ES8501416A1 - 5'-alquil o alquenil-fosfatos de nucleosidos. - Google Patents
5'-alquil o alquenil-fosfatos de nucleosidos.Info
- Publication number
- ES8501416A1 ES8501416A1 ES523523A ES523523A ES8501416A1 ES 8501416 A1 ES8501416 A1 ES 8501416A1 ES 523523 A ES523523 A ES 523523A ES 523523 A ES523523 A ES 523523A ES 8501416 A1 ES8501416 A1 ES 8501416A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- nucleoside
- alkenylphosphate
- base
- arabinonucleosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 title abstract 2
- -1 alkenyl phosphate compounds Chemical class 0.000 abstract 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
- 206010019799 Hepatitis viral Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000002215 arabinonucleoside Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 201000001862 viral hepatitis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE 5K-ALQUIL O ALQUENIL-FOSFATOS DE NUCLEOSIDOS.CONSISTE EN CONDENSAR EL 5K-MONOFOSFATO DE ARABINONUCLEOSIDO CON UN ALCOHOL DEL GRUPO ALQUILO O ALQUENILO, EN PRESENCIA DE UN DISOLVENTE INERTE A LA REACCION Y EN PRESENCIA DE UN AGENTE CONDENSANTE, PARA OBTENER 5K-ALQUILO O ALQUENILFOSFATOS DE NUCLEOSIDOS DE FORMULA (I); DONDE B ES UNA BASE PURINICA CON UN SUSTITUYENTE O UNA BASE DE URACILO 5-SUSTITUIDO; R1 ES UN GRUPO ALQUILO O ALQUENILO DE C 14 A 26. COMO DISOLVENTES SE EMPLEAN N, NK-DIMETIL FORMAMIDA, CLOROFORMO, PIRIDINA Y OTROS, Y COMO AGENTE CONDENSANTE SE UTILIZAN CLORUROS DE ARILSULFONILO. LA TEMPERATURA DE REACCION ESTA COMPRENDIDA ENTRE 0J Y 100JC, Y DURANTE 1 A 24 HORAS.TIENE APLICACION FARMACEUTICA POR SU ACTIVIDAD ANTIVIRICA, EN ESPECIAL, PARA EL TRATAMIENTO DE LA HEPATITIS VIRICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57108084A JPS58225097A (ja) | 1982-06-23 | 1982-06-23 | ヌクレオシド5′−アルキルもしくはアルケニルりん酸 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8501416A1 true ES8501416A1 (es) | 1984-11-16 |
ES523523A0 ES523523A0 (es) | 1984-11-16 |
Family
ID=14475463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523523A Granted ES523523A0 (es) | 1982-06-23 | 1983-06-22 | 5'-alquil o alquenil-fosfatos de nucleosidos. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4668778A (es) |
EP (1) | EP0097376B1 (es) |
JP (1) | JPS58225097A (es) |
CA (1) | CA1204106A (es) |
DE (1) | DE3366262D1 (es) |
ES (1) | ES523523A0 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3323621A1 (de) * | 1982-07-08 | 1984-03-01 | Yamasa Shoyu K.K., Choshi, Chiba | Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier |
GB8712745D0 (en) * | 1987-05-30 | 1987-07-01 | Wellcome Found | Antiviral compounds |
GB8912972D0 (en) * | 1989-06-06 | 1989-07-26 | Wellcome Found | Therapeutic nucleosides |
US5374626A (en) * | 1989-09-22 | 1994-12-20 | Farmitalia Carlo Erba | 5'-alkylphosphonylnucleosides as antivirals |
GB8921469D0 (en) * | 1989-09-22 | 1989-11-08 | Erba Carlo Spa | 5'-alkylphosphonylnucleosides as antivirals |
JPH04261191A (ja) * | 1991-02-13 | 1992-09-17 | Tsumura & Co | ヌクレオシド−5’−アルキルフォスフォネート類の合成方法 |
CA2085994A1 (en) * | 1991-04-24 | 1992-10-25 | Shinji Sakata | 1-beta-d-arabinofuranosyl-(e)-5- (2-halogenovinyl) uracil derivatives |
US5446031A (en) * | 1991-04-24 | 1995-08-29 | Yamasa Shuyu Kabushiki Kaisha | 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives |
RU2183213C2 (ru) * | 1996-11-05 | 2002-06-10 | ЗАО "Производственно-коммерческая ассоциация АЗТ" | Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3336289A (en) * | 1965-09-20 | 1967-08-15 | Upjohn Co | 9-beta-d-ribofuranosyl-7-deazapurine 5'-phosphate esters |
US3466273A (en) * | 1966-12-16 | 1969-09-09 | Asahi Chemical Ind | Process for producing nucleotide by a selective phosphorylation |
JPS5046696A (es) * | 1973-03-19 | 1975-04-25 | ||
US4093714A (en) * | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
GB1461493A (en) * | 1974-03-26 | 1977-01-13 | Icn Pharmaceuticals | 9-beta-d-arabinofuranoxyl hypoxanthine nucleotides |
US4123609A (en) * | 1976-11-03 | 1978-10-31 | Warner-Lambert Company | Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate |
US4230698A (en) * | 1978-05-12 | 1980-10-28 | Research Corporation | 2-Substituted arabinofuranosyl nucleosides and nucleotides |
JPS552602A (en) * | 1978-06-20 | 1980-01-10 | Yamasa Shoyu Co Ltd | 1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester |
JPS552601A (en) * | 1978-06-20 | 1980-01-10 | Yamasa Shoyu Co Ltd | Anti-tumor agent for non-injection use |
US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
JPS5639019A (en) * | 1979-09-05 | 1981-04-14 | Yamasa Shoyu Co Ltd | Antiviral agent |
JPS5687599A (en) * | 1979-12-19 | 1981-07-16 | Yamasa Shoyu Co Ltd | E 55 22halogenovinyl arabinofuranosyluracil and its preparation |
JPS55129299A (en) * | 1980-03-14 | 1980-10-06 | Yamasa Shoyu Co Ltd | 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester |
JPS5914480B2 (ja) * | 1980-07-16 | 1984-04-04 | 旭化成株式会社 | 新規ヌクレオシド誘導体 |
US4357324A (en) * | 1981-02-24 | 1982-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine |
JPS5843993A (ja) * | 1981-09-09 | 1983-03-14 | Yamasa Shoyu Co Ltd | 1−β−D−アラビノフラノシル−(E)−5−(2−ハロゲノビニル)ウラシル−5′−りん酸およびその製造法 |
DE3263939D1 (en) * | 1981-12-09 | 1985-07-04 | Teijin Ltd | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
-
1982
- 1982-06-23 JP JP57108084A patent/JPS58225097A/ja active Granted
-
1983
- 1983-06-22 DE DE8383106120T patent/DE3366262D1/de not_active Expired
- 1983-06-22 ES ES523523A patent/ES523523A0/es active Granted
- 1983-06-22 EP EP83106120A patent/EP0097376B1/en not_active Expired
- 1983-06-23 CA CA000431056A patent/CA1204106A/en not_active Expired
-
1985
- 1985-05-03 US US06/729,905 patent/US4668778A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3366262D1 (en) | 1986-10-23 |
EP0097376A1 (en) | 1984-01-04 |
JPS58225097A (ja) | 1983-12-27 |
US4668778A (en) | 1987-05-26 |
JPH0136838B2 (es) | 1989-08-02 |
ES523523A0 (es) | 1984-11-16 |
EP0097376B1 (en) | 1986-09-17 |
CA1204106A (en) | 1986-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |