KR870007101A - 아미노 알코홀의 제조방법 - Google Patents

아미노 알코홀의 제조방법 Download PDF

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KR870007101A
KR870007101A KR870000797A KR870000797A KR870007101A KR 870007101 A KR870007101 A KR 870007101A KR 870000797 A KR870000797 A KR 870000797A KR 870000797 A KR870000797 A KR 870000797A KR 870007101 A KR870007101 A KR 870007101A
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South Korea
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formula
compound
alkyl
nitrogen
cycle
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KR870000797A
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KR950006891B1 (ko
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오바르 질베르
뷔르 쟈끄
삐에르 깔베 알랭
구르 끌로드
젠비에브 그루에 앙줴
쥐니엔 쟝-루이
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끌로드 루
주베날 쏘시에떼 아노뉨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)

Abstract

내용 없음

Description

아미노 알코홀의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기식(Ⅱ)의 산을 보론 또는 알루미늄 하이드라이드로 환원시켜 R2와 R3이 수소인 식(Ia)의 화합물을 산출하고, 식(Ia)의 화합물을 시약[X-(CH2)m-R5-(CH|2)n-X']과 반응시켜 고리화를 하여 NR2R3이 헤테로 사이클을 형성하는 식(Ib)의 화합물을 산출하고, 식(Ia)의 화합물을 식(R4-COX)의 아실화제로 아실화하여 R3이 알카노일, 페닐 알카노일 또는 시클로 알킬 카르보닐인 식(Ic)의 화합물을 제조하고, 식(Ia)의 화합물을 식(R3-X)의 알킬화제로 알킬화거나 식(Ic)의 화합물을 환원하거나 또는 하기 식(Ⅳ)의 화합물을 보론 또는 알루미늄하이드라이드로 환원시키며 R2가 H, R3이 알킬 알케닐, 페닐 알킬 또는 시클로알킬인 식(Id)의 화합물을 제조하고, 식(Ia)의 화합물을 포름산의 존재하에서 식(R4CHO)의 화합물과 반응시켜 R2가 알킬, R3이 R2와 같은 식(Ie)의 화합물을 제조하고 식(Id)의 화합물을 포름산의 존재하에서 식(R4CHO)의 화합물과 반응시켜 R2가 알킬, R3이 알킬, 알케닐, 페닐알킬 또는 시클로알킬알킬인 식(Id)의 화합물을 제조하고 식(I)의 화합물 산과 반응시켜 그 산부가염을 제조하는 하기 식(Ⅰ) 화합물의 제조방법.
    상기식에서, R1은 저급알킬, R2는 H 또는 저급알킬, R3은 H, 저급알킬, 저급알케닐, 저급페닐알킬 또는 사이클에 3-6 탄소원자를 갖는 저급 시클로알킬알킬 또는 R2가 H, 저급알카노일, 저급페닐 알카노일 또는 사이클에 3-6 탄소원자를 갖는 시클로알킬 카르보닐, 또는 R2와 R3은 그들이 결합된 질소원자와 함께 5-7사슬로 포함된 헤테로사이클을 형성할 때, 두번째 헤테로 원자가 질소, 산소, 황 또는 질소원자에 직접 연결되지 않는 것과 마찬가지로 후자의, 질소 헤테로원자는 C1-C4에 알킬치환체를 갖는다.
    X와 X'는 같거나 다른 것으로 할로겐, R5는 일가공유결합, m과 n은 1 내지 3의 정수로서 m+n은 4이상 6 이하 또는 R5은 산소, 황 또는 NR6로서 R6는 H 또는 C1-C4의 알킬 그리고 m과 n은 1 내지 3의 정수로서 m+n은 3 이상 5 이하 R4는 R3에서 정의된 것과 같은 동족체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870000797A 1986-01-30 1987-01-30 아미노 알코올의 제조방법 KR950006891B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8601295 1986-01-30
FR8601295A FR2593499B1 (fr) 1986-01-30 1986-01-30 Aminoalcools, leur procede de preparation et leurs applications, notamment en therapeutique

Publications (2)

Publication Number Publication Date
KR870007101A true KR870007101A (ko) 1987-08-14
KR950006891B1 KR950006891B1 (ko) 1995-06-26

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Family Applications (1)

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KR1019870000797A KR950006891B1 (ko) 1986-01-30 1987-01-30 아미노 알코올의 제조방법

Country Status (17)

Country Link
US (1) US4994617A (ko)
EP (1) EP0237366B1 (ko)
JP (1) JPH089580B2 (ko)
KR (1) KR950006891B1 (ko)
AT (1) ATE42540T1 (ko)
AU (1) AU590664B2 (ko)
BR (1) BR1100977A (ko)
CA (1) CA1294961C (ko)
DE (1) DE3760117D1 (ko)
DK (1) DK169538B1 (ko)
ES (1) ES2008109B3 (ko)
FI (1) FI87068C (ko)
FR (1) FR2593499B1 (ko)
GR (1) GR3000026T3 (ko)
IE (1) IE59448B1 (ko)
NZ (1) NZ218988A (ko)
PT (1) PT84223B (ko)

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US4939133A (en) * 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade
US5482947A (en) * 1990-11-19 1996-01-09 Talley; John J. Retroviral protease inhibitors
FR2690917B1 (fr) * 1992-05-05 1994-06-17 Jouveinal Inst Rech Aminoesters, leur procede de preparation et leur application en therapeutique.
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics
FR2690916B1 (fr) * 1992-05-05 1994-06-17 Jouveinal Inst Rech Nouveaux enantiomeres derives du (s)-amino-2-(dichloro-3,4-benzyl)-2-propanol-1.
US5367094A (en) * 1993-06-04 1994-11-22 Yukong, Ltd. Convenient process for the preparation of chiral or racemic phenylalaninols and their N-blocked derivatives
FR2761686B1 (fr) * 1997-04-07 1999-05-14 Sipsy Sa Nouveau procede de preparation du (+/-)3-(3,4- dichlorophenyl)-2-dimethylamino-2-methyl-propan-1-ol ou cericlamine (inn)
US7216702B2 (en) * 2003-02-28 2007-05-15 Yates Petroleum Corporation Methods of evaluating undersaturated coalbed methane reservoirs
EP1691811B1 (en) 2003-12-11 2014-07-23 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
US7467260B2 (en) * 2004-10-08 2008-12-16 International Business Machines Corporation Method and apparatus to purge remote node cache lines to support hot node replace in a computing system
CZ2009385A3 (cs) * 2009-06-16 2010-07-28 Zentiva, K. S. Zpusob výroby (S)-4-methylamino-3-(3,4-dichlorfenyl)butan-1-olu

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US3132179A (en) * 1959-08-27 1964-05-05 Sterling Drug Inc Ethers of alpha-hydroxymethyl-beta-monocarbocyclic aryl ethyl amines and their preparation
US3193581A (en) * 1961-03-01 1965-07-06 Yamanouchi Pharma Co Ltd Process of preparing 1-phenyl-2-aminopropane
US3573304A (en) * 1968-12-03 1971-03-30 Delalande Sa 1-dimethylamino - 3 - methyl-2(pyridyl or pyridazinyl) pentane and the corresponding non-toxic acid addition salts thereof
US3706764A (en) * 1969-04-16 1972-12-19 Yoshitomi Pharmaceutical Phenethylaminomethyl-chromanones and- thiochromanones
US3896166A (en) * 1970-05-06 1975-07-22 Hoffmann La Roche Formyl-substituted tyrosine
NL7112938A (ko) * 1970-09-30 1972-04-05
ES399820A1 (es) * 1971-02-17 1975-07-01 Sandoz Ag Procedimiento para la obtencion de derivados de amino pro- panol.
GB1346401A (en) * 1971-05-12 1974-02-13 Lepetit Spa Cardioactive arylaminobutanols
US4058642A (en) * 1973-10-11 1977-11-15 Boehringer Ingelheim Gmbh 2-Amino-3-(3'-hydroxy-phenyl)-propanols and salts thereof
GB1434826A (en) * 1973-11-14 1976-05-05 Gallardo Antonio Sa Esters and carbamates of aminoalkanols
US4536601A (en) * 1982-09-28 1985-08-20 Dainippon Pharmaceutical Co., Ltd. Optically active N-substituted phenylalaninols and use thereof

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Publication number Publication date
ES2008109B3 (es) 1989-07-16
AU6795987A (en) 1987-08-06
DK40687D0 (da) 1987-01-26
CA1294961C (en) 1992-01-28
FR2593499B1 (fr) 1988-08-12
BR1100977A (pt) 1999-10-13
FI870418A (fi) 1987-07-31
US4994617A (en) 1991-02-19
EP0237366B1 (fr) 1989-04-26
DK40687A (da) 1987-07-31
GR3000026T3 (en) 1990-01-19
JPH089580B2 (ja) 1996-01-31
DE3760117D1 (en) 1989-06-01
PT84223B (pt) 1989-05-31
DK169538B1 (da) 1994-11-28
FI870418A0 (fi) 1987-01-30
FI87068C (fi) 1992-11-25
PT84223A (fr) 1987-02-01
FI87068B (fi) 1992-08-14
ATE42540T1 (de) 1989-05-15
AU590664B2 (en) 1989-11-09
KR950006891B1 (ko) 1995-06-26
IE59448B1 (en) 1994-02-23
IE870062L (en) 1987-07-30
EP0237366A1 (fr) 1987-09-16
NZ218988A (en) 1990-02-26
JPS62190150A (ja) 1987-08-20
FR2593499A1 (fr) 1987-07-31

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