FR2401163A1 - Nouvelles thieno(2,3-d)pyrimidines, leur procede de preparation et medicament anti-allergique les contenant - Google Patents

Nouvelles thieno(2,3-d)pyrimidines, leur procede de preparation et medicament anti-allergique les contenant

Info

Publication number
FR2401163A1
FR2401163A1 FR7731213A FR7731213A FR2401163A1 FR 2401163 A1 FR2401163 A1 FR 2401163A1 FR 7731213 A FR7731213 A FR 7731213A FR 7731213 A FR7731213 A FR 7731213A FR 2401163 A1 FR2401163 A1 FR 2401163A1
Authority
FR
France
Prior art keywords
pyrimidines
allergic
preparation process
product containing
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7731213A
Other languages
English (en)
Other versions
FR2401163B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/826,591 external-priority patent/US4159377A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2401163A1 publication Critical patent/FR2401163A1/fr
Application granted granted Critical
Publication of FR2401163B1 publication Critical patent/FR2401163B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne une nouvelle série de thiénoØ2,3-dõpyrimidines et les thiéno-oxazines apparentées par leur structure à ces composés. Des 2-amino-thiophène-3-carboxamides sont transformés en oxamates ou en fumaramides par acylation du groupe amino. Une cyclisation donne des thiénoØ2,3-dõpyrimidines qui peuvent aussi être préparées à partir des oxazines correspondantes. Les composés de l'invention sont doués d'activité antiallergique; ils exercent une action inhibitrice sur la réaction d'hypersensibilité immédiate chez les mammifères.
FR7731213A 1977-08-22 1977-10-17 Nouvelles thieno(2,3-d)pyrimidines, leur procede de preparation et medicament anti-allergique les contenant Granted FR2401163A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/826,591 US4159377A (en) 1975-09-10 1977-08-22 Selected thieno[2,3-d]pyrimidines

Publications (2)

Publication Number Publication Date
FR2401163A1 true FR2401163A1 (fr) 1979-03-23
FR2401163B1 FR2401163B1 (fr) 1982-04-02

Family

ID=25246995

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7731213A Granted FR2401163A1 (fr) 1977-08-22 1977-10-17 Nouvelles thieno(2,3-d)pyrimidines, leur procede de preparation et medicament anti-allergique les contenant
FR7821764A Granted FR2401152A1 (fr) 1977-08-22 1978-07-21 Nouveaux thienyloxamates, leur procede de preparation et medicaments anti-allergiques les contenant
FR7821765A Granted FR2401164A1 (fr) 1977-08-22 1978-07-21 Nouvelles thieno-oxazines et medicament anti-allergique les contenant

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7821764A Granted FR2401152A1 (fr) 1977-08-22 1978-07-21 Nouveaux thienyloxamates, leur procede de preparation et medicaments anti-allergiques les contenant
FR7821765A Granted FR2401164A1 (fr) 1977-08-22 1978-07-21 Nouvelles thieno-oxazines et medicament anti-allergique les contenant

Country Status (2)

Country Link
CA (1) CA1094063A (fr)
FR (3) FR2401163A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761474A (en) * 1986-02-25 1988-08-02 Merrell Dow Pharmaceuticals Inc. 3-(1H-tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9426021D0 (en) * 1994-12-22 1995-02-22 Smithkline Beecham Plc Pharmaceuticals
AU1595997A (en) * 1996-01-26 1997-08-20 Smithkline Beecham Plc Thienoxazinone derivatives useful as antiviral agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035767A1 (fr) * 1969-03-07 1970-12-24 Centre Etd Ind Pharma
FR2121341A1 (en) * 1971-01-04 1972-08-25 Ferlux 2-substd-3,1-benzoxazin-4-ones - antiinflammatories, analgesics sedatives and diuretics
GB1468012A (en) * 1973-08-09 1977-03-23 Beecham Group Ltd 2-amino-3-carboxy-thiophene derivatives
BE859818A (fr) * 1977-10-17 1978-04-17 Bristol Myers Co Thieno(2,3-d)pyrimidines antiallergiques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761474A (en) * 1986-02-25 1988-08-02 Merrell Dow Pharmaceuticals Inc. 3-(1H-tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones

Also Published As

Publication number Publication date
CA1094063A (fr) 1981-01-20
FR2401152B1 (fr) 1982-04-02
FR2401152A1 (fr) 1979-03-23
FR2401164B1 (fr) 1982-04-02
FR2401163B1 (fr) 1982-04-02
FR2401164A1 (fr) 1979-03-23

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Legal Events

Date Code Title Description
ST Notification of lapse