KR860009035A - 11-β 치환된 스테로이드의 제조방법 - Google Patents
11-β 치환된 스테로이드의 제조방법 Download PDFInfo
- Publication number
- KR860009035A KR860009035A KR1019860004283A KR860004283A KR860009035A KR 860009035 A KR860009035 A KR 860009035A KR 1019860004283 A KR1019860004283 A KR 1019860004283A KR 860004283 A KR860004283 A KR 860004283A KR 860009035 A KR860009035 A KR 860009035A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- alkyl
- hydrogen
- compound
- together form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003431 steroids Chemical class 0.000 title claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000008570 general process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8513723 | 1985-05-31 | ||
| GB858513723A GB8513723D0 (en) | 1985-05-31 | 1985-05-31 | 11-beta substituted steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860009035A true KR860009035A (ko) | 1986-12-19 |
Family
ID=10579949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860004283A Withdrawn KR860009035A (ko) | 1985-05-31 | 1986-05-30 | 11-β 치환된 스테로이드의 제조방법 |
Country Status (21)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE69820T1 (de) * | 1987-04-24 | 1991-12-15 | Akzo Nv | 11-arylestranderivate und 11-arylpregnanderivate. |
| DE3878198T2 (de) * | 1987-12-12 | 1993-06-24 | Akzo Nv | 11-arylsteroid-derivate. |
| FR2665901B2 (fr) * | 1989-02-24 | 1994-07-29 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments. |
| FR2643638B1 (fr) * | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| FR2701262B1 (fr) * | 1993-02-05 | 1995-03-24 | Roussel Uclaf | Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires. |
| TWI265167B (en) * | 1999-11-29 | 2006-11-01 | Akzo Nobel Nv | 3-methylene steroid derivatives |
| DE19961219A1 (de) * | 1999-12-15 | 2001-07-19 | Jenapharm Gmbh | 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| TW200531977A (en) | 2004-03-25 | 2005-10-01 | Akzo Nobel Nv | Progesterone receptor modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH488682A (de) * | 1965-07-30 | 1970-04-15 | Ciba Geigy | Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe |
| FR192F (enrdf_load_stackoverflow) * | 1965-10-22 | |||
| FR5913M (enrdf_load_stackoverflow) * | 1965-12-02 | 1968-04-01 | ||
| NL128375C (enrdf_load_stackoverflow) * | 1966-02-18 | |||
| FR2054527B1 (enrdf_load_stackoverflow) * | 1969-07-28 | 1973-06-08 | Roussel Uclaf | |
| FR2054525B1 (enrdf_load_stackoverflow) * | 1969-07-28 | 1973-01-12 | Roussel Uclaf | |
| FR2377418A1 (fr) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments |
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
| NZ214998A (en) * | 1985-02-07 | 1989-06-28 | Schering Ag | 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions |
-
1985
- 1985-05-31 GB GB858513723A patent/GB8513723D0/en active Pending
-
1986
- 1986-05-23 ES ES555298A patent/ES8707972A1/es not_active Expired
- 1986-05-27 HU HU862228A patent/HU197925B/hu not_active IP Right Cessation
- 1986-05-27 GB GB08612866A patent/GB2175905B/en not_active Expired
- 1986-05-28 IL IL78957A patent/IL78957A/xx unknown
- 1986-05-28 NZ NZ216325A patent/NZ216325A/xx unknown
- 1986-05-28 IT IT20598/86A patent/IT1190014B/it active
- 1986-05-28 CH CH2152/86A patent/CH669385A5/de not_active IP Right Cessation
- 1986-05-28 FR FR8607660A patent/FR2582654B1/fr not_active Expired
- 1986-05-28 DE DE19863617883 patent/DE3617883A1/de not_active Withdrawn
- 1986-05-28 PT PT82665A patent/PT82665B/pt not_active IP Right Cessation
- 1986-05-29 FI FI862278A patent/FI862278A7/fi not_active Application Discontinuation
- 1986-05-29 SU SU864027509A patent/SU1508963A3/ru active
- 1986-05-29 NL NL8601387A patent/NL8601387A/nl not_active Application Discontinuation
- 1986-05-29 DK DK251386A patent/DK251386A/da not_active Application Discontinuation
- 1986-05-29 SE SE8602449A patent/SE8602449L/ not_active Application Discontinuation
- 1986-05-29 GR GR861405A patent/GR861405B/el unknown
- 1986-05-29 AU AU58062/86A patent/AU587031B2/en not_active Ceased
- 1986-05-30 BE BE0/216722A patent/BE904846A/fr not_active IP Right Cessation
- 1986-05-30 ZA ZA864065A patent/ZA864065B/xx unknown
- 1986-05-30 KR KR1019860004283A patent/KR860009035A/ko not_active Withdrawn
- 1986-05-30 JP JP61123893A patent/JPS6212796A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HU197925B (en) | 1989-06-28 |
| ES555298A0 (es) | 1987-09-01 |
| GB2175905B (en) | 1989-01-18 |
| SE8602449D0 (sv) | 1986-05-29 |
| GB8612866D0 (en) | 1986-07-02 |
| AU5806286A (en) | 1986-12-04 |
| FR2582654A1 (fr) | 1986-12-05 |
| FI862278A7 (fi) | 1986-12-01 |
| NZ216325A (en) | 1989-01-27 |
| IT8620598A0 (it) | 1986-05-28 |
| IT1190014B (it) | 1988-02-10 |
| HUT44575A (en) | 1988-03-28 |
| DE3617883A1 (de) | 1986-12-04 |
| IL78957A0 (en) | 1986-09-30 |
| PT82665A (en) | 1986-06-01 |
| GB2175905A (en) | 1986-12-10 |
| SU1508963A3 (ru) | 1989-09-15 |
| GR861405B (en) | 1986-09-26 |
| IT8620598A1 (it) | 1987-11-28 |
| FI862278A0 (fi) | 1986-05-29 |
| BE904846A (fr) | 1986-12-01 |
| IL78957A (en) | 1990-11-29 |
| CH669385A5 (enrdf_load_stackoverflow) | 1989-03-15 |
| PT82665B (pt) | 1988-08-17 |
| SE8602449L (sv) | 1986-12-01 |
| ES8707972A1 (es) | 1987-09-01 |
| DK251386A (da) | 1986-12-01 |
| GB8513723D0 (en) | 1985-07-03 |
| JPS6212796A (ja) | 1987-01-21 |
| AU587031B2 (en) | 1989-08-03 |
| DK251386D0 (da) | 1986-05-29 |
| ZA864065B (en) | 1987-01-28 |
| FR2582654B1 (fr) | 1988-06-03 |
| NL8601387A (nl) | 1986-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19860530 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |