FI854926A - Foerfarande foer framstaellning av farmakologiskt aktiva pyrrolobensimidazoler. - Google Patents

Foerfarande foer framstaellning av farmakologiskt aktiva pyrrolobensimidazoler. Download PDF

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Publication number
FI854926A
FI854926A FI854926A FI854926A FI854926A FI 854926 A FI854926 A FI 854926A FI 854926 A FI854926 A FI 854926A FI 854926 A FI854926 A FI 854926A FI 854926 A FI854926 A FI 854926A
Authority
FI
Finland
Prior art keywords
pyrrolobensimidazoler
freezing
pharmacological active
present
prophylaxis
Prior art date
Application number
FI854926A
Other languages
English (en)
Other versions
FI79318B (fi
FI854926A0 (fi
FI79318C (fi
Inventor
Alfred Mertens
Jens-Peter Hoelck
Wolfgang Kampe
Bernd Mueller-Beckmann
Klaus Strein
Wolfgang Schaumann
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI854926A0 publication Critical patent/FI854926A0/fi
Publication of FI854926A publication Critical patent/FI854926A/fi
Publication of FI79318B publication Critical patent/FI79318B/fi
Application granted granted Critical
Publication of FI79318C publication Critical patent/FI79318C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI854926A 1984-12-14 1985-12-12 Foerfarande foer framstaellning av farmakologiskt aktiva 6,7-dihydro-3h,5h-pyrrolo/2,3-f/bensimidazol-6-oner. FI79318C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3445669 1984-12-14
DE19843445669 DE3445669A1 (de) 1984-12-14 1984-12-14 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (4)

Publication Number Publication Date
FI854926A0 FI854926A0 (fi) 1985-12-12
FI854926A true FI854926A (fi) 1986-06-15
FI79318B FI79318B (fi) 1989-08-31
FI79318C FI79318C (fi) 1989-12-11

Family

ID=6252801

Family Applications (1)

Application Number Title Priority Date Filing Date
FI854926A FI79318C (fi) 1984-12-14 1985-12-12 Foerfarande foer framstaellning av farmakologiskt aktiva 6,7-dihydro-3h,5h-pyrrolo/2,3-f/bensimidazol-6-oner.

Country Status (16)

Country Link
US (2) US4710510A (fi)
EP (1) EP0186010B1 (fi)
JP (1) JPS61158984A (fi)
AT (1) ATE49970T1 (fi)
AU (1) AU580822B2 (fi)
CA (1) CA1262908A (fi)
CS (1) CS276403B6 (fi)
DD (1) DD242045A5 (fi)
DE (2) DE3445669A1 (fi)
DK (1) DK579185A (fi)
ES (1) ES8702409A1 (fi)
FI (1) FI79318C (fi)
GR (1) GR852979B (fi)
HU (1) HU194241B (fi)
SU (1) SU1440348A3 (fi)
ZA (1) ZA859382B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626664A1 (de) * 1986-08-07 1988-02-11 Boehringer Mannheim Gmbh Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
ATE138658T1 (de) * 1987-12-30 1996-06-15 Orion Yhtymae Oy Heterocyclische verbindungen
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US7186745B2 (en) * 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
US6951848B2 (en) * 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
US20050165028A1 (en) * 2004-01-23 2005-07-28 Norman Mark H. Vanilloid receptor ligands and their use in treatments
AU2013314417B2 (en) 2012-09-13 2016-01-21 F. Hoffmann-La Roche Ag 2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders
US10752640B2 (en) 2014-08-01 2020-08-25 Nuevolution A/S Compounds active towards bromodomains
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
EP0033612B1 (en) * 1980-02-02 1984-04-11 Beecham Group Plc Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them
FR2476644A1 (fr) * 1980-02-21 1981-08-28 Sarget Lab Orthoarylydeneaminophenethylamine, leur preparation et leur utilisation therapeutique
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
SU1068439A1 (ru) * 1982-10-28 1984-01-23 Новокузнецкий научно-исследовательский химико-фармацевтический институт Производные имидазо(4,5- @ ) индолов
US4579865A (en) * 1983-02-14 1986-04-01 Usv Pharmaceutical Corp. Benzofuranyl carbamates
US4548943A (en) * 1984-05-11 1985-10-22 E. I. Du Pont De Nemours And Company Antiinflammatory, analgesic, or anti-primary dysmenorrheal arylmethylene- and arylmethylindenoimidazoles
PL144822B1 (en) * 1984-05-12 1988-07-30 Boehringer Mannheim Gmbh Method of obtaining novel pyrolobenzimidazoles
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
AU580822B2 (en) 1989-02-02
CA1262908A (en) 1989-11-14
HUT40436A (en) 1986-12-28
JPS61158984A (ja) 1986-07-18
DK579185D0 (da) 1985-12-13
US4710510A (en) 1987-12-01
FI79318B (fi) 1989-08-31
US4810801A (en) 1989-03-07
EP0186010B1 (de) 1990-01-31
DD242045A5 (de) 1987-01-14
ES549776A0 (es) 1987-01-16
DK579185A (da) 1986-06-15
FI854926A0 (fi) 1985-12-12
ES8702409A1 (es) 1987-01-16
FI79318C (fi) 1989-12-11
EP0186010A1 (de) 1986-07-02
CS276403B6 (en) 1992-05-13
GR852979B (fi) 1986-04-08
ZA859382B (en) 1986-08-27
DE3575725D1 (de) 1990-03-08
DE3445669A1 (de) 1986-06-19
CS919585A3 (en) 1992-01-15
AU5100685A (en) 1986-06-19
JPH0471914B2 (fi) 1992-11-16
HU194241B (en) 1988-01-28
SU1440348A3 (ru) 1988-11-23
ATE49970T1 (de) 1990-02-15

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MM Patent lapsed
MM Patent lapsed

Owner name: BOEHRINGER MANNHEIM GMBH