KR870001228A - 디스타마이신 A(Distamycin A) 유도체의 제조 방법 - Google Patents

디스타마이신 A(Distamycin A) 유도체의 제조 방법 Download PDF

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KR870001228A
KR870001228A KR1019860005716A KR860005716A KR870001228A KR 870001228 A KR870001228 A KR 870001228A KR 1019860005716 A KR1019860005716 A KR 1019860005716A KR 860005716 A KR860005716 A KR 860005716A KR 870001228 A KR870001228 A KR 870001228A
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compound
formula
alkyl
halogen
nhr
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KR1019860005716A
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KR940003495B1 (ko
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아르카모네 페데리코
몬겔리 니콜라
아니마티 파비오
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팜이탈리아 카를로 엘바 에스.피.에이.
비토리노 페라리오
팜이탈리아 카를로 엘바 에스. 피. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

내용 없음.

Description

디스타마이신 A(Distamycin A) 유도체의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. A) 하기 일반식(II)의 화합물을 하기의 일반식(III)의 화합물과 반응시켜 R이 -NHR3이고 R3가 -CON(NO)R4(여기서, R4는 하기에서 정의하는 바와 같다)인 하기 일반식(I)의 화합물을 수득하거나; B) 일반식(II)의 화합물을 하기 일반식(IV)의 화합물과 반응시켜 R이 -NHR3이고 R3이 -CO(CH2)m-R5(여기서, m 및 R5는 하기에서 정의하는 바와 같다)인 일반식(I)의 화합물을 수득하거나; C) 일반식(II)의 화합물을 하기 일반식(V)의 화합물과 반응시켜 하기의 일반식(VI)의 화합물을 수득한 다음, 이를 R이(여기서, R6및 R7은 하기에서 정의하는 바와같다)인 일반식(I)의 화합물로 전환시키고; 경우에 따라, 일반식(I)의 화합물을 일반식(I)의 다른 화합물로 전환시키고/거나, 경우에 따라, 일반식(I)의 화합물을 염화시키거나 염에서 유리화합물을 수득하고/거나, 경우에 따라, 일반식(I)의 이성체 혼합물을 단일 이성체로 분리함을 특징으로하여 일반식(I)의 화합물 및 약제학적으로 허용 가능한 이의 염을 제조하는 방법.
    상기 식에서, R은 -NHR3[여기서, R3은 -CON(NO)R4(여기서, R4는 할로겐에 의해 치환되거나 비치환된 C1내지 C4알킬이다). 또는 -CO(CH2)m-R5(여기서, R5는 할로겐, 옥시라닐, 메틸옥시라닐, 아지리디닐, 사이클로-프로필 또는 α,β-불포화 지환족 케톤 또는 락톤의 잔기이며, m은 0 또는 1 내지 4이다)이다]. 또는[여기서, R6및 R7은 동일하며, 각각은 옥시란메틸 또는 아지리딘 메틸, 또는 할로겐이나 -OSO2R8그룹(여기서, R8은 C1내지 C4알킬 또는 페닐이다)에 의해 2-치혼된 C2내지 C4알킬이거나, R6및 R7중 어느 하나가 수소이며 나머지는 상기에서 정의한 바와 같다]이며, R1은 각각 독립적으로 수소 또는 C1내지 C4알킬이며, Z 및 Z′은 이탈 그룹이며, X는 수소, C1내지 C2알킬 또는 할로메틸이다.
  2. 제1항에 있어서, R이 -NHR3[여기서, R3은 -CON(NO)R4(여기서, R4는 할로겐에 의해 치환된 C1내지 C4알킬이다) 또는 -CO(CH2)m-R5(여기서, R5는 할로겐 옥시라닐, 1-아지리디닐, 사이클로프로필, 또는 α,β-불포화 지환족 락톤의 잔기이며, m은 0,1 또는 2이다)이다]이며; R1은 각각 독립적으로 C1내지 C4알킬인 일반식(I)의 화합물 및 약제학적으로 허용 가능한 이의 염을 제조하는 방법.
  3. 제1항에 있어서, R이[여기서, R6및 R7은 동일하며, 각각은 옥시란메틸, 1-아지리딘메틸, 또는 할로겐이나 -OS2R8그룹(여기서, R8은 C1내지 C4알킬이다)에 의해 2-치환된 C2내지 C4알킬그룹이다]이며; R1은 각각 독립적으로 C1내지 C4알킬인 일반식(I)의 화합물 및 약제학적으로 허용 가능한 이의 염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860005716A 1985-07-16 1986-07-15 디스타마이신 a유도체의 제조방법 KR940003495B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517923A GB8517923D0 (en) 1985-07-16 1985-07-16 Distamycin derivatives
GB8517923 1985-07-16

Publications (2)

Publication Number Publication Date
KR870001228A true KR870001228A (ko) 1987-03-12
KR940003495B1 KR940003495B1 (ko) 1994-04-23

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US (1) US4738980A (ko)
JP (1) JPH0780842B2 (ko)
KR (1) KR940003495B1 (ko)
CN (2) CN85103908A (ko)
AT (1) AT386822B (ko)
AU (1) AU584723B2 (ko)
BE (1) BE905109A (ko)
CA (1) CA1247627A (ko)
CH (1) CH671958A5 (ko)
CZ (1) CZ277823B6 (ko)
DE (1) DE3623853C2 (ko)
DK (1) DK335886A (ko)
ES (1) ES2000346A6 (ko)
FI (1) FI82929C (ko)
FR (1) FR2585019B1 (ko)
GB (2) GB8517923D0 (ko)
GR (1) GR861840B (ko)
HU (1) HU198087B (ko)
IE (1) IE59275B1 (ko)
IL (1) IL79401A (ko)
IT (1) IT1213103B (ko)
NL (1) NL8601838A (ko)
NO (1) NO169014C (ko)
NZ (1) NZ216828A (ko)
PH (1) PH23459A (ko)
PT (1) PT82985B (ko)
SE (1) SE468594B (ko)
SU (2) SU1535378A3 (ko)
ZA (1) ZA865262B (ko)

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SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
US5049579A (en) * 1986-05-20 1991-09-17 Farmitalia Carlo Erba, S.R.L. Site specific alkylating agents
US5310752A (en) * 1986-05-20 1994-05-10 Farmitalia Carlo Erba Spa Site specific alkylating agents
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
WO1992013838A1 (en) * 1991-02-06 1992-08-20 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
DE4205948C2 (de) * 1992-02-24 1996-10-31 Mannesmann Ag Farbbandkassette für ein endloses Farbband
US5273991A (en) * 1992-07-29 1993-12-28 Research Corporation Technologies, Inc. Imidazole-containing compositions and methods of use thereof analogs of distamycin
US5637621A (en) * 1994-11-14 1997-06-10 Nzym, Inc. Methods and compositions for treating Botrytis infections
US5629348A (en) * 1994-11-14 1997-05-13 Nzym, Inc. Methods and compositions for treating septoria infections
EP0792262A2 (en) * 1994-11-14 1997-09-03 Nzym, Inc. Methods and compositions for treating phytopathogenic fungi infections
DE19805431A1 (de) * 1998-02-11 1999-08-12 Merck Patent Gmbh Heteroaromatische Oligoamide als Affinitätsliganden
US6555693B2 (en) 2000-03-16 2003-04-29 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
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ITTO20010633A1 (it) * 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
US7265129B2 (en) * 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
US20070269420A1 (en) * 2003-11-24 2007-11-22 Chunduru Srinivas K Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases
KR102155411B1 (ko) * 2015-03-30 2020-09-11 메이지 세이카 파루마 가부시키가이샤 에피루비신 제조방법 및 그의 신규한 제조 중간체

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CA557568A (en) * 1958-05-20 J. Weiss Martin Substituted aminopyrrolecarboxylic acids and esters
CA547128A (en) * 1957-10-08 W. Waller Coy Substituted pyrrolecarboxamidopyrroles
FR86210E (ko) * 1963-04-04 1966-03-23
BE666612A (ko) * 1963-07-26 1965-11-03
FR141F (ko) * 1963-07-26
BR6461040D0 (pt) * 1963-07-26 1973-08-02 Farmaceutici Italia Processo para preparar novos derivados de pirrol
DE1795539A1 (de) * 1963-07-26 1972-01-13 Farmaceutici Italia Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
NL130086C (ko) * 1964-07-14 1970-06-15
SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

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PT82985B (pt) 1989-01-30
DE3623853C2 (de) 1995-12-21
CS541186A3 (en) 1992-09-16
ATA188786A (de) 1988-03-15
ZA865262B (en) 1987-03-25
BE905109A (fr) 1987-01-15
NZ216828A (en) 1989-11-28
CH671958A5 (ko) 1989-10-13
US4738980A (en) 1988-04-19
NL8601838A (nl) 1987-02-16
SE8603099D0 (sv) 1986-07-11
IL79401A (en) 1991-05-12
CN86104774A (zh) 1987-02-11
HU198087B (en) 1989-07-28
AU584723B2 (en) 1989-06-01
KR940003495B1 (ko) 1994-04-23
JPS6230755A (ja) 1987-02-09
PT82985A (pt) 1986-08-01
GB2178037A (en) 1987-02-04
SE8603099L (sv) 1987-01-17
GB8617293D0 (en) 1986-08-20
AU6020386A (en) 1987-01-22
DE3623853A1 (de) 1987-01-29
PH23459A (en) 1989-08-07
CZ277823B6 (en) 1993-06-16
DK335886A (da) 1987-01-17
SE468594B (sv) 1993-02-15
JPH0780842B2 (ja) 1995-08-30
FI862960A0 (fi) 1986-07-16
FI862960A (fi) 1987-01-17
FI82929B (fi) 1991-01-31
IL79401A0 (en) 1986-10-31
DK335886D0 (da) 1986-07-15
IE861874L (en) 1987-01-16
NO862861L (no) 1987-01-19
NO169014B (no) 1992-01-20
AT386822B (de) 1988-10-25
CN85103908A (zh) 1986-11-05
ES2000346A6 (es) 1988-02-16
HUT41814A (en) 1987-05-28
SU1535378A3 (ru) 1990-01-07
GB8517923D0 (en) 1985-08-21
FI82929C (fi) 1991-05-10
NO169014C (no) 1992-04-29
GB2178037B (en) 1989-07-26
NO862861D0 (no) 1986-07-15
IT1213103B (it) 1989-12-07
GR861840B (en) 1986-11-18
FR2585019B1 (fr) 1989-07-13
IE59275B1 (en) 1994-02-09
SU1538893A3 (ru) 1990-01-23
IT8621124A0 (it) 1986-07-15
FR2585019A1 (fr) 1987-01-23
CA1247627A (en) 1988-12-28
CN1026984C (zh) 1994-12-14

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