KR870700209A - 즉석 균질마이크로 캎셀 현탁액의 제조방법 - Google Patents
즉석 균질마이크로 캎셀 현탁액의 제조방법Info
- Publication number
- KR870700209A KR870700209A KR860700872A KR860700872A KR870700209A KR 870700209 A KR870700209 A KR 870700209A KR 860700872 A KR860700872 A KR 860700872A KR 860700872 A KR860700872 A KR 860700872A KR 870700209 A KR870700209 A KR 870700209A
- Authority
- KR
- South Korea
- Prior art keywords
- formulation
- thickening
- agent
- suspension
- cellulose
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 7
- 239000000725 suspension Substances 0.000 title claims 5
- 239000002562 thickening agent Substances 0.000 claims 11
- 238000009472 formulation Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 4
- 239000000375 suspending agent Substances 0.000 claims 3
- 230000008719 thickening Effects 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- -1 hydroxy butylmethyl Chemical group 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003094 microcapsule Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940075420 xanthine Drugs 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 1
- 241000206672 Gelidium Species 0.000 claims 1
- 229920000569 Gum karaya Polymers 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229920000161 Locust bean gum Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 241000934878 Sterculia Species 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 235000010419 agar Nutrition 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 235000012730 carminic acid Nutrition 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 1
- 235000010494 karaya gum Nutrition 0.000 claims 1
- 239000000231 karaya gum Substances 0.000 claims 1
- 229940039371 karaya gum Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000010420 locust bean gum Nutrition 0.000 claims 1
- 239000000711 locust bean gum Substances 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920006254 polymer film Polymers 0.000 claims 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000003021 water soluble solvent Substances 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 다음으로 요약될 수 있는 단계, 즉 (a) 농후제의 미세화 또는 마쇄단계 (b) 농후제를 적당한 결합제의 용액중에 현탁화시키는 단계 (c) 현탁액을 제제의 하나 또는 그 이상의 성분의 입자주위에 분산시키는 단계 (d) 생성물을 건조 및 사과하는 단계를 거침을 특징으로 하여, 균질현탁액중에 고형입자 및 특히 약물 마이크로 캅셀을 보지할 수 있게, 응집괴의 형성없이 물 또는 액성 매에중에서 신속한 용해 및 분산성을 갖는 농후제 또는 현탁제로 이루어진 제제의 제조방법.
- 제1항에 있어서, 농후제 또는 현탁화제 단계대신에 200메쉬 특허 바람직하기는 100매쉬이하의 입자도를 갖는 이미 시판되는 농후제 및 현탁제를 사용함을 특징으로 하는 제제의 제조방법.
- 제1항 또는 제2항에 있어서, 농후제가 결합제가 용해되어 있는 용매중에서 불용성이거나 난용성이어야 하며, 반면에 물 및 유기용매중에서는 가용성임을 특징으로 하는 제제의 제조방법.
- 제1항 또는 제2항에 있어서, 현탁액이 분산되어지는 입자주위의 성분이 불활성의 부형제 또는 특히 감미제임을 특징으로 하는 제제의 제조방법.
- 상기항의 어느 하나에 있어서, 농후제가 알긴산 카라게난, 한천-한천, 트라가칸드검, 크산틴검, 가르검, 카로브검, 카라야검, 변형옥수수전분, 카르복시메틸 셀룰로즈, 결정셀룰로즈 단독 또는 수화콜로이드(아비셀 Re-591:FMC사 제품)와의 조합등으로 이루어진 구룹으로부터 선택된 것임을 특징으로 하는 제제의 제조방법.
- 상기항의 어느 하나에 있어서, 수용성 또는 유기용매에 가용성인 결합제가 메틸셀룰로즈, 히드록시 푸로필메틸 셀룰로즈, 히드록시 부틸메틸, 셀룰로즈, 히드록시 에틸셀룰로즈, 히드록시 푸로필 셀룰로즈, 폴리에틸렌 글라이콜, 폴리비닐알콜, 폴리비닐피롤리딘 등으로 구성된 구룹으로부터 선택된 것임을 특징으로 하는 제제의 제조방법.
- 상기항의 어느 하나에 있어서, 불활성 부형제가 슈크로즈, 락토즈, 레블로즈, 만니톨, 건조소르비톨, 말토덱스트린, 글라이코콜, 알라닌, 펜타에리드라이트 등으로 구성된 구룹으로부터 선택된 것임을 특징으로 하는 제제의 제조방법.
- 제5항에 있어서, 농후제로 사용하는 크산틴검이 상표 켈트롤로 알려진 것임을 특징으로 하는 제제의 제조방법.
- 상기항의 어느 하나에 있어서, 농후제의 습윤화를 촉진하기 위하여 계면활성제를 제제에 가하는 것을 특징으로 하는 제제의 제조방법.
- 일회용 백을 사용할 경우, 백 내용물을 물 또는 타액체에 가할 경우에 약물입자의 균질현탁액을 유지하기 위하여 상기의 하나 또는 그 이상의 항의 방법에 의하여서 제조한 제제.
- 제10항에 있어서, 약물입자가 중합막으로 피복된 약물의 마이크로캅셀로 이루어진 것을 특징으로 하는 제제.
- 제11항에 있어서, 마이크로 캅셀화된 약물이 염화카리임이 특징인 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20617/85A IT1183574B (it) | 1985-05-08 | 1985-05-08 | Metodo per ottenere una sospensione estemporanea omogenea di microcapsule |
| IT20617A/85 | 1985-05-08 | ||
| IT206178/85 | 1985-05-08 | ||
| PCT/EP1986/000280 WO1986006626A1 (en) | 1985-05-08 | 1986-05-02 | Method of preparing an extemporaneous homogeneous microcapsule suspension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR870700209A true KR870700209A (ko) | 1987-05-30 |
| KR900000212B1 KR900000212B1 (ko) | 1990-01-23 |
Family
ID=11169617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860700872A KR900000212B1 (ko) | 1985-05-08 | 1986-05-02 | 즉석 균질마이크로 캅셀 현탁액의 제조방법 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5008117A (ko) |
| EP (1) | EP0222856B1 (ko) |
| JP (1) | JP2609597B2 (ko) |
| KR (1) | KR900000212B1 (ko) |
| AT (1) | ATE59287T1 (ko) |
| AU (1) | AU589644B2 (ko) |
| CA (1) | CA1274144A (ko) |
| DE (1) | DE3676642D1 (ko) |
| DK (1) | DK157730C (ko) |
| ES (1) | ES8707103A1 (ko) |
| FI (1) | FI86596C (ko) |
| HU (1) | HUT44168A (ko) |
| IT (1) | IT1183574B (ko) |
| NO (1) | NO171949C (ko) |
| NZ (1) | NZ216062A (ko) |
| PT (1) | PT82541B (ko) |
| RU (1) | RU2059409C1 (ko) |
| WO (1) | WO1986006626A1 (ko) |
| ZA (1) | ZA863399B (ko) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8628359D0 (en) * | 1986-11-27 | 1986-12-31 | Zyma Sa | Galenical formulation |
| GB8702411D0 (en) * | 1987-02-03 | 1987-03-11 | Zyma Sa | Swellable pellets |
| AU618096B2 (en) * | 1988-04-19 | 1991-12-12 | Southwest Research Institute | Controlled release of active ingredients from capsules having a salt sensitive shell material |
| US5064650A (en) * | 1988-04-19 | 1991-11-12 | Southwest Research Institute | Controlled-release salt sensitive capsule for oral use and adhesive system |
| FR2634376B1 (fr) * | 1988-07-21 | 1992-04-17 | Farmalyoc | Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation |
| NZ234143A (en) * | 1989-06-28 | 1991-10-25 | Mcneil Ppc Inc | Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents |
| US5112604A (en) * | 1989-09-01 | 1992-05-12 | Riker Laboratories, Inc. | Oral suspension formulation |
| IT1246350B (it) * | 1990-07-11 | 1994-11-17 | Eurand Int | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
| US5300302A (en) * | 1990-10-04 | 1994-04-05 | Nestec S.A. | Pharmaceutical composition in gel form in a dispensing package |
| US5252337A (en) * | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
| US5599556A (en) * | 1991-12-31 | 1997-02-04 | Abbott Laboratories | Prolamine coatings for taste masking |
| US5272137A (en) * | 1992-02-14 | 1993-12-21 | Mcneil-Pfc, Inc. | Aqueous pharmaceutical suspension for pharmaceutical actives |
| ZA932273B (en) * | 1992-03-30 | 1993-11-26 | Alza Corp | Additives for bioerodible polymers to regulate degradation |
| US5540912A (en) * | 1992-03-30 | 1996-07-30 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| HU215958B (hu) * | 1992-04-30 | 1999-03-29 | Schering Corp. | Eljárás stabil, hidratált, száraz ceftibuten porkészítmény előállítására perorális szuszpenziókhoz |
| US5422122A (en) * | 1992-08-04 | 1995-06-06 | Eurand America, Incorporated | Controlled release potassium chloride tablet |
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| UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| GB9822170D0 (en) * | 1998-10-13 | 1998-12-02 | Danbioyst Uk Ltd | Novel formulations of fexofenadine |
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| KR20040025880A (ko) * | 2000-12-11 | 2004-03-26 | 다케다 야쿠힌 고교 가부시키가이샤 | 수용해성이 개선된 의약 조성물 |
| JP2004168703A (ja) * | 2002-11-20 | 2004-06-17 | Shin Etsu Chem Co Ltd | マイクロカプセル及びその製造方法 |
| US20040170686A1 (en) * | 2003-01-31 | 2004-09-02 | Fredrickson Jennifer K. | Suspension vehicle for coated drug particles |
| US20040191326A1 (en) * | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
| US7632521B2 (en) * | 2003-07-15 | 2009-12-15 | Eurand, Inc. | Controlled release potassium chloride tablets |
| US20050118194A1 (en) * | 2003-12-01 | 2005-06-02 | Sin Yoke M. | Oral vaccine, method for its preparation and use thereof |
| US20060134210A1 (en) * | 2004-12-22 | 2006-06-22 | Astrazeneca Ab | Solid dosage form comprising proton pump inhibitor and suspension made thereof |
| WO2018130876A1 (en) * | 2017-01-10 | 2018-07-19 | Dukebox Sp. Z O. O. | A method of manufacturing a suspension of nanoparticles of potassium salt or magnesium salt |
| CN113490486A (zh) | 2019-02-22 | 2021-10-08 | 康特伦英国斯温顿捷迪斯有限公司 | 最小化团聚、曝气和保持包含布洛芬的药物组合物的包衣 |
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| GB844772A (en) * | 1956-04-19 | 1960-08-17 | Pfizer & Co C | Granular pharmaceutical compositions and process for preparing same |
| FR2077696B1 (ko) * | 1970-02-06 | 1973-03-16 | Synthelabo | |
| DE2211019C3 (de) * | 1972-03-08 | 1980-08-28 | Bayer Ag, 5090 Leverkusen | Geschmacksverbessernde Formulierungen oraler Penicilline |
| US4155741A (en) * | 1974-05-01 | 1979-05-22 | Stauffer Chemical Company | Stable suspension system for microencapsulated flowable formulations, and method of preparing stable suspension of microcapsules |
| US4126672A (en) * | 1976-02-04 | 1978-11-21 | Hoffmann-La Roche Inc. | Sustained release pharmaceutical capsules |
| US4189499A (en) * | 1977-03-16 | 1980-02-19 | Biochefarm S.A. | Lysine 4-allyloxy-3-chlorophenylacetate and method of its preparation |
| IT1148784B (it) * | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
| IT1209276B (it) * | 1980-11-05 | 1989-07-16 | Magis Farmaceutici | Composizione farmaceutica per la somministrazione orale del metilestere dell'acido 13a-etil-2,3,5,6,12,13,13a,13b-ottaidro-12-idrossi1h-indolo-[3,2,1-de] pirido [3,2,1-ij] [1,5] naftiridina -12-carbossilico |
-
1985
- 1985-05-08 IT IT20617/85A patent/IT1183574B/it active
-
1986
- 1986-05-02 RU SU874028804A patent/RU2059409C1/ru active
- 1986-05-02 AU AU59031/86A patent/AU589644B2/en not_active Ceased
- 1986-05-02 JP JP61503027A patent/JP2609597B2/ja not_active Expired - Fee Related
- 1986-05-02 HU HU863345A patent/HUT44168A/hu unknown
- 1986-05-02 WO PCT/EP1986/000280 patent/WO1986006626A1/en active IP Right Grant
- 1986-05-02 AT AT86903323T patent/ATE59287T1/de not_active IP Right Cessation
- 1986-05-02 KR KR1019860700872A patent/KR900000212B1/ko not_active IP Right Cessation
- 1986-05-02 DE DE8686903323T patent/DE3676642D1/de not_active Expired - Lifetime
- 1986-05-02 EP EP86903323A patent/EP0222856B1/en not_active Expired - Lifetime
- 1986-05-05 NZ NZ216062A patent/NZ216062A/xx unknown
- 1986-05-07 CA CA000508635A patent/CA1274144A/en not_active Expired - Lifetime
- 1986-05-07 ZA ZA863399A patent/ZA863399B/xx unknown
- 1986-05-08 ES ES554777A patent/ES8707103A1/es not_active Expired
- 1986-05-08 PT PT82541A patent/PT82541B/pt not_active IP Right Cessation
- 1986-12-18 NO NO865162A patent/NO171949C/no not_active IP Right Cessation
- 1986-12-30 FI FI865336A patent/FI86596C/fi not_active IP Right Cessation
-
1987
- 1987-01-07 DK DK007487A patent/DK157730C/da not_active IP Right Cessation
-
1988
- 1988-12-20 US US07/287,401 patent/US5008117A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU589644B2 (en) | 1989-10-19 |
| KR900000212B1 (ko) | 1990-01-23 |
| ATE59287T1 (de) | 1991-01-15 |
| FI86596C (fi) | 1992-09-25 |
| EP0222856A1 (en) | 1987-05-27 |
| FI86596B (fi) | 1992-06-15 |
| RU2059409C1 (ru) | 1996-05-10 |
| US5008117A (en) | 1991-04-16 |
| NO865162L (no) | 1986-12-18 |
| EP0222856B1 (en) | 1990-12-27 |
| AU5903186A (en) | 1986-12-04 |
| DK7487A (da) | 1987-01-07 |
| FI865336A (fi) | 1986-12-30 |
| IT1183574B (it) | 1987-10-22 |
| HUT44168A (en) | 1988-02-29 |
| FI865336A0 (fi) | 1986-12-30 |
| WO1986006626A1 (en) | 1986-11-20 |
| IT8520617A0 (it) | 1985-05-08 |
| NZ216062A (en) | 1989-07-27 |
| ZA863399B (en) | 1987-01-28 |
| NO171949C (no) | 1993-05-26 |
| ES554777A0 (es) | 1987-07-16 |
| PT82541A (en) | 1986-06-01 |
| PT82541B (pt) | 1988-03-03 |
| DK7487D0 (da) | 1987-01-07 |
| JP2609597B2 (ja) | 1997-05-14 |
| JPS62502859A (ja) | 1987-11-12 |
| NO171949B (no) | 1993-02-15 |
| ES8707103A1 (es) | 1987-07-16 |
| DK157730C (da) | 1990-07-16 |
| DK157730B (da) | 1990-02-12 |
| DE3676642D1 (de) | 1991-02-07 |
| CA1274144A (en) | 1990-09-18 |
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