DK141590A - Benzodioxanderivater - Google Patents

Benzodioxanderivater Download PDF

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Publication number
DK141590A
DK141590A DK141590A DK141590A DK141590A DK 141590 A DK141590 A DK 141590A DK 141590 A DK141590 A DK 141590A DK 141590 A DK141590 A DK 141590A DK 141590 A DK141590 A DK 141590A
Authority
DK
Denmark
Prior art keywords
sup
alkyl
compounds
sub
general formula
Prior art date
Application number
DK141590A
Other languages
English (en)
Other versions
DK160824B (da
DK141590D0 (da
DK160824C (da
Inventor
John Kitchin
Peter Clive Cherry
Adrian John Pipe
Andrew James Crame
Alan David Borthwick
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848410456A external-priority patent/GB8410456D0/en
Priority claimed from GB858503975A external-priority patent/GB8503975D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK141590A publication Critical patent/DK141590A/da
Publication of DK141590D0 publication Critical patent/DK141590D0/da
Publication of DK160824B publication Critical patent/DK160824B/da
Application granted granted Critical
Publication of DK160824C publication Critical patent/DK160824C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Light Receiving Elements (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
DK141590A 1984-04-24 1990-06-08 Benzodioxanderivater DK160824C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8410456 1984-04-24
GB848410456A GB8410456D0 (en) 1984-04-24 1984-04-24 Chemical compounds
GB858503975A GB8503975D0 (en) 1985-02-15 1985-02-15 Chemical compounds
GB8503975 1985-02-15

Publications (4)

Publication Number Publication Date
DK141590A true DK141590A (da) 1990-06-08
DK141590D0 DK141590D0 (da) 1990-06-08
DK160824B DK160824B (da) 1991-04-22
DK160824C DK160824C (da) 1991-10-07

Family

ID=26287645

Family Applications (2)

Application Number Title Priority Date Filing Date
DK184085A DK160556C (da) 1984-04-24 1985-04-24 Benzodioxinpyrrolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK141590A DK160824C (da) 1984-04-24 1990-06-08 Benzodioxanderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK184085A DK160556C (da) 1984-04-24 1985-04-24 Benzodioxinpyrrolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Country Status (21)

Country Link
US (1) US4880801A (da)
EP (2) EP0162593B1 (da)
JP (2) JPH02270819A (da)
KR (1) KR920003065B1 (da)
AT (1) ATE55605T1 (da)
AU (1) AU577367B2 (da)
CA (1) CA1256111A (da)
CS (1) CS402491A3 (da)
CY (2) CY1532A (da)
DE (2) DE3579189D1 (da)
DK (2) DK160556C (da)
ES (2) ES8607311A1 (da)
FI (1) FI84069C (da)
GB (3) GB2201414B (da)
GR (1) GR850993B (da)
HK (2) HK42890A (da)
IL (1) IL75011A (da)
MX (1) MX9203233A (da)
NZ (1) NZ211885A (da)
PT (1) PT80344B (da)
SG (2) SG23590G (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8526210D0 (en) * 1985-10-23 1985-11-27 Glaxo Group Ltd Chemical compounds
GB8526209D0 (en) * 1985-10-23 1985-11-27 Glaxo Group Ltd Chemical process
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8828032D0 (en) * 1988-12-01 1989-01-05 Glaxo Group Ltd Medicaments
GB9012469D0 (en) * 1990-06-05 1990-07-25 Glaxo Group Ltd Medicaments
GB9119466D0 (en) * 1991-09-12 1991-10-23 Glaxo Group Ltd Chemical compounds
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
CA2522666A1 (en) * 2003-04-18 2004-10-28 Pharmacia & Upjohn Company Llc Combination therapies for chronic obstructive pulmonary disease (copd)
GB2503187A (en) * 2011-09-15 2013-12-25 Univ Sussex Composition for use in the treatment of neurodevelopmental disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485539A1 (fr) * 1980-06-26 1981-12-31 Sori Soc Rech Ind Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique
IL70034A0 (en) * 1982-10-25 1984-01-31 Glaxo Group Ltd Heterocyclic amino compounds,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GB2201414B (en) 1988-12-29
ES542516A0 (es) 1986-06-16
AU577367B2 (en) 1988-09-22
ES8607311A1 (es) 1986-06-16
ES551509A0 (es) 1988-02-01
CA1256111A (en) 1989-06-20
SG23590G (en) 1990-07-13
GR850993B (da) 1985-11-25
MX9203233A (es) 1992-07-01
US4880801A (en) 1989-11-14
HK112093A (en) 1993-10-29
EP0359290A1 (en) 1990-03-21
PT80344A (en) 1985-05-01
DK160556C (da) 1991-09-02
FI84069C (fi) 1991-10-10
ES8801545A1 (es) 1988-02-01
HK42890A (en) 1990-06-08
DK184085A (da) 1985-10-25
DK160824B (da) 1991-04-22
DE3587511D1 (de) 1993-09-09
GB2157691A (en) 1985-10-30
EP0359290B1 (en) 1993-08-04
FI851611L (fi) 1985-10-25
JPH02270819A (ja) 1990-11-05
CY1695A (en) 1994-01-14
DK141590D0 (da) 1990-06-08
NZ211885A (en) 1988-09-29
GB2157691B (en) 1989-07-05
DK160556B (da) 1991-03-25
GB8510449D0 (en) 1985-05-30
DK160824C (da) 1991-10-07
EP0162593A1 (en) 1985-11-27
KR920003065B1 (ko) 1992-04-13
GB8802949D0 (en) 1988-03-09
KR850007259A (ko) 1985-12-02
SG12293G (en) 1993-04-16
CY1532A (en) 1990-11-16
DE3579189D1 (de) 1990-09-20
FI851611A0 (fi) 1985-04-24
IL75011A (en) 1990-02-09
EP0162593B1 (en) 1990-08-16
FI84069B (fi) 1991-06-28
PT80344B (pt) 1987-09-30
GB8728949D0 (en) 1988-01-27
AU4166785A (en) 1985-10-31
DE3587511T2 (de) 1993-11-18
GB2201414A (en) 1988-09-01
ATE55605T1 (de) 1990-09-15
DK184085D0 (da) 1985-04-24
CS402491A3 (en) 1992-10-14
JPH02270878A (ja) 1990-11-05

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