KR860006486A - α－L－아스파르틸－L－페닐알라닌 메틸 에스테르의 제조방법 - Google Patents

α－L－아스파르틸－L－페닐알라닌 메틸 에스테르의 제조방법 Download PDF

Info

Publication number
KR860006486A
KR860006486A KR1019850009883A KR850009883A KR860006486A KR 860006486 A KR860006486 A KR 860006486A KR 1019850009883 A KR1019850009883 A KR 1019850009883A KR 850009883 A KR850009883 A KR 850009883A KR 860006486 A KR860006486 A KR 860006486A
Authority
KR
South Korea
Prior art keywords
aspartyl
phenylalanine
formyl
hydrochloric acid
acid
Prior art date
Application number
KR1019850009883A
Other languages
English (en)
Other versions
KR890005064B1 (ko
Inventor
미따류이찌(외4)
Original Assignee
도즈까 야스아끼
미쓰이 도오아쓰 가가꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59273701A external-priority patent/JPS61152698A/ja
Priority claimed from JP60036530A external-priority patent/JPS61197592A/ja
Application filed by 도즈까 야스아끼, 미쓰이 도오아쓰 가가꾸 가부시끼가이샤 filed Critical 도즈까 야스아끼
Publication of KR860006486A publication Critical patent/KR860006486A/ko
Application granted granted Critical
Publication of KR890005064B1 publication Critical patent/KR890005064B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

α－L－아스파르틸－L－페닐알라닌 메틸 에스테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 출발물질인 N－포르밀－α－L－아스파르틸－L－페닐알라닌을 산존재하에 메탄올 중에서 처리하여 주요 산물로 α－L－아스파르틸－L－페닐알라닌 디메틸 에스테르를 제조하고, α－L－아스파르틸－L－페닐알라닌 디메틸 에스테르 메탄올 존재하에 염산과 접촉시켜 가수분해한 뒤, 칠전된 α－L－아스파르틸－L－페닐알라닌 메틸 에스테르 히드로클로라이드를 분리하고, 이 히드로클로라이드를 중화함을 특징으로 하는, α－L－아스파르틸－L－페닐알라닌 메틸 에스테르의 제조방법.
  2. 제 1 항 있어서, 출발물질로 사용된 N－포르밀－α－L－아스파르틸－L－페닐알라닌이 30중량% 이하의 N－포르밀－β－L－아스파르틸－L－페닐알라닌을 함유하는 방법.
  3. 제 1 또는 2항에 있어서, 산이 무기산인 방법.
  4. 제 1 또는 2항에 있어서, 산이 유기술폰산인 방법.
  5. 제 1 또는 2항에 있어서, 10－70℃의 온도로 처리하여 α－L－아스파르틸－L－페닐알라닌 디메틸 에스테르를 제조하는 방법.
  6. 제 1 또는 2항에 있어서, α－L－아스파르틸－L－페닐알라닌 디메틸 에스테르와 접촉시키는 염산의 농도가 [염산/(염산＋수용액)]×100으로 3－30중량%인 방법.
  7. 제 1 또는 2항에 있어서, 사용된 염산의 양이 출발물질로 사용한 N－포르밀－α－L－아스파르틸－L－페닐알라닌의 몰 당, 또는 β－이성질체가 함유된 경우, N－포르밀－α－L－아스파르틸－L－페닐알라닌과 N－포르밀－β－L－아스파르틸－L－페닐알라닌의 혼합물의 몰당 0.5－10몰인 방법.
  8. 제 1 또는 2항에 있어서, α－L－아스파르틸－L－페닐 알라닌 디메틸 에스테르를 염산과 접촉시킴으로써 가수분해시켜 α－L－아스파르틸－L－페닐알라닌 메틸 메스테르 염산염을 제조하는데 필요한 메탄올의 양이 출발물질로 사용한 N－포르밀－α－L－아스파르틸－L－페닐알라닌의 물 당, 또는 β－이성질체가 함유된 경우, N－포르밀－α－L－아스파르틸－L－페닐알라닌과 N－포르밀－β－L－아스파르틸－L－페닐알라닌의 혼합물의 몰당 5몰 이하인 방법.
  9. 제 1 또는 2항에 있어서, α－L－아스파르틸－L－페닐알라닌 디메틸 에스테르와 염산을 접촉시키는 온도가 0－ 50℃인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850009883A 1984-12-27 1985-12-27 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법 KR890005064B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP273701 1984-12-27
JP59273701A JPS61152698A (ja) 1984-12-27 1984-12-27 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
JP60036530A JPS61197592A (ja) 1985-02-27 1985-02-27 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JP36530 1985-02-27

Publications (2)

Publication Number Publication Date
KR860006486A true KR860006486A (ko) 1986-09-11
KR890005064B1 KR890005064B1 (ko) 1989-12-09

Family

ID=26375586

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850009883A KR890005064B1 (ko) 1984-12-27 1985-12-27 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법

Country Status (6)

Country Link
US (1) US4801732A (ko)
EP (1) EP0187530A3 (ko)
KR (1) KR890005064B1 (ko)
BR (1) BR8506513A (ko)
CA (1) CA1277098C (ko)
ES (1) ES8703487A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
DE3780585T2 (de) * 1986-12-05 1993-03-18 Mitsui Toatsu Chemicals Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.
NL8701035A (nl) * 1987-05-01 1988-12-01 Stamicarbon Werkwijze voor de bereiding van aspartylfenylalaninemethylester uit n-formylaspartylfenylalaninemethylester.
US4892820A (en) * 1987-06-10 1990-01-09 The Nutrasweet Company Solvent system for enzymatic coupling process
JP2979761B2 (ja) * 1991-05-23 1999-11-15 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造法
JP3239452B2 (ja) * 1992-08-05 2001-12-17 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS461370Y1 (ko) * 1966-05-25 1971-01-19
BE791544A (fr) * 1971-11-19 1973-05-17 Stamicarbon Preparation d'esters alkyliques de dipeptide
JPS4896557A (ko) * 1972-03-22 1973-12-10
CA1028197A (en) * 1973-04-02 1978-03-21 Jeffrey H. Berg Concentrated liquid low calorie sweetener
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5140069A (ko) * 1974-10-02 1976-04-03 Hitachi Ltd
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ
JPS51113841A (en) * 1975-03-28 1976-10-07 Ajinomoto Co Inc Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine
US4088649A (en) * 1975-07-02 1978-05-09 Firmenich S.A. Process for preparing a diketo-piperazine
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
GB8300810D0 (en) * 1983-01-13 1983-02-16 Erba Farmitalia Aspartame synthesis
JPS59219258A (ja) * 1983-05-28 1984-12-10 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
JPS59225152A (ja) * 1983-06-02 1984-12-18 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
JPH0613550B2 (ja) * 1983-06-03 1994-02-23 味の素株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニン―低級アルキルエステルの製造法
JPS6050200A (ja) * 1983-08-30 1985-03-19 Nippon Kokan Kk <Nkk> 金属ストリップのクリーニング洗浄液の浄化装置
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法

Also Published As

Publication number Publication date
KR890005064B1 (ko) 1989-12-09
US4801732A (en) 1989-01-31
ES8703487A1 (es) 1987-03-01
EP0187530A2 (en) 1986-07-16
CA1277098C (en) 1990-11-27
EP0187530A3 (en) 1988-07-20
ES550282A0 (es) 1987-03-01
BR8506513A (pt) 1986-09-02

Similar Documents

Publication Publication Date Title
KR860003013A (ko) 안정화된 피록시캄 주사용액의 제조방법
KR830001375A (ko) 박테리아 발효에 의한 다당류 s-60의 제조방법
KR840009295A (ko) α-L-아스파르틸-L-페닐아라딘 메틸에스테르 및 그의 염산염의 제조방법
KR860006486A (ko) α－L－아스파르틸－L－페닐알라닌 메틸 에스테르의 제조방법
GB1546979A (en) Process for the preparation of alpha-l-aspartyl-l-phenylallanine methyl ester
KR860007214A (ko) 2-아미노-3-니트로-6-(4-플루오로벤질아미노)-피리딘 및 2-아미노-3-카브에톡시아미노-6-(4-플루오로-벤질아미노)- 피리딘의 제조방법
HUP0102098A2 (hu) Eljárás gél előállítására polivinilalkoholból, és az eljárás szerint előállított, nagy mechanikai stabilitású gél
KR850000466A (ko) α-L-아스파르틸-L-페닐알라닌메틸에스테르 및 그의 염산염의 제조방법
KR860007283A (ko) a-L-아스파르틸-L-페닐알라닌 메틸에스테르 또는 그의 염산염 제조방법
ATE38513T1 (de) Herstellung von mexamin.
JPS5535059A (en) Preparation of lower alkyl ester of alpha-l-aspartyl-l- phenylalanine
JPS53135925A (en) Decomposition of microbial cells
ATE16188T1 (de) Herstellung von bis-carbo xyethylgermaniumsesquioxyd und seiner propionsaeurederivate.
KR840006197A (ko) N-포르밀-l-아스파르트산 무수물의 제조방법
JPS548688A (en) Novel cation-modified polypeptide and its preparation
KR850001526A (ko) 분말상 섬유소 글리코올 칼슘의 제조법
KR890006561A (ko) 디알킬 디클로로숙시네이트의 개선된 제조방법
KR890001470A (ko) 전분질 식물체를 원료로 한 기호성 청량음료 원액의 제조방법
KR860009020A (ko) 히드록시메틸세펨 화합물의 제조방법
KR890015993A (ko) 피루베이트 제조 방법
KR900004712A (ko) 하이드로스민의 제조방법
GB1443097A (en) L-asparate of cyclic erythromycin a 6,9-hemiacetal carbonate and process of preparing the same
GB1491772A (en) Method for purifying 11-cyano-undecanoic acid
KR880007003A (ko) α-L-아스파르틸-L-페닐알라닌메틸에스테르 또는 그 할로겐화수소산의 제법
KR890000414A (ko) 엘-시스틴의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee