KR840007879A - 이미다조-헤테로싸이클 화합물의 제조방법 - Google Patents

이미다조-헤테로싸이클 화합물의 제조방법 Download PDF

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KR840007879A
KR840007879A KR1019840000871A KR840000871A KR840007879A KR 840007879 A KR840007879 A KR 840007879A KR 1019840000871 A KR1019840000871 A KR 1019840000871A KR 840000871 A KR840000871 A KR 840000871A KR 840007879 A KR840007879 A KR 840007879A
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compound
salt
formula
lower alkyl
substituted
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KR1019840000871A
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다까오 다까야
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후지사와 도모끼찌로
후지사와 야꾸힝 고교 가부시끼가이샤
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Publication of KR840007879A publication Critical patent/KR840007879A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

이미다조-헤테로싸이클 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 구조식(Ⅱ)의 화합물 또는 그 염을 구조식(Ⅲ)의 화합물 또는 그 염과 반응시켜서 구조식(Ia)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ⅳ)의 화합물 또는 그 염을 환상화시켜서 구조식(Ib)의 화합물 또는 그 염을 제조하거나, 구조식(Ⅴ)의 화합물 또는 그 염을 2유화탄소와 반응시킨 반응 생성물을 구조식(Ⅵ)의 화합물 또는 그 염과 반응시켜서 구조식(Ic)의 화합물 또는 그 염을 제조하거나 ; 구조식(Va)의 화합물 또는 그 아미노기에서의 반응성 유도체 또는 그 염을 구조식(Ⅶ)의 화합물 또느 srm 카복시기에서의 반응성유도체 또는 그 염과 반응시켜서 구조식(Id)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ⅷ)의 화합물 또는 그 염을 환원적 환상화 반응시켜서 구조식(Ie)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ih)의 화합물 또는 그 염을 알킬화시켜서 구조식(Ii)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ij)의 화합물 또는 그 염을 만니히 반응시켜서 구조식(Ik)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ik)의 화합물 또는 그 염을 알킬화 반응을 시킨 반응 생성물을 구조식(Ⅸ)또는 그 염과 반응시켜서 구조식(Il)의 화합물 또는 그 염을 제조함을 특징으로 하는 구조식(I)화합물을 제조하는 방법.
    상기식에서, R1은 수소, 저급알킬 또는 할로겐, R2는 수소, 저급알킬, 할로겐, 임의의 저급알킬로 치환 똔느 비치환된 아미노 메틸 또는 임의로 저급알킬로 치환 또는 비치환의 피페라진-1-일메틸, R2 a는 수소 저급알킬 또는 할로겐, R3는 벤조티아졸리닐, 벤족사졸리닐, 벤즈이미다졸리닐, 3,4-디하이드로-2H-1, 4-벤조티아지닐, 3,4-디하이드로-2H-1,4-벤족사지닐 및 1,2,3,4-테트 라하이드로 퀴녹살리닐에서 선택된 부분적으로 포화된 헤테로싸이클기이며, 이들 기는 옥소, 티옥소, 이미노 또는 저급알킬이미노로 치환되어 있으며, 또한 저급알카노일옥시, 저급알콕시카보닐, 피리딜 또는 저급알킬아미노로 치환되거나 비치환된 저급알킬로 치환될 수 있다 ; 또는 저급알킬 또는 피리딜(저급)알킬티오로 치환 또는 비치환된 벤족 사졸릴 및 벤즈 이미다졸릴에서 선택된 불포화 헤테로싸이클기, R3 b는 벤조티아졸리닐, 벤족사졸리닐, 벤즈이미다졸리닐, 3,4-디하이드로-2H-1, 4-벤조티아지닐, 3,4-디하이드로-2H-1,4-벤족사지닐 및 1,2,3,4-테트 라하이드로 퀴녹살리닐에서 선택된 헤테로싸이클기이며, 이들은 옥소, 티옥소, 이미노 또는 저급알킬이미노로 치환되어 있으며 ; 이들은 더욱 임의로 저급알카노일옥시, 저급알콕시카보닐, 피리딜 또는 저급 알킬아미노로 임의로 치환또는 비치환된 저급알킬로 더 치환되며, 또다른 저급알킬기로 더 치환될 수도 있다.
    R4 a는 저급알콕시 또는 아르(저급)알콕시, R9 a및 R9 2는 각각 수소 또는 저급알킬, A는 저급알킬렌, Q는이며, X는 이탈기이며, Y는 =N-또는이며, 여기에서 R4는 수소, 하이드록시, 저급 알킬, 저급알콕시 또는 아르(저급)알콕시이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000871A 1983-02-25 1984-02-22 이미다조-헤테로싸이클 화합물의 제조방법 KR840007879A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838305245A GB8305245D0 (en) 1983-02-25 1983-02-25 Imidazo-heterocyclic compounds
GB8305245 1983-02-25

Publications (1)

Publication Number Publication Date
KR840007879A true KR840007879A (ko) 1984-12-11

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KR1019840000871A KR840007879A (ko) 1983-02-25 1984-02-22 이미다조-헤테로싸이클 화합물의 제조방법

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Country Link
US (1) US4621084A (ko)
EP (1) EP0120589B1 (ko)
JP (1) JPS59186983A (ko)
KR (1) KR840007879A (ko)
AT (1) ATE34984T1 (ko)
AU (1) AU2482284A (ko)
DE (1) DE3471936D1 (ko)
DK (1) DK72784A (ko)
ES (1) ES8505963A1 (ko)
FI (1) FI840653A (ko)
GB (1) GB8305245D0 (ko)
GR (1) GR79810B (ko)
NO (1) NO840712L (ko)
ZA (1) ZA841156B (ko)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
GB8432073D0 (en) * 1984-12-19 1985-01-30 Roussel Lab Ltd Chemical compounds
DE3446812A1 (de) * 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP0226641B1 (en) * 1985-05-25 1989-10-18 Yoshitomi Pharmaceutical Industries, Ltd. Oxodiazine compounds
CA1256109A (en) * 1986-09-10 1989-06-20 Franz Rovenszky Process for the preparation of derivatives of 4, 5-dihydrooxazoles
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
EP0266890A1 (en) * 1986-10-07 1988-05-11 Yamanouchi Pharmaceutical Co. Ltd. Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them
US4731446A (en) * 1987-05-01 1988-03-15 The Dow Chemical Company Imidazo[1,2-a]pyrimidine sulfonic acids and acid halides
GB8820231D0 (en) * 1988-08-25 1988-09-28 Fujisawa Pharmaceutical Co New benzazole compounds processes for preparation thereof & pharmaceutical composition comprising same
EP0375819A1 (en) * 1988-12-20 1990-07-04 Merrell Dow Pharmaceuticals Inc. Novel derivatives of 1,7'-[imidazo-[1,2-a]pyridine]5'-(6'H)ones
GB8905130D0 (en) * 1989-03-07 1989-04-19 Pfizer Ltd Therapeutic agents
FR2645149A1 (ko) * 1989-03-30 1990-10-05 Adir
US5166353A (en) * 1989-04-28 1992-11-24 Adir Et Compagnie Benzothiazolinone compounds
FR2646350B1 (fr) * 1989-04-28 1991-06-28 Adir Nouveaux derives benzothiazolinoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
HRP950330A2 (en) * 1994-07-05 1997-10-31 Ciba Geigy Ag New herbicides
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
EP1606261B1 (en) 2003-03-10 2009-11-04 Nycomed GmbH Novel process for the preparation of roflumilast
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
EP1861074B1 (en) 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
TW200736252A (en) 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
CN101641354A (zh) * 2007-01-22 2010-02-03 阿斯利康(瑞典)有限公司 杂芳基取代的新咪唑并[1，2-a]吡啶衍生物
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
EP2300470A2 (en) * 2008-05-19 2011-03-30 Sepracor Inc. Imidazo[1,2-a]pyridine compounds as gaba-a receptor modulators
AR076126A1 (es) * 2009-03-18 2011-05-18 Schering Corp Compuestos biciclicos como inhibidores de diacilglicerol aciltransferasa
JP2016527184A (ja) * 2013-05-24 2016-09-08 イオメット ファーマ リミテッド Ｓｌｃ２ａ輸送体阻害剤
JP6730309B2 (ja) * 2015-04-08 2020-07-29 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての縮合二環式ヘテロ環誘導体及び中間体生成物
GB201509893D0 (en) * 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU600143A1 (ru) * 1976-12-06 1978-03-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср Способ получени гетероциклических систем, содержащих бормзамещенный имидазол
JPS5782390A (en) * 1980-11-11 1982-05-22 Otsuka Pharmaceut Co Ltd Carbostyril derivative
CA1164459A (en) * 1980-11-11 1984-03-27 Yung-Hsiung Yang Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives
JPS57102888A (en) * 1980-12-18 1982-06-26 Otsuka Pharmaceut Co Ltd Carbostyril derivative
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them

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Publication number Publication date
US4621084A (en) 1986-11-04
GB8305245D0 (en) 1983-03-30
AU2482284A (en) 1984-08-30
EP0120589A1 (en) 1984-10-03
DK72784A (da) 1984-08-26
FI840653A (fi) 1984-08-26
ZA841156B (en) 1984-09-26
ES530011A0 (es) 1985-06-16
JPS59186983A (ja) 1984-10-23
GR79810B (ko) 1984-10-31
ATE34984T1 (de) 1988-06-15
NO840712L (no) 1984-08-27
EP0120589B1 (en) 1988-06-08
FI840653A0 (fi) 1984-02-17
JPH0557989B2 (ko) 1993-08-25
ES8505963A1 (es) 1985-06-16
DE3471936D1 (en) 1988-07-14
DK72784D0 (da) 1984-02-16

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