KR870001508B1 - 8-치환된 에르골린 유도체를 이성질화시키는 방법 - Google Patents

8-치환된 에르골린 유도체를 이성질화시키는 방법 Download PDF

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Publication number
KR870001508B1
KR870001508B1 KR1019810003538A KR810003538A KR870001508B1 KR 870001508 B1 KR870001508 B1 KR 870001508B1 KR 1019810003538 A KR1019810003538 A KR 1019810003538A KR 810003538 A KR810003538 A KR 810003538A KR 870001508 B1 KR870001508 B1 KR 870001508B1
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KR
South Korea
Prior art keywords
ergoline
substituted
hydrogen
ergolin
prepared
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Expired
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KR1019810003538A
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English (en)
Korean (ko)
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KR830007641A (ko
Inventor
브리크 데네크
뮤레 헤르베르트
Original Assignee
산도즈 파마슈티칼스 코포레이션
게랄드 디 샤르킨
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Application filed by 산도즈 파마슈티칼스 코포레이션, 게랄드 디 샤르킨 filed Critical 산도즈 파마슈티칼스 코포레이션
Publication of KR830007641A publication Critical patent/KR830007641A/ko
Application granted granted Critical
Publication of KR870001508B1 publication Critical patent/KR870001508B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019810003538A 1980-09-23 1981-09-22 8-치환된 에르골린 유도체를 이성질화시키는 방법 Expired KR870001508B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH712280A CH644606A5 (de) 1980-09-23 1980-09-23 Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
CH7122/80 1980-09-23

Publications (2)

Publication Number Publication Date
KR830007641A KR830007641A (ko) 1983-11-04
KR870001508B1 true KR870001508B1 (ko) 1987-08-20

Family

ID=4320306

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003538A Expired KR870001508B1 (ko) 1980-09-23 1981-09-22 8-치환된 에르골린 유도체를 이성질화시키는 방법

Country Status (27)

Country Link
US (1) US4515950A (enExample)
EP (1) EP0048695B1 (enExample)
JP (1) JPS5785385A (enExample)
KR (1) KR870001508B1 (enExample)
AT (1) ATE7916T1 (enExample)
AU (1) AU547647B2 (enExample)
CA (1) CA1178581A (enExample)
CH (1) CH644606A5 (enExample)
CS (1) CS228518B2 (enExample)
DD (1) DD201679A5 (enExample)
DE (1) DE3164195D1 (enExample)
DK (1) DK418781A (enExample)
ES (1) ES8301982A1 (enExample)
FI (1) FI70018C (enExample)
GR (1) GR75044B (enExample)
HU (1) HU185317B (enExample)
IE (1) IE51593B1 (enExample)
IL (1) IL63902A (enExample)
MA (1) MA19281A1 (enExample)
NO (1) NO155967C (enExample)
NZ (1) NZ198436A (enExample)
PH (1) PH19436A (enExample)
PL (1) PL134179B1 (enExample)
PT (1) PT73713B (enExample)
SU (1) SU1152521A3 (enExample)
YU (1) YU42426B (enExample)
ZA (1) ZA816617B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3708028A1 (de) * 1987-03-10 1988-09-22 Schering Ag Verfahren zur herstellung von 2,3ss-dihydroergolinen, 2-substituierte 2,3ss-dihydroergoline und ihre verwendung als arzneimittel
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
CA2974113A1 (en) * 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817988A (en) * 1971-11-16 1974-06-18 Res Inst Medicine Chem PROCESS FOR 11,12-ENOLISATION OF 9a-HALO-11-KETO-STEROIDS
CH585750A5 (en) * 1973-10-12 1977-03-15 Sandoz Ag Prepn. of (8)-methyl-dihydro-lysergic acid derivs. - from (7)-ergolene-(8)-carboxylates by methylation and redn.
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
EP0021206B1 (de) * 1979-06-13 1983-06-22 Schering Aktiengesellschaft Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen

Also Published As

Publication number Publication date
ES505669A0 (es) 1982-12-16
CH644606A5 (de) 1984-08-15
CS228518B2 (en) 1984-05-14
IL63902A (en) 1986-07-31
PL233129A1 (enExample) 1982-05-10
FI70018C (fi) 1986-09-12
PT73713B (en) 1983-05-11
DD201679A5 (de) 1983-08-03
NZ198436A (en) 1985-07-12
KR830007641A (ko) 1983-11-04
GR75044B (enExample) 1984-07-12
YU42426B (en) 1988-08-31
CA1178581A (en) 1984-11-27
IE812201L (en) 1982-03-23
SU1152521A3 (en) 1985-04-23
MA19281A1 (fr) 1982-04-01
PT73713A (en) 1981-10-01
NO155967B (no) 1987-03-23
NO155967C (no) 1987-07-01
FI70018B (fi) 1986-01-31
EP0048695B1 (de) 1984-06-13
AU547647B2 (en) 1985-10-31
ATE7916T1 (de) 1984-06-15
AU7555681A (en) 1982-04-01
YU227581A (en) 1983-10-31
EP0048695A1 (de) 1982-03-31
ES8301982A1 (es) 1982-12-16
ZA816617B (en) 1983-04-27
JPS5785385A (en) 1982-05-28
FI812894L (fi) 1982-03-24
US4515950A (en) 1985-05-07
PL134179B1 (en) 1985-07-31
DE3164195D1 (en) 1984-07-19
IE51593B1 (en) 1987-01-21
NO813196L (no) 1982-03-24
IL63902A0 (en) 1981-12-31
DK418781A (da) 1982-03-24
PH19436A (en) 1986-04-15
HU185317B (en) 1985-01-28

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