KR840005428A - 4-아미노-6, 7-디메톡시퀴놀린 유도체의 제조방법 - Google Patents

4-아미노-6, 7-디메톡시퀴놀린 유도체의 제조방법 Download PDF

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KR840005428A
KR840005428A KR1019830003392A KR830003392A KR840005428A KR 840005428 A KR840005428 A KR 840005428A KR 1019830003392 A KR1019830003392 A KR 1019830003392A KR 830003392 A KR830003392 A KR 830003392A KR 840005428 A KR840005428 A KR 840005428A
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프레이저 캠프벨 시몬 (외 1)
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윌리암 존 윌슨
화이자 코포레이숀
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
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Abstract

내용 없음

Description

4-아미노-6,7-디메톡시퀴놀린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 일반식(Ⅱ)의 화합물을 폐환시키고 필요한 경우, (1) R이 4-벤질-피페라진-1-일 인 일반식(I)의 생성물을 R이 피페라지노인 화합물로 탈벤질화 시키는 반응; (2) R이인 화합물을 얻기 위해 R이 피페라지노인 일반식 R1COQ의 생성물을 일반식(I)의 화합물로 아실화 시키는 반응; (3) R이 피페라지노인 일반식(I)의 생성물을 일반식 R2.NCO의 이소시아네이트 또는 일반식 R2.NHCOCI의 카바모일 클로라이드와 반응시켜, R이인 화합물을 얻는 반응; (4) R이 피페라지노인 일반식(I)의 생성물을 일반식 R3OCOQ의 화합물과 반응시켜 R이인 화합물을 얻는 반응; (5) R이 피페라지노인 일반식(I)의 생성물을 화합물 YQ(여기서 Y는 질소를 함유한 방향족 헤테로사이클릭 그룹임)와 반응시켜 R이인 (여기서 Y는 상기와 같다)인 화합물을 얻는 반응; 중 하나 이상의 단계를 수행한 다음 필요한 경우, 생성물을 그의 약제학적으로 무독한 산부가염으로 전환시킴을 특징으로 하여 다음 일반식(I)의 화합물 또는 이의 약제학적으로 무독한 산부가염을 제조하는 방법.
  3. 상기에서 R은 -N(C1-C4알킬)2, 피페리디노 6,7-디메톡시-1,2,3,4,-테트라하이드로이소퀴놀-2-일 또는 일반식의 그룹을 나타내는데, 여기서 Y는 수소, C1-C6알킬, 아릴, 아릴로 치환된 C1-C4알킬, 또는 피페라지닐그룹의 인접한 질소원자에 탄소원자에 의해서 부착된 질소-함유 방향족 헤테로사이클릭 그룹을 나타내거나, -COR1, -CONHR2및 -COOR2중에서 선택된 것이며, R1은 C1-C6알킬, 아릴로 치환된 C1-C4알킬, C3-C6사이클로알킬, (C3-C6사이클로알킬) 메틸, 아릴, 스티릴 또는 헤테로사이클릭 그룹이며, R2는 C1-C6알킬, 아릴, 아릴로 치환된 C1-C4알킬, (C2-C4알케닐)메틸, C3-C6사이클로알킬 또는 (C3-C6사이클로알킬)메틸이며, R3는 C1-C6알킬, 아릴로 치환된 C1-C4알킬, α탄소원자 이외의 탄소원자에서 하이드록시로 치환된 C2-C4알킬, C3-C6사이클로알킬, (C3-C6사이클로알킬)메틸, (C2-C4알케닐)메틸, 또는 아릴이며, Q는 쉽게 이탈될 수 있는 것이다.
  4. 제1항에 있어서, R이 피페라지노이거나 4-벤질-피페라진-1-일이고 R1이 2-푸릴그룹인 제(2)단계가 포함되는 방법.
  5. 제1항에 있어서, R이 피페라지노이거나 4-벤질-피페라진-1-일이고 R1이 벤조-1,4-디옥산-2-일 그룹인 제(2)단계가 포함되는 방법.
  6. 제1항에 있어서, 생성물을 추가로 진한 황산과 반응시켜 R3가 하이드록시알킬-메틸그룹인 화합물을 제조하고, 필요한 경우, 이의 생성물을 약제학적으로 무독한 산부가염으로 전환시키는, R이 피페라지노이거나 4-벤질-피페라진-1-일이고 R3가 알케닐-메틸 그룹인 제(4)단계가 포함되는 방법.
  7. 제1항에 있어서, 생성물을 추가로 페놀 또는 아민과 반응기켜 Y가 페녹시-
  8. 또는 아미노-치환된 질소-함유 방향족 헤테로사이클릭 그룹인 화합물을 제조하고, 필요한 경우, 이의 생성물을 약제학적으로 무독한 산부가염으로 전환시키는, R이 이피페라지노 이거나 4-펜질-피페라진-1-일이고 Y가 클로로 치환된 질소-함유 방향족 헤테로사이클릭 그룹인 제(5)단계가 포함되는 방법.
  9. 제1항에 있어서, R이 6,7-디메톡시-1,2,3,4-테트라하이드로이소퀴놀린-2-일 그룹인 방법.
  10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003392A 1982-07-24 1983-07-22 4-아미노-6, 7-디메톡시퀴놀린 유도체의 제조방법 KR880001315B1 (ko)

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NO171594B (no) 1992-12-28
DD211555A5 (de) 1984-07-18
DE3371336D1 (en) 1987-06-11
NO171594C (no) 1993-04-07
DK337383D0 (da) 1983-07-22
IE831730L (en) 1984-01-24
HU190907B (en) 1986-12-28
FI832658A (fi) 1984-01-25
PT77082B (en) 1986-04-11
JPH0219112B2 (ko) 1990-04-27
SU1340589A3 (ru) 1987-09-23
AU1722283A (en) 1984-01-26
NO832688L (no) 1984-01-25
GR79603B (ko) 1984-10-31
YU42628B (en) 1988-10-31
IL69311A0 (en) 1983-11-30
YU157283A (en) 1986-02-28
DK337383A (da) 1984-01-25
NZ204996A (en) 1986-05-09
CA1255670A (en) 1989-06-13
FI78296C (fi) 1989-07-10
PL139498B1 (en) 1987-01-31
PL243131A1 (en) 1984-12-17
US4686228A (en) 1987-08-11
IE55798B1 (en) 1991-01-16
IL69311A (en) 1987-01-30
HK32289A (en) 1989-04-28
AU548036B2 (en) 1985-11-21
SG6489G (en) 1989-06-09
ES524320A0 (es) 1985-04-16
PT77082A (en) 1983-08-01
EP0100200A1 (en) 1984-02-08
DK166821B1 (da) 1993-07-19
SU1251801A3 (ru) 1986-08-15
FI78296B (fi) 1989-03-31
KR880001315B1 (ko) 1988-07-23
EP0100200B1 (en) 1987-05-06
PH19424A (en) 1986-04-15
ES8504131A1 (es) 1985-04-16
JPS5933264A (ja) 1984-02-23
US4656174A (en) 1987-04-07
US4758568A (en) 1988-07-19
FI832658A0 (fi) 1983-07-21
ZA835355B (en) 1984-05-30
CS247073B2 (en) 1986-11-13

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