KR890000471A - 신규 글리세롤 아세탈의 아미노아실레이트 - Google Patents

신규 글리세롤 아세탈의 아미노아실레이트 Download PDF

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KR890000471A
KR890000471A KR1019880007029A KR880007029A KR890000471A KR 890000471 A KR890000471 A KR 890000471A KR 1019880007029 A KR1019880007029 A KR 1019880007029A KR 880007029 A KR880007029 A KR 880007029A KR 890000471 A KR890000471 A KR 890000471A
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formula
compound
acid
reacted
nitrogen
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KR1019880007029A
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KR960005153B1 (ko
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브로께 꼴레트
브라께 삐에트
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게라트 보푸트
소시에떼드 꽁세이으 드 르 세르세 에 다쁠리까시옹 시앙띠피끄
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

신규 글리세롤 아세탈의 아미노아실레이트
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식I로 표시되는 신규 글리세롤 아세탈의 아미노아실레이트(분리된 이성질체 또는 이성질체의 임의의 혼합물 형태).
    상기 식중, R1은 치환페닐기 또는 구조식CmH2m+1(m은 9 내지 25의 정수임)의 기이고, R2는 수소 원자, 페닐기 또는 구조식CnH2n+1(n은 1 내지 10의 정수임)의 기이고, P는 3 내지 10의 정수이고, 는 피리디늄, 3-타아졸리늄, 퀴놀리늄, 이소퀴놀리늄, 이미다졸륨 및 피라지늄과 같은 질소 함유 헤테로시클릭기이며,는 제약상 허용되는 무기산 또는 유기산의 음이온 또는 할로겐 이온(예, 염소, 브롬, 요오드) 또는 벤조산, 아세트산, 메탄술포산, 타르타르산의 음이온을 의미한다.
  2. 구조식 R1COR2(식중, R1및 R2는 상기 정의한 바와 같음)의 알데히드 또는 케톤의 약간의 화학양론적 과량을 P-톨루엔술폰산 존재하에, 환류 조건에서 비극성 용매중의 글리세롤과 반응시키고, 생성된 4-히드록시메틸 1,3-디옥솔란 유도체를 실온에서, 유기 염기(예, 트리에틸아민) 존재 하에 구조식 CLCO(CH2)pX(식중, P 및 X는 상기 정의한 바와 같음)의 ω-할로알카노일 클로라이드와 반응시킨 다음, 50°-80℃에서 질소 순환 분위기 하에, 생성된 구조식
    의 화합물을 구조식 N의 질소 함유 헤테로시클릭 화합물과 반응시키는 것으로 되는 제1항의 화합물의 제조방법.
  3. 적합한 희석제 또는 담체와 함께 유효 성분으로서 제1항에 의한 화합물 중의 적어도 하나의 유효량을 함유하는 물질의 치료 조성물.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880007029A 1987-06-12 1988-06-11 신규 글리세롤 아세탈의 아미노아실레이트 KR960005153B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8713745 1987-06-12
GB878713745A GB8713745D0 (en) 1987-06-12 1987-06-12 Aminoacylates of glycerol
FR8713745 1987-10-05

Publications (2)

Publication Number Publication Date
KR890000471A true KR890000471A (ko) 1989-03-14
KR960005153B1 KR960005153B1 (ko) 1996-04-22

Family

ID=10618794

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880007029A KR960005153B1 (ko) 1987-06-12 1988-06-11 신규 글리세롤 아세탈의 아미노아실레이트

Country Status (33)

Country Link
US (1) US4921865A (ko)
JP (1) JPH0615540B2 (ko)
KR (1) KR960005153B1 (ko)
AR (1) AR245121A1 (ko)
AT (1) AT396236B (ko)
AU (1) AU621298B2 (ko)
BE (1) BE1000700A4 (ko)
CA (1) CA1337297C (ko)
CH (1) CH674516A5 (ko)
DE (1) DE3819829C2 (ko)
DK (1) DK319188A (ko)
DZ (1) DZ1215A1 (ko)
ES (1) ES2009283A6 (ko)
FI (1) FI90421C (ko)
FR (2) FR2616326B1 (ko)
GB (1) GB8713745D0 (ko)
GR (1) GR1000889B (ko)
HK (1) HK77191A (ko)
IE (1) IE61447B1 (ko)
IN (1) IN172782B (ko)
IT (1) IT1218067B (ko)
LU (1) LU87235A1 (ko)
MA (1) MA21298A1 (ko)
MY (1) MY103577A (ko)
NL (1) NL192521C (ko)
NO (1) NO170632C (ko)
NZ (1) NZ224936A (ko)
OA (1) OA08879A (ko)
PT (1) PT87689B (ko)
SE (1) SE466450B (ko)
SG (1) SG73191G (ko)
TN (1) TNSN88057A1 (ko)
ZA (1) ZA884024B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2556849B2 (ja) * 1986-02-13 1996-11-27 三共株式会社 グリセリン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035178A (en) * 1976-08-31 1977-07-12 Fmc Corporation Herbicidal 1,3-dioxanes
IN146343B (ko) * 1976-08-31 1979-05-05 Fmc Corp
US4375474A (en) * 1982-02-11 1983-03-01 Syntex (U.S.A.) Inc. Dioxalane containing imidazole compounds, compositions and use
GB8612940D0 (en) * 1986-05-28 1986-07-02 Dow Chemical Co Derivative esters

Also Published As

Publication number Publication date
IT1218067B (it) 1990-04-12
DK319188A (da) 1989-02-03
AT396236B (de) 1993-07-26
FI882705A (fi) 1988-12-13
ES2009283A6 (es) 1989-09-16
OA08879A (fr) 1989-10-31
AU1756288A (en) 1988-12-15
CH674516A5 (ko) 1990-06-15
AR245121A1 (es) 1993-12-30
NO882564D0 (no) 1988-06-10
SG73191G (en) 1991-11-22
MA21298A1 (fr) 1988-12-31
SE466450B (sv) 1992-02-17
IE61447B1 (en) 1994-11-02
PT87689B (pt) 1992-09-30
FR2616432B1 (fr) 1990-05-11
DK319188D0 (da) 1988-06-10
US4921865A (en) 1990-05-01
MY103577A (en) 1993-08-28
AU621298B2 (en) 1992-03-12
NZ224936A (en) 1990-03-27
GR880100363A (en) 1989-03-08
ATA152988A (de) 1992-11-15
FR2616432A1 (fr) 1988-12-16
TNSN88057A1 (fr) 1990-07-10
NL192521B (nl) 1997-05-01
DZ1215A1 (fr) 2004-09-13
IT8820940A0 (it) 1988-06-10
BE1000700A4 (fr) 1989-03-14
FR2616326B1 (fr) 1989-12-01
PT87689A (pt) 1988-07-01
SE8802162D0 (sv) 1988-06-09
ZA884024B (en) 1989-02-22
JPH0615540B2 (ja) 1994-03-02
GR1000889B (el) 1993-03-16
NL8801484A (nl) 1989-01-02
NL192521C (nl) 1997-09-02
IE881752L (en) 1988-12-12
LU87235A1 (fr) 1988-12-13
IN172782B (ko) 1993-11-27
KR960005153B1 (ko) 1996-04-22
NO170632B (no) 1992-08-03
CA1337297C (en) 1995-10-10
NO882564L (no) 1988-12-13
FI90421C (fi) 1994-02-10
NO170632C (no) 1992-11-11
HK77191A (en) 1991-10-11
DE3819829C2 (de) 1993-10-21
FI882705A0 (fi) 1988-06-08
FR2616326A1 (fr) 1988-12-16
GB8713745D0 (en) 1987-07-15
SE8802162L (sv) 1988-12-13
JPS6413085A (en) 1989-01-17
DE3819829A1 (de) 1988-12-22
FI90421B (fi) 1993-10-29

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