BE904846A - Steroides 11beta-substitues utiles notamment dans le traitement des tumeurs hormono-dependantes et procede pour la fabrication. - Google Patents

Steroides 11beta-substitues utiles notamment dans le traitement des tumeurs hormono-dependantes et procede pour la fabrication.

Info

Publication number
BE904846A
BE904846A BE0/216722A BE216722A BE904846A BE 904846 A BE904846 A BE 904846A BE 0/216722 A BE0/216722 A BE 0/216722A BE 216722 A BE216722 A BE 216722A BE 904846 A BE904846 A BE 904846A
Authority
BE
Belgium
Prior art keywords
11beta
treatment
hormono
production
dependent tumors
Prior art date
Application number
BE0/216722A
Other languages
English (en)
Inventor
F Faustini
R D Alessio
V Villa
E Di Salle
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE904846A publication Critical patent/BE904846A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Les stéroides 11beta-substitués sont des 3-oxo- ou 3-méthylène-4(5), 9(10)-oestradiènes de formule générale ci-dessous. Applications : Compositions pharmaceutiques utiles en médecine humaine ou vétérinaire, notamment comme agents anti-progestérone et antiglucocorticoide et dans le traitement des tumeurs hormono-dépendantes.
BE0/216722A 1985-05-31 1986-05-30 Steroides 11beta-substitues utiles notamment dans le traitement des tumeurs hormono-dependantes et procede pour la fabrication. BE904846A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858513723A GB8513723D0 (en) 1985-05-31 1985-05-31 11-beta substituted steroids

Publications (1)

Publication Number Publication Date
BE904846A true BE904846A (fr) 1986-12-01

Family

ID=10579949

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216722A BE904846A (fr) 1985-05-31 1986-05-30 Steroides 11beta-substitues utiles notamment dans le traitement des tumeurs hormono-dependantes et procede pour la fabrication.

Country Status (21)

Country Link
JP (1) JPS6212796A (fr)
KR (1) KR860009035A (fr)
AU (1) AU587031B2 (fr)
BE (1) BE904846A (fr)
CH (1) CH669385A5 (fr)
DE (1) DE3617883A1 (fr)
DK (1) DK251386A (fr)
ES (1) ES8707972A1 (fr)
FI (1) FI862278A (fr)
FR (1) FR2582654B1 (fr)
GB (2) GB8513723D0 (fr)
GR (1) GR861405B (fr)
HU (1) HU197925B (fr)
IL (1) IL78957A (fr)
IT (1) IT1190014B (fr)
NL (1) NL8601387A (fr)
NZ (1) NZ216325A (fr)
PT (1) PT82665B (fr)
SE (1) SE8602449L (fr)
SU (1) SU1508963A3 (fr)
ZA (1) ZA864065B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2045082T3 (es) * 1987-04-24 1994-01-16 Akzo Nv Un metodo para la preparacion de nuevos derivados 11-arilestrano y 11-arilpregnano.
ES2053714T3 (es) * 1987-12-12 1994-08-01 Akzo Nv Proceso para la preparacion de 11-arilesteroides.
FR2665901B2 (fr) * 1989-02-24 1994-07-29 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
DE19961219A1 (de) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH488682A (de) * 1965-07-30 1970-04-15 Ciba Geigy Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
FR205F (fr) * 1965-10-22
FR5913M (fr) * 1965-12-02 1968-04-01
NL128375C (fr) * 1966-02-18
FR2054525B1 (fr) * 1969-07-28 1973-01-12 Roussel Uclaf
FR2054527B1 (fr) * 1969-07-28 1973-06-08 Roussel Uclaf
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
GB8612866D0 (en) 1986-07-02
ES555298A0 (es) 1987-09-01
NZ216325A (en) 1989-01-27
FI862278A (fi) 1986-12-01
FR2582654B1 (fr) 1988-06-03
DK251386D0 (da) 1986-05-29
PT82665B (pt) 1988-08-17
DK251386A (da) 1986-12-01
SU1508963A3 (ru) 1989-09-15
IT8620598A0 (it) 1986-05-28
AU587031B2 (en) 1989-08-03
FI862278A0 (fi) 1986-05-29
ZA864065B (en) 1987-01-28
IT8620598A1 (it) 1987-11-28
NL8601387A (nl) 1986-12-16
GR861405B (en) 1986-09-26
JPS6212796A (ja) 1987-01-21
DE3617883A1 (de) 1986-12-04
GB2175905A (en) 1986-12-10
ES8707972A1 (es) 1987-09-01
KR860009035A (ko) 1986-12-19
PT82665A (en) 1986-06-01
IL78957A0 (en) 1986-09-30
HUT44575A (en) 1988-03-28
GB8513723D0 (en) 1985-07-03
GB2175905B (en) 1989-01-18
CH669385A5 (fr) 1989-03-15
FR2582654A1 (fr) 1986-12-05
SE8602449D0 (sv) 1986-05-29
IT1190014B (it) 1988-02-10
SE8602449L (sv) 1986-12-01
AU5806286A (en) 1986-12-04
HU197925B (en) 1989-06-28
IL78957A (en) 1990-11-29

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19910531