KR890006657A - 6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2- 티아진-3 -카복스아미드 1,1- 디옥사이드의 엔올에테르 이의 제조방법 및 이의 용도 - Google Patents
6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2- 티아진-3 -카복스아미드 1,1- 디옥사이드의 엔올에테르 이의 제조방법 및 이의 용도 Download PDFInfo
- Publication number
- KR890006657A KR890006657A KR1019880014013A KR880014013A KR890006657A KR 890006657 A KR890006657 A KR 890006657A KR 1019880014013 A KR1019880014013 A KR 1019880014013A KR 880014013 A KR880014013 A KR 880014013A KR 890006657 A KR890006657 A KR 890006657A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- thieno
- carboxamide
- pyridyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- QSROMHGADXCEBY-UHFFFAOYSA-N 6-chloro-4-hydroxy-2-methyl-n-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide Chemical compound CN1SC=2C=C(Cl)SC=2C(O)=C1C(=O)NC1=CC=CC=N1 QSROMHGADXCEBY-UHFFFAOYSA-N 0.000 title 1
- 150000002084 enol ethers Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 7
- -1 1-ethoxycarbonyloxy Chemical group 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003880 polar aprotic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 다음 일반식 (I)의 화합물.상기식에서 R은 (C1-C6)-알킬, (C3-C7)사이클로알킬 또는 벤질이다.
- 6-클로로-4-1(1-에톡시카르보닐옥시)에톡시-2-메틸-N-(2-피리딜)-2H-티에노-(2,3-e)-1,2-티아진-3-카복스아미드 1,1-디옥사이드.
- 일반식(II)의 클로르텐옥시캄의 염을 반응에 대해 불활성인 극성 비양성자성 용매중에서 일반식(III)의 화합물과 반응시킴을 특징으로 하여 일반식(I)의 화합물을 제조하는 방법.상기식에서, R은 제1항에서 정의한 바와 같고, M+는 알칼리 금속 양이온 또는 알칼리토금속 양이온 또는 테트라알킬암모늄이며, X는 할로겐이다.
- 염증 질환을 치료하기에 유효한 양의 제1항에 따른 일반식(I)의 화합물을 약제학적으로 허용되는 부형제, 담체 또는 희석제와 함께 혼합 함유하는 약제학적 조성물.
- 염증질환을 치료하기에 유효한 양의 제1항에 따른 일반식(I)의 화합물을 다른 치료학적 활성 화합물 약제학적으로 허용되는 부형제, 담체 또는 희석제와 함께 혼합 함유하는 약제학적 조성물.
- 유효량의 제1항에 따른 일반식(I)의 화합물을 약제학적으로 허용되는 부형제, 담체 또는 희석제와 배합하여 환자에게 투여함을 특징으로 하여, 염증질환을 치료하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATA2855/87 | 1987-10-29 | ||
AT285587 | 1987-10-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890006657A true KR890006657A (ko) | 1989-06-15 |
KR970011395B1 KR970011395B1 (ko) | 1997-07-10 |
Family
ID=3541372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880014013A KR970011395B1 (ko) | 1987-10-29 | 1988-10-27 | 6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2-티아진-3-카복스아미드 1,1-디옥사이드의 에놀 에테르, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
Country Status (25)
Country | Link |
---|---|
US (1) | US4927821A (ko) |
EP (1) | EP0313935B1 (ko) |
JP (1) | JP2588598B2 (ko) |
KR (1) | KR970011395B1 (ko) |
CN (1) | CN1019577B (ko) |
AT (1) | ATE109152T1 (ko) |
AU (1) | AU613416B2 (ko) |
CA (1) | CA1314883C (ko) |
CZ (1) | CZ278281B6 (ko) |
DD (1) | DD275689A5 (ko) |
DE (1) | DE3850845D1 (ko) |
DK (1) | DK168384B1 (ko) |
ES (1) | ES2056868T3 (ko) |
FI (1) | FI86855C (ko) |
HU (1) | HU201082B (ko) |
IL (1) | IL87951A (ko) |
MY (1) | MY103782A (ko) |
NO (1) | NO174928C (ko) |
NZ (1) | NZ226477A (ko) |
PL (1) | PL150950B1 (ko) |
SK (1) | SK278141B6 (ko) |
SU (1) | SU1591813A3 (ko) |
UA (1) | UA5916A1 (ko) |
YU (1) | YU48037B (ko) |
ZA (1) | ZA887731B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT399880B (de) * | 1992-07-03 | 1995-08-25 | Chem Pharm Forsch Gmbh | Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung |
EP0658559A1 (de) * | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
DE4400867A1 (de) * | 1994-01-14 | 1995-07-20 | Nycomed Arzneimittel Gmbh | Neue Thienothiazinderivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung |
US5538966A (en) * | 1994-01-21 | 1996-07-23 | Alcon Laboratories, Inc. | Carbonic anhydrase inhibitors |
US6254057B1 (en) * | 1998-10-22 | 2001-07-03 | Integra Dynamics Inc. | Valve control system |
AT413944B (de) * | 2003-05-27 | 2006-07-15 | Binder Eva Dkfm | Verwendung von oxicam-verbindungen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
ATE26720T1 (de) * | 1982-09-09 | 1987-05-15 | Hoffmann La Roche | Thieno(2,3-e)-1,2-thiazin-derivate. |
US4551452A (en) * | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
-
1988
- 1988-10-06 IL IL87951A patent/IL87951A/xx not_active IP Right Cessation
- 1988-10-06 NZ NZ226477A patent/NZ226477A/xx unknown
- 1988-10-12 MY MYPI88001131A patent/MY103782A/en unknown
- 1988-10-12 NO NO884543A patent/NO174928C/no unknown
- 1988-10-13 CA CA000580051A patent/CA1314883C/en not_active Expired - Fee Related
- 1988-10-14 EP EP88117090A patent/EP0313935B1/de not_active Expired - Lifetime
- 1988-10-14 ES ES88117090T patent/ES2056868T3/es not_active Expired - Lifetime
- 1988-10-14 AT AT88117090T patent/ATE109152T1/de not_active IP Right Cessation
- 1988-10-14 DE DE3850845T patent/DE3850845D1/de not_active Expired - Fee Related
- 1988-10-17 ZA ZA887731A patent/ZA887731B/xx unknown
- 1988-10-18 US US07/262,499 patent/US4927821A/en not_active Expired - Fee Related
- 1988-10-20 SK SK6951-88A patent/SK278141B6/sk unknown
- 1988-10-20 CZ CS886951A patent/CZ278281B6/cs unknown
- 1988-10-25 YU YU199288A patent/YU48037B/sh unknown
- 1988-10-27 PL PL1988275523A patent/PL150950B1/pl unknown
- 1988-10-27 KR KR1019880014013A patent/KR970011395B1/ko active IP Right Grant
- 1988-10-27 AU AU24403/88A patent/AU613416B2/en not_active Ceased
- 1988-10-27 CN CN88107381A patent/CN1019577B/zh not_active Expired
- 1988-10-27 DD DD88321145A patent/DD275689A5/de not_active IP Right Cessation
- 1988-10-28 SU SU884356752A patent/SU1591813A3/ru active
- 1988-10-28 HU HU885638A patent/HU201082B/hu not_active IP Right Cessation
- 1988-10-28 FI FI884976A patent/FI86855C/fi not_active IP Right Cessation
- 1988-10-28 UA UA4356752A patent/UA5916A1/uk unknown
- 1988-10-28 DK DK600188A patent/DK168384B1/da not_active Application Discontinuation
- 1988-10-28 JP JP63271064A patent/JP2588598B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO915122L (no) | N-substituerte cykloalkyl- og polycykloalkyl- alfa-substituerte trp-phe- og fenetylamin-derivater | |
SE8102193L (sv) | Terapeutiskt aktiv organisk forening och dess anvendning | |
FI842760A0 (fi) | Menetelmä terapeuttisesti aktiivisten imidatsoliumyhdisteiden valmistamiseksi | |
FR2385719A1 (fr) | Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant | |
EP0146516A3 (en) | Derivatives of guanine, process for their preparation and a pharmaceutical preparation | |
FI854926A (fi) | Foerfarande foer framstaellning av farmakologiskt aktiva pyrrolobensimidazoler. | |
FR2621316B1 (fr) | Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant | |
KR890006657A (ko) | 6-클로로-4-하이드록시-2-메틸-N-(2-피리딜)-2H-티에노(2,3-e)-1,2- 티아진-3 -카복스아미드 1,1- 디옥사이드의 엔올에테르 이의 제조방법 및 이의 용도 | |
DE2735832A1 (de) | Schwefelanaloge von penicillinen und cephalosporinen | |
ES455691A1 (es) | Procedimiento para la produccion de derivados de piperacina. | |
AU6216586A (en) | New tricyclic compounds, processes for the preparation thereof and pharmaceutical compositions containing them | |
KR900011768A (ko) | 신규 치환 피리도 [2,3-d] 피리미던 | |
KR890008136A (ko) | 항균성 9-데옥소-9a-알릴 및 프로파길-9a-아자-9a-호모에리트로 마이신 A 유도체 | |
PH15640A (en) | A method for the treatment of pyrexia due to the accentuation of central nerve by administering a derivative of o-aminobenzoic acid | |
HUT46214A (en) | Process for producing medical preparation suitable for treatment of peptic ulcer | |
SE8701592D0 (sv) | A pharmaceutical composition comprising an organic zinc complex and a process for preparing the active substance | |
EP0207483A3 (en) | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | |
HUT44515A (en) | Process for producing isoquinolinol compounds of heart activity increasing, phosphodiesterase iii inhibiting and/or renal vasodilating activity and pharmaceutical composition containing them | |
KR910002450A (ko) | 당뇨병 치료용 제약 조성물 | |
KR927003536A (ko) | 키누렌산 유도체, 그의 제조방법 및 이를 함유하는 약제학적 조성물 | |
KR880001652A (ko) | 이소퀴놀린 유도체 및 이의 제조 방법 | |
KR900016130A (ko) | 2-피리딜메틸티오 유도체 및 궤양 치료제 | |
EP0280868A3 (en) | Imidazo- and triazolothiadiazines, process for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | |
KR880012585A (ko) | 2-티에닐옥시아세트산 유도체, 이의 제조방법 및 이를 함유하는 약제 | |
KR890005107A (ko) | 약제 제조를 위한 특정 6-머캅토푸린의 용도 및 이 약제의 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
NORF | Unpaid initial registration fee |