) 1993-03-23
AU2440388A (en) 1989-05-04
ZA887731B (en) 1989-07-26
HU201082B (en) 1990-09-28
DE3850845D1 (de) 1994-09-01
KR970011395B1 (ko) 1997-07-10
SU1591813A3 (ru) 1990-09-07
IL87951A (en) 1992-03-29
FI884976A0 (fi) 1988-10-28
CN1033809A (zh) 1989-07-12
CZ278281B6 (en) 1993-11-17
MY103782A (en) 1993-09-30
IL87951A0 (en) 1989-03-31
FI884976A (fi) 1989-04-30
FI86855C (fi) 1992-10-26
NZ226477A (en) 1990-07-26
CN1019577B (zh) 1992-12-23
NO884543D0 (no) 1988-10-12
YU199288A (en) 1989-12-31
ES2056868T3 (es) 1994-10-16
FI86855B (fi) 1992-07-15
HUT50837A (en) 1990-03-28

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