TW350846B - 1,2,5-thiadiazol substituted azabicyclic compounds and their preparation and use as muscarinic cholinergic agonists - Google Patents
1,2,5-thiadiazol substituted azabicyclic compounds and their preparation and use as muscarinic cholinergic agonistsInfo
- Publication number
- TW350846B TW350846B TW083101718A TW83101718A TW350846B TW 350846 B TW350846 B TW 350846B TW 083101718 A TW083101718 A TW 083101718A TW 83101718 A TW83101718 A TW 83101718A TW 350846 B TW350846 B TW 350846B
- Authority
- TW
- Taiwan
- Prior art keywords
- branched chain
- straight chain
- alkyl
- chain
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- UDGKZGLPXCRRAM-UHFFFAOYSA-N 1,2,5-thiadiazole Chemical group C=1C=NSN=1 UDGKZGLPXCRRAM-UHFFFAOYSA-N 0.000 title 1
- 239000000472 muscarinic agonist Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/026,943 US5418240A (en) | 1990-08-21 | 1993-03-05 | Heterocyclic compounds and their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW350846B true TW350846B (en) | 1999-01-21 |
Family
ID=21834696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW083101718A TW350846B (en) | 1993-03-05 | 1994-02-28 | 1,2,5-thiadiazol substituted azabicyclic compounds and their preparation and use as muscarinic cholinergic agonists |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5418240A (zh) |
| EP (1) | EP0687266B1 (zh) |
| JP (1) | JP3411923B2 (zh) |
| KR (1) | KR100344329B1 (zh) |
| CN (1) | CN1046722C (zh) |
| AT (1) | ATE173257T1 (zh) |
| AU (1) | AU694415B2 (zh) |
| CZ (1) | CZ290639B6 (zh) |
| DE (1) | DE69414554T2 (zh) |
| DK (1) | DK0687266T3 (zh) |
| ES (1) | ES2126099T3 (zh) |
| FI (1) | FI954130A (zh) |
| HU (1) | HUT72443A (zh) |
| IL (1) | IL108865A (zh) |
| NO (1) | NO312676B1 (zh) |
| NZ (1) | NZ262372A (zh) |
| PH (1) | PH31394A (zh) |
| SK (1) | SK281005B6 (zh) |
| TW (1) | TW350846B (zh) |
| WO (1) | WO1994020496A1 (zh) |
| ZA (1) | ZA941542B (zh) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
| MX9300875A (es) | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
| US5663182A (en) * | 1993-08-19 | 1997-09-02 | Bymaster; Franklin Porter | Antipsychotic method |
| US6281232B1 (en) | 1993-08-19 | 2001-08-28 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
| US6265419B1 (en) * | 1993-12-21 | 2001-07-24 | Novo Nordisk A/S | Method of treating gastrointestinal motility disorders |
| NZ336596A (en) * | 1993-08-19 | 2001-02-23 | Novo Nordisk As | Oxa or thia-diazole substituted azabicyclic ring compounds for treating schizophreniform diseases |
| GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
| US5821370A (en) * | 1994-10-24 | 1998-10-13 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
| US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5998404A (en) | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5726193A (en) * | 1994-10-31 | 1998-03-10 | Eli Lilly And Company | Method for treating anxiety |
| US5488056A (en) * | 1994-10-31 | 1996-01-30 | Eli Lilly And Company | Method for treating anxiety |
| US5612351A (en) * | 1994-11-08 | 1997-03-18 | Novo Nordisk A/S | Method of treating urinary bladder dysfunctions |
| AU7125096A (en) * | 1995-09-22 | 1997-04-09 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
| TR199800628T2 (xx) * | 1995-10-13 | 1998-07-21 | Neurosearch A/S | 8-Azabisiklo$3.2.1]okt-2-en t�revleri, bunlar�n haz�rlanmas� ve kullan�m�. |
| AU1128297A (en) * | 1995-12-06 | 1997-06-27 | Eli Lilly And Company | Composition for treating pain |
| WO1997020561A1 (en) * | 1995-12-07 | 1997-06-12 | Eli Lilly And Company | Composition for treating pain |
| AU1093797A (en) * | 1996-01-04 | 1997-08-01 | Novo Nordisk A/S | A method of treating hypercholesterolemia and related disorders |
| US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
| AU2991397A (en) * | 1996-04-23 | 1997-11-12 | Eli Lilly And Company | Heterocyclic compounds |
| JP2000513712A (ja) * | 1996-04-24 | 2000-10-17 | ノボ ノルディスク アクティーゼルスカブ | 複素環化合物およびその調製およびその使用 |
| US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
| EP1009403A4 (en) * | 1997-04-11 | 2002-08-28 | Lilly Co Eli | METHOD FOR TREATING SCHIZOPHRENIA |
| JP2002503224A (ja) * | 1997-04-11 | 2002-01-29 | エリ リリー アンド カンパニー | 疼痛を処置するための組成物 |
| US6015813A (en) * | 1997-04-22 | 2000-01-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| AU6919398A (en) * | 1997-04-22 | 1998-11-13 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| CA2291157A1 (en) * | 1997-05-29 | 1998-12-03 | Eli Lilly And Company | Process for preparing heterocyclic compounds |
| EP1098883A4 (en) * | 1997-05-29 | 2001-11-14 | Lilly Co Eli | USEFUL PROCESS FOR THE PREPARATION OF HETEROCYCLIC COMPOUNDS |
| US6465467B1 (en) * | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| AU8656101A (en) * | 2000-08-21 | 2002-03-04 | Univ Georgetown | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| EP2296471A4 (en) | 2008-05-15 | 2012-03-14 | Univ Toledo | MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS |
| WO2012149524A1 (en) | 2011-04-29 | 2012-11-01 | The University Of Toledo | Muscarinic agonists as enhancers of working memory and cognitive flexibility |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
| GB8610432D0 (en) * | 1986-04-29 | 1986-06-04 | Akzo Nv | Amino-thiazole & oxazole derivatives |
| GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
| GB8717446D0 (en) * | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
| NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
| IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
| EP0322182A3 (en) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
| DK162892C (da) * | 1988-07-04 | 1992-05-11 | Novo Nordisk As | 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse |
| US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| EP0459568A3 (en) * | 1990-05-31 | 1992-09-30 | Merck Sharp & Dohme Ltd. | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use |
| DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
-
1993
- 1993-03-05 US US08/026,943 patent/US5418240A/en not_active Expired - Lifetime
-
1994
- 1994-02-28 TW TW083101718A patent/TW350846B/zh active
- 1994-03-04 HU HU9502588A patent/HUT72443A/hu unknown
- 1994-03-04 JP JP51948094A patent/JP3411923B2/ja not_active Expired - Fee Related
- 1994-03-04 CZ CZ19952251A patent/CZ290639B6/cs not_active IP Right Cessation
- 1994-03-04 ES ES94908990T patent/ES2126099T3/es not_active Expired - Lifetime
- 1994-03-04 WO PCT/DK1994/000092 patent/WO1994020496A1/en active IP Right Grant
- 1994-03-04 AT AT94908990T patent/ATE173257T1/de not_active IP Right Cessation
- 1994-03-04 AU AU62027/94A patent/AU694415B2/en not_active Ceased
- 1994-03-04 EP EP94908990A patent/EP0687266B1/en not_active Expired - Lifetime
- 1994-03-04 SK SK1101-95A patent/SK281005B6/sk unknown
- 1994-03-04 CN CN94191810A patent/CN1046722C/zh not_active Expired - Fee Related
- 1994-03-04 IL IL10886594A patent/IL108865A/xx active IP Right Grant
- 1994-03-04 DE DE69414554T patent/DE69414554T2/de not_active Expired - Fee Related
- 1994-03-04 KR KR1019950703745A patent/KR100344329B1/ko not_active IP Right Cessation
- 1994-03-04 DK DK94908990T patent/DK0687266T3/da active
- 1994-03-04 ZA ZA941542A patent/ZA941542B/xx unknown
- 1994-03-04 PH PH47880A patent/PH31394A/en unknown
- 1994-03-04 NZ NZ262372A patent/NZ262372A/en unknown
-
1995
- 1995-09-04 FI FI954130A patent/FI954130A/fi not_active Application Discontinuation
- 1995-09-05 NO NO19953491A patent/NO312676B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK110195A3 (en) | 1996-10-02 |
| NO312676B1 (no) | 2002-06-17 |
| NZ262372A (en) | 1997-07-27 |
| EP0687266B1 (en) | 1998-11-11 |
| JP3411923B2 (ja) | 2003-06-03 |
| EP0687266A1 (en) | 1995-12-20 |
| HUT72443A (en) | 1996-04-29 |
| KR960701049A (ko) | 1996-02-24 |
| AU6202794A (en) | 1994-09-26 |
| HU9502588D0 (en) | 1995-11-28 |
| FI954130A0 (fi) | 1995-09-04 |
| CN1046722C (zh) | 1999-11-24 |
| NO953491D0 (no) | 1995-09-05 |
| IL108865A0 (en) | 1994-06-24 |
| CZ225195A3 (en) | 1996-04-17 |
| ATE173257T1 (de) | 1998-11-15 |
| JPH08507499A (ja) | 1996-08-13 |
| DE69414554T2 (de) | 1999-06-17 |
| IL108865A (en) | 2000-07-16 |
| KR100344329B1 (ko) | 2002-11-30 |
| SK281005B6 (sk) | 2000-10-09 |
| US5418240A (en) | 1995-05-23 |
| ES2126099T3 (es) | 1999-03-16 |
| FI954130A (fi) | 1995-10-27 |
| ZA941542B (en) | 1995-09-04 |
| AU694415B2 (en) | 1998-07-23 |
| WO1994020496A1 (en) | 1994-09-15 |
| DK0687266T3 (da) | 1999-07-26 |
| CZ290639B6 (cs) | 2002-09-11 |
| PH31394A (en) | 1998-10-29 |
| CN1121349A (zh) | 1996-04-24 |
| NO953491L (no) | 1995-09-05 |
| DE69414554D1 (de) | 1998-12-17 |
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