ES2045082T3 - Un metodo para la preparacion de nuevos derivados 11-arilestrano y 11-arilpregnano. - Google Patents

Un metodo para la preparacion de nuevos derivados 11-arilestrano y 11-arilpregnano.

Info

Publication number
ES2045082T3
ES2045082T3 ES88200689T ES88200689T ES2045082T3 ES 2045082 T3 ES2045082 T3 ES 2045082T3 ES 88200689 T ES88200689 T ES 88200689T ES 88200689 T ES88200689 T ES 88200689T ES 2045082 T3 ES2045082 T3 ES 2045082T3
Authority
ES
Spain
Prior art keywords
group
aciloxi
arilpregnano
preparation
hydrocarbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88200689T
Other languages
English (en)
Inventor
Marinus Bernard Groen
Jongh Hendrik Paul De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of ES2045082T3 publication Critical patent/ES2045082T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Abstract

LA PRESENTE INVENCION CONCIERNE A DERIVADOS DE 11-ANTIESTRANO Y 11-ARILPREGNANO, CARACTERIZADOS POR TENER LA ESTRUCTURA (I), EN LA QUE R1 ES UN GRUPO ARILO CON UN GRUPO (II) COMO SUSTITUYENTE SIENDO X E Y POR SEPARADO H O UN RADICAL HIDROCARBONADO DE 1 A 4 C, JUNTOS FORMAN UN RADICAL HIDROCARBONADODE 2 A 6 C; R2 ES UN GRUPO ALQUILO DE 1 A 4 C: R3 ES H, OH, UN RADICAL HIDROCARBONADO SATURADO O INSATURADO DE 1 A 8 C, QUE TIENE POR LO MENOS UN GRUPO OH, OXO, HALOGENO, AZIDO O NITRILO; UN GRUPO ACILOXI O ALCOXI; R4 ES OH, UN GRUPO ACILOXI O ALCOXI O UN GRUPO ACILO QUE PUEDE LLEVAR UN GRUPO OH, ACILO, ACILOXI O HALOGENO; O BIEN R3 Y R4 JUNTOS PUEDEN FORMAR UN SISTEMA CICLICO; Y R5 ES UN GRUPO HIDROCARBONADO QUE CONTIENE DE 1 A 4 C. TAMBIEN TRATA LA INVENCION DE PROCESOS PARA LA PREPARACION DE ESTOS COMPUESTOS Y DE PREPARACIONES FARMACEUTICAS QUE LOS CONTIENEN. LOS COMPUESTOS DE LA PRESENTE INVENCION MUESTRAN ACTIVIDAD ANTIPROGESTINA.
ES88200689T 1987-04-24 1988-04-12 Un metodo para la preparacion de nuevos derivados 11-arilestrano y 11-arilpregnano. Expired - Lifetime ES2045082T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8700970 1987-04-24

Publications (1)

Publication Number Publication Date
ES2045082T3 true ES2045082T3 (es) 1994-01-16

Family

ID=19849909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88200689T Expired - Lifetime ES2045082T3 (es) 1987-04-24 1988-04-12 Un metodo para la preparacion de nuevos derivados 11-arilestrano y 11-arilpregnano.

Country Status (17)

Country Link
US (1) US4871724A (es)
EP (1) EP0289073B1 (es)
JP (1) JP2655676B2 (es)
KR (1) KR970005318B1 (es)
CN (1) CN1019978C (es)
AT (1) ATE69820T1 (es)
AU (1) AU608831B2 (es)
CA (1) CA1297472C (es)
DE (1) DE3866410D1 (es)
DK (1) DK168294B1 (es)
ES (1) ES2045082T3 (es)
FI (1) FI88396C (es)
GR (1) GR3003363T3 (es)
IE (1) IE60783B1 (es)
NZ (1) NZ224355A (es)
PT (1) PT87322B (es)
ZA (1) ZA882643B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411733B1 (de) * 1989-08-04 1998-10-21 Schering Aktiengesellschaft 11 Beta-Aryl-gona-4,9-dien-3-one
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
CN1117759C (zh) * 1999-09-02 2003-08-13 上海中西药业股份有限公司 甾体化合物,其制备方法和其药物组合物及其应用
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
HUE036870T2 (hu) 2006-10-24 2018-08-28 Repros Therapeutics Inc Az endometriális proliferáció elnyomására szolgáló készítmények és módszerek
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
KR102166867B1 (ko) 2010-03-22 2020-10-19 앨러간 파마슈티컬스 인터내셔널 리미티드 항프로게스틴의 비독성 전달을 위한 조성물들과 그 방법들
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424769A (en) * 1966-04-04 1969-01-28 Syntex Corp Process for the preparation of novel 6alpha-methyl-delta4,9(10)- diene steroids
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3461090D1 (en) * 1983-02-18 1986-12-04 Schering Ag 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
US4678282A (en) * 1985-02-19 1987-07-07 Ovonic Imaging Systems, Inc. Active display matrix addressable without crossed lines on any one substrate and method of using the same
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids

Also Published As

Publication number Publication date
FI881826A (fi) 1988-10-25
DE3866410D1 (de) 1992-01-09
EP0289073B1 (en) 1991-11-27
CN1019978C (zh) 1993-03-03
GR3003363T3 (en) 1993-02-17
AU1507288A (en) 1988-10-27
DK221888A (da) 1988-10-25
DK221888D0 (da) 1988-04-22
AU608831B2 (en) 1991-04-18
JP2655676B2 (ja) 1997-09-24
ATE69820T1 (de) 1991-12-15
EP0289073A1 (en) 1988-11-02
US4871724A (en) 1989-10-03
FI881826A0 (fi) 1988-04-19
FI88396B (fi) 1993-01-29
IE60783B1 (en) 1994-08-10
FI88396C (fi) 1993-05-10
IE881131L (en) 1988-10-24
PT87322B (pt) 1992-08-31
KR880012637A (ko) 1988-11-28
DK168294B1 (da) 1994-03-07
CA1297472C (en) 1992-03-17
CN88102416A (zh) 1988-12-14
KR970005318B1 (ko) 1997-04-15
NZ224355A (en) 1990-03-27
JPS63280097A (ja) 1988-11-17
PT87322A (pt) 1988-05-01
ZA882643B (en) 1988-10-04

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