KR870003776A - 비타민-함유 과립 및 그의 제조방법 - Google Patents

비타민-함유 과립 및 그의 제조방법 Download PDF

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KR870003776A
KR870003776A KR1019860008291A KR860008291A KR870003776A KR 870003776 A KR870003776 A KR 870003776A KR 1019860008291 A KR1019860008291 A KR 1019860008291A KR 860008291 A KR860008291 A KR 860008291A KR 870003776 A KR870003776 A KR 870003776A
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South Korea
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vitamin
compound
binder
granules
weight
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KR1019860008291A
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English (en)
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KR930008951B1 (ko
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세이지 이즈하라
노부유끼 기따모리
마사야 마에노
Original Assignee
우메모또 요시마사
다께다 야꾸힝 고오교 가부시끼가이샤
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Application filed by 우메모또 요시마사, 다께다 야꾸힝 고오교 가부시끼가이샤 filed Critical 우메모또 요시마사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

비타민-함유 과립 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 비타민 B6,비타민 B2, 니코틴아미드 및 판토텐산염으로 구성된 군으로부터 선택된 1종 이상의 화합물 및 결합체를 함유하여, 이때 상기 화합물은 건조상태를 기준으로 하여 약 90∼99중량%의 양으로 함유함을 특징으로 하는 비타민-함유 과립.
  2. 비타민 B6, 니코틴아미드 및 판토텐산염으로 구성된 군으로부터 선택된 1종 이상의 화합물 및 결합제를 함유하며, 이때 상기 화합물은 건조상태를 기준으로 하여 약90∼99중량%에 달하는 양으로 함유함을 특징으로 하는 비타민-함유 과립.
  3. 비타민 B2, 및 결합제를 함유하며, 이때 상기 화합물은 건조상태를 기준으로 하여 약 90∼99중량%에 달하는 양으로 함유함을 특징으로 하는 비타민-함유 과립.
  4. 제1항에 있어서, 결합제가 수용성 셀룰로오스임을 특징으로 하는 비타민-함유 과립.
  5. 제4항에 있어서, 수용성 셀룰로오스가 히드록시 프로필셀롤로오스, 히드록시메틸셀룰로오스, 히드록시프로필메틸셀롤로오스, 카르복시메틸셀룰로오스 또는 메틸셀룰로오스임을 특징으로 하는 비타민-함유 과립.
  6. 비타민 B6,비타민 B2, 니코틴아미드 및 판토텐산염으로 구성된 군으로부터 선택된 1종 이상의 화합물들의, 최소한 약 95중량%가 100-메쉬시이브(일본국 공업표준)를 통과하는 분말을 유동층 제립기내에 분산시키고, 이어서 상기 분말에 제제의 총 건조중량의 약 1∼10중량%에 달하는 결합제를 함유하는 용액을 분무하여 과립들을 수득함을 특징으로 하는 비타민-함유 과립의 제조방법.
  7. 제6항에 있어서, 결합제는 수용성 셀룰로오스임을 특징으로 하는 방법.
  8. 제7항에 있어서, 용액내의 결합제의 농도가 약1∼15중량%임을 특징으로 하는 방법.
  9. 비타민 B6,비타민 B2, 니코틴아미드 및 판토텐산염으로 구성된 군으로부터 선택된 1종 이상의 화합물 및 결합제를 함유하여, 이때 상기 화합물(들)은 건조상태를 기준으로 하여 약 90∼99중량%의 양을 실질적 으로 함유하는 비타민 과립을 그 자체로 또는 1종 이상의 다른 정제 화용 성분을 첨가한 후에 압축시켜 제조되는 정제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008291A 1985-10-07 1986-10-02 비타민-함유 과립의 제조방법 KR930008951B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP224079 1985-10-07
JP22407985 1985-10-07

Publications (2)

Publication Number Publication Date
KR870003776A true KR870003776A (ko) 1987-05-04
KR930008951B1 KR930008951B1 (ko) 1993-09-17

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Country Link
US (1) US4868180A (ko)
EP (1) EP0219276B1 (ko)
JP (1) JPH0751504B2 (ko)
KR (1) KR930008951B1 (ko)
CN (1) CN1022024C (ko)
AT (1) ATE77942T1 (ko)
AU (1) AU587863B2 (ko)
CA (1) CA1308024C (ko)
DE (1) DE3685927T2 (ko)
DK (1) DK167339B1 (ko)
ES (1) ES2041641T3 (ko)

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Also Published As

Publication number Publication date
JPH0751504B2 (ja) 1995-06-05
ATE77942T1 (de) 1992-07-15
DK167339B1 (da) 1993-10-18
KR930008951B1 (ko) 1993-09-17
EP0219276A3 (en) 1988-09-21
CN1022024C (zh) 1993-09-08
ES2041641T3 (es) 1993-12-01
JPS62174013A (ja) 1987-07-30
DE3685927T2 (de) 1992-12-24
CN86106839A (zh) 1988-04-20
US4868180A (en) 1989-09-19
DK459486A (da) 1987-04-08
AU6291986A (en) 1987-04-09
AU587863B2 (en) 1989-08-31
CA1308024C (en) 1992-09-29
EP0219276A2 (en) 1987-04-22
DE3685927D1 (de) 1992-08-13
DK459486D0 (da) 1986-09-26
EP0219276B1 (en) 1992-07-08

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