ES2042583T3 - Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros. - Google Patents

Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros.

Info

Publication number
ES2042583T3
ES2042583T3 ES87310584T ES87310584T ES2042583T3 ES 2042583 T3 ES2042583 T3 ES 2042583T3 ES 87310584 T ES87310584 T ES 87310584T ES 87310584 T ES87310584 T ES 87310584T ES 2042583 T3 ES2042583 T3 ES 2042583T3
Authority
ES
Spain
Prior art keywords
aspartil
alpha
methyl ester
phenyl alanine
alanina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87310584T
Other languages
English (en)
Inventor
Ryuichi Mita
Toshio Katoh
Chojiro Higuchi
Takeshi Oura
Akihiro Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP28888986A external-priority patent/JPH07116226B2/ja
Priority claimed from JP61288888A external-priority patent/JPH07116225B2/ja
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of ES2042583T3 publication Critical patent/ES2042583T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Abstract

SE OBTIENE ESTER METIL (ALFA)-L-ASPARTIL-L-FENIL ALANINA O SU HIDROHALURO ESTERIFICANDO (ALFA)-L-ASPARTIL-L-FENIL ALANINA O (ALFA)-L-ASPARTIL-L-FENILALANINA QUE SE HA OBTENIDO IN SITU TRATANDO UNA (ALFA)-L-ASPARTIL-L-FENIL ALANINA PROTEGIDA EN N EN UNA DISOLUCION ACUOSA DE ACIDO SULFURICO O UNA DISOLUCION ACUOSA DE ACIDO SULFURICO QUE CONTIENE METANOL EN PRESENCIA DE UN HALURO DE METAL ALCALINO O DE METAL ALCALINOTERREO EN UN MEDIO COMPUESTO DE ACIDO SULFURICO, AGUA Y METANOL, CON LO QUE SEPERMITE QUE EL ESTER METIL (ALFA)-L-ASPARTIL-L-FENIL ALANINA RESULTANTE PRECIPITE COMO SU CORRESPONDIENTE HIDROHALURO, Y LUEGO AISLANDO EL HIDROHALURO, Y CUANDO SE DESEA LA OBTENCION DEL ESTER METILICO, NEUTRALIZANDO EL HIDROHALURO.
ES87310584T 1986-12-05 1987-12-01 Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros. Expired - Lifetime ES2042583T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28888986A JPH07116226B2 (ja) 1986-12-05 1986-12-05 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはそのハロゲン化水素酸塩の製法
JP61288888A JPH07116225B2 (ja) 1986-12-05 1986-12-05 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルのハロゲン化水素酸塩の製造方法

Publications (1)

Publication Number Publication Date
ES2042583T3 true ES2042583T3 (es) 1993-12-16

Family

ID=26557366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87310584T Expired - Lifetime ES2042583T3 (es) 1986-12-05 1987-12-01 Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros.

Country Status (8)

Country Link
US (1) US4918216A (es)
EP (1) EP0270345B1 (es)
KR (1) KR900003726B1 (es)
AU (1) AU587351B2 (es)
BR (1) BR8706569A (es)
CA (1) CA1298682C (es)
DE (1) DE3780585T2 (es)
ES (1) ES2042583T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3239431B2 (ja) * 1991-05-31 2001-12-17 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルまたはその塩酸塩の製造方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833553A (en) * 1970-01-31 1974-09-03 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters
BE791544A (fr) * 1971-11-19 1973-05-17 Stamicarbon Preparation d'esters alkyliques de dipeptide
JPS4896557A (es) * 1972-03-22 1973-12-10
CA1028197A (en) * 1973-04-02 1978-03-21 Jeffrey H. Berg Concentrated liquid low calorie sweetener
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
JPS5140069A (es) * 1974-10-02 1976-04-03 Hitachi Ltd
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ
JPS51113841A (en) * 1975-03-28 1976-10-07 Ajinomoto Co Inc Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine
US4088649A (en) * 1975-07-02 1978-05-09 Firmenich S.A. Process for preparing a diketo-piperazine
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
US4333872A (en) * 1980-05-27 1982-06-08 Chimicasa Gmbh Method of producing α-L-aspartyl-L-phenylalanine methylester
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
GB2133409B (en) * 1983-01-13 1986-03-05 Erba Farmitalia Aspartame synthesis
GB8300810D0 (en) * 1983-01-13 1983-02-16 Erba Farmitalia Aspartame synthesis
JPS59219258A (ja) * 1983-05-28 1984-12-10 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
JPH0613550B2 (ja) * 1983-06-03 1994-02-23 味の素株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニン―低級アルキルエステルの製造法
JPS59225152A (ja) * 1983-06-02 1984-12-18 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
JPS6050200A (ja) * 1983-08-30 1985-03-19 Nippon Kokan Kk <Nkk> 金属ストリップのクリーニング洗浄液の浄化装置
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
CA1277098C (en) * 1984-12-27 1990-11-27 Mitsui Toatsu Chemicals, Inc. Preparation process of -l-aspartyl-l-phenylalanine methyl ester
JPH0680074B2 (ja) * 1985-07-01 1994-10-12 味の素株式会社 Ｎ―ホルミル―Ｌ―α―アスパルチル―Ｌ―フェニルアラニンの製法
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
JPH07637B2 (ja) * 1985-03-26 1995-01-11 三井東圧化学株式会社 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩を製造する方法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof

Also Published As

Publication number Publication date
AU8204987A (en) 1988-06-09
DE3780585D1 (de) 1992-08-27
DE3780585T2 (de) 1993-03-18
EP0270345A2 (en) 1988-06-08
BR8706569A (pt) 1988-07-12
EP0270345B1 (en) 1992-07-22
EP0270345A3 (en) 1989-05-24
KR900003726B1 (ko) 1990-05-30
CA1298682C (en) 1992-04-07
US4918216A (en) 1990-04-17
AU587351B2 (en) 1989-08-10
KR880007003A (ko) 1988-08-26

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