ES278409A1 - Procedure for preparing new amino acids (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing new amino acids (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES278409A1
ES278409A1 ES278409A ES278409A ES278409A1 ES 278409 A1 ES278409 A1 ES 278409A1 ES 278409 A ES278409 A ES 278409A ES 278409 A ES278409 A ES 278409A ES 278409 A1 ES278409 A1 ES 278409A1
Authority
ES
Spain
Prior art keywords
hydrogen
translation
reaction
procedure
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES278409A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES278409A1 publication Critical patent/ES278409A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing new amino acids, and especially a compound of the formula ** (See formula) ** wherein R1 is selected from the group consisting of hydrogen and alkyls; R2 and R3 are levyalkyls; R4 and R5 are selected from the group consisting of hydrogen and levialcanoyls; R5 is hydrogen when R4 is also hydrogen; X is taken from the group consisting of hydrogen, halogens, hydroxyl, light alkanoyloxy, levyalkyl and trifluoromethyl; and n is a positive integer less than 3 when X is hydrogen, halogen, alkyl or trifluoromethyl, and less than 2 when X is hydroxyl or alkanoyloxy; which comprises the reaction of a formula ketone ** (See formula) ** with ammonium carbonate and a water-soluble cyanide to form a hydantoin; the decomposition of the latter with barium hydroxide to form the corresponding methoxyphenyl amino acid; and hydrolysis by reaction with a hydrohalic acid; or alternatively, the reaction of the ketone with ammonium carbonate and a water-soluble cyanide to directly form an α-amino- α, β -dialyl- β -mononetoxi- or dimethoxyphenylalanine, and, if desired, esterification with a levialcanol in the presence of an acid catalyst, and optional acylation with a levialcanoic anhydride or an alkanoyl halide. (Machine-translation by Google Translate, not legally binding)
ES278409A 1961-08-09 1962-06-08 Procedure for preparing new amino acids (Machine-translation by Google Translate, not legally binding) Expired ES278409A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11590361A 1961-08-09 1961-08-09

Publications (1)

Publication Number Publication Date
ES278409A1 true ES278409A1 (en) 1963-01-16

Family

ID=22364046

Family Applications (1)

Application Number Title Priority Date Filing Date
ES278409A Expired ES278409A1 (en) 1961-08-09 1962-06-08 Procedure for preparing new amino acids (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
BE (1) BE618686A (en)
BR (1) BR6239521D0 (en)
CH (2) CH433375A (en)
ES (1) ES278409A1 (en)
FR (2) FR1500754A (en)
GB (1) GB998355A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
GB9325360D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
AU2006238933B2 (en) * 2005-04-28 2011-12-01 Pfizer Limited Amino acid derivatives

Also Published As

Publication number Publication date
BR6239521D0 (en) 1973-06-14
CH433375A (en) 1967-04-15
BE618686A (en) 1962-12-14
CH431470A (en) 1967-03-15
GB998355A (en) 1965-07-14
FR2297M (en) 1964-01-27
FR1500754A (en) 1967-11-10

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