ES8707972A1 - 11 beta -substituted DELTA <4,9>-steroids - Google Patents

11 beta -substituted DELTA <4,9>-steroids

Info

Publication number
ES8707972A1
ES8707972A1 ES555298A ES555298A ES8707972A1 ES 8707972 A1 ES8707972 A1 ES 8707972A1 ES 555298 A ES555298 A ES 555298A ES 555298 A ES555298 A ES 555298A ES 8707972 A1 ES8707972 A1 ES 8707972A1
Authority
ES
Spain
Prior art keywords
steroids
beta
ofch2
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555298A
Other languages
Spanish (es)
Other versions
ES555298A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8707972A1 publication Critical patent/ES8707972A1/en
Publication of ES555298A0 publication Critical patent/ES555298A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDURE FOR PREPARING NEW 11-B-SUBSTITUTED STEROIDS. IT CONSISTS OF DEHYDRATING A COMPOUND OF FORMULA (II) WITH SULFURIC ACID IN METHANOL AND BETWEEN 0ºC AND 50ºC, TO OBTAIN A COMPOUND OF FORMULA (I). BEING: A, CYCLOALKYL RING FROM C 4 TO 7, PHENYL AND OTHERS; R1 AND R2, H AND TOGETHER OXO OFCH2; RK1 AND RK2, H AND TOGETHER OXO OFCH2; R3, ALKYL FROM C 1 TO 6, ALKYLL FROM C 2 TO 5 AND OTHERS; R4, -A (CH2) N -A-Z; R5, ALKYL FROM C 1 TO 6; R6, HYDROXY; R7, H; Z IS H; Y N, FROM 0 TO 3. IT IS USED FOR THE TREATMENT OF BREAST CANCER AND ENDOMETRY. (Machine-translation by Google Translate, not legally binding)
ES555298A 1985-05-31 1986-05-23 11 beta -substituted DELTA <4,9>-steroids Expired ES8707972A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858513723A GB8513723D0 (en) 1985-05-31 1985-05-31 11-beta substituted steroids

Publications (2)

Publication Number Publication Date
ES8707972A1 true ES8707972A1 (en) 1987-09-01
ES555298A0 ES555298A0 (en) 1987-09-01

Family

ID=10579949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555298A Expired ES8707972A1 (en) 1985-05-31 1986-05-23 11 beta -substituted DELTA <4,9>-steroids

Country Status (21)

Country Link
JP (1) JPS6212796A (en)
KR (1) KR860009035A (en)
AU (1) AU587031B2 (en)
BE (1) BE904846A (en)
CH (1) CH669385A5 (en)
DE (1) DE3617883A1 (en)
DK (1) DK251386A (en)
ES (1) ES8707972A1 (en)
FI (1) FI862278A (en)
FR (1) FR2582654B1 (en)
GB (2) GB8513723D0 (en)
GR (1) GR861405B (en)
HU (1) HU197925B (en)
IL (1) IL78957A (en)
IT (1) IT1190014B (en)
NL (1) NL8601387A (en)
NZ (1) NZ216325A (en)
PT (1) PT82665B (en)
SE (1) SE8602449L (en)
SU (1) SU1508963A3 (en)
ZA (1) ZA864065B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289073B1 (en) * 1987-04-24 1991-11-27 Akzo N.V. Novel 11-aryloestrane and 11-arylpregnane derivatives
ES2053714T3 (en) * 1987-12-12 1994-08-01 Akzo Nv PROCESS FOR THE PREPARATION OF 11-ARILESTEROIDES.
FR2643638B1 (en) * 1989-02-24 1991-06-14 Roussel Uclaf NOVEL 19-NOR STEROIDS HAVING IN THE 11BETA POSITION A CARBON CHAIN COMPRISING AN AMIDE OR CARBAMATE FUNCTION, THEIR PREPARATION METHOD AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2665901B2 (en) * 1989-02-24 1994-07-29 Roussel Uclaf NEW 19-NOR STEROUIDES HAVING IN THE 11BETA POSITION A CARBON CHAIN COMPRISING AN AMIDE FUNCTION, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS.
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
DE19961219A1 (en) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-phenyltratriene derivatives with fluoroalkyl groups in the aromatic side chain, their preparation and pharmaceutical compositions containing these compounds
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH488682A (en) * 1965-07-30 1970-04-15 Ciba Geigy Process for the preparation of 4,9,11-trienes of the 19-nor-androstane series
FR190F (en) * 1965-10-22
FR5913M (en) * 1965-12-02 1968-04-01
NL128375C (en) * 1966-02-18
FR2054525B1 (en) * 1969-07-28 1973-01-12 Roussel Uclaf
FR2054527B1 (en) * 1969-07-28 1973-06-08 Roussel Uclaf
FR2377418A1 (en) * 1977-01-13 1978-08-11 Roussel Uclaf NEW 4,9-DIENIC 11B-SUBSTITUTE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (en) * 1982-03-01 1986-02-14 Roussel Uclaf NEW PRODUCTS DERIVED FROM THE STRUCTURE 3-CETO 4,9 19-NOR STEROIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
DE3617883A1 (en) 1986-12-04
SE8602449D0 (en) 1986-05-29
FR2582654B1 (en) 1988-06-03
IT8620598A1 (en) 1987-11-28
DK251386D0 (en) 1986-05-29
HU197925B (en) 1989-06-28
SU1508963A3 (en) 1989-09-15
IT8620598A0 (en) 1986-05-28
CH669385A5 (en) 1989-03-15
BE904846A (en) 1986-12-01
KR860009035A (en) 1986-12-19
FI862278A0 (en) 1986-05-29
ZA864065B (en) 1987-01-28
IT1190014B (en) 1988-02-10
DK251386A (en) 1986-12-01
HUT44575A (en) 1988-03-28
GR861405B (en) 1986-09-26
GB2175905A (en) 1986-12-10
SE8602449L (en) 1986-12-01
GB8513723D0 (en) 1985-07-03
PT82665B (en) 1988-08-17
GB2175905B (en) 1989-01-18
JPS6212796A (en) 1987-01-21
IL78957A (en) 1990-11-29
PT82665A (en) 1986-06-01
AU587031B2 (en) 1989-08-03
AU5806286A (en) 1986-12-04
NL8601387A (en) 1986-12-16
GB8612866D0 (en) 1986-07-02
NZ216325A (en) 1989-01-27
FI862278A (en) 1986-12-01
ES555298A0 (en) 1987-09-01
IL78957A0 (en) 1986-09-30
FR2582654A1 (en) 1986-12-05

Similar Documents

Publication Publication Date Title
GB1454801A (en) 1,3-oxazino 5,6-c- rifamycins and method for preparing same
FR2424904A1 (en) PROCESS FOR THE PREPARATION OF A, B-UNSATURATED, N-SUBSTITUTES AMIDES
ES8707972A1 (en) 11 beta -substituted DELTA &lt;4,9&gt;-steroids
ES8505999A1 (en) Method of preparation of 7-substitute theophylines. (Machine-translation by Google Translate, not legally binding)
ES331961A1 (en) Procedure for preparing iminotiazolines. (Machine-translation by Google Translate, not legally binding)
DE3160534D1 (en) Process for the preparation of phenylacetonitriles with basic substituents
ES314246A1 (en) The procedure for the preparation of new den-benzodioxyl carbamates. (Machine-translation by Google Translate, not legally binding)
JPS527972A (en) Process for preparing novel morpholine derivatives
JPS5210218A (en) Preparation of beta-sulfenylacrylamides
JPS51138664A (en) Process for preparing 4-exo-hydroxy-endo-tri cyclo 95.2.2.02,6)-undeca-8-ene
ES453121A1 (en) Substituted aminoalkylaminopyridine compounds
JPS5265299A (en) Synthesis of 2-substituted-thioadenosine-n-oxides
ES278409A1 (en) Procedure for preparing new amino acids (Machine-translation by Google Translate, not legally binding)
LU88287I2 (en) Cyproternacetate (Climen)
JPS5359664A (en) Novel imidazole derivatives
FR2360639A1 (en) PREPARATION OF AN AZOMETHINIC PIGMENT
JPS5225854A (en) Epoxy resin composition
ES8402573A1 (en) Process for the preparation of optionally substituted 1,2,3,4-tetrahydro-9-cyanomethyl-carbazol-1-ones.
JPS5239672A (en) Process for preparing indole-2-allyl-3- thioeter compounds
ES8308322A1 (en) 8-Haloalkyl-4H-(1)-benzopyran-4-ones and preparation processes.
ES8404337A1 (en) Process for the inversion of the configuration of optically active compounds, and optically active intermediates for this process.
JPS51133249A (en) A process for preparing alkyl-2,4- dichloro-nitrophenylcarbonates
ES469913A1 (en) 6,11-dihydrodibenzo-(b. e.)-thiepin-11-one-3-aldehyde and 3-acetal derivatives
JPS5283671A (en) 3-substituted-3-alkoxycarbonyl-2-piperidon
JPS51127060A (en) Process for preparing 4-homoisotwistane- exo-2-ol