KR830004201A - 트랜스-4-페닐-1,2,3,4-테트라하이드로-1-나프탈렌아민의 항우울제 유도체 - Google Patents

트랜스-4-페닐-1,2,3,4-테트라하이드로-1-나프탈렌아민의 항우울제 유도체 Download PDF

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KR830004201A
KR830004201A KR1019800004175A KR800004175A KR830004201A KR 830004201 A KR830004201 A KR 830004201A KR 1019800004175 A KR1019800004175 A KR 1019800004175A KR 800004175 A KR800004175 A KR 800004175A KR 830004201 A KR830004201 A KR 830004201A
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맥코완 웰크 윌라드
알몬 하버트 챨스
켄네스 코에 빌리
리챠드 크라스카 알렌
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폴 에스. 밀러
화이자 인크
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

트랜스-4-페닐-1,2,3,4-테트라하이드로-1-나프탈렌아민의 항우울제 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. (a) 다음 구조식(Ⅱ)의 화합물을 산촉매의 존재하에 HNR1R2구조식의 아민으로 축합시켜 R1이 수소인 다음 구조식(Ⅲ)의 화합물 또는 R1이 n-알킬인 구조식(Ⅳ)의 화합물을 얻고,
    (b) 수득된 다음 구조식(Ⅲ) 또는 (Ⅳ)의 화합물을 환원시켜 다음 구조식(Ⅰ)의 시스-및 트랜스 이성체 염기의 혼합물을 얻고,
    (c) 상기 (b)단계로부터 수득한 혼합물로부터 다음 구조식(Ⅰ)의 트랜스 이성체 염기를 분리하며,
    (d) 필요하다면 (c)단계로부터 수득한 다음 구조식(Ⅰ)의 트랜스-이성체 염기를 약학적으로 수용 가능한 그것의 산부가염으로 전환시킴을 특징으로 하는,
    다음 구조식(Ⅰ)의 트랜스-이성체 염기로 구성하는 그룹으로부터 선택된 화합물 및 약학적으로 수용가능한 그것의 산부가염의 제조방법.
    상기 구조식에서
    R1은 수소 및 1 내지 3 탄소원자의 n-알킬로 구성되는 그룹에서 선택된 것이며,
    R2는 1 내지 3 탄소원자의 n-알킬이며,
    Z는
    X 및 Y는 수소, 불소, 염소, 브롬, 트리플루오로메틸 및 시아노로 구성되는 그룹에서 각각 선택되며, 단 적어도 X 및 Y의 하나는 수소가 아니어야 하며,
    W는 수소, 불소, 염소, 브롬, 트리플루오로 메틸 및 1 내지 3 탄소원자의 알콕시로 구성되는 그룹에서 선택된 것이다.
  2. (a) 다음 구조식(Ⅴ)의 화합물을 수소화하여 다음 구조식(Ⅰ)의 시스-및 트랜스-이성체 염기인 혼합물을 얻고,
    (b) (a)단계에서 수득한 상기 혼합물로 부터 다음 구조식(Ⅰ)의 트랜스-이성체 염기를 분리하고,
    (c) 필요하다면 (b)단계에서 수득한 다음 구조식(Ⅰ)의 트랜스-이성체 염기를 약학적으로 수용 가능한 그것의 산부가염으로 전환시킴을 특징으로 하는 다음 구조식(Ⅰ)의 트랜스-이성체 염기로 구성되는 그룹에서 선택된 화합물 및 약학적으로 수용가능한 그것의 산부가염의 제조방법.
    상기 구조식에서
    R1은 수소 및 1 내지 3 탄소원자의 n-알킬로 구성되는 그룹에서 선택된 것이며,
    R2는 1 내지 3탄소원자의 n-알킬이며,
    Z는이며,
    X 및 Y는 수소, 불소, 염소, 브롬, 트리플루오로메틸 및 시아노로 구성되는 그룹에서 각각 선택되며, 단 적어도 X 및 Y의 하나는 수소가 아니어야 하며
    W는 수소, 불소, 염소, 브롬, 트리플루오로 메틸 및 1 내지 3 탄소원자의 알콕시로 구성되는 그룹에서 선택된 것이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800004175A 1979-11-01 1980-10-31 트랜스-4-페닐-1, 2, 3, 4-테트라하이드로-1-나프탈렌아민 유도체의 제조방법 KR840002021B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9023779A 1979-11-01 1979-11-01
US090237 1979-11-01
US06/184,447 US4556676A (en) 1979-11-01 1980-09-05 Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US184447 1980-09-05
US90237 1987-08-27

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Application Number Title Priority Date Filing Date
KR1019840003056A Division KR840002020B1 (ko) 1979-11-01 1984-06-01 트랜스-4-페닐-1, 2, 3, 4-테트라하이드로-1-나프탈렌아민 유도체의 제조방법

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KR830004201A true KR830004201A (ko) 1983-07-06
KR840002021B1 KR840002021B1 (ko) 1984-11-05

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US (1) US4556676A (ko)
EP (1) EP0028901B1 (ko)
KR (1) KR840002021B1 (ko)
AR (2) AR225196A1 (ko)
AT (1) ATE2667T1 (ko)
AU (1) AU517842B2 (ko)
CA (1) CA1130816A (ko)
DE (1) DE3062226D1 (ko)
DK (1) DK149308C (ko)
ES (2) ES496441A0 (ko)
FI (1) FI68807C (ko)
GR (1) GR70782B (ko)
IE (1) IE50396B1 (ko)
IL (1) IL61376A (ko)
NO (1) NO149102C (ko)
PH (1) PH15468A (ko)
PT (1) PT72005B (ko)
YU (2) YU41744B (ko)

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AR225196A1 (es) 1982-02-26
PT72005A (en) 1980-11-01
IL61376A (en) 1983-10-31
AU6389880A (en) 1981-05-07
FI803399L (fi) 1981-05-02
ES8207120A1 (es) 1982-09-01
YU41744B (en) 1987-12-31
ES506893A0 (es) 1982-09-01
DK149308B (da) 1986-04-28
EP0028901B1 (en) 1983-03-02
IL61376A0 (en) 1980-12-31
GR70782B (ko) 1983-03-23
NO149102C (no) 1984-02-15
NO803259L (no) 1981-05-04
PH15468A (en) 1983-01-24
ES8201948A1 (es) 1982-01-16
NO149102B (no) 1983-11-07
FI68807C (fi) 1985-11-11
DK149308C (da) 1986-12-08
DE3062226D1 (en) 1983-04-07
CA1130816A (en) 1982-08-31
ES496441A0 (es) 1982-01-16
KR840002021B1 (ko) 1984-11-05
ATE2667T1 (de) 1983-03-15
PT72005B (en) 1981-08-31
YU277480A (en) 1983-09-30
IE802260L (en) 1981-05-01
FI68807B (fi) 1985-07-31
YU3383A (en) 1983-09-30
EP0028901A1 (en) 1981-05-20
US4556676A (en) 1985-12-03
IE50396B1 (en) 1986-04-16
AR229106A1 (es) 1983-06-15
AU517842B2 (en) 1981-08-27
DK462480A (da) 1981-05-02
YU42066B (en) 1988-04-30

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