KR870001670B1 - 세포 선별장치 및 방법 - Google Patents

세포 선별장치 및 방법 Download PDF

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Publication number
KR870001670B1
KR870001670B1 KR1019830002002A KR830002002A KR870001670B1 KR 870001670 B1 KR870001670 B1 KR 870001670B1 KR 1019830002002 A KR1019830002002 A KR 1019830002002A KR 830002002 A KR830002002 A KR 830002002A KR 870001670 B1 KR870001670 B1 KR 870001670B1
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KR
South Korea
Prior art keywords
cells
carrier
cell
openings
opening
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Expired
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KR1019830002002A
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Korean (ko)
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KR840004780A (ko
Inventor
와인렙 아레
듀취 모르데카이
Original Assignee
바아-일란 유니버시트
이삭 코헨, 다비드 알트만
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Publication of KR840004780A publication Critical patent/KR840004780A/ko
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Publication of KR870001670B1 publication Critical patent/KR870001670B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Communication Control (AREA)
KR1019830002002A 1982-05-10 1983-05-10 세포 선별장치 및 방법 Expired KR870001670B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2897/82-3 1982-05-10
CH289782 1982-05-10

Publications (2)

Publication Number Publication Date
KR840004780A KR840004780A (ko) 1984-10-24
KR870001670B1 true KR870001670B1 (ko) 1987-09-21

Family

ID=4244064

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002002A Expired KR870001670B1 (ko) 1982-05-10 1983-05-10 세포 선별장치 및 방법

Country Status (21)

Country Link
US (1) US4729949A (enExample)
EP (1) EP0094193B1 (enExample)
JP (1) JPS5931685A (enExample)
KR (1) KR870001670B1 (enExample)
AR (1) AR243282A1 (enExample)
AT (1) ATE29070T1 (enExample)
AU (1) AU562301B2 (enExample)
BR (1) BR8302395A (enExample)
CA (1) CA1202870A (enExample)
CS (1) CS268157B2 (enExample)
DE (1) DE3373143D1 (enExample)
DK (1) DK170721B1 (enExample)
ES (1) ES522207A0 (enExample)
HU (1) HU195245B (enExample)
IL (1) IL68507A (enExample)
IN (1) IN159538B (enExample)
MX (1) MX163377B (enExample)
NO (1) NO164134C (enExample)
NZ (1) NZ204056A (enExample)
RU (1) RU1776352C (enExample)
ZA (1) ZA833141B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101252829B1 (ko) * 2009-10-06 2013-04-11 한국전자통신연구원 단일세포 분주용 어레이 장치
WO2017155171A1 (ko) * 2016-03-08 2017-09-14 삼성전자 주식회사 단일세포 검출 및 채집용 슬라이드

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US5310674A (en) * 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
AU2780284A (en) * 1983-05-16 1985-11-21 Packard Instrument Co. Inc. Method of measuring atp and concentrating and measuring unicellular organisms
EP0162907B1 (en) * 1983-11-08 1992-01-15 Bar Ilan University System and methods for cell selection
US4675065A (en) * 1985-08-30 1987-06-23 Bar Ilan University Method for securing a microsieve to a support member
JPH07105870B2 (ja) * 1986-07-03 1995-11-13 松下電器産業株式会社 原稿読取装置
JP2662215B2 (ja) * 1986-11-19 1997-10-08 株式会社日立製作所 細胞保持装置
JP2559760B2 (ja) * 1987-08-31 1996-12-04 株式会社日立製作所 細胞搬送方法
CN1034617A (zh) * 1987-10-09 1989-08-09 奈吉尼股份有限公司 鉴定生化物种之方法及装置
EP0339980B1 (en) * 1988-04-26 1994-07-20 Nippon Telegraph And Telephone Corporation Magnetic micro-particles, method and apparatus for collecting specimens for use in labelling immune reactions, and method and device for preparing specimens
US5183744A (en) * 1988-10-26 1993-02-02 Hitachi, Ltd. Cell handling method for cell fusion processor
JP2685544B2 (ja) * 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
JP2966904B2 (ja) * 1990-08-08 1999-10-25 株式会社日立製作所 細胞の処理方法、および処理装置
JP3067347B2 (ja) * 1991-10-30 2000-07-17 株式会社島津製作所 ゲル状ビーズの選別装置
US5314829A (en) * 1992-12-18 1994-05-24 California Institute Of Technology Method for imaging informational biological molecules on a semiconductor substrate
US6054287A (en) * 1994-05-27 2000-04-25 Methodist Hospital Of Indiana, Inc. Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
US5733507A (en) * 1995-06-07 1998-03-31 Inphocyte, Inc. Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder
US5848977A (en) * 1996-02-16 1998-12-15 Inphocyte, Inc. Sample holder for cells
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
DE69729101T2 (de) * 1996-06-07 2005-05-12 Immunivest Corp., Wilmington Magnetische trennung mit hilfe von externen und internen gradienten
US7666308B2 (en) * 1996-06-07 2010-02-23 Veridex, Llc. Magnetic separation apparatus and methods
US6890426B2 (en) * 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US6660159B1 (en) 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
DE19629141A1 (de) 1996-07-19 1998-04-16 Bayer Ag Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand
EP0938674B1 (de) 1996-11-16 2005-06-01 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
AU734957B2 (en) 1997-05-16 2001-06-28 Alberta Research Council Inc. Microfluidic system and methods of use
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
EP1040349B2 (de) 1997-12-17 2012-12-19 Ecole Polytechnique Federale De Lausanne (Epfl) Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
DE69903800T2 (de) * 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
CA2335951C (en) * 1998-06-24 2013-07-30 Mark S. Chee Decoding of array sensors with microspheres
AU4180500A (en) * 1999-03-31 2000-10-16 Optigon Technologies High throughput screening apparatus and methods for arraying microparticles
GB9925904D0 (en) 1999-11-03 1999-12-29 Univ Belfast Cell migration and chemotaxis chamber
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
WO2002021128A2 (en) * 2000-09-05 2002-03-14 Illumina, Inc. Cellular arrays comprising encoded cells
GB2371626B (en) * 2000-10-11 2005-03-16 Axon Instr Inc Parallel electrode assembly and method of positioning cells for electrophysiological testing
AU2002230524A1 (en) * 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US6495340B2 (en) * 2000-11-28 2002-12-17 Medis El Ltd. Cell carrier grids
JP3738899B2 (ja) * 2000-12-07 2006-01-25 株式会社 エフェクター細胞研究所 微量試料処理装置
TWI241343B (en) 2000-12-07 2005-10-11 Effector Cell Inst Inc Well unit for detecting cell chemotaxis and separating chemotactic cells
US20030036049A1 (en) * 2001-01-03 2003-02-20 Medis El Ltd. Optical method for testing sensitivity of cells
US20020106715A1 (en) * 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
JP4192097B2 (ja) * 2001-10-25 2008-12-03 バル−イラン ユニバーシティ 相互作用型透明個別細胞バイオチッププロセッサー
US20030213741A1 (en) * 2002-05-16 2003-11-20 Wright Allen B. Filter and method of manufacture
US6852527B2 (en) * 2002-06-06 2005-02-08 Inovyx, Inc. Apparatus and method for the measurement of cells in biological samples
JP2006501449A (ja) 2002-09-27 2006-01-12 ザ ジェネラル ホスピタル コーポレーション 細胞分離のためのマイクロ流体デバイスおよびその使用
US7190449B2 (en) * 2002-10-28 2007-03-13 Nanopoint, Inc. Cell tray
EP1566635B1 (en) * 2002-11-14 2011-12-07 Vivalis Microwell array chip for detecting antigen-specific lymphocyte, method of detecting antigen-specific lymphocyte and method of cloning antigen-specific lymphocyte antigen receptor gene
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US20040171091A1 (en) * 2003-02-27 2004-09-02 Cell Work, Inc. Standardized evaluation of therapeutic efficacy based on cellular biomarkers
KR20060002879A (ko) * 2003-03-28 2006-01-09 자이단호진 토야마켄 신세키 산교기코 1개의 항원 특이적 ｂ림프구를 이용한 항원 특이적 항체를생산하는 하이브리도마의 제조방법 및 단일 클론 항체의제조방법
TW200506364A (en) * 2003-04-09 2005-02-16 Effector Cell Inst Inc Apparatus for detecting cell chemo-taxis
AU2004250131A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US8597597B2 (en) 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US20060240548A1 (en) * 2003-06-26 2006-10-26 Mordechai Deutsch Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof
WO2005008626A1 (en) * 2003-07-11 2005-01-27 University Of North Carolina At Chapel Hill Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
CN102928584B (zh) 2003-09-25 2017-06-13 富山县政府 微孔阵列芯片及其制造方法
JP2007520546A (ja) * 2004-02-03 2007-07-26 ケマジス リミティド モンテルカストナトリウムの安定な非晶質性形態
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
EP1773978B1 (en) * 2004-05-19 2014-04-02 Massachusetts Institute Of Technology Perfused three-dimensional cell/tissue disease models
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
EP1774334B1 (en) * 2004-08-03 2017-10-04 Becton, Dickinson and Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
EP1781404A2 (en) * 2004-08-25 2007-05-09 Seng Enterprises Limited Method and device for isolating cells
JP2006081491A (ja) * 2004-09-17 2006-03-30 Univ Of Tokyo 細胞配列装置及びその製造方法
JP2006149227A (ja) * 2004-11-25 2006-06-15 Fujitsu Ltd 微小物体の捕獲装置及び方法
DE602005023534D1 (de) 2005-01-25 2010-10-21 Seng Entpr Ltd Mikrofluidische vorrichtung zur untersuchung zellen
JP4579745B2 (ja) * 2005-03-31 2010-11-10 富士通株式会社 細胞捕捉装置
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE102005034043B4 (de) * 2005-07-18 2019-12-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
US8288120B2 (en) 2005-11-03 2012-10-16 Seng Enterprises Ltd. Method for studying floating, living cells
WO2007055302A1 (ja) * 2005-11-10 2007-05-18 National University Corporation University Of Toyama 生体物質と生体物質結合性物質との結合性評価方法
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
JP5205798B2 (ja) * 2007-04-27 2013-06-05 富士通株式会社 マイクロインジェクション装置、捕捉プレート、およびマイクロインジェクション方法
JP2008295376A (ja) * 2007-05-31 2008-12-11 Fujitsu Ltd 細胞捕捉プレート、マイクロインジェクション装置、および細胞捕捉プレートの製造方法
DK2171098T3 (en) * 2007-06-29 2018-05-22 Becton Dickinson Co PROCEDURES FOR EXTRACTION AND CLEANING COMPONENTS IN BIOLOGICAL SAMPLES
JP4148367B1 (ja) 2007-08-02 2008-09-10 富山県 細胞のスクリーニング方法
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
US9975118B2 (en) 2007-11-15 2018-05-22 Seng Enterprises Ltd. Device for the study of living cells
JP5295733B2 (ja) * 2007-11-30 2013-09-18 キヤノン株式会社 生体の保持方法、生体の試験方法、生体の成育方法、生体の保持用シートおよび生体の処理装置
KR100940099B1 (ko) * 2008-04-02 2010-02-02 한국기계연구원 암세포와 정상세포를 구별하기 위한 세포구별장치 및 그세포구별방법
WO2009145925A1 (en) * 2008-05-30 2009-12-03 Massachusetts Institute Of Technology Compositions and methods for spatial separation and screening of cells
US9404924B2 (en) * 2008-12-04 2016-08-02 Massachusetts Institute Of Technology Method of performing one-step, single cell RT-PCR
EP2370814B1 (en) 2008-12-04 2015-04-29 Massachusetts Institute of Technology Method for diagnosing allergic reactions
AU2009338127B2 (en) 2009-01-21 2015-11-26 Massachusetts Institute Of Technology Compositions and methods for assessing cytotoxicity of single cells
JP2010273655A (ja) * 2009-05-29 2010-12-09 Canon Inc 細胞保持方法、細胞試験方法及び細胞処理装置
US20130136673A1 (en) * 2010-07-09 2013-05-30 Sophion Bioscience A/S Chip assembly for use in a microfluidic analysis sytem
US20120322144A1 (en) * 2011-06-14 2012-12-20 Emory University Microfluidic devices and systems
US8770216B2 (en) * 2012-03-01 2014-07-08 Pro-Iroda Industries, Inc. Device adapted to withdraw gas and to control gas flow rate discharged therefrom
EP2831265B1 (en) * 2012-03-29 2016-07-27 Centre National De La Recherche Scientifique Methods for observing cells with cell wall or invertebrate embryos with oblong eggshell
WO2016117541A1 (ja) * 2015-01-22 2016-07-28 株式会社村田製作所 空隙配置構造体およびその製造方法
US11359175B2 (en) 2015-09-29 2022-06-14 Tokyo Ohka Kogyo Co., Ltd. Substrate, structure, structure-manufacturing method, cell-sorting method, cell-manufacturing method, and secretion-producing method
KR102430124B1 (ko) 2016-12-07 2022-08-05 도오꾜오까고오교 가부시끼가이샤 입자 포착 디바이스
EP4085128A4 (en) 2020-01-03 2023-03-22 Bioloomics, Inc. Systems and methods for cell sorting and cell extraction
WO2024015809A1 (en) * 2022-07-12 2024-01-18 The Regents Of The University Of California Device and method for automatic cellular sorting and analysis via robotic motor-driven flow

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1915568A (en) * 1928-08-20 1933-06-27 Northwest Paper Company Recovery and purification of materials by electrodialysis
US2923669A (en) * 1954-11-22 1960-02-02 Millipore Filter Corp Method of bacterial analysis
GB770229A (en) * 1954-11-24 1957-03-20 Filtrox Werk Ag A process and apparatus for the rapid determination of micro-organisms in filtered beers, malt liquor and the like
US2910406A (en) * 1957-02-13 1959-10-27 Ohio Commw Eng Co Method for biological particle separation
NL110949C (enExample) * 1960-10-06
US3303254A (en) * 1963-06-27 1967-02-07 C B Messenger Method for preparing a membrane
US3177945A (en) * 1963-06-27 1965-04-13 Donald W Fether Well liner with inwardly convergent passages
GB1050074A (enExample) * 1964-05-25
US3207684A (en) * 1964-12-17 1965-09-21 Jr Walter M Dotts Method for changing the distribution of ions in a solution of an electrolyte
GB1077881A (en) * 1965-01-05 1967-08-02 Ici Ltd Microscope slides
US3719583A (en) * 1970-07-06 1973-03-06 D Ustick Apparatus for the separation of ions from solution
US3776699A (en) * 1971-10-20 1973-12-04 Cooke Eng Co Red cell rinser
US3888770A (en) * 1971-10-21 1975-06-10 Shlomo Avital Plural-sample filter device
US3726597A (en) * 1972-03-09 1973-04-10 Us Health Education & Welfare Controlled environment culture system for light microscopy
US3768914A (en) * 1972-09-18 1973-10-30 T Kinney Electron microscopy tissue grid staining and storing rack and method
CH565020A5 (enExample) * 1973-04-03 1975-08-15 Filtrox Maschinenbau Ag
US3947121A (en) * 1973-07-30 1976-03-30 Corning Glass Works Method for aligning microstructures
US3851972A (en) * 1973-10-18 1974-12-03 Coulter Electronics Automatic method and system for analysis and review of a plurality of stored slides
US4009435A (en) * 1973-10-19 1977-02-22 Coulter Electronics, Inc. Apparatus for preservation and identification of particles analyzed by flow-through apparatus
US3924947A (en) * 1973-10-19 1975-12-09 Coulter Electronics Apparatus for preservation and identification of particles analyzed by flow-through apparatus
US3874851A (en) * 1973-11-15 1975-04-01 Robert John Wilkins Method and apparatus for the detection of microfilariae
CA1001994A (en) * 1973-12-14 1976-12-21 Michael A. Dudley Electroimpregnation of paper and non-woven fabrics
US3899610A (en) * 1974-01-07 1975-08-12 Donald E Henry Means for preparing cells for inspection
DE2502621C3 (de) * 1975-01-23 1978-09-14 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen
DE2526295B2 (de) * 1975-06-12 1978-11-23 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung einer Nutsche
US3929583A (en) * 1975-08-14 1975-12-30 Canadian Patents Dev Apparatus for enumerating microorganisms
US4162850A (en) * 1976-03-01 1979-07-31 Case Western Reserve University Field test for Schistosoma eggs
US4066359A (en) * 1976-05-21 1978-01-03 Louis Bucalo Method and structure for treating body fluids with cells therein
IL49776A (en) * 1976-06-13 1979-05-31 Elscint Ltd Method and appararus for differentiating of normal and abnormal mammalian cells
US4025306A (en) * 1976-08-16 1977-05-24 Arnold David Studer Process and apparatus for heartworm microfilariae detection
JPS5423993A (en) * 1977-07-22 1979-02-22 Hitachi Ltd Construction of cord outlet of electric equipment
DE2741638C3 (de) * 1977-09-15 1980-03-27 Ernst Dipl.-Phys. Dr. 8000 Muenchen Remy Präparattrager mit Elektrodenanordnung fur die Zelluntersuchung, sowie seine Herstellung
DE2928790A1 (de) * 1979-07-17 1981-02-12 Sartorius Gmbh Verfahren und vorrichtung zur gewinnung und auswertung von zellpraeparaten aus fluessigen medien, insbesondere aus urin u.a. koerperfluessigkeiten fuer die pruefung auf tumorverdacht
US4326934A (en) * 1979-12-31 1982-04-27 Pohl Herbert A Continuous dielectrophoretic cell classification method
US4374644A (en) * 1981-04-06 1983-02-22 Coulter Electronics, Inc. Blood cell volume monitoring
US4415405A (en) * 1981-08-19 1983-11-15 Yale University Method for engraving a grid pattern on microscope slides and slips
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US4441972A (en) * 1983-04-08 1984-04-10 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101252829B1 (ko) * 2009-10-06 2013-04-11 한국전자통신연구원 단일세포 분주용 어레이 장치
WO2017155171A1 (ko) * 2016-03-08 2017-09-14 삼성전자 주식회사 단일세포 검출 및 채집용 슬라이드

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ATE29070T1 (de) 1987-09-15
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HU195245B (en) 1988-04-28
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