LTIP965A - Novel vitamin d analogues - Google Patents
Novel vitamin d analoguesInfo
- Publication number
- LTIP965A LTIP965A LTIP965A LTIP965A LTIP965A LT IP965 A LTIP965 A LT IP965A LT IP965 A LTIP965 A LT IP965A LT IP965 A LTIP965 A LT IP965A LT IP965 A LTIP965 A LT IP965A
- Authority
- LT
- Lithuania
- Prior art keywords
- analogues
- derivs
- substd
- opt
- deuterium
- Prior art date
Links
- 229940046008 vitamin d Drugs 0.000 title abstract 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
- 229910052805 deuterium Inorganic materials 0.000 abstract 2
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphate ester Chemical class 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Vitamin D derivs. of formula (I) are new. In (I) X = H or OH, R1 and R2 = H, 1-6C hydrocarbyl, or together with C (asterisk) bearing the X gp. can form a 3-8C carbocyclic ring; Q = single bond or 1-8C hydrocarbylene diradical; Hydrocarbylene = residue after removal of 1 or 2H from hydrocarbon; m = 0, 1 or 2. R1, R2 Q opt. substd. with deuterium or F; C(.) atom opt. substd. by deuterium, F or 1-2C alkyl gp. and derivs. of (I) where OH gp. are O-acyl, O-glycosyl gp. f or phosphate ester, or masked gp. hydrolysable in-vivo. Also described 1(S),3(R)-bis-tert-butyldimethyl silyloxy-2O(R)-2,2-dichlorovinyl-9, 10-seco-pregna-5(E),7(E),10(19)-triene as an intermediate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909017890A GB9017890D0 (en) | 1990-08-15 | 1990-08-15 | Chemical compounds i |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP965A true LTIP965A (en) | 1995-03-27 |
LT3666B LT3666B (en) | 1996-01-25 |
Family
ID=10680686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP965A LT3666B (en) | 1990-08-15 | 1993-09-10 | Novel vitamin d analogues |
Country Status (20)
Country | Link |
---|---|
US (1) | US5447924A (en) |
EP (1) | EP0543864B1 (en) |
JP (1) | JP3246914B2 (en) |
KR (1) | KR100203227B1 (en) |
AT (1) | ATE115562T1 (en) |
AU (1) | AU636510B2 (en) |
CA (1) | CA2078555C (en) |
CZ (1) | CZ286485B6 (en) |
DE (1) | DE69105981T2 (en) |
DK (1) | DK0543864T3 (en) |
ES (1) | ES2068601T3 (en) |
FI (1) | FI103791B1 (en) |
GB (1) | GB9017890D0 (en) |
GR (1) | GR3014922T3 (en) |
IE (1) | IE66241B1 (en) |
LT (1) | LT3666B (en) |
LV (1) | LV10089B (en) |
RU (1) | RU2126384C1 (en) |
SK (1) | SK281443B6 (en) |
WO (1) | WO1992003414A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2062520C (en) * | 1991-03-11 | 1998-08-11 | Hector F. Deluca | Synthesis of 1-alpha-hydroxy-secosterol compounds |
US5486509A (en) * | 1991-06-28 | 1996-01-23 | University Of Miami | Method of preventing and treating chemotherapy-induced alopecia |
GB9206648D0 (en) * | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
GB9214202D0 (en) * | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
GB9226860D0 (en) * | 1992-12-23 | 1993-02-17 | Leo Pharm Prod Ltd | Novel treatment |
US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
US5880114A (en) * | 1993-06-16 | 1999-03-09 | Wisconsin Alumni Research Foundation | Treatment of immune deficiency with vitamin D compounds |
US6291444B1 (en) | 1993-06-16 | 2001-09-18 | Wisconsin Alumni Research Foundation | Treatment of t-cell immunodeficiencies with vitamin D compounds |
US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
US5384314B1 (en) * | 1994-03-11 | 1997-08-05 | Hoffmann La Roche | 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol |
US5661140A (en) * | 1994-11-21 | 1997-08-26 | Wisconsin Alumni Research Foundation | 18-nor-vitamin D compounds |
DE19519273A1 (en) * | 1995-05-22 | 1996-11-28 | Schering Ag | Topical agents for the treatment and prophylaxis of alopecia |
US5939408A (en) | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
SG70009A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Vitamin d3 analogs |
NO971934L (en) * | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Fluorinated vitamin D3 analogues |
GB9622590D0 (en) * | 1996-10-30 | 1997-01-08 | Leo Pharm Prod Ltd | Chemical compounds |
MA26481A1 (en) * | 1997-04-21 | 2004-12-20 | Hoffmann La Roche | ARYLSECOCHOLADIAN DERIVATIVES |
CA2296145A1 (en) * | 1997-07-17 | 1999-01-28 | F. Hoffmann-La Roche Ag | Dihomo-seco-cholestanes with two unsaturated bonds in the side chain |
AU1022999A (en) * | 1997-09-08 | 1999-03-29 | F. Hoffmann-La Roche Ag | 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
ATE515265T1 (en) | 1998-03-27 | 2011-07-15 | Univ Oregon Health & Science | VITAMIN D AND ITS ANALOGUES FOR THE TREATMENT OF TUMORS AND OTHER HYPERPROLIFERATIVE DISEASES |
JP4261355B2 (en) | 2001-10-19 | 2009-04-30 | アイソテクニカ インコーポレイテッド | A method for the synthesis of cyclosporine analogues. |
JP4512490B2 (en) * | 2002-10-23 | 2010-07-28 | レオ ファーマ アクティーゼルスカブ | Vitamin D analogs, compositions comprising the analogs and uses thereof |
AR041696A1 (en) | 2002-10-23 | 2005-05-26 | Leo Pharm Prod Ltd | VITAMIN D ANALOG COMPOUNDS, COMPOSITIONS THAT INCLUDE SUCH ANALOG COMPOUNDS AND THEIR USE |
US7351869B2 (en) * | 2002-11-18 | 2008-04-01 | Teva Pharmaceutical Industries Ltd | Crystallization method for purification of calcipotriene |
ES2233209B1 (en) | 2003-11-28 | 2006-04-01 | Laboratorios Viñas S.A. | COMPUESTOS MONOHALOGENOVINILDERIVADOS DE VITAMINA D. |
ES2234423B1 (en) * | 2003-12-05 | 2006-03-01 | Laboratorios Viñas, S.A. | PROCEDURE FOR OBTAINING VITAMIN DERIVATIVES FROM MONOHALOGENOVINYL COMPOUNDS. |
CN101193641B (en) * | 2005-05-10 | 2013-05-29 | 德米普瑟尔有限公司 | Compositions and methods for treating hyperproliferative epidermal diseases |
CN101217868A (en) * | 2005-05-10 | 2008-07-09 | 德米普瑟尔有限公司 | Compositions and methods for skin care |
MX2009002337A (en) * | 2006-08-29 | 2009-03-20 | Teva Pharma | Pharmaceutical compositions including vitamin d and corticosteroid. |
CR20170434A (en) | 2009-01-27 | 2017-11-21 | Berg Llc | VITAMIN D3 AND ANALOGS OF THE SAME TO RELIEF SECONDARY EFFECTS ASSOCIATED WITH CHEMOTHERAPY. (Divisional 2011-0445) |
KR101791828B1 (en) | 2009-08-14 | 2017-10-31 | 베르그 엘엘씨 | Vitamin D3 and analogs thereof for treating alopecia |
AR083541A1 (en) * | 2010-10-25 | 2013-03-06 | Teijin Pharma Ltd | DERIVED FROM 23-INO-VITAMIN D |
AU2014274099A1 (en) | 2013-05-29 | 2015-12-24 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin D |
US20190183908A1 (en) | 2016-05-13 | 2019-06-20 | Case Western Reserve University | Autophagy activators for treating or preventing skin injury |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4594432A (en) * | 1983-01-28 | 1986-06-10 | Hoffman-La Roche Inc. | Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol |
US4719205A (en) * | 1984-01-30 | 1988-01-12 | Wisconsin Alumini Research Foundation | Side-chain unsaturated 1-hydroxyvitamin D compounds |
JPS6144860A (en) * | 1984-08-10 | 1986-03-04 | Taisho Pharmaceut Co Ltd | 1alpha, 25-dihydroxy-26,27-dimethylvitamin d3 |
JPS6172652A (en) * | 1984-09-14 | 1986-04-14 | Asahi Glass Co Ltd | Calcium phosphate-based crystalline glass for dental material |
US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
DE3664909D1 (en) * | 1985-05-30 | 1989-09-14 | Taisho Pharmaceutical Co Ltd | Vitamin d3 derivatives |
WO1987000834A1 (en) | 1985-08-02 | 1987-02-12 | Leo Pharmaceutical Products Ltd. A/S | Novel vitamin d analogues |
WO1987003282A1 (en) * | 1985-11-21 | 1987-06-04 | Taisho Pharmaceutical Co., Ltd. | Vitamin d3 derivative |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
DE68907483T2 (en) | 1988-04-21 | 1993-10-21 | Leo Pharm Prod Ltd | VITAMIN D ANALOG. |
US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
US5053401A (en) | 1989-02-28 | 1991-10-01 | Chugai Seiyaku Kabushiki Kaisha | Osteogenesis promotion with use of vitamin d derivatives |
US4948789A (en) | 1989-03-28 | 1990-08-14 | Chugai Seiyaku Kabushiki Kaisha | Suppression of parathyroid hormone synthesis and secretion |
DK0398217T3 (en) * | 1989-05-18 | 1994-02-14 | Hoffmann La Roche | Dehydrocholecalciferol derivatives |
GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
DE4011682A1 (en) * | 1990-04-06 | 1991-10-10 | Schering Ag | 24-OXA DERIVATIVES IN THE VITAMIN D SERIES |
US5200536A (en) * | 1992-02-10 | 1993-04-06 | Daikin Industries Ltd. | Fluorine-containing vitamin D3 analogues |
US5194431A (en) * | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
-
1990
- 1990-08-15 GB GB909017890A patent/GB9017890D0/en active Pending
-
1991
- 1991-07-11 AT AT91914384T patent/ATE115562T1/en not_active IP Right Cessation
- 1991-07-11 RU RU92016313A patent/RU2126384C1/en not_active IP Right Cessation
- 1991-07-11 DK DK91914384.2T patent/DK0543864T3/en active
- 1991-07-11 EP EP91914384A patent/EP0543864B1/en not_active Expired - Lifetime
- 1991-07-11 AU AU84223/91A patent/AU636510B2/en not_active Ceased
- 1991-07-11 ES ES91914384T patent/ES2068601T3/en not_active Expired - Lifetime
- 1991-07-11 WO PCT/DK1991/000200 patent/WO1992003414A1/en active IP Right Grant
- 1991-07-11 CA CA002078555A patent/CA2078555C/en not_active Expired - Fee Related
- 1991-07-11 JP JP51385491A patent/JP3246914B2/en not_active Expired - Fee Related
- 1991-07-11 DE DE69105981T patent/DE69105981T2/en not_active Expired - Fee Related
- 1991-07-15 IE IE246291A patent/IE66241B1/en not_active IP Right Cessation
-
1992
- 1992-09-22 US US07/927,420 patent/US5447924A/en not_active Expired - Fee Related
- 1992-09-30 KR KR1019920702385A patent/KR100203227B1/en not_active IP Right Cessation
- 1992-12-07 FI FI925547A patent/FI103791B1/en active
- 1992-12-17 SK SK3726-92A patent/SK281443B6/en unknown
- 1992-12-17 CZ CZ19923726A patent/CZ286485B6/en not_active IP Right Cessation
-
1993
- 1993-02-15 LV LVP-93-243A patent/LV10089B/en unknown
- 1993-09-10 LT LTIP965A patent/LT3666B/en not_active IP Right Cessation
-
1995
- 1995-02-01 GR GR950400186T patent/GR3014922T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB9017890D0 (en) | 1990-09-26 |
EP0543864A1 (en) | 1993-06-02 |
LT3666B (en) | 1996-01-25 |
FI103791B (en) | 1999-09-30 |
RU2126384C1 (en) | 1999-02-20 |
LV10089A (en) | 1994-05-10 |
FI103791B1 (en) | 1999-09-30 |
ATE115562T1 (en) | 1994-12-15 |
US5447924A (en) | 1995-09-05 |
GR3014922T3 (en) | 1995-05-31 |
LV10089B (en) | 1994-10-20 |
SK281443B6 (en) | 2001-03-12 |
JPH06500089A (en) | 1994-01-06 |
KR100203227B1 (en) | 1999-06-15 |
DE69105981T2 (en) | 1995-04-20 |
DE69105981D1 (en) | 1995-01-26 |
CZ372692A3 (en) | 1993-05-12 |
JP3246914B2 (en) | 2002-01-15 |
DK0543864T3 (en) | 1995-05-08 |
IE912462A1 (en) | 1992-02-26 |
WO1992003414A1 (en) | 1992-03-05 |
CZ286485B6 (en) | 2000-04-12 |
SK372692A3 (en) | 1995-04-12 |
CA2078555A1 (en) | 1992-02-16 |
ES2068601T3 (en) | 1995-04-16 |
FI925547A0 (en) | 1992-12-07 |
AU8422391A (en) | 1992-03-17 |
AU636510B2 (en) | 1993-04-29 |
EP0543864B1 (en) | 1994-12-14 |
CA2078555C (en) | 2002-11-26 |
IE66241B1 (en) | 1995-12-13 |
FI925547A (en) | 1992-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9A | Lapsed patents |
Effective date: 20020910 |