KR840007879A - 이미다조-헤테로싸이클 화합물의 제조방법 - Google Patents
이미다조-헤테로싸이클 화합물의 제조방법 Download PDFInfo
- Publication number
- KR840007879A KR840007879A KR1019840000871A KR840000871A KR840007879A KR 840007879 A KR840007879 A KR 840007879A KR 1019840000871 A KR1019840000871 A KR 1019840000871A KR 840000871 A KR840000871 A KR 840000871A KR 840007879 A KR840007879 A KR 840007879A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- salt
- formula
- lower alkyl
- substituted
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 11
- -1 piperazin-1-yl Methyl Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005277 alkyl imino group Chemical group 0.000 claims 2
- 125000004935 benzoxazolinyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 1
- 230000002829 reductive effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식(Ⅱ)의 화합물 또는 그 염을 구조식(Ⅲ)의 화합물 또는 그 염과 반응시켜서 구조식(Ia)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ⅳ)의 화합물 또는 그 염을 환상화시켜서 구조식(Ib)의 화합물 또는 그 염을 제조하거나, 구조식(Ⅴ)의 화합물 또는 그 염을 2유화탄소와 반응시킨 반응 생성물을 구조식(Ⅵ)의 화합물 또는 그 염과 반응시켜서 구조식(Ic)의 화합물 또는 그 염을 제조하거나 ; 구조식(Va)의 화합물 또는 그 아미노기에서의 반응성 유도체 또는 그 염을 구조식(Ⅶ)의 화합물 또느 srm 카복시기에서의 반응성유도체 또는 그 염과 반응시켜서 구조식(Id)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ⅷ)의 화합물 또는 그 염을 환원적 환상화 반응시켜서 구조식(Ie)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ih)의 화합물 또는 그 염을 알킬화시켜서 구조식(Ii)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ij)의 화합물 또는 그 염을 만니히 반응시켜서 구조식(Ik)의 화합물 또는 그 염을 제조하거나 ; 구조식(Ik)의 화합물 또는 그 염을 알킬화 반응을 시킨 반응 생성물을 구조식(Ⅸ)또는 그 염과 반응시켜서 구조식(Il)의 화합물 또는 그 염을 제조함을 특징으로 하는 구조식(I)화합물을 제조하는 방법.상기식에서, R1은 수소, 저급알킬 또는 할로겐, R2는 수소, 저급알킬, 할로겐, 임의의 저급알킬로 치환 똔느 비치환된 아미노 메틸 또는 임의로 저급알킬로 치환 또는 비치환의 피페라진-1-일메틸, R2 a는 수소 저급알킬 또는 할로겐, R3는 벤조티아졸리닐, 벤족사졸리닐, 벤즈이미다졸리닐, 3,4-디하이드로-2H-1, 4-벤조티아지닐, 3,4-디하이드로-2H-1,4-벤족사지닐 및 1,2,3,4-테트 라하이드로 퀴녹살리닐에서 선택된 부분적으로 포화된 헤테로싸이클기이며, 이들 기는 옥소, 티옥소, 이미노 또는 저급알킬이미노로 치환되어 있으며, 또한 저급알카노일옥시, 저급알콕시카보닐, 피리딜 또는 저급알킬아미노로 치환되거나 비치환된 저급알킬로 치환될 수 있다 ; 또는 저급알킬 또는 피리딜(저급)알킬티오로 치환 또는 비치환된 벤족 사졸릴 및 벤즈 이미다졸릴에서 선택된 불포화 헤테로싸이클기, R3 b는 벤조티아졸리닐, 벤족사졸리닐, 벤즈이미다졸리닐, 3,4-디하이드로-2H-1, 4-벤조티아지닐, 3,4-디하이드로-2H-1,4-벤족사지닐 및 1,2,3,4-테트 라하이드로 퀴녹살리닐에서 선택된 헤테로싸이클기이며, 이들은 옥소, 티옥소, 이미노 또는 저급알킬이미노로 치환되어 있으며 ; 이들은 더욱 임의로 저급알카노일옥시, 저급알콕시카보닐, 피리딜 또는 저급 알킬아미노로 임의로 치환또는 비치환된 저급알킬로 더 치환되며, 또다른 저급알킬기로 더 치환될 수도 있다.R4 a는 저급알콕시 또는 아르(저급)알콕시, R9 a및 R9 2는 각각 수소 또는 저급알킬, A는 저급알킬렌, Q는이며, X는 이탈기이며, Y는 =N-또는이며, 여기에서 R4는 수소, 하이드록시, 저급 알킬, 저급알콕시 또는 아르(저급)알콕시이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8305245 | 1983-02-25 | ||
GB838305245A GB8305245D0 (en) | 1983-02-25 | 1983-02-25 | Imidazo-heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840007879A true KR840007879A (ko) | 1984-12-11 |
Family
ID=10538591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840000871A KR840007879A (ko) | 1983-02-25 | 1984-02-22 | 이미다조-헤테로싸이클 화합물의 제조방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4621084A (ko) |
EP (1) | EP0120589B1 (ko) |
JP (1) | JPS59186983A (ko) |
KR (1) | KR840007879A (ko) |
AT (1) | ATE34984T1 (ko) |
AU (1) | AU2482284A (ko) |
DE (1) | DE3471936D1 (ko) |
DK (1) | DK72784A (ko) |
ES (1) | ES8505963A1 (ko) |
FI (1) | FI840653A (ko) |
GB (1) | GB8305245D0 (ko) |
GR (1) | GR79810B (ko) |
NO (1) | NO840712L (ko) |
ZA (1) | ZA841156B (ko) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
GB8432073D0 (en) * | 1984-12-19 | 1985-01-30 | Roussel Lab Ltd | Chemical compounds |
DE3446812A1 (de) * | 1984-12-21 | 1986-06-26 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3666434D1 (de) * | 1985-05-25 | 1989-11-23 | Yoshitomi Pharmaceutical | Oxodiazine compounds |
CA1256109A (en) * | 1986-09-10 | 1989-06-20 | Franz Rovenszky | Process for the preparation of derivatives of 4, 5-dihydrooxazoles |
US4791117A (en) * | 1986-09-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers |
EP0266890A1 (en) * | 1986-10-07 | 1988-05-11 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them |
US4731446A (en) * | 1987-05-01 | 1988-03-15 | The Dow Chemical Company | Imidazo[1,2-a]pyrimidine sulfonic acids and acid halides |
GB8820231D0 (en) * | 1988-08-25 | 1988-09-28 | Fujisawa Pharmaceutical Co | New benzazole compounds processes for preparation thereof & pharmaceutical composition comprising same |
EP0375819A1 (en) * | 1988-12-20 | 1990-07-04 | Merrell Dow Pharmaceuticals Inc. | Novel derivatives of 1,7'-[imidazo-[1,2-a]pyridine]5'-(6'H)ones |
GB8905130D0 (en) * | 1989-03-07 | 1989-04-19 | Pfizer Ltd | Therapeutic agents |
FR2645149A1 (ko) * | 1989-03-30 | 1990-10-05 | Adir | |
US5166353A (en) * | 1989-04-28 | 1992-11-24 | Adir Et Compagnie | Benzothiazolinone compounds |
FR2646350B1 (fr) * | 1989-04-28 | 1991-06-28 | Adir | Nouveaux derives benzothiazolinoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
KR910011852A (ko) * | 1989-12-04 | 1991-08-07 | 폴 디. 매튜카이티스 | 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물 |
US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
HRP950330A2 (en) * | 1994-07-05 | 1997-10-31 | Ciba Geigy Ag | New herbicides |
UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
EA009985B1 (ru) | 2003-03-10 | 2008-04-28 | Никомед Гмбх | Новый способ получения рофлумиласта |
GT200600042A (es) * | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
EP1861074B1 (en) | 2005-03-16 | 2013-04-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
AU2008208091A1 (en) * | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
CA2724842A1 (en) * | 2008-05-19 | 2009-11-26 | Sunovion Pharmaceuticals Inc. | Imidazo[1,2-a]pyridine compounds |
US20120022057A1 (en) * | 2009-03-18 | 2012-01-26 | Schering Corporation | Bicyclic compounds as inhibitors of diacyglycerol acyltransferase |
EP3004088A1 (en) * | 2013-05-24 | 2016-04-13 | Iomet Pharma Ltd. | Slc2a transporter inhibitors |
US10188108B2 (en) | 2015-04-08 | 2019-01-29 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
GB201509893D0 (en) * | 2015-06-08 | 2015-07-22 | Ucb Biopharma Sprl | Therapeutic agents |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU600143A1 (ru) * | 1976-12-06 | 1978-03-30 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср | Способ получени гетероциклических систем, содержащих бормзамещенный имидазол |
JPS5782390A (en) * | 1980-11-11 | 1982-05-22 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
CA1164459A (en) * | 1980-11-11 | 1984-03-27 | Yung-Hsiung Yang | Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives |
JPS57102888A (en) * | 1980-12-18 | 1982-06-26 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
DE3269604D1 (en) * | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
-
1983
- 1983-02-25 GB GB838305245A patent/GB8305245D0/en active Pending
-
1984
- 1984-02-15 GR GR73804A patent/GR79810B/el unknown
- 1984-02-16 ZA ZA841156A patent/ZA841156B/xx unknown
- 1984-02-16 DK DK72784A patent/DK72784A/da not_active Application Discontinuation
- 1984-02-17 AT AT84301058T patent/ATE34984T1/de not_active IP Right Cessation
- 1984-02-17 EP EP84301058A patent/EP0120589B1/en not_active Expired
- 1984-02-17 DE DE8484301058T patent/DE3471936D1/de not_active Expired
- 1984-02-17 FI FI840653A patent/FI840653A/fi not_active Application Discontinuation
- 1984-02-22 KR KR1019840000871A patent/KR840007879A/ko not_active Application Discontinuation
- 1984-02-22 AU AU24822/84A patent/AU2482284A/en not_active Abandoned
- 1984-02-24 JP JP59035072A patent/JPS59186983A/ja active Granted
- 1984-02-24 NO NO840712A patent/NO840712L/no unknown
- 1984-02-24 ES ES530011A patent/ES8505963A1/es not_active Expired
- 1984-02-27 US US06/583,609 patent/US4621084A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB8305245D0 (en) | 1983-03-30 |
DK72784A (da) | 1984-08-26 |
ES530011A0 (es) | 1985-06-16 |
ATE34984T1 (de) | 1988-06-15 |
EP0120589B1 (en) | 1988-06-08 |
JPH0557989B2 (ko) | 1993-08-25 |
ZA841156B (en) | 1984-09-26 |
ES8505963A1 (es) | 1985-06-16 |
JPS59186983A (ja) | 1984-10-23 |
US4621084A (en) | 1986-11-04 |
AU2482284A (en) | 1984-08-30 |
FI840653A (fi) | 1984-08-26 |
DK72784D0 (da) | 1984-02-16 |
EP0120589A1 (en) | 1984-10-03 |
DE3471936D1 (en) | 1988-07-14 |
NO840712L (no) | 1984-08-27 |
GR79810B (ko) | 1984-10-31 |
FI840653A0 (fi) | 1984-02-17 |
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