GB1420472A - Aminophenyltetralin compounds - Google Patents
Aminophenyltetralin compoundsInfo
- Publication number
- GB1420472A GB1420472A GB326573A GB326573A GB1420472A GB 1420472 A GB1420472 A GB 1420472A GB 326573 A GB326573 A GB 326573A GB 326573 A GB326573 A GB 326573A GB 1420472 A GB1420472 A GB 1420472A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- hydrogen atom
- compounds
- phenyltetralone
- alkyl radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
Abstract
1420472 Aminophenyltetralins PFIZER Inc 22 Jan 1973 [27 Sept 1972] 3265/73 Heading C2C The invention comprises compounds having the general formula wherein R 1 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms, and R 2 is a hydrogen atom, an alkyl radical having 1 to 3 carbon atoms or a cycloalkyl radical having 3 to 6 carbon atoms, R 2 only being a cycloalkyl radical when R 1 is a hydrogen atom. They may be prepared by reacting 4-phenyltetralone with an amine of Formula (II) R 1 R 2 NH in the presence of titanium tetrachloride, to form an intermediate ketimine or enamine which is then reduced, or by converting 4-phenyltetralone to its oxime and reducing this to form the corresponding primary amine which may be alkylated to form the secondary and tertiary amines. The compounds of the invention exhibit antidepressant and psychomotor stimulant activity and may be administered alone or in admixture with pharmaceutical diluents or carriers orally as tablets, capsules, lozenges, troches, hard candies, powders, sprays, suspensions, solutions, elixirs and syrups or parenterally as injectable solutions intravenously, intramuscularly, subcutaneously or intraperitoneally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29252672A | 1972-09-27 | 1972-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1420472A true GB1420472A (en) | 1976-01-07 |
Family
ID=23125032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB326573A Expired GB1420472A (en) | 1972-09-27 | 1973-01-22 | Aminophenyltetralin compounds |
Country Status (13)
| Country | Link |
|---|---|
| JP (2) | JPS5416492B2 (en) |
| AR (2) | AR197831A1 (en) |
| AU (1) | AU476277B2 (en) |
| BE (1) | BE805311A (en) |
| CA (1) | CA1012555A (en) |
| CH (2) | CH605611A5 (en) |
| DE (1) | DE2348577C2 (en) |
| ES (1) | ES419097A1 (en) |
| FI (1) | FI57252C (en) |
| FR (1) | FR2200015B1 (en) |
| GB (1) | GB1420472A (en) |
| NL (1) | NL167413C (en) |
| SE (1) | SE409029B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091429A (en) * | 1987-11-26 | 1992-02-25 | Laboratoires Lucien | Derivatives of 4-amino-1-trifluoromethyltetralines their preparation and their therapeutic application |
| US10125830B2 (en) * | 2017-04-06 | 2018-11-13 | FEV Europe GmbH | Wedge actuated drum-in-hat parking brake |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556676A (en) * | 1979-11-01 | 1985-12-03 | Pfizer Inc. | Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| US4981870A (en) * | 1989-03-07 | 1991-01-01 | Pfizer Inc. | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants |
| IL142367A0 (en) * | 1998-10-30 | 2002-03-10 | Ciba Sc Holding Ag | Method of producing ketimines |
| DK2816024T3 (en) * | 2006-03-31 | 2017-10-30 | Sunovion Pharmaceuticals Inc | CHIRALE AMINER |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3663608A (en) * | 1969-12-10 | 1972-05-16 | Bristol Myers Co | 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof |
-
1973
- 1973-01-22 GB GB326573A patent/GB1420472A/en not_active Expired
- 1973-09-20 CA CA181,502A patent/CA1012555A/en not_active Expired
- 1973-09-21 FI FI2967/73A patent/FI57252C/en active
- 1973-09-25 AU AU60658/73A patent/AU476277B2/en not_active Expired
- 1973-09-26 NL NL7313257.A patent/NL167413C/en not_active IP Right Cessation
- 1973-09-26 FR FR7334518A patent/FR2200015B1/fr not_active Expired
- 1973-09-26 SE SE7313133A patent/SE409029B/en unknown
- 1973-09-26 ES ES419097A patent/ES419097A1/en not_active Expired
- 1973-09-26 BE BE1005386A patent/BE805311A/en not_active IP Right Cessation
- 1973-09-27 CH CH1385773A patent/CH605611A5/xx not_active IP Right Cessation
- 1973-09-27 CH CH1329477A patent/CH605607A5/xx not_active IP Right Cessation
- 1973-09-27 DE DE2348577A patent/DE2348577C2/en not_active Expired
- 1973-09-27 AR AR250261A patent/AR197831A1/en active
- 1973-09-27 JP JP10808073A patent/JPS5416492B2/ja not_active Expired
-
1974
- 1974-03-29 AR AR253045A patent/AR200772A1/en active
-
1978
- 1978-11-02 JP JP13565778A patent/JPS5484560A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091429A (en) * | 1987-11-26 | 1992-02-25 | Laboratoires Lucien | Derivatives of 4-amino-1-trifluoromethyltetralines their preparation and their therapeutic application |
| US10125830B2 (en) * | 2017-04-06 | 2018-11-13 | FEV Europe GmbH | Wedge actuated drum-in-hat parking brake |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1012555A (en) | 1977-06-21 |
| AR200772A1 (en) | 1974-12-13 |
| AR197831A1 (en) | 1974-05-10 |
| CH605607A5 (en) | 1978-09-29 |
| AU6065873A (en) | 1975-03-27 |
| FR2200015B1 (en) | 1977-01-28 |
| AU476277B2 (en) | 1976-09-16 |
| BE805311A (en) | 1974-03-26 |
| ES419097A1 (en) | 1976-03-01 |
| FR2200015A1 (en) | 1974-04-19 |
| NL167413B (en) | 1981-07-16 |
| SE7313133L (en) | 1974-03-28 |
| JPS5484560A (en) | 1979-07-05 |
| JPS4969646A (en) | 1974-07-05 |
| CH605611A5 (en) | 1978-09-29 |
| DE2348577C2 (en) | 1982-06-03 |
| NL167413C (en) | 1981-12-16 |
| SE409029B (en) | 1979-07-23 |
| FI57252C (en) | 1980-07-10 |
| DE2348577A1 (en) | 1974-04-11 |
| FI57252B (en) | 1980-03-31 |
| JPS569500B2 (en) | 1981-03-02 |
| JPS5416492B2 (en) | 1979-06-22 |
| NL7313257A (en) | 1974-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |