DE69414554D1 - Heterocyclische verbindungen und ihre herstellung und verwendung - Google Patents
Heterocyclische verbindungen und ihre herstellung und verwendungInfo
- Publication number
- DE69414554D1 DE69414554D1 DE69414554T DE69414554T DE69414554D1 DE 69414554 D1 DE69414554 D1 DE 69414554D1 DE 69414554 T DE69414554 T DE 69414554T DE 69414554 T DE69414554 T DE 69414554T DE 69414554 D1 DE69414554 D1 DE 69414554D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- production
- heterocyclic compounds
- forebrain
- hippocampus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000003920 cognitive function Effects 0.000 abstract 1
- 210000001320 hippocampus Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000004129 prosencephalon Anatomy 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/026,943 US5418240A (en) | 1990-08-21 | 1993-03-05 | Heterocyclic compounds and their preparation and use |
| PCT/DK1994/000092 WO1994020496A1 (en) | 1993-03-05 | 1994-03-04 | Heterocyclic compounds and their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69414554D1 true DE69414554D1 (de) | 1998-12-17 |
| DE69414554T2 DE69414554T2 (de) | 1999-06-17 |
Family
ID=21834696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69414554T Expired - Fee Related DE69414554T2 (de) | 1993-03-05 | 1994-03-04 | Heterocyclische verbindungen und ihre herstellung und verwendung |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5418240A (de) |
| EP (1) | EP0687266B1 (de) |
| JP (1) | JP3411923B2 (de) |
| KR (1) | KR100344329B1 (de) |
| CN (1) | CN1046722C (de) |
| AT (1) | ATE173257T1 (de) |
| AU (1) | AU694415B2 (de) |
| CZ (1) | CZ290639B6 (de) |
| DE (1) | DE69414554T2 (de) |
| DK (1) | DK0687266T3 (de) |
| ES (1) | ES2126099T3 (de) |
| FI (1) | FI954130A (de) |
| HU (1) | HUT72443A (de) |
| IL (1) | IL108865A (de) |
| NO (1) | NO312676B1 (de) |
| NZ (1) | NZ262372A (de) |
| PH (1) | PH31394A (de) |
| SK (1) | SK281005B6 (de) |
| TW (1) | TW350846B (de) |
| WO (1) | WO1994020496A1 (de) |
| ZA (1) | ZA941542B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
| MX9300875A (es) | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
| US5663182A (en) * | 1993-08-19 | 1997-09-02 | Bymaster; Franklin Porter | Antipsychotic method |
| PT714394E (pt) * | 1993-08-19 | 2001-12-28 | Novo Nordisk As | Metodo antipsicotico com derivados de tiadiazol e oxadiazol |
| US6271229B1 (en) | 1993-08-19 | 2001-08-07 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
| US6265419B1 (en) * | 1993-12-21 | 2001-07-24 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
| GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
| US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5672709A (en) * | 1994-10-24 | 1997-09-30 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
| US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5488056A (en) * | 1994-10-31 | 1996-01-30 | Eli Lilly And Company | Method for treating anxiety |
| US5726193A (en) * | 1994-10-31 | 1998-03-10 | Eli Lilly And Company | Method for treating anxiety |
| US5612351A (en) * | 1994-11-08 | 1997-03-18 | Novo Nordisk A/S | Method of treating urinary bladder dysfunctions |
| US5936088A (en) * | 1995-09-22 | 1999-08-10 | Novo Nordisk A/S | Substituted azacyclic or azabicyclic compounds with affinity and selectivity for nicotinic cholinergic receptors |
| DK0859777T3 (da) * | 1995-10-13 | 2007-09-03 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-en-derivater, deres fremstilling og anvendelse |
| US5998434A (en) * | 1995-12-06 | 1999-12-07 | Eli Lilly And Company | Composition for treating pain |
| NZ324988A (en) * | 1995-12-07 | 1999-08-30 | Lilly Co Eli | Composition for treating pain comprising a selected muscarinic compound and an analgesic or nsaid |
| EP0873124A1 (de) * | 1996-01-04 | 1998-10-28 | Novo Nordisk A/S | Verfahren zur behandlung von hypercholesterolämie und verwandter störungen |
| US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
| JP2000509042A (ja) * | 1996-04-23 | 2000-07-18 | イーライ・リリー・アンド・カンパニー | ヘテロサイクリック化合物群 |
| WO1997040045A1 (en) * | 1996-04-24 | 1997-10-30 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
| AU7107998A (en) * | 1997-04-11 | 1998-11-11 | Eli Lilly And Company | Method for treating schizophrenia |
| JP2002503224A (ja) * | 1997-04-11 | 2002-01-29 | エリ リリー アンド カンパニー | 疼痛を処置するための組成物 |
| EP0977755B1 (de) * | 1997-04-22 | 2005-07-13 | Novo Nordisk A/S | Heterozyklische verbindungen, ihre herstellung und ihre anwendung |
| US6015813A (en) * | 1997-04-22 | 2000-01-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| CA2291157A1 (en) * | 1997-05-29 | 1998-12-03 | Eli Lilly And Company | Process for preparing heterocyclic compounds |
| AU7697198A (en) * | 1997-05-29 | 1998-12-30 | Eli Lilly And Company | Process for preparing heterocyclic compounds |
| US6465467B1 (en) * | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| CA2420235A1 (en) * | 2000-08-21 | 2002-02-28 | Georgetown University | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| EP2296471A4 (de) | 2008-05-15 | 2012-03-14 | Univ Toledo | Muskarinsäureagonisten als kognitive enhancer |
| WO2012149524A1 (en) | 2011-04-29 | 2012-11-01 | The University Of Toledo | Muscarinic agonists as enhancers of working memory and cognitive flexibility |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
| GB8610432D0 (en) * | 1986-04-29 | 1986-06-04 | Akzo Nv | Amino-thiazole & oxazole derivatives |
| GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
| GB8717446D0 (en) * | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
| NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
| IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
| EP0322182A3 (de) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
| DK162892C (da) * | 1988-07-04 | 1992-05-11 | Novo Nordisk As | 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse |
| US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| EP0459568A3 (en) * | 1990-05-31 | 1992-09-30 | Merck Sharp & Dohme Ltd. | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use |
| DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
-
1993
- 1993-03-05 US US08/026,943 patent/US5418240A/en not_active Expired - Lifetime
-
1994
- 1994-02-28 TW TW083101718A patent/TW350846B/zh active
- 1994-03-04 WO PCT/DK1994/000092 patent/WO1994020496A1/en active IP Right Grant
- 1994-03-04 CZ CZ19952251A patent/CZ290639B6/cs not_active IP Right Cessation
- 1994-03-04 AU AU62027/94A patent/AU694415B2/en not_active Ceased
- 1994-03-04 NZ NZ262372A patent/NZ262372A/en unknown
- 1994-03-04 SK SK1101-95A patent/SK281005B6/sk unknown
- 1994-03-04 DE DE69414554T patent/DE69414554T2/de not_active Expired - Fee Related
- 1994-03-04 CN CN94191810A patent/CN1046722C/zh not_active Expired - Fee Related
- 1994-03-04 EP EP94908990A patent/EP0687266B1/de not_active Expired - Lifetime
- 1994-03-04 DK DK94908990T patent/DK0687266T3/da active
- 1994-03-04 PH PH47880A patent/PH31394A/en unknown
- 1994-03-04 ZA ZA941542A patent/ZA941542B/xx unknown
- 1994-03-04 KR KR1019950703745A patent/KR100344329B1/ko not_active IP Right Cessation
- 1994-03-04 HU HU9502588A patent/HUT72443A/hu unknown
- 1994-03-04 IL IL10886594A patent/IL108865A/xx active IP Right Grant
- 1994-03-04 JP JP51948094A patent/JP3411923B2/ja not_active Expired - Fee Related
- 1994-03-04 ES ES94908990T patent/ES2126099T3/es not_active Expired - Lifetime
- 1994-03-04 AT AT94908990T patent/ATE173257T1/de not_active IP Right Cessation
-
1995
- 1995-09-04 FI FI954130A patent/FI954130A/fi not_active Application Discontinuation
- 1995-09-05 NO NO19953491A patent/NO312676B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI954130A0 (fi) | 1995-09-04 |
| KR960701049A (ko) | 1996-02-24 |
| WO1994020496A1 (en) | 1994-09-15 |
| TW350846B (en) | 1999-01-21 |
| CZ290639B6 (cs) | 2002-09-11 |
| CN1121349A (zh) | 1996-04-24 |
| IL108865A0 (en) | 1994-06-24 |
| US5418240A (en) | 1995-05-23 |
| SK110195A3 (en) | 1996-10-02 |
| NO953491L (no) | 1995-09-05 |
| EP0687266A1 (de) | 1995-12-20 |
| DK0687266T3 (da) | 1999-07-26 |
| ATE173257T1 (de) | 1998-11-15 |
| HU9502588D0 (en) | 1995-11-28 |
| CN1046722C (zh) | 1999-11-24 |
| NO953491D0 (no) | 1995-09-05 |
| SK281005B6 (sk) | 2000-10-09 |
| PH31394A (en) | 1998-10-29 |
| CZ225195A3 (en) | 1996-04-17 |
| AU694415B2 (en) | 1998-07-23 |
| FI954130A (fi) | 1995-10-27 |
| JPH08507499A (ja) | 1996-08-13 |
| KR100344329B1 (ko) | 2002-11-30 |
| NZ262372A (en) | 1997-07-27 |
| ES2126099T3 (es) | 1999-03-16 |
| JP3411923B2 (ja) | 2003-06-03 |
| NO312676B1 (no) | 2002-06-17 |
| EP0687266B1 (de) | 1998-11-11 |
| IL108865A (en) | 2000-07-16 |
| HUT72443A (en) | 1996-04-29 |
| ZA941542B (en) | 1995-09-04 |
| AU6202794A (en) | 1994-09-26 |
| DE69414554T2 (de) | 1999-06-17 |
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| ATE173257T1 (de) | Heterocyclische verbindungen und ihre herstellung und verwendung | |
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| ATE174027T1 (de) | Heterozyklische verbindungen, ihre herstellung und anwendung | |
| ATE159940T1 (de) | 1,2,5,6-tetrahydro-1-methylpyridine, ihre herstellung und anwendung | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |