KR840005726A - 고혈압 치료제로서 유용한 치환페닐 피페라진 화합물의 제조방법 - Google Patents

고혈압 치료제로서 유용한 치환페닐 피페라진 화합물의 제조방법 Download PDF

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Publication number
KR840005726A
KR840005726A KR1019830002796A KR830002796A KR840005726A KR 840005726 A KR840005726 A KR 840005726A KR 1019830002796 A KR1019830002796 A KR 1019830002796A KR 830002796 A KR830002796 A KR 830002796A KR 840005726 A KR840005726 A KR 840005726A
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KR
South Korea
Prior art keywords
hypertension
compound
therapeutic agent
substituted phenyl
compound useful
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KR1019830002796A
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English (en)
Inventor
알. 맥스웰 도날드
Original Assignee
에드워드 에프. 엘스라거
워너-램버트 컴페니
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Application filed by 에드워드 에프. 엘스라거, 워너-램버트 컴페니 filed Critical 에드워드 에프. 엘스라거
Publication of KR840005726A publication Critical patent/KR840005726A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

고혈압 치료제로서 유용한 치환페닐 피페라진 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 일반식(2)의 화합물을 강산 또는 강염기 환화제로 환화(Cyclizing)시켜 A가 A1인 일반식(1)의 화합물을 제조하거나, 일반식(3)의 화합물을 5, 5-디메틸-1, 3-사이클로헥산디온과 반응시켜 A가 A2인 일반식 (1)의 화합물을 제조한 후 일반식 (1) A1또는 (1) A2의 화합물을 분리해내는 것으로 구성된 일반식(1)의 화합물을 제조하는 방법.
  3. 식중,
  4. n은 2, 3 또는 4; R1은 수소, 탄소원자 1 내지 6개의 알킬 또는 탄소원자 1 내지 6개의 알콕시이다. 다만, A가 A1이며 n이 3일때, R1은 3-OCH3가 아니며, A가 A2이고 n이 3일때 R1은 2-OCH3또는 4-OCH3가 아니며, A가 A2이고 n이 4일때 R1은, 4-CH3또는 4-OCH3가 아니다.
  5. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002796A 1982-06-22 1983-06-21 고혈압 치료제로서 유용한 치환페닐 피페라진 화합물의 제조방법 KR840005726A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/391,198 US4452798A (en) 1982-06-22 1982-06-22 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents
US391198 1982-06-22

Publications (1)

Publication Number Publication Date
KR840005726A true KR840005726A (ko) 1984-11-16

Family

ID=23545665

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002796A KR840005726A (ko) 1982-06-22 1983-06-21 고혈압 치료제로서 유용한 치환페닐 피페라진 화합물의 제조방법

Country Status (17)

Country Link
US (1) US4452798A (ko)
EP (1) EP0103357A3 (ko)
JP (1) JPS5925376A (ko)
KR (1) KR840005726A (ko)
AU (1) AU537383B2 (ko)
CA (1) CA1204754A (ko)
DK (1) DK285683A (ko)
ES (2) ES8504776A1 (ko)
FI (1) FI832241L (ko)
GR (1) GR78313B (ko)
HU (1) HU187941B (ko)
IL (1) IL68942A (ko)
NO (1) NO832254L (ko)
NZ (1) NZ204658A (ko)
PH (1) PH18302A (ko)
PT (1) PT76899B (ko)
ZA (1) ZA834500B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA954688B (en) * 1994-06-08 1996-01-29 Lundbeck & Co As H Serotonin 5-HT1A and dopamin D2 receptor ligands
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
AU1979799A (en) * 1998-07-21 2000-02-14 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers
MXPA01000637A (es) * 1998-07-21 2002-04-08 Ranbaxy Lab Ltd Derivados de arilpiperazina utiles como bloqueadores uroselectivos de alfa 1-adrenoceptor.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2836595A (en) * 1958-05-27 Piperazine derivatives and process for
US3037024A (en) * 1962-05-29 Chjchj
FR1012751A (fr) * 1949-01-24 1952-07-17 Rhone Poulenc Sa Nouveau dérivé de la pipérazine et de la quinoléïne et son procédé de préparation
ES291187A1 (es) * 1963-04-04 1964-01-16 American Cyanamid Co Un procedimiento para preparar piperazinas sustituidas
DE1445547C3 (de) * 1964-10-13 1975-04-30 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 3-Amino-2,1-benzoisothiazolen
US3494932A (en) * 1967-06-26 1970-02-10 American Cyanamid Co Aminoalkyl substituted aryl hydantoins
US3576808A (en) * 1967-09-15 1971-04-27 Miles Lab N-4-phenyl-1-piperazinylalkyl-5-phenyl-oxazolidinones
BE788280A (fr) * 1971-09-04 1973-02-28 Pfizer Nouvelles 1-(3-trifluoro-methyl-phenyl)-4-((amido cyclique)- alkyl) piperazines et composition pharmaceutique les contenant
US3806510A (en) * 1972-09-18 1974-04-23 Parke Davis & Co 4(orthoalkylthio phenyl)piperazin-1-yl hydantoins
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
DE2263211A1 (de) * 1972-12-23 1974-07-04 Boehringer Sohn Ingelheim Neue arylpiperazine und verfahren zu ihrer herstellung
GB1443598A (en) * 1973-07-06 1976-07-21 Acraf 1- 3-acetylaminopropyl-4-2,5-dichlorophenyl-piperazine
US3892748A (en) * 1973-07-20 1975-07-01 Miles Lab 5,5-Diphenyl-3-(piperidino, tetrahydropyridyl-1-and piperazino)-hydantoins
US3879395A (en) * 1973-10-23 1975-04-22 Parke Davis & Co 3-(1-Piperazinylalkylamino)-2-cycloalken-1-one compounds and methods for their production
FR2306694A1 (fr) * 1975-04-07 1976-11-05 Parcor Derives de la piperazine
BE503170A (ko) * 1975-09-02

Also Published As

Publication number Publication date
EP0103357A3 (en) 1986-01-08
ZA834500B (en) 1984-03-28
FI832241L (fi) 1983-12-23
DK285683A (da) 1983-12-23
DK285683D0 (da) 1983-06-21
GR78313B (ko) 1984-09-26
IL68942A0 (en) 1983-10-31
PT76899B (en) 1986-01-24
IL68942A (en) 1987-02-27
EP0103357A2 (en) 1984-03-21
NZ204658A (en) 1985-12-13
HU187941B (en) 1986-03-28
PT76899A (en) 1983-07-01
ES523462A0 (es) 1985-04-16
ES537961A0 (es) 1985-11-01
FI832241A0 (fi) 1983-06-20
AU1565883A (en) 1984-01-05
AU537383B2 (en) 1984-06-21
NO832254L (no) 1983-12-23
ES8601948A1 (es) 1985-11-01
ES8504776A1 (es) 1985-04-16
US4452798A (en) 1984-06-05
JPS5925376A (ja) 1984-02-09
CA1204754A (en) 1986-05-20
PH18302A (en) 1985-05-29

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