PT82985A - Process for the preparation of distamycin derivatives and of pharmaceutical compositions containing the same - Google Patents

Process for the preparation of distamycin derivatives and of pharmaceutical compositions containing the same

Info

Publication number
PT82985A
PT82985A PT82985A PT8298586A PT82985A PT 82985 A PT82985 A PT 82985A PT 82985 A PT82985 A PT 82985A PT 8298586 A PT8298586 A PT 8298586A PT 82985 A PT82985 A PT 82985A
Authority
PT
Portugal
Prior art keywords
distammic
derivatives
preparation
same
pharmaceutical compositions
Prior art date
Application number
PT82985A
Other languages
English (en)
Other versions
PT82985B (pt
Inventor
Federico Arcamone
Nicola Mongelli
Fabio Animati
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of PT82985A publication Critical patent/PT82985A/pt
Publication of PT82985B publication Critical patent/PT82985B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PT82985A 1985-07-16 1986-07-15 Processo para a preparacao de derivados de distamicina e de composicoes farmaceuticas que os contem PT82985B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517923A GB8517923D0 (en) 1985-07-16 1985-07-16 Distamycin derivatives

Publications (2)

Publication Number Publication Date
PT82985A true PT82985A (pt) 1986-08-01
PT82985B PT82985B (pt) 1989-01-30

Family

ID=10582358

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82985A PT82985B (pt) 1985-07-16 1986-07-15 Processo para a preparacao de derivados de distamicina e de composicoes farmaceuticas que os contem

Country Status (29)

Country Link
US (1) US4738980A (pt)
JP (1) JPH0780842B2 (pt)
KR (1) KR940003495B1 (pt)
CN (2) CN85103908A (pt)
AT (1) AT386822B (pt)
AU (1) AU584723B2 (pt)
BE (1) BE905109A (pt)
CA (1) CA1247627A (pt)
CH (1) CH671958A5 (pt)
CZ (1) CZ277823B6 (pt)
DE (1) DE3623853C2 (pt)
DK (1) DK335886A (pt)
ES (1) ES2000346A6 (pt)
FI (1) FI82929C (pt)
FR (1) FR2585019B1 (pt)
GB (2) GB8517923D0 (pt)
GR (1) GR861840B (pt)
HU (1) HU198087B (pt)
IE (1) IE59275B1 (pt)
IL (1) IL79401A (pt)
IT (1) IT1213103B (pt)
NL (1) NL8601838A (pt)
NO (1) NO169014C (pt)
NZ (1) NZ216828A (pt)
PH (1) PH23459A (pt)
PT (1) PT82985B (pt)
SE (1) SE468594B (pt)
SU (2) SU1535378A3 (pt)
ZA (1) ZA865262B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
US5049579A (en) * 1986-05-20 1991-09-17 Farmitalia Carlo Erba, S.R.L. Site specific alkylating agents
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
US5310752A (en) * 1986-05-20 1994-05-10 Farmitalia Carlo Erba Spa Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
CA2103665C (en) * 1991-02-06 2003-04-15 J. William Lown Oligopeptide antiretroviral agents
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
DE4205948C2 (de) * 1992-02-24 1996-10-31 Mannesmann Ag Farbbandkassette für ein endloses Farbband
US5273991A (en) * 1992-07-29 1993-12-28 Research Corporation Technologies, Inc. Imidazole-containing compositions and methods of use thereof analogs of distamycin
US5637621A (en) * 1994-11-14 1997-06-10 Nzym, Inc. Methods and compositions for treating Botrytis infections
AU4107796A (en) * 1994-11-14 1996-06-06 Nzym, Inc. Methods and compositions for treating phytopathogenic fungi infections
US5629348A (en) * 1994-11-14 1997-05-13 Nzym, Inc. Methods and compositions for treating septoria infections
DE19805431A1 (de) * 1998-02-11 1999-08-12 Merck Patent Gmbh Heteroaromatische Oligoamide als Affinitätsliganden
EP1265921B1 (en) * 2000-03-16 2007-05-23 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
ITTO20010633A1 (it) * 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7265129B2 (en) * 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
WO2004052304A2 (en) * 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
WO2005051318A2 (en) * 2003-11-24 2005-06-09 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
KR102155411B1 (ko) * 2015-03-30 2020-09-11 메이지 세이카 파루마 가부시키가이샤 에피루비신 제조방법 및 그의 신규한 제조 중간체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA557568A (en) * 1958-05-20 J. Weiss Martin Substituted aminopyrrolecarboxylic acids and esters
CA547128A (en) * 1957-10-08 W. Waller Coy Substituted pyrrolecarboxamidopyrroles
FR86210E (pt) * 1963-04-04 1966-03-23
BR6461040D0 (pt) * 1963-07-26 1973-08-02 Farmaceutici Italia Processo para preparar novos derivados de pirrol
BE666612A (pt) * 1963-07-26 1965-11-03
FR90359E (pt) * 1963-07-26 1968-02-14
DE1795539A1 (de) * 1963-07-26 1972-01-13 Farmaceutici Italia Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
NL130086C (pt) * 1964-07-14 1970-06-15
SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
FR2585019A1 (fr) 1987-01-23
IL79401A0 (en) 1986-10-31
KR870001228A (ko) 1987-03-12
FI862960A (fi) 1987-01-17
IT8621124A0 (it) 1986-07-15
KR940003495B1 (ko) 1994-04-23
DE3623853C2 (de) 1995-12-21
AU6020386A (en) 1987-01-22
GR861840B (en) 1986-11-18
NO169014C (no) 1992-04-29
HUT41814A (en) 1987-05-28
GB8517923D0 (en) 1985-08-21
IL79401A (en) 1991-05-12
CN85103908A (zh) 1986-11-05
SU1535378A3 (ru) 1990-01-07
DK335886A (da) 1987-01-17
SU1538893A3 (ru) 1990-01-23
NO862861L (no) 1987-01-19
FI82929C (fi) 1991-05-10
ATA188786A (de) 1988-03-15
BE905109A (fr) 1987-01-15
SE468594B (sv) 1993-02-15
ZA865262B (en) 1987-03-25
ES2000346A6 (es) 1988-02-16
AT386822B (de) 1988-10-25
AU584723B2 (en) 1989-06-01
FR2585019B1 (fr) 1989-07-13
JPH0780842B2 (ja) 1995-08-30
PH23459A (en) 1989-08-07
FI82929B (fi) 1991-01-31
US4738980A (en) 1988-04-19
CZ277823B6 (en) 1993-06-16
CA1247627A (en) 1988-12-28
FI862960A0 (fi) 1986-07-16
SE8603099L (sv) 1987-01-17
GB2178037B (en) 1989-07-26
GB2178037A (en) 1987-02-04
JPS6230755A (ja) 1987-02-09
NZ216828A (en) 1989-11-28
DE3623853A1 (de) 1987-01-29
NO169014B (no) 1992-01-20
DK335886D0 (da) 1986-07-15
CH671958A5 (pt) 1989-10-13
PT82985B (pt) 1989-01-30
GB8617293D0 (en) 1986-08-20
CS541186A3 (en) 1992-09-16
IE861874L (en) 1987-01-16
NL8601838A (nl) 1987-02-16
NO862861D0 (no) 1986-07-15
IE59275B1 (en) 1994-02-09
IT1213103B (it) 1989-12-07
SE8603099D0 (sv) 1986-07-11
CN1026984C (zh) 1994-12-14
HU198087B (en) 1989-07-28
CN86104774A (zh) 1987-02-11

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Legal Events

Date Code Title Description
NF3A Restitutio in integrum

Effective date: 19920619

PC3A Transfer or assignment

Free format text: 961212 PHARMACIA & UPJOHN S.P.A. IT

TE3A Change of address (patent)
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990131