DE3164195D1 - Isomerisation process of ergoline derivatives - Google Patents
Isomerisation process of ergoline derivativesInfo
- Publication number
- DE3164195D1 DE3164195D1 DE8181810382T DE3164195T DE3164195D1 DE 3164195 D1 DE3164195 D1 DE 3164195D1 DE 8181810382 T DE8181810382 T DE 8181810382T DE 3164195 T DE3164195 T DE 3164195T DE 3164195 D1 DE3164195 D1 DE 3164195D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- ergoline derivatives
- sec
- isomerisation process
- date apr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
- 238000006317 isomerization reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005588 protonation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH712280A CH644606A5 (de) | 1980-09-23 | 1980-09-23 | Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3164195D1 true DE3164195D1 (en) | 1984-07-19 |
Family
ID=4320306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8181810382T Expired DE3164195D1 (en) | 1980-09-23 | 1981-09-17 | Isomerisation process of ergoline derivatives |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4515950A (enExample) |
| EP (1) | EP0048695B1 (enExample) |
| JP (1) | JPS5785385A (enExample) |
| KR (1) | KR870001508B1 (enExample) |
| AT (1) | ATE7916T1 (enExample) |
| AU (1) | AU547647B2 (enExample) |
| CA (1) | CA1178581A (enExample) |
| CH (1) | CH644606A5 (enExample) |
| CS (1) | CS228518B2 (enExample) |
| DD (1) | DD201679A5 (enExample) |
| DE (1) | DE3164195D1 (enExample) |
| DK (1) | DK418781A (enExample) |
| ES (1) | ES8301982A1 (enExample) |
| FI (1) | FI70018C (enExample) |
| GR (1) | GR75044B (enExample) |
| HU (1) | HU185317B (enExample) |
| IE (1) | IE51593B1 (enExample) |
| IL (1) | IL63902A (enExample) |
| MA (1) | MA19281A1 (enExample) |
| NO (1) | NO155967C (enExample) |
| NZ (1) | NZ198436A (enExample) |
| PH (1) | PH19436A (enExample) |
| PL (1) | PL134179B1 (enExample) |
| PT (1) | PT73713B (enExample) |
| SU (1) | SU1152521A3 (enExample) |
| YU (1) | YU42426B (enExample) |
| ZA (1) | ZA816617B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3309493A1 (de) * | 1983-03-14 | 1984-09-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel |
| HU197569B (en) * | 1984-01-12 | 1989-04-28 | Sandoz Ag | Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds |
| DE3533672A1 (de) * | 1985-09-19 | 1987-03-26 | Schering Ag | Neue 12- und 13-substituierte ergolinderivate |
| DE3533675A1 (de) * | 1985-09-19 | 1987-03-26 | Schering Ag | Neue 12- und 13-brom-ergolinderivate |
| DE3708028A1 (de) * | 1987-03-10 | 1988-09-22 | Schering Ag | Verfahren zur herstellung von 2,3ss-dihydroergolinen, 2-substituierte 2,3ss-dihydroergoline und ihre verwendung als arzneimittel |
| BR112017015487A2 (pt) | 2015-01-20 | 2018-01-30 | Xoc Pharmaceuticals Inc | Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo |
| CN107405346A (zh) * | 2015-01-20 | 2017-11-28 | Xoc制药股份有限公司 | 异麦角灵化合物及其用途 |
| CA3064274A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817988A (en) * | 1971-11-16 | 1974-06-18 | Res Inst Medicine Chem | PROCESS FOR 11,12-ENOLISATION OF 9a-HALO-11-KETO-STEROIDS |
| CH585750A5 (en) * | 1973-10-12 | 1977-03-15 | Sandoz Ag | Prepn. of (8)-methyl-dihydro-lysergic acid derivs. - from (7)-ergolene-(8)-carboxylates by methylation and redn. |
| GB1517971A (en) * | 1974-07-19 | 1978-07-19 | Sandoz Ltd | 8alpha-substituted ergoline i derivatives |
| US3968111A (en) * | 1974-12-06 | 1976-07-06 | Eli Lilly And Company | 8,8-Disubstituted-6-methylergolines and related compounds |
| DE2656344A1 (de) * | 1975-12-23 | 1977-07-07 | Sandoz Ag | Ergolinderivate, ihre verwendung und herstellung |
| DE3063869D1 (en) * | 1979-06-13 | 1983-07-28 | Schering Ag | (ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them |
| US4246265A (en) * | 1979-10-01 | 1981-01-20 | Eli Lilly And Company | 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds |
| DE3001752A1 (de) * | 1980-01-16 | 1981-07-30 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen |
-
1980
- 1980-09-23 CH CH712280A patent/CH644606A5/de not_active IP Right Cessation
-
1981
- 1981-09-16 FI FI812894A patent/FI70018C/fi not_active IP Right Cessation
- 1981-09-17 AT AT81810382T patent/ATE7916T1/de not_active IP Right Cessation
- 1981-09-17 EP EP81810382A patent/EP0048695B1/de not_active Expired
- 1981-09-17 DE DE8181810382T patent/DE3164195D1/de not_active Expired
- 1981-09-21 SU SU813338647A patent/SU1152521A3/ru active
- 1981-09-21 DK DK418781A patent/DK418781A/da not_active Application Discontinuation
- 1981-09-21 IL IL63902A patent/IL63902A/xx unknown
- 1981-09-21 PT PT73713A patent/PT73713B/pt unknown
- 1981-09-21 GR GR66104A patent/GR75044B/el unknown
- 1981-09-21 DD DD81233439A patent/DD201679A5/de not_active IP Right Cessation
- 1981-09-21 ES ES505669A patent/ES8301982A1/es not_active Expired
- 1981-09-21 NO NO813196A patent/NO155967C/no unknown
- 1981-09-22 PH PH26242A patent/PH19436A/en unknown
- 1981-09-22 AU AU75556/81A patent/AU547647B2/en not_active Ceased
- 1981-09-22 MA MA19482A patent/MA19281A1/fr unknown
- 1981-09-22 JP JP56150516A patent/JPS5785385A/ja active Pending
- 1981-09-22 CA CA000386357A patent/CA1178581A/en not_active Expired
- 1981-09-22 IE IE2201/81A patent/IE51593B1/en unknown
- 1981-09-22 HU HU812740A patent/HU185317B/hu not_active IP Right Cessation
- 1981-09-22 YU YU2275/81A patent/YU42426B/xx unknown
- 1981-09-22 PL PL1981233129A patent/PL134179B1/pl unknown
- 1981-09-22 NZ NZ198436A patent/NZ198436A/en unknown
- 1981-09-22 KR KR1019810003538A patent/KR870001508B1/ko not_active Expired
- 1981-09-23 US US06/375,290 patent/US4515950A/en not_active Expired - Fee Related
- 1981-09-23 CS CS817022A patent/CS228518B2/cs unknown
- 1981-09-23 ZA ZA816617A patent/ZA816617B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SANDOZ-PATENT-GMBH, 7850 LOERRACH, DE |
|
| 8339 | Ceased/non-payment of the annual fee |