DK337383A - Fremgangsmaade til fremstilling af 4-amino-6,7-dimethoxyquinolin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 4-amino-6,7-dimethoxyquinolin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf Download PDF

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Publication number
DK337383A
DK337383A DK337383A DK337383A DK337383A DK 337383 A DK337383 A DK 337383A DK 337383 A DK337383 A DK 337383A DK 337383 A DK337383 A DK 337383A DK 337383 A DK337383 A DK 337383A
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DK
Denmark
Prior art keywords
dimethoxyquinoline
amino
preparing
compounds
procedure
Prior art date
Application number
DK337383A
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English (en)
Other versions
DK337383D0 (da
DK166821B1 (da
Inventor
Simon Fraser Campbell
John David Hardstone
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK337383D0 publication Critical patent/DK337383D0/da
Publication of DK337383A publication Critical patent/DK337383A/da
Application granted granted Critical
Publication of DK166821B1 publication Critical patent/DK166821B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK337383A 1982-07-24 1983-07-22 Analogifremgangsmaade til fremstilling af 4-amino-6,7-dimethoxyquinolinderivater eller farmaceutisk acceptable syreadditionssalte deraf DK166821B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8221457 1982-07-24
GB8221457 1982-07-24

Publications (3)

Publication Number Publication Date
DK337383D0 DK337383D0 (da) 1983-07-22
DK337383A true DK337383A (da) 1984-01-25
DK166821B1 DK166821B1 (da) 1993-07-19

Family

ID=10531886

Family Applications (1)

Application Number Title Priority Date Filing Date
DK337383A DK166821B1 (da) 1982-07-24 1983-07-22 Analogifremgangsmaade til fremstilling af 4-amino-6,7-dimethoxyquinolinderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (26)

Country Link
US (3) US4656174A (da)
EP (1) EP0100200B1 (da)
JP (1) JPS5933264A (da)
KR (1) KR880001315B1 (da)
AU (1) AU548036B2 (da)
CA (1) CA1255670A (da)
CS (1) CS247073B2 (da)
DD (1) DD211555A5 (da)
DE (1) DE3371336D1 (da)
DK (1) DK166821B1 (da)
ES (1) ES8504131A1 (da)
FI (1) FI78296C (da)
GR (1) GR79603B (da)
HK (1) HK32289A (da)
HU (1) HU190907B (da)
IE (1) IE55798B1 (da)
IL (1) IL69311A (da)
NO (1) NO171594C (da)
NZ (1) NZ204996A (da)
PH (1) PH19424A (da)
PL (1) PL139498B1 (da)
PT (1) PT77082B (da)
SG (1) SG6489G (da)
SU (2) SU1251801A3 (da)
YU (1) YU42628B (da)
ZA (1) ZA835355B (da)

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AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
GB8716972D0 (en) * 1987-07-17 1987-08-26 Pfizer Ltd Treatment of cardiac arrhythmias
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
US4882337A (en) * 1988-08-12 1989-11-21 Pfizer Inc. Tetrahydroisoquinoline antiarrhythmic agents
US5304554A (en) * 1990-04-27 1994-04-19 Emory University 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
TW304945B (da) * 1992-06-27 1997-05-11 Hoechst Ag
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9526546D0 (en) * 1995-12-23 1996-02-28 Pfizer Ltd Compounds useful in therapy
ATE215950T1 (de) * 1996-05-10 2002-04-15 Icos Corp Carbolinderivate
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
GB9711650D0 (en) * 1997-06-05 1997-07-30 Pfizer Ltd Compounds useful in therapy
AU8066701A (en) 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
EP1178036A1 (en) 2000-08-04 2002-02-06 Aventis Cropscience S.A. Fungicidal phenylimidate derivatives
US6900220B2 (en) 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
KR100420663B1 (ko) * 2001-01-09 2004-03-02 주식회사 켐온 퀴놀린 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
US6734303B2 (en) 2001-05-18 2004-05-11 Pfizer Inc. Process for the production of quinazolines
US7084156B2 (en) * 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
CN101304743B (zh) * 2005-09-19 2012-09-05 诺伊罗纳森特公司 刺激神经形成和抑制神经元变性的方法和组合物
AU2013211455B2 (en) * 2005-09-19 2017-12-07 Neuronascent, Inc. Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
WO2008070121A1 (en) * 2006-12-06 2008-06-12 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2013192345A1 (en) 2012-06-20 2013-12-27 Novartis Ag Complement pathway modulators and uses thereof
TWI649308B (zh) * 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物

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GB890533A (en) * 1959-11-09 1962-03-07 Allen & Hanburys Ltd Improvements in or relating to heterocyclic quaternary ammonium salts
CH414637A (de) * 1962-08-31 1966-06-15 Geigy Ag J R Verfahren zur Herstellung von Carbostyrilderivaten
US3272824A (en) * 1962-12-06 1966-09-13 Norwich Pharma Co 4-amino-6, 7-di(lower) alkoxyquinolines
US3542785A (en) * 1967-05-15 1970-11-24 Ciba Geigy Corp 2-hydroxy-4-aryl-quinolines
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
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US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
JPS54125688A (en) * 1978-02-27 1979-09-29 Mitsubishi Yuka Yakuhin Kk Novel quinazoline derivative*its manufacture and antihypertensive drug
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JPS54128588A (en) * 1978-03-29 1979-10-05 Dainippon Pharmaceut Co Ltd Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
JPS54128582A (en) * 1978-03-30 1979-10-05 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
US4287341A (en) * 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
DE3034001A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Also Published As

Publication number Publication date
NO171594B (no) 1992-12-28
ZA835355B (en) 1984-05-30
NO171594C (no) 1993-04-07
NO832688L (no) 1984-01-25
PT77082A (en) 1983-08-01
DK337383D0 (da) 1983-07-22
HK32289A (en) 1989-04-28
DD211555A5 (de) 1984-07-18
PH19424A (en) 1986-04-15
HU190907B (en) 1986-12-28
GR79603B (da) 1984-10-31
SU1251801A3 (ru) 1986-08-15
YU157283A (en) 1986-02-28
SG6489G (en) 1989-06-09
IL69311A (en) 1987-01-30
FI78296B (fi) 1989-03-31
PL243131A1 (en) 1984-12-17
EP0100200B1 (en) 1987-05-06
CS247073B2 (en) 1986-11-13
FI832658A (fi) 1984-01-25
ES524320A0 (es) 1985-04-16
AU1722283A (en) 1984-01-26
YU42628B (en) 1988-10-31
US4686228A (en) 1987-08-11
KR880001315B1 (ko) 1988-07-23
DE3371336D1 (en) 1987-06-11
FI832658A0 (fi) 1983-07-21
JPH0219112B2 (da) 1990-04-27
US4656174A (en) 1987-04-07
CA1255670A (en) 1989-06-13
JPS5933264A (ja) 1984-02-23
IL69311A0 (en) 1983-11-30
SU1340589A3 (ru) 1987-09-23
KR840005428A (ko) 1984-11-12
IE831730L (en) 1984-01-24
US4758568A (en) 1988-07-19
FI78296C (fi) 1989-07-10
PT77082B (en) 1986-04-11
ES8504131A1 (es) 1985-04-16
EP0100200A1 (en) 1984-02-08
DK166821B1 (da) 1993-07-19
AU548036B2 (en) 1985-11-21
PL139498B1 (en) 1987-01-31
IE55798B1 (en) 1991-01-16
NZ204996A (en) 1986-05-09

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