KR870007933A - 3-(1H-테트라졸-5-일) 티에노 [2,3-d] 피리미딘-4(3H)-온 - Google Patents

3-(1H-테트라졸-5-일) 티에노 [2,3-d] 피리미딘-4(3H)-온 Download PDF

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KR870007933A
KR870007933A KR870001502A KR870001502A KR870007933A KR 870007933 A KR870007933 A KR 870007933A KR 870001502 A KR870001502 A KR 870001502A KR 870001502 A KR870001502 A KR 870001502A KR 870007933 A KR870007933 A KR 870007933A
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hydrogen
carbon atoms
lower alkyl
compound
tetrazol
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KR870001502A
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KR900001549B1 (ko
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피. 비노그라도프 안나
피. 피트 노튼
썬더 샴
Original Assignee
개리 디. 스트리트
메렡 다우 파마슈티칼즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
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Abstract

내용 없음

Description

3-(1H-테트라졸-5-일) 티에노 [2,3-d] 피리미딘-4(3H)-온
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식 (Ⅰ)의 화합물 및 이의 약제학적으로 허용되는 염.
    상기 식에서,
    R은 수소 또는 탄소수 1 내지 4의 저급 알킬이고,
    R'는 수소, 탄소수 1 내지 4의 저급 알킬 또는 페닐이거나,
    R 및 R'는 함께 트리메틸렌 또는 테트라메틸렌이고,
    R"는 수소, 메틸 또는 에틸 그룹이다.
  2. 제 1 항에 있어서, 하기 일반식의 화합물 및 이의 알칼리 금속염.
    상기 식에서,
    R은 수소 또는 탄소수 1 내지 4의 저급 알킬이고,
    R'는 수소, 탄소수 1 내지 4의 저급 알킬 또는 페닐이거나,
    R 및 R'는 함께 트리메틸렌 또는 테트라메틸렌이다.
  3. 제 1 항에 있어서, 3-(1H-테트라졸-5-일)-6-프로필티에노 [2,3-d] 피리미딘-4(3H)-온인 화합물.
  4. 제 1 항에 있어서, 3-(1H-테트라졸-5-일)-5,6-디메틸티에노 [2,3-d] 피리미딘-4(3H)-온인 화합물.
  5. 제 1 항에 있어서, 3-(1H-테트라졸-5-일)-5,6-테트라메틸렌티에노 [2,3-d] 피리미딘-4(3H)-온인 화합물.
  6. 일반식 (Ⅱ)의 아미딘을 불활성 용매 중에서 알칼리 금속 염기와 반응시킴을 특징으로 하여 일반식 (Ⅰ)의 화합물 및 이의 약제학적으로 허용되는 염을 제조하는 방법.
    상기 식에서,
    R은 수소 또는 탄소수 1 내지 4의 저급 알킬이고,
    R'는 수소, 탄소수 1 내지 4의 저급 알킬 또는 페닐이거나,
    R 및 R'는 함께 트리메틸렌 또는 테트라메틸렌이고,
    R"는 수소, 메틸 또는 에틸 이고,
    알킬은 메틸 또는 에틸이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870001502A 1986-02-25 1987-02-23 3-(1H-테트라졸-5-일)티에노[2,3-d]피리미딘-4(3H)-온 KR900001549B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US833,871 1986-02-25
US833871 1986-02-25
US06/833,871 US4761474A (en) 1986-02-25 1986-02-25 3-(1H-tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones

Publications (2)

Publication Number Publication Date
KR870007933A true KR870007933A (ko) 1987-09-23
KR900001549B1 KR900001549B1 (ko) 1990-03-12

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KR1019870001502A KR900001549B1 (ko) 1986-02-25 1987-02-23 3-(1H-테트라졸-5-일)티에노[2,3-d]피리미딘-4(3H)-온

Country Status (20)

Country Link
US (1) US4761474A (ko)
EP (1) EP0234557B1 (ko)
JP (1) JP2514812B2 (ko)
KR (1) KR900001549B1 (ko)
CN (1) CN1019490B (ko)
AT (1) ATE58738T1 (ko)
AU (1) AU588434B2 (ko)
CA (1) CA1301153C (ko)
DE (1) DE3766379D1 (ko)
DK (1) DK92787A (ko)
ES (1) ES2019072B3 (ko)
FI (1) FI85485C (ko)
GR (1) GR3002540T3 (ko)
HU (1) HU196805B (ko)
IL (1) IL81656A0 (ko)
NO (1) NO165294C (ko)
NZ (1) NZ219390A (ko)
PH (1) PH22591A (ko)
PT (1) PT84340B (ko)
ZA (1) ZA871259B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2677337C2 (ru) * 2016-12-22 2019-01-16 федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный технический университет" N-замещенные N'-(1-алкилтетразол-5-ил)-тринитроацетимидамиды и способ их получения

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2411273A1 (de) * 1974-03-06 1975-09-18 Schering Ag Neue thieno eckige klammer auf 2,3-d eckige klammer zu pyrimidinone und verfahren zu ihrer herstellung
US4054656A (en) * 1975-09-10 1977-10-18 Mead Johnson & Company Thieno[2,3-d]pyrimidine antiallergic agents
FR2401163A1 (fr) * 1977-08-22 1979-03-23 Bristol Myers Co Nouvelles thieno(2,3-d)pyrimidines, leur procede de preparation et medicament anti-allergique les contenant
GB1583679A (en) * 1977-10-11 1981-01-28 Bristol Myers Co Thieno (2,3-d) pyrimidine and other thiophene-derived anti-allergic agents
US4419357A (en) * 1982-01-18 1983-12-06 The Dow Chemical Company 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones
US4644065A (en) * 1984-05-15 1987-02-17 Merrell Dow Pharmaceuticals Inc. Process for the preparation of 4(3H)-quinazolinones
DE3669315D1 (de) * 1985-03-14 1990-04-12 Sankyo Co Phenoxyalkylaminopyrimidinderivate, deren herstellung und diese enthaltende insektizide und akarizide zusammensetzungen.

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Publication number Publication date
ATE58738T1 (de) 1990-12-15
GR3002540T3 (en) 1993-01-25
PH22591A (en) 1988-10-17
EP0234557B1 (en) 1990-11-28
CN1019490B (zh) 1992-12-16
NZ219390A (en) 1989-02-24
HU196805B (en) 1989-01-30
JP2514812B2 (ja) 1996-07-10
US4761474A (en) 1988-08-02
FI85485B (fi) 1992-01-15
CA1301153C (en) 1992-05-19
AU588434B2 (en) 1989-09-14
AU6915487A (en) 1987-08-27
ES2019072B3 (es) 1991-06-01
HUT45257A (en) 1988-06-28
NO870750L (no) 1987-08-26
CN87100912A (zh) 1987-12-23
EP0234557A1 (en) 1987-09-02
IL81656A0 (en) 1987-09-16
FI870762A0 (fi) 1987-02-23
NO165294B (no) 1990-10-15
ZA871259B (en) 1987-09-30
FI870762A (fi) 1987-08-26
FI85485C (fi) 1992-04-27
DE3766379D1 (de) 1991-01-10
DK92787D0 (da) 1987-02-24
PT84340B (pt) 1989-09-14
NO870750D0 (no) 1987-02-24
NO165294C (no) 1991-01-23
DK92787A (da) 1987-08-26
KR900001549B1 (ko) 1990-03-12
PT84340A (en) 1987-03-01
JPS62198684A (ja) 1987-09-02

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