KR860007283A - a-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법 - Google Patents
a-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법 Download PDFInfo
- Publication number
- KR860007283A KR860007283A KR1019860002220A KR860002220A KR860007283A KR 860007283 A KR860007283 A KR 860007283A KR 1019860002220 A KR1019860002220 A KR 1019860002220A KR 860002220 A KR860002220 A KR 860002220A KR 860007283 A KR860007283 A KR 860007283A
- Authority
- KR
- South Korea
- Prior art keywords
- aspartyl
- phenylalanine
- methyl ester
- formyl
- phenylalanine methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/801—Peptide sweetners
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- L-페닐알라닌 몰당 6몰 이하의 메탄올 존재하 또는 부재하, pH 7∼12에서 페닐알라닌의 10배 이하의 양으로 존재하는 물 중에서 N-포르밀-L-아스파르트 산무수물과 L-페닐알라닌을 축합시켜서 N-포르밀-α-L-아스파르틸-L-페닐알라닌을 생성하고 ;이 N-포르밀-α-L-아스파르틸-L-페닐알라닌을 메탄올 존재하에서 염산과 접촉시켜서 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 염산염을 침전시키기 위해서 이 N-포르밀-α-L-아스파르틸-L-페닐 알라닌을 분리시키지 않고 메탄올 존재하에서 이 반응 혼합물을 염산으로 연속적으로 산성화 시켜서 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 염산염을 분리하고 ;필요에 따라서 이 염산염을 중화 시킴을 특징으로 하는 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 또는 그의 염산염 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5955785A JPH07637B2 (ja) | 1985-03-26 | 1985-03-26 | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩を製造する方法 |
JP59557 | 1985-03-26 | ||
JP66095 | 1985-03-29 | ||
JP6609585A JPH07639B2 (ja) | 1985-03-29 | 1985-03-29 | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860007283A true KR860007283A (ko) | 1986-10-10 |
KR890005038B1 KR890005038B1 (ko) | 1989-12-08 |
Family
ID=26400602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860002220A KR890005038B1 (ko) | 1985-03-26 | 1986-03-25 | α-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US4778916A (ko) |
EP (1) | EP0200311B1 (ko) |
KR (1) | KR890005038B1 (ko) |
AU (1) | AU561384B2 (ko) |
BR (1) | BR8601335A (ko) |
CA (1) | CA1278400C (ko) |
DE (1) | DE3674830D1 (ko) |
ES (1) | ES8705365A1 (ko) |
MX (1) | MX161989A (ko) |
NO (1) | NO168944C (ko) |
SU (1) | SU1556542A3 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
DE3600731A1 (de) * | 1986-01-13 | 1987-07-16 | Green Cross Korea | Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester |
ES2042583T3 (es) * | 1986-12-05 | 1993-12-16 | Mitsui Toatsu Chemicals | Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros. |
NL8701035A (nl) * | 1987-05-01 | 1988-12-01 | Stamicarbon | Werkwijze voor de bereiding van aspartylfenylalaninemethylester uit n-formylaspartylfenylalaninemethylester. |
JP2910228B2 (ja) * | 1990-11-20 | 1999-06-23 | 味の素株式会社 | α―L―アスパルチル―L―フェニルアラニンメチルエステル塩酸塩の製法 |
JP2979761B2 (ja) * | 1991-05-23 | 1999-11-15 | 味の素株式会社 | α−L−アスパルチル−L−フェニルアラニンメチルエステル塩酸塩の製造法 |
JPH05117246A (ja) * | 1991-10-23 | 1993-05-14 | Ajinomoto Co Inc | 新規2,5−ジオキソピペラジン化合物とその製造法及びα−L−アスパルチル−L−フエニルアラニンメチルエステル誘導体の製造法 |
CN102206246A (zh) * | 2011-04-18 | 2011-10-05 | 吴江 | 水相合成N-甲酰-α-L-天门冬氨酰-L-苯丙氨酸的方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE791544A (fr) * | 1971-11-19 | 1973-05-17 | Stamicarbon | Preparation d'esters alkyliques de dipeptide |
JPS4896557A (ko) * | 1972-03-22 | 1973-12-10 | ||
CA1028197A (en) * | 1973-04-02 | 1978-03-21 | Jeffrey H. Berg | Concentrated liquid low calorie sweetener |
US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
JPS5140069A (ko) * | 1974-10-02 | 1976-04-03 | Hitachi Ltd | |
JPS5823380B2 (ja) * | 1974-12-05 | 1983-05-14 | 味の素株式会社 | ホルミルキノ ダツリホウ |
JPS51113841A (en) * | 1975-03-28 | 1976-10-07 | Ajinomoto Co Inc | Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine |
US4088649A (en) * | 1975-07-02 | 1978-05-09 | Firmenich S.A. | Process for preparing a diketo-piperazine |
JPS5223001A (en) * | 1975-08-14 | 1977-02-21 | Ajinomoto Co Inc | Process for elimination of formyl group |
MX4704E (es) * | 1976-12-27 | 1982-08-04 | Monsanto Co | Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina |
JPS5526133A (en) * | 1978-08-11 | 1980-02-25 | Hitachi Ltd | Gripper for tension reel drum |
JPS58185545A (ja) * | 1982-04-22 | 1983-10-29 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
GB8300810D0 (en) * | 1983-01-13 | 1983-02-16 | Erba Farmitalia | Aspartame synthesis |
GB2133409B (en) * | 1983-01-13 | 1986-03-05 | Erba Farmitalia | Aspartame synthesis |
JPH0631312B2 (ja) * | 1983-03-18 | 1994-04-27 | 味の素株式会社 | ジペプチド結晶及びその製造方法 |
JPS59219258A (ja) * | 1983-05-28 | 1984-12-10 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
JPH0613550B2 (ja) * | 1983-06-03 | 1994-02-23 | 味の素株式会社 | α―L―アスパルチル―L―フェニルアラニン―低級アルキルエステルの製造法 |
JPS59225152A (ja) * | 1983-06-02 | 1984-12-18 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
JPS6050200A (ja) * | 1983-08-30 | 1985-03-19 | Nippon Kokan Kk <Nkk> | 金属ストリップのクリーニング洗浄液の浄化装置 |
JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
ES8703487A1 (es) * | 1984-12-27 | 1987-03-01 | Mitsui Toatsu Chemicals | Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester |
JPS61174799A (ja) * | 1985-01-30 | 1986-08-06 | 日本電気ホームエレクトロニクス株式会社 | リ−ド線付円柱状部品の自動供給取付装置 |
AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
-
1986
- 1986-03-06 AU AU54354/86A patent/AU561384B2/en not_active Ceased
- 1986-03-10 CA CA000503684A patent/CA1278400C/en not_active Expired - Fee Related
- 1986-03-10 DE DE8686301681T patent/DE3674830D1/de not_active Expired - Fee Related
- 1986-03-10 EP EP86301681A patent/EP0200311B1/en not_active Expired - Lifetime
- 1986-03-20 MX MX1938A patent/MX161989A/es unknown
- 1986-03-25 SU SU4027212A patent/SU1556542A3/ru active
- 1986-03-25 ES ES553390A patent/ES8705365A1/es not_active Expired
- 1986-03-25 BR BR8601335A patent/BR8601335A/pt unknown
- 1986-03-25 KR KR1019860002220A patent/KR890005038B1/ko not_active IP Right Cessation
- 1986-03-25 NO NO861189A patent/NO168944C/no unknown
-
1987
- 1987-11-17 US US07/122,583 patent/US4778916A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU5435486A (en) | 1986-10-02 |
ES8705365A1 (es) | 1987-05-16 |
AU561384B2 (en) | 1987-05-07 |
ES553390A0 (es) | 1987-05-16 |
NO861189L (no) | 1986-09-29 |
NO168944B (no) | 1992-01-13 |
EP0200311A2 (en) | 1986-11-05 |
EP0200311A3 (en) | 1987-10-28 |
NO168944C (no) | 1992-04-22 |
MX161989A (es) | 1991-03-18 |
CA1278400C (en) | 1990-12-27 |
DE3674830D1 (de) | 1990-11-15 |
EP0200311B1 (en) | 1990-10-10 |
BR8601335A (pt) | 1986-12-02 |
KR890005038B1 (ko) | 1989-12-08 |
US4778916A (en) | 1988-10-18 |
SU1556542A3 (ru) | 1990-04-07 |
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