LTIP965A - Novel vitamin d analogues - Google Patents

Novel vitamin d analogues

Info

Publication number
LTIP965A
LTIP965A LTIP965A LTIP965A LTIP965A LT IP965 A LTIP965 A LT IP965A LT IP965 A LTIP965 A LT IP965A LT IP965 A LTIP965 A LT IP965A LT IP965 A LTIP965 A LT IP965A
Authority
LT
Lithuania
Prior art keywords
analogues
derivs
substd
opt
deuterium
Prior art date
Application number
LTIP965A
Inventor
Claus Aage Svensgaard Bretting
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of LTIP965A publication Critical patent/LTIP965A/en
Publication of LT3666B publication Critical patent/LT3666B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)

Abstract

Vitamin D derivs. of formula (I) are new. In (I) X = H or OH, R1 and R2 = H, 1-6C hydrocarbyl, or together with C (asterisk) bearing the X gp. can form a 3-8C carbocyclic ring; Q = single bond or 1-8C hydrocarbylene diradical; Hydrocarbylene = residue after removal of 1 or 2H from hydrocarbon; m = 0, 1 or 2. R1, R2 Q opt. substd. with deuterium or F; C(.) atom opt. substd. by deuterium, F or 1-2C alkyl gp. and derivs. of (I) where OH gp. are O-acyl, O-glycosyl gp. f or phosphate ester, or masked gp. hydrolysable in-vivo. Also described 1(S),3(R)-bis-tert-butyldimethyl silyloxy-2O(R)-2,2-dichlorovinyl-9, 10-seco-pregna-5(E),7(E),10(19)-triene as an intermediate.
LTIP965A 1990-08-15 1993-09-10 Novel vitamin d analogues LT3666B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017890A GB9017890D0 (en) 1990-08-15 1990-08-15 Chemical compounds i

Publications (2)

Publication Number Publication Date
LTIP965A true LTIP965A (en) 1995-03-27
LT3666B LT3666B (en) 1996-01-25

Family

ID=10680686

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP965A LT3666B (en) 1990-08-15 1993-09-10 Novel vitamin d analogues

Country Status (20)

Country Link
US (1) US5447924A (en)
EP (1) EP0543864B1 (en)
JP (1) JP3246914B2 (en)
KR (1) KR100203227B1 (en)
AT (1) ATE115562T1 (en)
AU (1) AU636510B2 (en)
CA (1) CA2078555C (en)
CZ (1) CZ286485B6 (en)
DE (1) DE69105981T2 (en)
DK (1) DK0543864T3 (en)
ES (1) ES2068601T3 (en)
FI (1) FI103791B (en)
GB (1) GB9017890D0 (en)
GR (1) GR3014922T3 (en)
IE (1) IE66241B1 (en)
LT (1) LT3666B (en)
LV (1) LV10089B (en)
RU (1) RU2126384C1 (en)
SK (1) SK281443B6 (en)
WO (1) WO1992003414A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2062520C (en) * 1991-03-11 1998-08-11 Hector F. Deluca Synthesis of 1-alpha-hydroxy-secosterol compounds
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
GB9214202D0 (en) * 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
US5880114A (en) * 1993-06-16 1999-03-09 Wisconsin Alumni Research Foundation Treatment of immune deficiency with vitamin D compounds
US6291444B1 (en) 1993-06-16 2001-09-18 Wisconsin Alumni Research Foundation Treatment of t-cell immunodeficiencies with vitamin D compounds
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
DE19519273A1 (en) * 1995-05-22 1996-11-28 Schering Ag Topical agents for the treatment and prophylaxis of alopecia
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
NO971934L (en) * 1996-05-23 1997-11-24 Hoffmann La Roche Fluorinated vitamin D3 analogues
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
MA26481A1 (en) * 1997-04-21 2004-12-20 Hoffmann La Roche ARYLSECOCHOLADIAN DERIVATIVES
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
AU1022999A (en) * 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
CA2326117A1 (en) 1998-03-27 1999-10-07 Oregon Health Sciences University Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
WO2006120681A2 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
KR100982466B1 (en) * 2001-10-19 2010-09-16 이소테크니카 인코포레이티드 Synthesis of cyclosporin analogs
AR041696A1 (en) 2002-10-23 2005-05-26 Leo Pharm Prod Ltd VITAMIN D ANALOG COMPOUNDS, COMPOSITIONS THAT INCLUDE SUCH ANALOG COMPOUNDS AND THEIR USE
CA2500640A1 (en) * 2002-10-23 2004-05-06 Leo Pharma A/S Vitamin d analogues, compositions comprising said analogues and their use
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
ES2233209B1 (en) 2003-11-28 2006-04-01 Laboratorios Viñas S.A. COMPUESTOS MONOHALOGENOVINILDERIVADOS DE VITAMINA D.
ES2234423B1 (en) * 2003-12-05 2006-03-01 Laboratorios Viñas, S.A. PROCEDURE FOR OBTAINING VITAMIN DERIVATIVES FROM MONOHALOGENOVINYL COMPOUNDS.
BRPI0609630A2 (en) * 2005-05-10 2010-04-20 Dermipsor Ltd compositions and methods for treating hyperproliferative epidermal diseases
BRPI0715636A2 (en) * 2006-08-29 2013-07-02 Teva Pharma stable pharmacologically active compositions including low ph compatibility vitamin D and corticosteroid-containing compounds
EP2393494A1 (en) 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CA2770683C (en) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamin d3 and analogs thereof for treating alopecia
ES2541719T3 (en) 2010-10-25 2015-07-24 Teijin Pharma Limited 23-ino-vitamin D3 derivative
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2017209934A1 (en) 2016-05-13 2017-12-07 Case Western Reserve University Autophagy activators for treating or preventing skin injury

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (en) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd 1alpha, 25-dihydroxy-26,27-dimethylvitamin d3
JPS6172652A (en) * 1984-09-14 1986-04-14 Asahi Glass Co Ltd Calcium phosphate-based crystalline glass for dental material
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
EP0205285B1 (en) * 1985-05-30 1989-08-09 Taisho Pharmaceutical Co. Ltd Vitamin d3 derivatives
WO1987000834A1 (en) 1985-08-02 1987-02-12 Leo Pharmaceutical Products Ltd. A/S Novel vitamin d analogues
EP0245524B1 (en) * 1985-11-21 1991-04-17 Taisho Pharmaceutical Co. Ltd Vitamin d 3 derivative
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5206229A (en) 1988-04-21 1993-04-27 Leo Pharmaceutical Products Ltd Vitamin d analogues
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
CA2010982C (en) 1989-02-28 2000-06-13 Toshio Matsumoto Osteogenesis promotion with use of vitamin d derivatives
US4948789A (en) 1989-03-28 1990-08-14 Chugai Seiyaku Kabushiki Kaisha Suppression of parathyroid hormone synthesis and secretion
DE69005897D1 (en) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferol derivatives.
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4011682A1 (en) * 1990-04-06 1991-10-10 Schering Ag 24-OXA DERIVATIVES IN THE VITAMIN D SERIES
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives

Also Published As

Publication number Publication date
DK0543864T3 (en) 1995-05-08
LV10089B (en) 1994-10-20
RU2126384C1 (en) 1999-02-20
SK372692A3 (en) 1995-04-12
WO1992003414A1 (en) 1992-03-05
CA2078555A1 (en) 1992-02-16
EP0543864A1 (en) 1993-06-02
AU636510B2 (en) 1993-04-29
SK281443B6 (en) 2001-03-12
US5447924A (en) 1995-09-05
DE69105981T2 (en) 1995-04-20
DE69105981D1 (en) 1995-01-26
CZ372692A3 (en) 1993-05-12
FI925547A (en) 1992-12-07
LT3666B (en) 1996-01-25
CA2078555C (en) 2002-11-26
AU8422391A (en) 1992-03-17
EP0543864B1 (en) 1994-12-14
LV10089A (en) 1994-05-10
JPH06500089A (en) 1994-01-06
CZ286485B6 (en) 2000-04-12
GB9017890D0 (en) 1990-09-26
FI103791B1 (en) 1999-09-30
GR3014922T3 (en) 1995-05-31
FI925547A0 (en) 1992-12-07
FI103791B (en) 1999-09-30
IE912462A1 (en) 1992-02-26
ATE115562T1 (en) 1994-12-15
KR100203227B1 (en) 1999-06-15
ES2068601T3 (en) 1995-04-16
JP3246914B2 (en) 2002-01-15
IE66241B1 (en) 1995-12-13

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Effective date: 20020910