KR850007259A - 벤조디옥시노피롤 유도체의 제조방법 - Google Patents
벤조디옥시노피롤 유도체의 제조방법 Download PDFInfo
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- KR850007259A KR850007259A KR1019850002771A KR850002771A KR850007259A KR 850007259 A KR850007259 A KR 850007259A KR 1019850002771 A KR1019850002771 A KR 1019850002771A KR 850002771 A KR850002771 A KR 850002771A KR 850007259 A KR850007259 A KR 850007259A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Light Receiving Elements (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pyrrole Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Cephalosporin Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- (a) 일반식(Ⅱ)의 화합물을 암모니아, 수성암모니아 또는 일반식 RNH2의 아민(여기서, R은 수소 또는 -CHO 그룹이 아닌 경우를 제외하고는 일반식(Ⅰ)의 R에 대하여 정의한 바와 같다)으로 아민화시키거나; (b) R이 수소인 일반식(Ⅰ)의 화합물을 제조하기 위하여 R이 보호그룹인 상응하는 화합물을 탈보호시키거나; (c) R이 알킬인 일반식(Ⅰ)의 화합물을 제조하기 위하여 R이 아실인 상응하는 화합물을 환원시키고, 경우에 따라서는 이와같이 제조된 화합물 또는 그의 염을, (D)(i) 일반식(Ⅰ)의 다른 화합물로 전환시키고/시키거나, (D)(ⅱ) 생리학적으로 허용가능한 그의 염으로 전환시킴을 특징으로 하여, 일반식(Ⅰ)의 화합물 또는 생리학적으로 허용가능한 그의 염을 제조하는 방법.상기식에서, R은 수소, C1-C6알킬(C3-C7시클로-알킬로 임의 치환됨), C3-C6알케닐, C3-C6알키닐, C3-C7시클로알킬, 아르알킬(여기서 알킬잔기는 1 내지 5개의 탄소원자를 함유한다)또는 -CHO이고; R1은 할로겐, C1-C4알킬, C1-C4알콕시, 히드록실, 시아노, 니트로 및 -NR3R4(여기서 R3및 R5는 각각 수소 또는 C1-C4알킬이다)이고; R2는 수소, 할로겐, C1-C4알킬, C1-C4알콕시, 히드록실시아노, 니트로 또는 -NR3R4(여기서 R3및 R4는 각각 수소 또는 C1-C4-알킬이다)이다.
- 제1항에 있어서, R이 수소인 방법.
- 제1항에 있어서, R이 C1-C3알킬인 방법.
- 제1항에 있어서, R1이 할로겐, C1-C4-알킬 또는 C1-C4알콕시인 방법.
- 제1항에 있어서, R2가 수소 또는 불소인 방법.
- 제1항에 있어서, R이 수소, 메틸 또는 에틸이고, R1이 염소, 불소, 메틸 또는 메톡시이고, R2가 수소 또는 불소인 방법.
- 제1항에 있어서, (±)-트란스-2,3,3a,9a-테트라히드로-5-메틸-1H-[,4] 벤조디옥시노 [2,3-C] 피롤, 그의 3aS-, 3aR-이성체; (±)-트란스-5-클로로-2,3,3a,9a-테트라히드로-1H-[1,4] 벤조디옥시노 [2,3-C] 피롤, 그의 3aS-, 3aR-이성체;(±)-트란스-5,8-디플루오로-2,3,3a,9a-테트라히드로-1H-[1,4] 벤조디옥시노 [2,3-C] 피롤, 그의 3aS-, 3aR-이성체; 및 생리학적으로 허용가능한 그들의 염을 제조하는 방법.
- 제1항에 있어서, (±)-트란스-5-플루오로-2,3,3a,9a-테트라히드로-1H-[1,4] 벤조디옥시노 [2,3-C] 피롤, 그의 3aS-, 3aR-이성체 및 생리학적으로 허용가능한 그들의 염을 제조하는 방법.
- 제8항에 있어서, (±)-트란스-5-플루오로-2,3,3a,9a-테트라히드로-1H-[1,4] 벤조디옥시노 [2,3-C] 피롤히드로클로라이드 또는 그의 3aS- 또는 3aR-이성체인 방법.
- 제1항 내지 제9항중 어느 하나에 있어서, 공정(a)에서 바람직하게는 적절한 염기의 존재하에 또는 과량의 아민(RNH2)의 존재하에 임의로는 용매중, 승온에서 아민화 반응을 수행하는 방법.
- 제1항 내지 제10항중 어느 하나에 있어서, 공정(b)에서 R이 수소인 일반식(Ⅰ)의 화합물을 제조하기 위하여 R이 아릴메틸인 상응하는 화합물을 가수소분해시키거나 산성 조건하에 처리하는 방법.
- 제1항 내지 제10항중 어느 하나에 있어서, 공정(b)에서 R이 수소인 일반식(Ⅰ)의 화합물을 제조하기 위하여 R이 아실인 상응하는 화합물을 산 또는 염기를 사용하여 가수분해시키는 방법.
- 제1항 내지 제12항중 어느 하나에 있어서, 공정(c)에서 R이 알킬인 일반식(Ⅰ)의 화합물을 제조하기 위하여 R이 아실인 상응하는 화합물을 환원시키는 방법.
- 제12항에 있어서, 에테르 또는 테트라히드로-푸란과 같은 적절한 용매중 리튬알루미늄 히드라이드 또는 디보란과 같은 환원제를 사용하여 환류조건과 같은 승온에서 환원시키는 방법.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848410456A GB8410456D0 (en) | 1984-04-24 | 1984-04-24 | Chemical compounds |
GB8410456 | 1984-04-24 | ||
GB8503975 | 1985-02-15 | ||
GB858503975A GB8503975D0 (en) | 1985-02-15 | 1985-02-15 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850007259A true KR850007259A (ko) | 1985-12-02 |
KR920003065B1 KR920003065B1 (ko) | 1992-04-13 |
Family
ID=26287645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850002771A KR920003065B1 (ko) | 1984-04-24 | 1985-04-24 | 벤조디옥시노피롤 유도체의 제조방법 |
Country Status (21)
Country | Link |
---|---|
US (1) | US4880801A (ko) |
EP (2) | EP0162593B1 (ko) |
JP (2) | JPH02270878A (ko) |
KR (1) | KR920003065B1 (ko) |
AT (1) | ATE55605T1 (ko) |
AU (1) | AU577367B2 (ko) |
CA (1) | CA1256111A (ko) |
CS (1) | CS402491A3 (ko) |
CY (2) | CY1532A (ko) |
DE (2) | DE3579189D1 (ko) |
DK (2) | DK160556C (ko) |
ES (2) | ES8607311A1 (ko) |
FI (1) | FI84069C (ko) |
GB (3) | GB2201414B (ko) |
GR (1) | GR850993B (ko) |
HK (2) | HK42890A (ko) |
IL (1) | IL75011A (ko) |
MX (1) | MX9203233A (ko) |
NZ (1) | NZ211885A (ko) |
PT (1) | PT80344B (ko) |
SG (2) | SG23590G (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8526210D0 (en) * | 1985-10-23 | 1985-11-27 | Glaxo Group Ltd | Chemical compounds |
GB8526209D0 (en) * | 1985-10-23 | 1985-11-27 | Glaxo Group Ltd | Chemical process |
US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
GB8828032D0 (en) * | 1988-12-01 | 1989-01-05 | Glaxo Group Ltd | Medicaments |
GB9012469D0 (en) * | 1990-06-05 | 1990-07-25 | Glaxo Group Ltd | Medicaments |
GB9119466D0 (en) * | 1991-09-12 | 1991-10-23 | Glaxo Group Ltd | Chemical compounds |
US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
BRPI0409492A (pt) * | 2003-04-18 | 2006-05-02 | Pharmacia & Up John Company Ll | terapias de combinação |
GB2503187A (en) * | 2011-09-15 | 2013-12-25 | Univ Sussex | Composition for use in the treatment of neurodevelopmental disorders |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2485539A1 (fr) * | 1980-06-26 | 1981-12-31 | Sori Soc Rech Ind | Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique |
IL70034A0 (en) * | 1982-10-25 | 1984-01-31 | Glaxo Group Ltd | Heterocyclic amino compounds,their preparation and pharmaceutical compositions containing them |
-
1985
- 1985-04-24 FI FI851611A patent/FI84069C/fi not_active IP Right Cessation
- 1985-04-24 GR GR850993A patent/GR850993B/el unknown
- 1985-04-24 AT AT85302854T patent/ATE55605T1/de not_active IP Right Cessation
- 1985-04-24 NZ NZ211885A patent/NZ211885A/xx unknown
- 1985-04-24 EP EP85302854A patent/EP0162593B1/en not_active Expired - Lifetime
- 1985-04-24 DE DE8585302854T patent/DE3579189D1/de not_active Expired - Fee Related
- 1985-04-24 PT PT80344A patent/PT80344B/pt not_active IP Right Cessation
- 1985-04-24 KR KR1019850002771A patent/KR920003065B1/ko not_active IP Right Cessation
- 1985-04-24 DE DE89117732T patent/DE3587511T2/de not_active Expired - Fee Related
- 1985-04-24 AU AU41667/85A patent/AU577367B2/en not_active Ceased
- 1985-04-24 EP EP89117732A patent/EP0359290B1/en not_active Expired - Lifetime
- 1985-04-24 CA CA000479944A patent/CA1256111A/en not_active Expired
- 1985-04-24 ES ES542516A patent/ES8607311A1/es not_active Expired
- 1985-04-24 IL IL75011A patent/IL75011A/xx not_active IP Right Cessation
- 1985-04-24 GB GB08802949A patent/GB2201414B/en not_active Expired
- 1985-04-24 DK DK184085A patent/DK160556C/da not_active IP Right Cessation
- 1985-04-24 GB GB8510449A patent/GB2157691B/en not_active Expired
-
1986
- 1986-01-31 ES ES551509A patent/ES8801545A1/es not_active Expired
-
1987
- 1987-12-11 GB GB878728949A patent/GB8728949D0/en active Pending
-
1988
- 1988-05-26 US US07/198,971 patent/US4880801A/en not_active Expired - Fee Related
-
1990
- 1990-03-22 JP JP2073144A patent/JPH02270878A/ja active Pending
- 1990-03-22 JP JP2073145A patent/JPH02270819A/ja active Pending
- 1990-03-24 SG SG235/90A patent/SG23590G/en unknown
- 1990-05-31 HK HK428/90A patent/HK42890A/xx unknown
- 1990-06-08 DK DK141590A patent/DK160824C/da not_active IP Right Cessation
- 1990-11-16 CY CY1532A patent/CY1532A/xx unknown
-
1991
- 1991-12-23 CS CS914024A patent/CS402491A3/cs unknown
-
1992
- 1992-06-24 MX MX9203233A patent/MX9203233A/es unknown
-
1993
- 1993-02-05 SG SG122/93A patent/SG12293G/en unknown
- 1993-10-21 HK HK1120/93A patent/HK112093A/xx not_active IP Right Cessation
-
1994
- 1994-01-14 CY CY169594A patent/CY1695A/xx unknown
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