BE904846A - 11BETA-SUBSTITUTED STEROIDS USEFUL IN PARTICULAR IN THE TREATMENT OF HORMONO-DEPENDENT TUMORS AND METHOD FOR THE PRODUCTION THEREOF. - Google Patents

11BETA-SUBSTITUTED STEROIDS USEFUL IN PARTICULAR IN THE TREATMENT OF HORMONO-DEPENDENT TUMORS AND METHOD FOR THE PRODUCTION THEREOF.

Info

Publication number
BE904846A
BE904846A BE0/216722A BE216722A BE904846A BE 904846 A BE904846 A BE 904846A BE 0/216722 A BE0/216722 A BE 0/216722A BE 216722 A BE216722 A BE 216722A BE 904846 A BE904846 A BE 904846A
Authority
BE
Belgium
Prior art keywords
11beta
treatment
hormono
production
dependent tumors
Prior art date
Application number
BE0/216722A
Other languages
French (fr)
Inventor
F Faustini
R D Alessio
V Villa
E Di Salle
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE904846A publication Critical patent/BE904846A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Les stéroides 11beta-substitués sont des 3-oxo- ou 3-méthylène-4(5), 9(10)-oestradiènes de formule générale ci-dessous. Applications : Compositions pharmaceutiques utiles en médecine humaine ou vétérinaire, notamment comme agents anti-progestérone et antiglucocorticoide et dans le traitement des tumeurs hormono-dépendantes.The 11beta-substituted steroids are 3-oxo- or 3-methylene-4 (5), 9 (10) -oestradienes of the general formula below. Applications: Pharmaceutical compositions useful in human or veterinary medicine, in particular as anti-progesterone and anti-glucocorticoid agents and in the treatment of hormone-dependent tumors.

BE0/216722A 1985-05-31 1986-05-30 11BETA-SUBSTITUTED STEROIDS USEFUL IN PARTICULAR IN THE TREATMENT OF HORMONO-DEPENDENT TUMORS AND METHOD FOR THE PRODUCTION THEREOF. BE904846A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858513723A GB8513723D0 (en) 1985-05-31 1985-05-31 11-beta substituted steroids

Publications (1)

Publication Number Publication Date
BE904846A true BE904846A (en) 1986-12-01

Family

ID=10579949

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216722A BE904846A (en) 1985-05-31 1986-05-30 11BETA-SUBSTITUTED STEROIDS USEFUL IN PARTICULAR IN THE TREATMENT OF HORMONO-DEPENDENT TUMORS AND METHOD FOR THE PRODUCTION THEREOF.

Country Status (21)

Country Link
JP (1) JPS6212796A (en)
KR (1) KR860009035A (en)
AU (1) AU587031B2 (en)
BE (1) BE904846A (en)
CH (1) CH669385A5 (en)
DE (1) DE3617883A1 (en)
DK (1) DK251386A (en)
ES (1) ES8707972A1 (en)
FI (1) FI862278A (en)
FR (1) FR2582654B1 (en)
GB (2) GB8513723D0 (en)
GR (1) GR861405B (en)
HU (1) HU197925B (en)
IL (1) IL78957A (en)
IT (1) IT1190014B (en)
NL (1) NL8601387A (en)
NZ (1) NZ216325A (en)
PT (1) PT82665B (en)
SE (1) SE8602449L (en)
SU (1) SU1508963A3 (en)
ZA (1) ZA864065B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE69820T1 (en) * 1987-04-24 1991-12-15 Akzo Nv 11-ARYLESTRAND DERIVATIVES AND 11-ARYLPREGNAN DERIVATIVES.
EP0321010B1 (en) * 1987-12-12 1993-02-03 Akzo N.V. New 11-arylsteroid compounds
FR2665901B2 (en) * 1989-02-24 1994-07-29 Roussel Uclaf NEW 19-NOR STEROUIDES HAVING IN THE 11BETA POSITION A CARBON CHAIN COMPRISING AN AMIDE FUNCTION, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS.
FR2643638B1 (en) * 1989-02-24 1991-06-14 Roussel Uclaf NOVEL 19-NOR STEROIDS HAVING IN THE 11BETA POSITION A CARBON CHAIN COMPRISING AN AMIDE OR CARBAMATE FUNCTION, THEIR PREPARATION METHOD AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
TWI265167B (en) 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
DE19961219A1 (en) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-phenyltratriene derivatives with fluoroalkyl groups in the aromatic side chain, their preparation and pharmaceutical compositions containing these compounds
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH488682A (en) * 1965-07-30 1970-04-15 Ciba Geigy Process for the preparation of 4,9,11-trienes of the 19-nor-androstane series
FR192F (en) * 1965-10-22
FR5913M (en) * 1965-12-02 1968-04-01
NL128375C (en) * 1966-02-18
FR2054525B1 (en) * 1969-07-28 1973-01-12 Roussel Uclaf
FR2054527B1 (en) * 1969-07-28 1973-06-08 Roussel Uclaf
FR2377418A1 (en) * 1977-01-13 1978-08-11 Roussel Uclaf NEW 4,9-DIENIC 11B-SUBSTITUTE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (en) * 1982-03-01 1986-02-14 Roussel Uclaf NEW PRODUCTS DERIVED FROM THE STRUCTURE 3-CETO 4,9 19-NOR STEROIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
JPS6212796A (en) 1987-01-21
IT1190014B (en) 1988-02-10
AU587031B2 (en) 1989-08-03
DK251386A (en) 1986-12-01
KR860009035A (en) 1986-12-19
IT8620598A1 (en) 1987-11-28
ZA864065B (en) 1987-01-28
ES555298A0 (en) 1987-09-01
GB8612866D0 (en) 1986-07-02
PT82665B (en) 1988-08-17
FI862278A0 (en) 1986-05-29
FR2582654A1 (en) 1986-12-05
GB2175905B (en) 1989-01-18
NZ216325A (en) 1989-01-27
GB8513723D0 (en) 1985-07-03
GB2175905A (en) 1986-12-10
FI862278A (en) 1986-12-01
DE3617883A1 (en) 1986-12-04
DK251386D0 (en) 1986-05-29
HUT44575A (en) 1988-03-28
AU5806286A (en) 1986-12-04
PT82665A (en) 1986-06-01
IL78957A0 (en) 1986-09-30
GR861405B (en) 1986-09-26
SE8602449D0 (en) 1986-05-29
IT8620598A0 (en) 1986-05-28
CH669385A5 (en) 1989-03-15
SE8602449L (en) 1986-12-01
NL8601387A (en) 1986-12-16
IL78957A (en) 1990-11-29
HU197925B (en) 1989-06-28
SU1508963A3 (en) 1989-09-15
FR2582654B1 (en) 1988-06-03
ES8707972A1 (en) 1987-09-01

Similar Documents

Publication Publication Date Title
EP0221041A3 (en) Benzimidazole derivatives, process for their preparation and their pharmaceutical use
FR2442054A1 (en) PURIFIED PROTEINS, IN PARTICULAR INTERFERON, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE3582439D1 (en) MEDICINE FOR TREATING HEART DISEASES.
KR870700599A (en) Carboxylic acid derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses thereof
BE873695A (en) METHOD AND PREPARATION FOR THE INACTIVATION OF VIRUSES AND APPLICATIONS OF THE latter FOR PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF FOOD MATERIALS
FR2333807A1 (en) NEW DERIVATIVES OF FUSIDIC ACID, USEFUL IN PARTICULAR AS AN ANTIBACTERIAL IN HUMAN AND VETERINARY MEDICINE AND THEIR PREPARATION PROCESS
BE904846A (en) 11BETA-SUBSTITUTED STEROIDS USEFUL IN PARTICULAR IN THE TREATMENT OF HORMONO-DEPENDENT TUMORS AND METHOD FOR THE PRODUCTION THEREOF.
ATE31300T1 (en) IMIDAZOLE-2-YL-MERCAPTOALKANIC ACIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM.
BE900012A (en) NEW PEPTIDE.
ATE40793T1 (en) PHARMACEUTICAL PREPARATION FOR THERAPEUTIC TREATMENT OF RHEUMATIC DISEASES.
FR2507605B1 (en) PROCESS FOR THE PREPARATION OF APOVINCAMINIC ACID ESTERS, ESTERS THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS PREPARED THEREWITH
FR2363324A1 (en) AQUEOUS OR HYDROALCOOLIC STABLE SOLUTIONS OF PERFUMED ESSENCES OR OIL SOLUBLE MEDICINAL PRODUCTS
FR2614203B1 (en) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SKIN DISEASES AND ITS PREPARATION METHOD.
FR2612774B1 (en) COSMETIC AND PHARMACEUTICAL COMPOSITIONS USED TO TREAT THE PROCESS OF ANDROGENOGENETIC ALOPECIA, CONTAINING AZELAIC ACID
EP0252033B1 (en) A "gel" pharmaceutical form containing n-(2.6-dichloro-m-tolil)-anthranilic acid (mechlophenamic acid) for use in therapy by topical application
FR2374036A1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING 3-PHENOXYPYRIDINE
TNSN96074A1 (en) PYRROLIDINYL-METHYL-INDOLE SALT
FR2427822A1 (en) MEDICINE FOR THE TREATMENT OF CIRCULATORY DISEASES, BASED ON 5-METHYL-7-DIMETHYLAMINO-S-TRIAZOLO (1,5-A) PYRIMIDINE
FR2392988A1 (en) NEW ESTERS WITH PARTICULAR PHARMACOLOGICAL ACTIVITY, PROCESSES FOR PREPARING SUCH ESTERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2385738A1 (en) NEW STEROIDS OF THE ANDROSTANE SERIES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF DERMATOLOGICAL DISORDERS
FR2603484A1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING (NAPHTYL-2 METHOXY) -4 PIPERIDINE
BE873912A (en) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERLIPOIDEMIA AND HYPERLIPOPROTEINEMIA
BE904737A (en) OCTENOIC ACID DERIVATIVES.
GEP19980954B (en) Ointment “Hypoaskane”
ATE73664T1 (en) PHARMACEUTICALS FOR THE REGULATION OF HORMONAL SECRETIONS AND THE TREATMENT OF FEMALE STERILITY.

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19910531