KR860007283A - a-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법 - Google Patents

a-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법 Download PDF

Info

Publication number
KR860007283A
KR860007283A KR1019860002220A KR860002220A KR860007283A KR 860007283 A KR860007283 A KR 860007283A KR 1019860002220 A KR1019860002220 A KR 1019860002220A KR 860002220 A KR860002220 A KR 860002220A KR 860007283 A KR860007283 A KR 860007283A
Authority
KR
South Korea
Prior art keywords
aspartyl
phenylalanine
methyl ester
formyl
phenylalanine methyl
Prior art date
Application number
KR1019860002220A
Other languages
English (en)
Other versions
KR890005038B1 (ko
Inventor
미따료우이찌
료우이찌 미따
도시오 가또오
쬬오지로 히구찌
다께시 오우라
아끼히로 야구찌
Original Assignee
미쓰이도오아쓰가가꾸가부시끼가이샤
도즈까 야스아끼
미쓰이도오 아쓰 가가꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5955785A external-priority patent/JPH07637B2/ja
Priority claimed from JP6609585A external-priority patent/JPH07639B2/ja
Application filed by 미쓰이도오아쓰가가꾸가부시끼가이샤, 도즈까 야스아끼, 미쓰이도오 아쓰 가가꾸 가부시끼 가이샤 filed Critical 미쓰이도오아쓰가가꾸가부시끼가이샤
Publication of KR860007283A publication Critical patent/KR860007283A/ko
Application granted granted Critical
Publication of KR890005038B1 publication Critical patent/KR890005038B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/801—Peptide sweetners

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)

Abstract

내용 없음

Description

α-L-아스파리틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. L-페닐알라닌 몰당 6몰 이하의 메탄올 존재하 또는 부재하, pH 7∼12에서 페닐알라닌의 10배 이하의 양으로 존재하는 물 중에서 N-포르밀-L-아스파르트 산무수물과 L-페닐알라닌을 축합시켜서 N-포르밀-α-L-아스파르틸-L-페닐알라닌을 생성하고 ;
    이 N-포르밀-α-L-아스파르틸-L-페닐알라닌을 메탄올 존재하에서 염산과 접촉시켜서 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 염산염을 침전시키기 위해서 이 N-포르밀-α-L-아스파르틸-L-페닐 알라닌을 분리시키지 않고 메탄올 존재하에서 이 반응 혼합물을 염산으로 연속적으로 산성화 시켜서 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 염산염을 분리하고 ;
    필요에 따라서 이 염산염을 중화 시킴을 특징으로 하는 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 또는 그의 염산염 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002220A 1985-03-26 1986-03-25 α-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법 KR890005038B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5955785A JPH07637B2 (ja) 1985-03-26 1985-03-26 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩を製造する方法
JP59557 1985-03-26
JP6609585A JPH07639B2 (ja) 1985-03-29 1985-03-29 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
JP66095 1985-03-29

Publications (2)

Publication Number Publication Date
KR860007283A true KR860007283A (ko) 1986-10-10
KR890005038B1 KR890005038B1 (ko) 1989-12-08

Family

ID=26400602

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860002220A KR890005038B1 (ko) 1985-03-26 1986-03-25 α-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법

Country Status (11)

Country Link
US (1) US4778916A (ko)
EP (1) EP0200311B1 (ko)
KR (1) KR890005038B1 (ko)
AU (1) AU561384B2 (ko)
BR (1) BR8601335A (ko)
CA (1) CA1278400C (ko)
DE (1) DE3674830D1 (ko)
ES (1) ES8705365A1 (ko)
MX (1) MX161989A (ko)
NO (1) NO168944C (ko)
SU (1) SU1556542A3 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
EP0270345B1 (en) * 1986-12-05 1992-07-22 MITSUI TOATSU CHEMICALS, Inc. Preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester or hydrohalide thereof
NL8701035A (nl) * 1987-05-01 1988-12-01 Stamicarbon Werkwijze voor de bereiding van aspartylfenylalaninemethylester uit n-formylaspartylfenylalaninemethylester.
JP2910228B2 (ja) * 1990-11-20 1999-06-23 味の素株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩の製法
JP2979761B2 (ja) * 1991-05-23 1999-11-15 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
CN102206246A (zh) * 2011-04-18 2011-10-05 吴江 水相合成N-甲酰-α-L-天门冬氨酰-L-苯丙氨酸的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791544A (fr) * 1971-11-19 1973-05-17 Stamicarbon Preparation d'esters alkyliques de dipeptide
JPS4896557A (ko) * 1972-03-22 1973-12-10
CA1028197A (en) * 1973-04-02 1978-03-21 Jeffrey H. Berg Concentrated liquid low calorie sweetener
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5140069A (ko) * 1974-10-02 1976-04-03 Hitachi Ltd
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ
JPS51113841A (en) * 1975-03-28 1976-10-07 Ajinomoto Co Inc Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine
US4088649A (en) * 1975-07-02 1978-05-09 Firmenich S.A. Process for preparing a diketo-piperazine
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
JPS5526133A (en) * 1978-08-11 1980-02-25 Hitachi Ltd Gripper for tension reel drum
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
GB8300810D0 (en) * 1983-01-13 1983-02-16 Erba Farmitalia Aspartame synthesis
GB2133409B (en) * 1983-01-13 1986-03-05 Erba Farmitalia Aspartame synthesis
JPH0631312B2 (ja) * 1983-03-18 1994-04-27 味の素株式会社 ジペプチド結晶及びその製造方法
JPS59219258A (ja) * 1983-05-28 1984-12-10 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
JPS59225152A (ja) * 1983-06-02 1984-12-18 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
JPH0613550B2 (ja) * 1983-06-03 1994-02-23 味の素株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニン―低級アルキルエステルの製造法
JPS6050200A (ja) * 1983-08-30 1985-03-19 Nippon Kokan Kk <Nkk> 金属ストリップのクリーニング洗浄液の浄化装置
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
CA1277098C (en) * 1984-12-27 1990-11-27 Mitsui Toatsu Chemicals, Inc. Preparation process of -l-aspartyl-l-phenylalanine methyl ester
JPS61174799A (ja) * 1985-01-30 1986-08-06 日本電気ホームエレクトロニクス株式会社 リ−ド線付円柱状部品の自動供給取付装置
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof

Also Published As

Publication number Publication date
SU1556542A3 (ru) 1990-04-07
ES8705365A1 (es) 1987-05-16
EP0200311A2 (en) 1986-11-05
ES553390A0 (es) 1987-05-16
NO168944B (no) 1992-01-13
EP0200311B1 (en) 1990-10-10
EP0200311A3 (en) 1987-10-28
US4778916A (en) 1988-10-18
AU561384B2 (en) 1987-05-07
DE3674830D1 (de) 1990-11-15
BR8601335A (pt) 1986-12-02
NO861189L (no) 1986-09-29
NO168944C (no) 1992-04-22
CA1278400C (en) 1990-12-27
AU5435486A (en) 1986-10-02
MX161989A (es) 1991-03-18
KR890005038B1 (ko) 1989-12-08

Similar Documents

Publication Publication Date Title
GB1464140A (en) Alpha-l-aspartyl-l-phenylalanine derivatives
LU91087I2 (fr) Advate(Octocog alfa) soustotes ses formes protégées par le brevet de base.
ATE254667T1 (de) Nukleinsäuresonden zum nachweis von e. coli 0157:h7
KR860007283A (ko) a-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법
KR880011332A (ko) 미생물에 의한 l-페닐 알라닌의 제조방법
KR910016767A (ko) 신규한 펩티드
AU567747B2 (en) Early detection of mammalian pregnancy
KR870006084A (ko) N-포르밀-α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 제조방법
KR860007284A (ko) α-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염의 제조방법
KR850000466A (ko) α-L-아스파르틸-L-페닐알라닌메틸에스테르 및 그의 염산염의 제조방법
ES2148667T3 (es) Procedimiento para la carbonilacion de butadieno o un derivado de butadieno.
KR860006486A (ko) α－L－아스파르틸－L－페닐알라닌 메틸 에스테르의 제조방법
KR900011470A (ko) 외용제
KR840002346A (ko) 펩타이드의 제조방법
DE69830307D1 (de) Verfahren zur herstellung pharmakologisch verträglicher salze von n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl aminosäuren
KR910014122A (ko) 에토포시드-2-디메틸아미노 화합물의 동결건조 제제
KR870001236A (ko) N-보호된-L-α-아스파틸-L-페닐알라닌의 제조 방법
KR850008271A (ko) α-L-아스파틸-L-페닐알라닌 에스텔(α-L-Aspartyl-L-Phenylalanine ester)의 제조방법
KR890013054A (ko) α-L-아스파르틸-L-페닐알라닌 메틸에스테르의 제조방법
NO982227L (no) Urogenitalcarcinom-TPL komplekspeptider og antistoffer derav
ATE109468T1 (de) Verbindungen zur einführung einer sh-gruppe in tyrosin.
KR860003787A (ko) α-L-아스파틸-L-페닐알라닌 에스테르 제조방법
KR900000323A (ko) 비닐 아세테이트의 제조방법
KR880009040A (ko) α-L-아스파르틸-L-페닐알라닌 메틸에스테르의 제조방법
KR920005894A (ko) 액상 조미 농축액

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20011128

Year of fee payment: 13

LAPS Lapse due to unpaid annual fee