DE3780585D1 - Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide. - Google Patents
Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.Info
- Publication number
- DE3780585D1 DE3780585D1 DE8787310584T DE3780585T DE3780585D1 DE 3780585 D1 DE3780585 D1 DE 3780585D1 DE 8787310584 T DE8787310584 T DE 8787310584T DE 3780585 T DE3780585 T DE 3780585T DE 3780585 D1 DE3780585 D1 DE 3780585D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrohalides
- aspartyl
- alpha
- production
- methyl esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 ALPHA-L-ASPARTYL-L-PHENYLALANINE METHYL ESTERS Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61288888A JPH07116225B2 (ja) | 1986-12-05 | 1986-12-05 | α−L−アスパルチル−L−フエニルアラニンメチルエステルのハロゲン化水素酸塩の製造方法 |
JP28888986A JPH07116226B2 (ja) | 1986-12-05 | 1986-12-05 | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはそのハロゲン化水素酸塩の製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3780585D1 true DE3780585D1 (de) | 1992-08-27 |
DE3780585T2 DE3780585T2 (de) | 1993-03-18 |
Family
ID=26557366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787310584T Expired - Fee Related DE3780585T2 (de) | 1986-12-05 | 1987-12-01 | Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4918216A (de) |
EP (1) | EP0270345B1 (de) |
KR (1) | KR900003726B1 (de) |
AU (1) | AU587351B2 (de) |
BR (1) | BR8706569A (de) |
CA (1) | CA1298682C (de) |
DE (1) | DE3780585T2 (de) |
ES (1) | ES2042583T3 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3239431B2 (ja) * | 1991-05-31 | 2001-12-17 | 味の素株式会社 | α−L−アスパルチル−L−フェニルアラニンメチルエステルまたはその塩酸塩の製造方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3833553A (en) * | 1970-01-31 | 1974-09-03 | Ajinomoto Kk | Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters |
BE791544A (fr) * | 1971-11-19 | 1973-05-17 | Stamicarbon | Preparation d'esters alkyliques de dipeptide |
JPS4896557A (de) * | 1972-03-22 | 1973-12-10 | ||
CA1028197A (en) * | 1973-04-02 | 1978-03-21 | Jeffrey H. Berg | Concentrated liquid low calorie sweetener |
US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
JPS5113737A (en) * | 1974-07-23 | 1976-02-03 | Ajinomoto Kk | Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho |
JPS5140069A (de) * | 1974-10-02 | 1976-04-03 | Hitachi Ltd | |
JPS5823380B2 (ja) * | 1974-12-05 | 1983-05-14 | 味の素株式会社 | ホルミルキノ ダツリホウ |
JPS51113841A (en) * | 1975-03-28 | 1976-10-07 | Ajinomoto Co Inc | Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine |
US4088649A (en) * | 1975-07-02 | 1978-05-09 | Firmenich S.A. | Process for preparing a diketo-piperazine |
JPS5223001A (en) * | 1975-08-14 | 1977-02-21 | Ajinomoto Co Inc | Process for elimination of formyl group |
US4173562A (en) * | 1976-12-27 | 1979-11-06 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
MX4704E (es) * | 1976-12-27 | 1982-08-04 | Monsanto Co | Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina |
US4333872A (en) * | 1980-05-27 | 1982-06-08 | Chimicasa Gmbh | Method of producing α-L-aspartyl-L-phenylalanine methylester |
JPS58185545A (ja) * | 1982-04-22 | 1983-10-29 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
GB8300810D0 (en) * | 1983-01-13 | 1983-02-16 | Erba Farmitalia | Aspartame synthesis |
GB2133409B (en) * | 1983-01-13 | 1986-03-05 | Erba Farmitalia | Aspartame synthesis |
JPS59219258A (ja) * | 1983-05-28 | 1984-12-10 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
JPS59225152A (ja) * | 1983-06-02 | 1984-12-18 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
JPH0613550B2 (ja) * | 1983-06-03 | 1994-02-23 | 味の素株式会社 | α―L―アスパルチル―L―フェニルアラニン―低級アルキルエステルの製造法 |
JPS6050200A (ja) * | 1983-08-30 | 1985-03-19 | Nippon Kokan Kk <Nkk> | 金属ストリップのクリーニング洗浄液の浄化装置 |
JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
CA1277098C (en) * | 1984-12-27 | 1990-11-27 | Mitsui Toatsu Chemicals, Inc. | Preparation process of -l-aspartyl-l-phenylalanine methyl ester |
JPH0680074B2 (ja) * | 1985-07-01 | 1994-10-12 | 味の素株式会社 | N―ホルミル―L―α―アスパルチル―L―フェニルアラニンの製法 |
AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
JPH07637B2 (ja) * | 1985-03-26 | 1995-01-11 | 三井東圧化学株式会社 | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩を製造する方法 |
AU586669B2 (en) * | 1985-03-29 | 1989-07-20 | Mitsui Toatsu Chemicals Inc. | Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
-
1987
- 1987-12-01 DE DE8787310584T patent/DE3780585T2/de not_active Expired - Fee Related
- 1987-12-01 EP EP87310584A patent/EP0270345B1/de not_active Expired - Lifetime
- 1987-12-01 ES ES87310584T patent/ES2042583T3/es not_active Expired - Lifetime
- 1987-12-03 AU AU82049/87A patent/AU587351B2/en not_active Ceased
- 1987-12-03 CA CA000553487A patent/CA1298682C/en not_active Expired - Fee Related
- 1987-12-04 BR BR8706569A patent/BR8706569A/pt unknown
- 1987-12-05 KR KR1019870013880A patent/KR900003726B1/ko not_active IP Right Cessation
-
1989
- 1989-05-25 US US07/357,618 patent/US4918216A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BR8706569A (pt) | 1988-07-12 |
AU587351B2 (en) | 1989-08-10 |
EP0270345B1 (de) | 1992-07-22 |
CA1298682C (en) | 1992-04-07 |
US4918216A (en) | 1990-04-17 |
KR900003726B1 (ko) | 1990-05-30 |
EP0270345A3 (en) | 1989-05-24 |
EP0270345A2 (de) | 1988-06-08 |
DE3780585T2 (de) | 1993-03-18 |
KR880007003A (ko) | 1988-08-26 |
AU8204987A (en) | 1988-06-09 |
ES2042583T3 (es) | 1993-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP |
|
8339 | Ceased/non-payment of the annual fee |