GB1434826A - Esters and carbamates of aminoalkanols - Google Patents

Esters and carbamates of aminoalkanols

Info

Publication number
GB1434826A
GB1434826A GB3231874A GB3231874A GB1434826A GB 1434826 A GB1434826 A GB 1434826A GB 3231874 A GB3231874 A GB 3231874A GB 3231874 A GB3231874 A GB 3231874A GB 1434826 A GB1434826 A GB 1434826A
Authority
GB
United Kingdom
Prior art keywords
alkyl
aryl
hydrogen
amino
carbamates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3231874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antonio Gallardo SA
Original Assignee
Antonio Gallardo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Gallardo SA filed Critical Antonio Gallardo SA
Priority to GB3231874A priority Critical patent/GB1434826A/en
Priority to ES432131A priority patent/ES432131A1/en
Publication of GB1434826A publication Critical patent/GB1434826A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

1434826 Esters and carbamates of amino alkanols ANTONIO GALLARDO SA 31 Oct 1974 [14 Nov 1973 22 July 1974] 52750/73 and 32318/74 Heading C2C The invention comprises compounds of the general formula wherein: each of the radicals R 1 , R 2 and R 3 , which may be the same or different is hydrogen, C 1 to C 6 alkyl, hydroxyl, C 1 to C 6 alkoxyl, trifluoromethyl or halogen; R 4 is hydrogen, C 1 to C 6 alkyl, cyclo alkyl or aryl; R 5 and R 6 , which may be the same or different, are each hydrogen, C 1 to C 6 alkyl or arylalkyl, or the radicals R 5 and R 6 , together with the adjoining N-atom, form a ring structure optionally containing an additional heteroatom; R 7 is alkyl, arylalkyl, aryl, arylalkenyl, diarylalkyl, aryl cyclo alkyl-alkyl heteroaryl, amino or an amino group substituted by and alkyl or heteroaryl or aryl group; and each of x, y and z is 0 or 1, or a pharmaceutically acceptable salt thereof.
GB3231874A 1973-11-14 1974-07-22 Esters and carbamates of aminoalkanols Expired GB1434826A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB3231874A GB1434826A (en) 1973-11-14 1974-07-22 Esters and carbamates of aminoalkanols
ES432131A ES432131A1 (en) 1973-11-14 1974-11-13 Esters and carbamates of aminoalkanols

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5275073 1973-11-14
GB3231874A GB1434826A (en) 1973-11-14 1974-07-22 Esters and carbamates of aminoalkanols

Publications (1)

Publication Number Publication Date
GB1434826A true GB1434826A (en) 1976-05-05

Family

ID=26261313

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3231874A Expired GB1434826A (en) 1973-11-14 1974-07-22 Esters and carbamates of aminoalkanols

Country Status (2)

Country Link
ES (1) ES432131A1 (en)
GB (1) GB1434826A (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593499A1 (en) * 1986-01-30 1987-07-31 Jouveinal Sa AMINOALCOHOLS, PROCESS FOR THEIR PREPARATION AND THEIR USE, IN PARTICULAR THERAPEUTICS
FR2613719A1 (en) * 1987-04-10 1988-10-14 Sanofi Sa AROMATIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIALS
US4820717A (en) * 1985-10-11 1989-04-11 Sanofi Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them
EP0431321A1 (en) * 1989-11-06 1991-06-12 Warner-Lambert Company Acat inhibitors
US5087726A (en) * 1990-02-13 1992-02-11 Warner-Lambert Company Carbamate ACAT inhibitors
FR2690917A1 (en) * 1992-05-05 1993-11-12 Jouveinal Inst Rech New amino-di:chloro-benzyl-propanol ester cpds. - used to treat depression, neuroses, mood disturbance, migraine, insomnia and nausea
WO1995010501A1 (en) * 1993-10-15 1995-04-20 Institut De Recherche Jouveinal (I.R.J.) Allylaminoesters, method for their preparation and therapeutic use thereof
FR2711137A1 (en) * 1993-10-15 1995-04-21 Irj Allylamino esters, their process of preparation and their application in therapeutics
WO1996007637A1 (en) * 1994-09-09 1996-03-14 Yukong Limited Novel phenylalkylaminoalcohol carbamates and process for preparing the same
WO1996032375A1 (en) * 1995-04-10 1996-10-17 Yukong Limited O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same
US5693650A (en) * 1994-12-09 1997-12-02 Bayer Aktiengesellschaft 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives
FR2765218A1 (en) * 1997-06-30 1998-12-31 Jouveinal Inst Rech 2-METHYLAMINO-2-PHENYL-N-BUTYL (S) 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN
FR2927076A1 (en) * 2008-01-31 2009-08-07 Oroxcell 2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2011012810A1 (en) 2009-07-30 2011-02-03 Oroxcell 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
CN102276487A (en) * 2011-06-29 2011-12-14 岳阳亚王精细化工有限公司 Preparation method of trimebutine
CN103896782A (en) * 2012-12-26 2014-07-02 北京奥得赛化学股份有限公司 Method of preparing 2-(N, N- dimethylamino)-2 phenyl butanol
WO2015132733A1 (en) * 2014-03-05 2015-09-11 Universita' Degli Studi Di Pavia Use of arylalkanolamines as sigma-1 receptor antagonists
CN105037139B (en) * 2015-07-07 2018-04-17 浙江博聚新材料有限公司 A kind of 2 phenylpropionic acid preparation methods
RU2752086C1 (en) * 2020-04-27 2021-07-22 Общество С Ограниченной Ответственностью "Валента-Интеллект" New [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimetoxybenzoate 4-methyl-2h-chromen-2-on-7-ilsulphate compound and application thereof

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820717A (en) * 1985-10-11 1989-04-11 Sanofi Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them
FR2593499A1 (en) * 1986-01-30 1987-07-31 Jouveinal Sa AMINOALCOHOLS, PROCESS FOR THEIR PREPARATION AND THEIR USE, IN PARTICULAR THERAPEUTICS
EP0237366A1 (en) * 1986-01-30 1987-09-16 Jouveinal S.A. Amino alcohols, process for their preparation and their applications, in particular for therepeutical use
AU590664B2 (en) * 1986-01-30 1989-11-09 Jouveinal S.A. Aminoalcohols, method of their preparation and their applications, particularly for therapeutics
US4994617A (en) * 1986-01-30 1991-02-19 Jouveinal S.A. Aminoalcohols, their preparation process and their applications, particularly in therapeutics
FR2613719A1 (en) * 1987-04-10 1988-10-14 Sanofi Sa AROMATIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIALS
EP0288352A1 (en) * 1987-04-10 1988-10-26 Sanofi Aromatic derivatives, their preparation and their use as antimicrobics
US4916156A (en) * 1987-04-10 1990-04-10 Sanofi Aromatic derivatives, their preparation and their use as antimicrobial agents
US5142094A (en) * 1989-11-06 1992-08-25 Warner-Lambert Company Aryl substituted carbamate derivatives which are acat inhibitors
EP0431321A1 (en) * 1989-11-06 1991-06-12 Warner-Lambert Company Acat inhibitors
US5087726A (en) * 1990-02-13 1992-02-11 Warner-Lambert Company Carbamate ACAT inhibitors
FR2690917A1 (en) * 1992-05-05 1993-11-12 Jouveinal Inst Rech New amino-di:chloro-benzyl-propanol ester cpds. - used to treat depression, neuroses, mood disturbance, migraine, insomnia and nausea
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics
WO1995010501A1 (en) * 1993-10-15 1995-04-20 Institut De Recherche Jouveinal (I.R.J.) Allylaminoesters, method for their preparation and therapeutic use thereof
FR2711137A1 (en) * 1993-10-15 1995-04-21 Irj Allylamino esters, their process of preparation and their application in therapeutics
WO1996007637A1 (en) * 1994-09-09 1996-03-14 Yukong Limited Novel phenylalkylaminoalcohol carbamates and process for preparing the same
CN1069635C (en) * 1994-09-09 2001-08-15 Sk株式会社 Novel phenylalkylaminoalcohol carbamates and process for prepn. of same
US5693650A (en) * 1994-12-09 1997-12-02 Bayer Aktiengesellschaft 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives
WO1996032375A1 (en) * 1995-04-10 1996-10-17 Yukong Limited O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same
CN1071741C (en) * 1995-04-10 2001-09-26 Sk株式会社 O-carbamoyl-phenylalaninol having substituent at benzene ring ,its pharmaceutically useful salts and method for preparing the same
AU731887B2 (en) * 1997-06-30 2001-04-05 Parke, Davis & Company (S) 2-methylamino-2-phenyl-(n)-butyl 3,4,5-trimethoxybenzoate, its application to the treatment of chronic pain
FR2765218A1 (en) * 1997-06-30 1998-12-31 Jouveinal Inst Rech 2-METHYLAMINO-2-PHENYL-N-BUTYL (S) 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN
WO1999001417A1 (en) * 1997-06-30 1999-01-14 Parke-Davis (S) 2-METHYLAMINO-2-PHENYL-n-BUTYL 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN
US8217075B2 (en) 2008-01-31 2012-07-10 Oroxcell 2-amino-2-phenyl-alkanol derivatives, their preparation and pharmaceutical compositions containing them
FR2927076A1 (en) * 2008-01-31 2009-08-07 Oroxcell 2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2009112703A1 (en) 2008-01-31 2009-09-17 Oroxcell 2-amino-2-phenylalkanol derivatives, preparation thereof and pharmaceutical compositions containing same
CN101932552A (en) * 2008-01-31 2010-12-29 奥洛克塞尔公司 2-amino-2-phenylalkanol derivatives, preparation thereof and pharmaceutical compositions containing same
CN101932552B (en) * 2008-01-31 2014-06-18 奥洛克塞尔公司 2-amino-2-phenylalkanol derivatives, preparation thereof and pharmaceutical compositions containing same
US8436192B2 (en) 2009-07-30 2013-05-07 Oraxcell 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
WO2011012810A1 (en) 2009-07-30 2011-02-03 Oroxcell 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
AU2010277400B2 (en) * 2009-07-30 2014-11-27 Oroxcell 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
FR2948660A1 (en) * 2009-07-30 2011-02-04 Oroxcell 2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN102471259A (en) * 2009-07-30 2012-05-23 奥若科斯赛欧 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
CN102276487B (en) * 2011-06-29 2013-06-12 岳阳亚王精细化工有限公司 Preparation method of trimebutine
CN102276487A (en) * 2011-06-29 2011-12-14 岳阳亚王精细化工有限公司 Preparation method of trimebutine
CN103896782A (en) * 2012-12-26 2014-07-02 北京奥得赛化学股份有限公司 Method of preparing 2-(N, N- dimethylamino)-2 phenyl butanol
CN103896782B (en) * 2012-12-26 2015-10-28 北京奥得赛化学股份有限公司 The method of preparation 2-(N, N-dimethylamino)-2 phenylbutanol
WO2015132733A1 (en) * 2014-03-05 2015-09-11 Universita' Degli Studi Di Pavia Use of arylalkanolamines as sigma-1 receptor antagonists
CN105037139B (en) * 2015-07-07 2018-04-17 浙江博聚新材料有限公司 A kind of 2 phenylpropionic acid preparation methods
RU2752086C1 (en) * 2020-04-27 2021-07-22 Общество С Ограниченной Ответственностью "Валента-Интеллект" New [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimetoxybenzoate 4-methyl-2h-chromen-2-on-7-ilsulphate compound and application thereof
WO2021221544A1 (en) * 2020-04-27 2021-11-04 Общество С Ограниченной Ответственностью "Валента-Интеллект" Novel compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2н-chromen-2-on-7-yl sulphate and use thereof
CN115443264A (en) * 2020-04-27 2022-12-06 瓦伦塔有限责任公司 Novel compound [2- (dimethylamino) -2-phenylbutyl ] -3,4, 5-trimethoxybenzoate 4-methyl-2H-chromen-2-one-7-yl sulfate and use thereof

Also Published As

Publication number Publication date
ES432131A1 (en) 1977-03-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee