FR2585019B1 - Derives de distamycine et leur procede de fabrication - Google Patents

Derives de distamycine et leur procede de fabrication

Info

Publication number
FR2585019B1
FR2585019B1 FR868610295A FR8610295A FR2585019B1 FR 2585019 B1 FR2585019 B1 FR 2585019B1 FR 868610295 A FR868610295 A FR 868610295A FR 8610295 A FR8610295 A FR 8610295A FR 2585019 B1 FR2585019 B1 FR 2585019B1
Authority
FR
France
Prior art keywords
manufacturing
distamycin derivatives
distamycin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR868610295A
Other languages
English (en)
Other versions
FR2585019A1 (fr
Inventor
Federico Arcamone
Nicola Mongelli
Fabio Animati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2585019A1 publication Critical patent/FR2585019A1/fr
Application granted granted Critical
Publication of FR2585019B1 publication Critical patent/FR2585019B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR868610295A 1985-07-16 1986-07-15 Derives de distamycine et leur procede de fabrication Expired FR2585019B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517923A GB8517923D0 (en) 1985-07-16 1985-07-16 Distamycin derivatives

Publications (2)

Publication Number Publication Date
FR2585019A1 FR2585019A1 (fr) 1987-01-23
FR2585019B1 true FR2585019B1 (fr) 1989-07-13

Family

ID=10582358

Family Applications (1)

Application Number Title Priority Date Filing Date
FR868610295A Expired FR2585019B1 (fr) 1985-07-16 1986-07-15 Derives de distamycine et leur procede de fabrication

Country Status (29)

Country Link
US (1) US4738980A (fr)
JP (1) JPH0780842B2 (fr)
KR (1) KR940003495B1 (fr)
CN (2) CN85103908A (fr)
AT (1) AT386822B (fr)
AU (1) AU584723B2 (fr)
BE (1) BE905109A (fr)
CA (1) CA1247627A (fr)
CH (1) CH671958A5 (fr)
CZ (1) CZ277823B6 (fr)
DE (1) DE3623853C2 (fr)
DK (1) DK335886A (fr)
ES (1) ES2000346A6 (fr)
FI (1) FI82929C (fr)
FR (1) FR2585019B1 (fr)
GB (2) GB8517923D0 (fr)
GR (1) GR861840B (fr)
HU (1) HU198087B (fr)
IE (1) IE59275B1 (fr)
IL (1) IL79401A (fr)
IT (1) IT1213103B (fr)
NL (1) NL8601838A (fr)
NO (1) NO169014C (fr)
NZ (1) NZ216828A (fr)
PH (1) PH23459A (fr)
PT (1) PT82985B (fr)
SE (1) SE468594B (fr)
SU (2) SU1535378A3 (fr)
ZA (1) ZA865262B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) * 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
US5049579A (en) * 1986-05-20 1991-09-17 Farmitalia Carlo Erba, S.R.L. Site specific alkylating agents
US5310752A (en) * 1986-05-20 1994-05-10 Farmitalia Carlo Erba Spa Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
AU1224392A (en) * 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
DE4205948C2 (de) * 1992-02-24 1996-10-31 Mannesmann Ag Farbbandkassette für ein endloses Farbband
US5273991A (en) * 1992-07-29 1993-12-28 Research Corporation Technologies, Inc. Imidazole-containing compositions and methods of use thereof analogs of distamycin
EP0792262A2 (fr) * 1994-11-14 1997-09-03 Nzym, Inc. Methodes et compositions pour le traitement de mycoses phytopathogenes
US5629348A (en) * 1994-11-14 1997-05-13 Nzym, Inc. Methods and compositions for treating septoria infections
US5637621A (en) * 1994-11-14 1997-06-10 Nzym, Inc. Methods and compositions for treating Botrytis infections
DE19805431A1 (de) * 1998-02-11 1999-08-12 Merck Patent Gmbh Heteroaromatische Oligoamide als Affinitätsliganden
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
DE60128551D1 (de) * 2000-03-16 2007-07-05 Genesoft Inc Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
ITTO20010633A1 (it) * 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
AU2003258022A1 (en) 2002-08-02 2004-02-23 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
AU2003285958A1 (en) * 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
WO2004052304A2 (fr) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Composes antibacteriens possedant un motif (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide)
WO2005051318A2 (fr) * 2003-11-24 2005-06-09 Viropharma Incorporated Composes, compositions et procedes pour le traitement et la prophylaxie d'infections de l'hepatite c virale et de maladies associees
TWI712611B (zh) * 2015-03-30 2020-12-11 日商明治製菓藥業股份有限公司 泛艾黴素之製造方法及其新穎之製造中間體

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA557568A (fr) * 1958-05-20 J. Weiss Martin Acides et esters aminopyrrolecarboxyliques substitues
CA547128A (fr) * 1957-10-08 W. Waller Coy Pyrrolecarboxamidopyrroles substitues
FR86210E (fr) * 1963-04-04 1966-03-23
DE1795539A1 (de) * 1963-07-26 1972-01-13 Farmaceutici Italia Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
BE666612A (fr) * 1963-07-26 1965-11-03
DE1470284B1 (de) * 1963-07-26 1971-12-16 Farmaceutici Italia Beta-{1-Methyl-4-[1-methyl-4-(1-methyl-4-formylamino-pyrrol-2-carboxamido)-pyrrol-2-carboxamido]-pyrrol-2-carboxamido}-propionamidin sowie dessen Saeureadditionssalze
FR90359E (fr) * 1963-07-26 1968-02-14
NL130086C (fr) * 1964-07-14 1970-06-15
AT387013B (de) * 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
IE59275B1 (en) 1994-02-09
NL8601838A (nl) 1987-02-16
GB8517923D0 (en) 1985-08-21
SE8603099L (sv) 1987-01-17
AU584723B2 (en) 1989-06-01
IE861874L (en) 1987-01-16
NO169014B (no) 1992-01-20
IT8621124A0 (it) 1986-07-15
IT1213103B (it) 1989-12-07
ZA865262B (en) 1987-03-25
DE3623853A1 (de) 1987-01-29
IL79401A0 (en) 1986-10-31
PT82985B (pt) 1989-01-30
DK335886A (da) 1987-01-17
GB2178037A (en) 1987-02-04
SU1535378A3 (ru) 1990-01-07
BE905109A (fr) 1987-01-15
SU1538893A3 (ru) 1990-01-23
IL79401A (en) 1991-05-12
ATA188786A (de) 1988-03-15
NO169014C (no) 1992-04-29
GB2178037B (en) 1989-07-26
HU198087B (en) 1989-07-28
KR940003495B1 (ko) 1994-04-23
SE468594B (sv) 1993-02-15
NO862861D0 (no) 1986-07-15
FI862960A (fi) 1987-01-17
DK335886D0 (da) 1986-07-15
FI82929C (fi) 1991-05-10
CA1247627A (fr) 1988-12-28
FI82929B (fi) 1991-01-31
ES2000346A6 (es) 1988-02-16
PT82985A (pt) 1986-08-01
CN86104774A (zh) 1987-02-11
NO862861L (no) 1987-01-19
CS541186A3 (en) 1992-09-16
US4738980A (en) 1988-04-19
CH671958A5 (fr) 1989-10-13
DE3623853C2 (de) 1995-12-21
HUT41814A (en) 1987-05-28
JPH0780842B2 (ja) 1995-08-30
GR861840B (en) 1986-11-18
CN85103908A (zh) 1986-11-05
PH23459A (en) 1989-08-07
NZ216828A (en) 1989-11-28
KR870001228A (ko) 1987-03-12
JPS6230755A (ja) 1987-02-09
GB8617293D0 (en) 1986-08-20
SE8603099D0 (sv) 1986-07-11
AT386822B (de) 1988-10-25
CN1026984C (zh) 1994-12-14
AU6020386A (en) 1987-01-22
FI862960A0 (fi) 1986-07-16
FR2585019A1 (fr) 1987-01-23
CZ277823B6 (en) 1993-06-16

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Legal Events

Date Code Title Description
TP Transmission of property
CD Change of name or company name
TP Transmission of property
ST Notification of lapse