FI103791B1 - Menetelmä ja välituote uusien D-vitamiinianalogien valmistamiseksi - Google Patents

Menetelmä ja välituote uusien D-vitamiinianalogien valmistamiseksi

Info

Publication number
FI103791B1
FI103791B1 FI925547A FI925547A FI103791B1 FI 103791 B1 FI103791 B1 FI 103791B1 FI 925547 A FI925547 A FI 925547A FI 925547 A FI925547 A FI 925547A FI 103791 B1 FI103791 B1 FI 103791B1
Authority
FI
Finland
Prior art keywords
analogs
preparation
derivs
substd
opt
Prior art date
Application number
FI925547A
Other languages
English (en)
Swedish (sv)
Other versions
FI925547A (fi
FI925547A0 (fi
FI103791B (fi
Inventor
Claus Aage Svensgaard Bretting
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of FI925547A publication Critical patent/FI925547A/fi
Publication of FI925547A0 publication Critical patent/FI925547A0/fi
Application granted granted Critical
Publication of FI103791B1 publication Critical patent/FI103791B1/fi
Publication of FI103791B publication Critical patent/FI103791B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI925547A 1990-08-15 1992-12-07 Menetelmä ja välituote uusien D-vitamiinianalogien valmistamiseksi FI103791B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909017890A GB9017890D0 (en) 1990-08-15 1990-08-15 Chemical compounds i
GB9017890 1990-08-15
PCT/DK1991/000200 WO1992003414A1 (en) 1990-08-15 1991-07-11 Novel vitamin d analogues
DK9100200 1991-07-11

Publications (4)

Publication Number Publication Date
FI925547A FI925547A (fi) 1992-12-07
FI925547A0 FI925547A0 (fi) 1992-12-07
FI103791B1 true FI103791B1 (fi) 1999-09-30
FI103791B FI103791B (fi) 1999-09-30

Family

ID=10680686

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925547A FI103791B (fi) 1990-08-15 1992-12-07 Menetelmä ja välituote uusien D-vitamiinianalogien valmistamiseksi

Country Status (20)

Country Link
US (1) US5447924A (fi)
EP (1) EP0543864B1 (fi)
JP (1) JP3246914B2 (fi)
KR (1) KR100203227B1 (fi)
AT (1) ATE115562T1 (fi)
AU (1) AU636510B2 (fi)
CA (1) CA2078555C (fi)
CZ (1) CZ286485B6 (fi)
DE (1) DE69105981T2 (fi)
DK (1) DK0543864T3 (fi)
ES (1) ES2068601T3 (fi)
FI (1) FI103791B (fi)
GB (1) GB9017890D0 (fi)
GR (1) GR3014922T3 (fi)
IE (1) IE66241B1 (fi)
LT (1) LT3666B (fi)
LV (1) LV10089B (fi)
RU (1) RU2126384C1 (fi)
SK (1) SK281443B6 (fi)
WO (1) WO1992003414A1 (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2062520C (en) * 1991-03-11 1998-08-11 Hector F. Deluca Synthesis of 1-alpha-hydroxy-secosterol compounds
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
GB9214202D0 (en) * 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
US5880114A (en) * 1993-06-16 1999-03-09 Wisconsin Alumni Research Foundation Treatment of immune deficiency with vitamin D compounds
US6291444B1 (en) 1993-06-16 2001-09-18 Wisconsin Alumni Research Foundation Treatment of t-cell immunodeficiencies with vitamin D compounds
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
DE19519273A1 (de) * 1995-05-22 1996-11-28 Schering Ag Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
MA26481A1 (fr) * 1997-04-21 2004-12-20 Hoffmann La Roche Derives d'arylsecocholadiene
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
JP4219553B2 (ja) * 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2368824T3 (es) 1998-03-27 2011-11-22 Oregon Health & Science University Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos.
ES2326040T3 (es) * 2001-10-19 2009-09-29 Isotechnika Inc. Sintesis de analogos de ciclosporina.
KR20050055784A (ko) * 2002-10-23 2005-06-13 레오 파마 에이/에스 비타민 디 유사체, 이 유사체를 포함하는 조성물 및 이들의용도
AR041696A1 (es) 2002-10-23 2005-05-26 Leo Pharm Prod Ltd Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
ES2233209B1 (es) * 2003-11-28 2006-04-01 Laboratorios Viñas S.A. Compuestos monohalogenovinilderivados de vitamina d.
ES2234423B1 (es) * 2003-12-05 2006-03-01 Laboratorios Viñas, S.A. Procedimiento para la obtencion de derivados de vitamina d a partir de compuestos monohalogenovinilicos.
BRPI0609630A2 (pt) * 2005-05-10 2010-04-20 Dermipsor Ltd composições e métodos para tratamento de doenças epidérmicas hiperproliferativas
EP1879449A4 (en) * 2005-05-10 2009-12-16 Dermipsor Ltd SKIN CARE COMPOSITIONS AND METHODS
US20080064669A1 (en) * 2006-08-29 2008-03-13 Rakefet Cohen Stable pharmacologically active compositions including vitamin D-containing and corticosteroid compounds with low pH compatibility
CA2981549A1 (en) 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
PL2634171T3 (pl) 2010-10-25 2015-12-31 Teijin Ltd 23-ynowa pochodna witaminy D3
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
WO2017209934A1 (en) 2016-05-13 2017-12-07 Case Western Reserve University Autophagy activators for treating or preventing skin injury

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
JPS6172652A (ja) * 1984-09-14 1986-04-14 Asahi Glass Co Ltd 歯科材料用リン酸カルシウム系結晶性ガラス
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
JPS6253960A (ja) * 1985-05-30 1987-03-09 Taisho Pharmaceut Co Ltd ビタミンｄ↓３の誘導体
US4866048A (en) 1985-08-02 1989-09-12 Leo Pharmaceutical Products Ltd. Novel vitamin D analogues
EP0245524B1 (en) * 1985-11-21 1991-04-17 Taisho Pharmaceutical Co. Ltd Vitamin d 3 derivative
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0412110B1 (en) 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5053401A (en) 1989-02-28 1991-10-01 Chugai Seiyaku Kabushiki Kaisha Osteogenesis promotion with use of vitamin d derivatives
US4948789A (en) 1989-03-28 1990-08-14 Chugai Seiyaku Kabushiki Kaisha Suppression of parathyroid hormone synthesis and secretion
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives

Also Published As

Publication number Publication date
FI925547A (fi) 1992-12-07
IE66241B1 (en) 1995-12-13
JP3246914B2 (ja) 2002-01-15
DE69105981D1 (de) 1995-01-26
GR3014922T3 (en) 1995-05-31
CZ372692A3 (en) 1993-05-12
FI925547A0 (fi) 1992-12-07
CA2078555C (en) 2002-11-26
CZ286485B6 (en) 2000-04-12
KR100203227B1 (ko) 1999-06-15
DE69105981T2 (de) 1995-04-20
LV10089B (en) 1994-10-20
US5447924A (en) 1995-09-05
JPH06500089A (ja) 1994-01-06
LTIP965A (en) 1995-03-27
EP0543864B1 (en) 1994-12-14
AU636510B2 (en) 1993-04-29
AU8422391A (en) 1992-03-17
ES2068601T3 (es) 1995-04-16
LV10089A (lv) 1994-05-10
FI103791B (fi) 1999-09-30
WO1992003414A1 (en) 1992-03-05
RU2126384C1 (ru) 1999-02-20
DK0543864T3 (da) 1995-05-08
ATE115562T1 (de) 1994-12-15
LT3666B (en) 1996-01-25
GB9017890D0 (en) 1990-09-26
SK281443B6 (sk) 2001-03-12
EP0543864A1 (en) 1993-06-02
CA2078555A1 (en) 1992-02-16
IE912462A1 (en) 1992-02-26
SK372692A3 (en) 1995-04-12

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